J Cell Physiol September 2020 PMID 31990070

Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma.

Ekaterina V Semina, Kseniya A Rubina, Anna A Shmakova, Karina D Rysenkova, Polina S Klimovich, Natalya A Aleksanrushkina, Veronika Y Sysoeva, Maxim N Karagyaur, Vsevolod A Tkachuk

Mentions

2
Peak: 1 in Apr 2020
across 2 sources since Apr 2020

Extended reach

497
potential audience

Total likes

7

Video views

336

Mentions per month

Apr 2020 – Feb 2021

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

This discussion reflects a positive but surface-level response, appreciating the inclusion of RRIDs to support reproducibility. The tone is supportive and focused on scientific integrity rather than the article's broader implications, showing moderate agreement and interest with minimal engagement and impact.

AgreementModerate agreement

The discussion shows moderate support for the publication, highlighted by appreciation for reproducibility efforts, indicating alignment with scientific standards.

InterestModerate interest

The post expresses some interest by focusing on reproducibility, but overall engagement with the research's implications is limited.

EngagementNeutral engagement

The comment is brief and primarily praise rather than a deep exploration of the findings, reflecting low-to-moderate engagement.

ImpactNeutral impact

The post's content does not suggest a significant impact of the research; instead, it emphasizes methodological support, which is important but not groundbreaking.

Abstract in brief

  • Downregulating uPAR in neuroblastoma cells promotes their transition from an epithelial to a mesenchymal state, which increases their ability to migrate.
  • The study shows that uPAR helps maintain epithelial characteristics like cell adhesion, and removing uPAR reduces these traits while increasing mesenchymal markers, facilitating tumor progression.
  • Without uPAR, uPA moves into the nucleus, likely activating transcription factors that drive the epithelial-to-mesenchymal transition, suggesting a new role for uPA in cancer cell behavior.]

Top posts

Most liked on X and Bluesky
RRID Robot
@RobotRrid · X

The authors of "Downregulation of uPAR promotes urokinase transloc…" (https://t.co/gW0oQUNEFQ) included RRIDs in their paper! We appreciate the author's support of reproducibility. #reproducibility #STMpublishing

Feb 25, 2021 · 161 followers View post →

All mentions

RRID Robot
@RobotRrid · X

The authors of "Downregulation of uPAR promotes urokinase transloc…" (https://t.co/gW0oQUNEFQ) included RRIDs in their paper! We appreciate the author's support of reproducibility. #reproducibility #STMpublishing

Feb 25, 2021 · 161 followers View post →