The authors of "Downregulation of uPAR promotes urokinase transloc…" (https://t.co/gW0oQUNEFQ) included RRIDs in their paper! We appreciate the author's support of reproducibility. #reproducibility #STMpublishing
Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma.
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Apr 2020 – Feb 2021Where it's discussed
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This discussion reflects a positive but surface-level response, appreciating the inclusion of RRIDs to support reproducibility. The tone is supportive and focused on scientific integrity rather than the article's broader implications, showing moderate agreement and interest with minimal engagement and impact.
The discussion shows moderate support for the publication, highlighted by appreciation for reproducibility efforts, indicating alignment with scientific standards.
The post expresses some interest by focusing on reproducibility, but overall engagement with the research's implications is limited.
The comment is brief and primarily praise rather than a deep exploration of the findings, reflecting low-to-moderate engagement.
The post's content does not suggest a significant impact of the research; instead, it emphasizes methodological support, which is important but not groundbreaking.
Abstract in brief
- Downregulating uPAR in neuroblastoma cells promotes their transition from an epithelial to a mesenchymal state, which increases their ability to migrate.
- The study shows that uPAR helps maintain epithelial characteristics like cell adhesion, and removing uPAR reduces these traits while increasing mesenchymal markers, facilitating tumor progression.
- Without uPAR, uPA moves into the nucleus, likely activating transcription factors that drive the epithelial-to-mesenchymal transition, suggesting a new role for uPA in cancer cell behavior.]
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uPAR Regulation and Nuclear Translocation of uPA in Neuroblastoma
Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma cells, increasing migration and tumor progression.
The authors of "Downregulation of uPAR promotes urokinase transloc…" (https://t.co/gW0oQUNEFQ) included RRIDs in their paper! We appreciate the author's support of reproducibility. #reproducibility #STMpublishing
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