June 2020 PMID 31994019

Kratom-Pharmacology, Clinical Implications, and Outlook: A Comprehensive Review.

Steven C Eastlack, Elyse M Cornett, Alan D Kaye

Mentions

27
Peak: 7 in Oct 2022
across 6 sources since Jan 2020

Extended reach

291,787
potential audience

Total likes

5,412

Video views

290,205

Mentions per month

Jan 2020 – Nov 2025

Where it's discussed

  • Reddit10 posts
  • News8 articles
  • X / Twitter3 posts
  • Blogs3 articles
  • YouTube2 videos
  • Facebook1 posts

AI synopsis

What people are saying

The discussions reflect a mix of curiosity and acknowledgment of kratom's relevance, as seen in posts asking about personal experiences with kratom for pain and fatigue, and highlighting the review’s importance in the context of the opioid epidemic. The tone is inquisitive and somewhat analytical, suggesting moderate engagement and recognition of the article’s significance.

AgreementModerate agreement

Posts show general agreement with the review's focus on kratom's pharmacology and its relation to the opioid crisis, indicating approval of the article's relevance.

InterestHigh interest

Many comments express high interest by asking about personal experiences and noting the importance of kratom's clinical implications.

EngagementModerate engagement

Discussions reflect some depth through questions about personal use and considerations of kratom's role in pain management, but lack detailed analysis.

ImpactModerate impact

The conversation hints at awareness of kratom's potential influence on current drug safety debates and the opioid crisis, but is not deeply transformative.

Abstract in brief

  • Kratom, a tropical plant from Southeast Asia, is used for its unique effects, including pain relief, euphoria, and stimulant properties, which may lead to dependence and addiction.
  • Recent studies show that kratom's physiological effects are similar to opioids, raising concerns about its safety and potential for misuse.
  • The use of kratom is increasing worldwide, prompting healthcare providers to consider its pharmacology, toxicity, and role in the broader context of the opioid epidemic.

Top posts

Most liked on X and Bluesky
Pain and Therapy
@Pain_Ther · X

A comprehensive review looking into the pharmacology, clinical implications and outlook of Kratom in relation to the current #opioidcrisis https://t.co/9VGbfwHJCO https://t.co/iNhXpuMEA8

Jan 28, 2020 · 3 likes · 1 share · 724 followers View post →
Johnny Smithe
@bottieboi · X

@FantomPills @FantomPunks https://t.co/b8f1qYchsz https://t.co/mv6fP2Rgrk

Dec 18, 2022 · 1 like · 91 followers View post →

All mentions

Kratom's Pharmacology and Risks Overview

Kratom is a tropical plant used for relief, euphoria, and stimulation, with effects similar to opioids. Its increasing global use raises concerns about dependence, safety, and its role in the opioid epidemic. This video…

MeCrat · May 16, 2025 10,920 views
Johnny Smithe
@bottieboi · X

@FantomPills @FantomPunks https://t.co/b8f1qYchsz https://t.co/mv6fP2Rgrk

Dec 18, 2022 · 1 like · 91 followers View post →
Victor M. Cartwright
@VictorMCartwri1 · X

RT https://t.co/LJuoaI8UgF Any tweeps have experience taking kratom? To treat pain, fatigue, or other https://t.co/QSVJ7dCrXP #kratom https://t.co/4vPRst0alj

May 16, 2021 · 545 followers View post →
Pain and Therapy
@Pain_Ther · X

A comprehensive review looking into the pharmacology, clinical implications and outlook of Kratom in relation to the current #opioidcrisis https://t.co/9VGbfwHJCO https://t.co/iNhXpuMEA8

Jan 28, 2020 · 3 likes · 1 share · 724 followers View post →
Kratom for opioid withdrawal: Does it work? - Mayo Clinic
News

2017; doi:10.1007/s40122-020-00151-x. Sevarino KA. Medically supervised opioid withdrawal during treatment for addiction. https://www.uptodate.com/contents ...

Dec 13, 2025 View →
HOUSE OF DELEGATES HANDBOOK - NOT FOR ...
News

doi:10.1007/s40122-020-00151-x. 12. Leong Bin Abdullah MFI, Singh D. The Adverse Cardiovascular Effects and Cardiotoxicity of Kratom (Mitragyna speciosa.

Dec 13, 2025 View →
HOUSE OF DELEGATES HANDBOOK ADDENDUM - NOT FOR ...
News

doi:10.1007/s40122-020-00151-x. 12. Leong Bin Abdullah MFI, Singh D. The Adverse Cardiovascular Effects and Cardiotoxicity of Kratom (Mitragyna speciosa.

Dec 13, 2025 View →
Kratom Controversies: Exploring Use and Regulation | Pharmacy ...
News

doi:10.1007/s40122-020-00151-x. Key substance use and mental health indicators in the United States: results from the 2022 National Survey on ...

Nov 21, 2025 View →
Opioid Analgesics: An ED-Focused Overview - emDocs
Blogs

x PMID: 18503626; Chou R, Fanciullo GJ, Fine PG, et al. Clinical ... doi:10.1007/s40122-020-00151-2 PMID: 32108093; Pergolizzi JV, Raffa ...

Sep 23, 2025 View →
Kratom's Impact on Healthcare | PDF | Opioid | Opioid Use Disorder
News

Pain Ther (2020) 9:55–69. https://doi.org/10.1007/s40122-020-00151-x. REVIEW. Kratom—Pharmacology, Clinical Implications,.

Jul 14, 2024 View →
¿Funciona el kratom para la abstinencia de medicamentos opioides ...
News

2017; doi:10.1007/s40122-020-00151-x. Sevarino KA. Medically supervised opioid withdrawal during treatment for addiction. https://www ...

Apr 20, 2024 View →
采用卡痛叶戒断阿片类药物:有效吗? - 妙佑医疗国际
News

2017; doi:10.1007/s40122-020-00151-x. Sevarino KA. Medically supervised opioid withdrawal during treatment for addiction. https://www ...

Apr 17, 2024 View →
القرطوم للانسحاب من الأفيون: هل تفي بالغرض؟ - Mayo Clinic (مايو ...
News

2017; doi:10.1007/s40122-020-00151-x. Sevarino KA. Medically supervised opioid withdrawal during treatment for addiction. https://www ...

Apr 17, 2024 View →
Mayo Clinic article on kratom is such a joke : r/kratom
Reddit

... A Comprehensive Review". Pain and Therapy. 9 (1): 55–69. doi:10.1007/s40122-020-00151-x. PMC 7203303. PMID 31994019. khInstability. • 2y ago.

May 31, 2023 View →
The seizures were conducted at Botanic Tonics LLC, a business ...
Facebook

doi: 10.1007/s40122-020-00151-x. PMC 7203303. PMID 31994019. But a cursory google search shows no recent news stories of tainted kratom ...

May 2, 2023 View →
Tanong patungkol sa drug interaction ng CYP : r/pharmacology
Reddit

Bigyan ng award. I-share. KetamineUser6666. • 3 taon ang nakalipas · https://link.springer.com/article/10.1007/s40122-020-00151-x. I-upvote 1

Oct 23, 2022 View →
CYP ilaç etkileşimi sorusu : r/pharmacology - Reddit
Reddit

... değiştirebilir. KetamineUser6666. • 3 yıl önce · https://link.springer.com/article/10.1007/s40122-020-00151-x · KetamineUser6666. • 3 yıl önce.

Oct 23, 2022 View →
CYP gyógyszerkölcsönhatás kérdés : r/pharmacology - Reddit
Reddit

Megosztás. KetamineUser6666. • 3 évvel ezelőtt · https://link.springer.com/article/10.1007/s40122-020-00151-x. Felpontozás 1. Lepontozás Díjazás

Oct 23, 2022 View →
CYP薬物相互作用に関する質問 : r/pharmacology - Reddit
Reddit

... を変える可能性があります。 KetamineUser6666. • 3 年前 · https://link.springer.com/article/10.1007/s40122-020-00151-x · KetamineUser6666. • 3 年 ...

Oct 23, 2022 View →
Frage zur Wechselwirkung von Medikamenten auf CYP-Basis : r ...
Reddit

... metabolisieren. KetamineUser6666. • vor 3 Jahren · https://link.springer.com/article/10.1007/s40122-020-00151-x · KetamineUser6666. • vor 3 ...

Oct 23, 2022 View →
Domanda sull'interazione farmacologica con CYP : r/pharmacology
Reddit

... progenitore. KetamineUser6666. • 3 anni fa · https://link.springer.com/article/10.1007/s40122-020-00151-x · KetamineUser6666. • 3 anni fa.

Oct 23, 2022 View →
Pergunta sobre interação medicamentosa CYP : r/pharmacology
Reddit

... original. KetamineUser6666. • há 3 anos · https://link.springer.com/article/10.1007/s40122-020-00151-x · KetamineUser6666. • há 3 anos.

Oct 23, 2022 View →
ToxCard: Kratom - emDocs
Blogs

doi: 10.1007/s40122-020-00151-x. Epub 2020 Jan 28. PMID: 31994019; PMCID: PMC7203303. Raehal KM, Walker JK, Bohn LM. Morphine side effects ...

Sep 7, 2021 View →
Isolation of mitragynine tek without ether or chloroform : r ...
Reddit

... 10.1007/s40122-020-00151-x https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.fda.gov/files/drugs/published/Adverse-event ...

Jun 8, 2021 View →
Interesting excerpts from Kratom—Pharmacology, Clinical ...
Reddit

https://link.springer.com/article/10.1007/s40122-020-00151-x. >Kratom does not denote a single, specific compound, but rather a cocktail of ...

Oct 7, 2020 View →
Two Cases of Provoked Seizure Associated With Kratom Ingestion ...
Blogs

https://doi.org/10.1007/s40122-020-00151-x · Crossref. Loading... View Options. View options. PDF and All Supplements. Download PDF and ...

Apr 9, 2019 View →