Anaphylaxis-a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis.

Marcus S Shaker, Dana V Wallace, David B K Golden, John Oppenheimer, Jonathan A Bernstein, Ronna L Campbell, Chitra Dinakar, Anne Ellis, Matthew Greenhawt, David A Khan, David M Lang, Eddy S Lang, Jay A Lieberman, Jay Portnoy, Matthew A Rank

April 2020

Synopsis of Social media discussions

The overall tone demonstrates strong agreement and high interest, with posts emphasizing the importance of epinephrine and the ineffectiveness of antihistamines for biphasic reactions, such as describing it as a 'game changer.' Although posts show active engagement through sharing detailed opinions and referencing the publication, the perceived impact remains moderate, as some discussions focus on reaffirming existing practices rather than widespread changes.

A
Agreement
 Moderate agreement

Most posts note that the publication aligns with current best practices, supporting the emphasis on epinephrine as the primary treatment.

I
Interest
 High level of interest

Readers show high interest by frequently referencing the article and actively discussing treatment strategies and implications.

E
Engagement
 Moderate level of engagement

Many discussions include references to specific guidelines and practice updates, indicating thoughtful engagement.

I
Impact
 Moderate level of impact

The social discussions reflect an awareness of how this publication might influence clinical practices, though some appear to treat it as informational rather than transformative.

Social Mentions

YouTube

4 Videos

Facebook

6 Posts

Twitter

19 Posts

Blogs

6 Articles

News

38 Articles

Metrics

Video Views

644

Total Likes

34

Extended Reach

53,400

Social Features

73

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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Abstract Synopsis

  • Anaphylaxis is a potentially life-threatening allergic reaction with diverse symptoms, and severe cases or those needing multiple epinephrine doses are at higher risk for biphasic responses.
  • Current evidence indicates that antihistamines and glucocorticoids are not effective in preventing biphasic anaphylaxis, though they may be useful as premedication in specific situations like certain chemotherapy or allergen immunotherapy protocols.
  • Epinephrine remains the primary treatment for both uniphasic and biphasic anaphylaxis, and all patients should be monitored until symptoms resolve, receive education on managing future episodes, and be instructed on trigger avoidance and self-injection of epinephrine.