February 2020 PMID 32016310

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials.

Myles Wolf, Janet Rubin, Maureen Achebe, Michael J Econs, Munro Peacock, Erik A Imel, Lars L Thomsen, Thomas O Carpenter, Thomas Weber, Vincent Brandenburg, Heinz Zoller

Mentions

74
Peak: 36 in Feb 2020
across 5 sources since Feb 2020

Extended reach

1,216,042
potential audience

Total likes

309

Video views

13,710

Mentions per month

Feb 2020 – Oct 2025

Where it's discussed

  • X / Twitter63 posts
  • Facebook4 posts
  • YouTube3 videos
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

Numerous discussions reference the clinical significance of the research, particularly pointing out the lower incidence of hypophosphatemia with iron isomaltoside. Phrases like 'this paper shows almost 75% incidence with ferric carboxymaltose' highlight the urgency and importance of these findings. The tone is both informative and urgent, suggesting that the findings could lead to a shift in clinical practices surrounding iron treatments.

AgreementStrong agreement

The majority of posts express strong support for the findings of the study, highlighting the advantages of iron isomaltoside.

InterestHigh interest

There is a high level of curiosity and relevance as many participants actively engage with the study's implications for treatment.

EngagementHigh engagement

Users show deep engagement by discussing specific data points, safety concerns, and biochemical mechanisms involved in hypophosphatemia.

ImpactHigh impact

Contributors perceive significant potential implications for clinical practice, as evidenced by discussions around patient experiences and treatment choices.

Abstract in brief

  • The study compares the effects of two intravenous iron formulations, iron isomaltoside and ferric carboxymaltose, on hypophosphatemia in patients with iron-deficiency anemia.
  • A total of 245 patients were enrolled in two clinical trials, with serum phosphate and other related biomarkers measured at multiple points during the study.
  • Results showed that the incidence of hypophosphatemia was significantly lower in patients receiving iron isomaltoside compared to those receiving ferric carboxymaltose.

Top posts

Most liked on X and Bluesky
JAMA
@JAMA_current · X

Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose) vs ferric carboxymaltose and report the former resulted in lower hypophosphatemia over 35 days https://t.co/UKyHy81oq1 #VisualAbstract

Feb 4, 2020 · 46 likes · 24 shares · 488,377 followers View post →
Kelly Issokson MS RD LDN (she/her)
@GIdietitian · X

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials | Clinical Pharmacy and Pharmacology | ⁦@JAMA_current⁩ https://t.co/VWdzlgRUUj

Feb 4, 2020 · 30 likes · 8 shares · 4,503 followers View post →
Salvador Payán-Pernía
@salvadorpayan · X

En este estudio, 2 dosis de 750 mg de hierro #carboximaltosa separadas por una semana produjeron un 11% de hipofosfatemia grave (<1 mg/dl). Ojo al fósforo si dosis repetidas o síntomas: "Doctor, me pone hierro pero me canso más, no puedo con las piernas". https://t.co/iwfxfjuSAP https://t.co/YnyrQoFwUG

Nov 19, 2022 · 18 likes · 4 shares · 2,777 followers View post →
Duke Kidney
@DukeKidney · X

Myles Wolf and colleagues in @JAMA_current Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: 2 RCTs https://t.co/1Dx0Gl4HTE

Feb 6, 2020 · 14 likes · 2 shares · 5,518 followers View post →
Anitha Vijayan
@VijayanMD · X

@kidney_boy Great case @TheSkeletonKG! Have had a few cases including severe hypophos with osteomalacia after regular ferric carboxymaltose infusions over yrs. Not a high incidence with other iron preparations.This paper shows almost 75% incidence with ferr carbmalt. https://t.co/7plW0WAZUz

Jun 17, 2020 · 9 likes · 3 shares · 5,338 followers View post →
Nasim Wiegley, MD, FASN
@NWiegley · X

Great job #nephtwitter! Yes, Hypophosphatemia is the answer. ✨ Ferric carboxymaltose causes increase in FGF-23 levels ➡️ phosphaturic hormone leading to kidney phos excretion ✨ @TheSkeletonKG case 9 addresses this perfectly! https://t.co/9EEoEKvUU5 https://t.co/eg3dJtZvrK https://t.co/3YUrUY2pAp

Nov 10, 2020 · 9 likes · 3 shares · 2,717 followers View post →

All mentions

Piyush 
@drpiyushENT · X

https://t.co/Kny5F01WSK

Oct 11, 2025 · 1,362 followers View post →
sejal kotwani
@KotwaniSejal · X

RT @PA_Maday: Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia https://t.co/VqBhwMXkCV…

Sep 11, 2025 · 1 share · 426 followers View post →
くりにかる3A5@Ph.D.
@clinical89314 · X

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia https://t.co/66Jf00Gyxr

Jun 20, 2025 · 1 like · 1,288 followers View post →
kakugari_pharmacist
@kakugaripharma · X

@ph_ttkt https://t.co/zpfqIyzMcL

Jun 19, 2025 · 623 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

RT @pinacol: 【RCT】経口鉄剤1ヶ月以上へ忍容性がない又は不応の鉄欠乏性貧血患者へのイソマルトシド鉄静注は、カルボキシマルトース鉄注と比較して、低リン血症の発生率を減少させた。 https://t.co/nv8YjJbRmY

Mar 29, 2024 · 2 shares · 1,784 followers View post →
pinacol
@pinacol · X

RT @pinacol: 【RCT】経口鉄剤1ヶ月以上へ忍容性がない又は不応の鉄欠乏性貧血患者へのイソマルトシド鉄静注は、カルボキシマルトース鉄注と比較して、低リン血症の発生率を減少させた。 https://t.co/nv8YjJbRmY

Mar 29, 2024 · 2 shares · 1,615 followers View post →
Gabriel Yanes
@gabiyavi · X

RT @salvadorpayan: En este estudio, 2 dosis de 750 mg de hierro #carboximaltosa separadas por una semana produjeron un 11% de hipofosfatemi…

Nov 20, 2022 · 4 shares · 564 followers View post →
emfv
@emfv87 · X

RT @salvadorpayan: En este estudio, 2 dosis de 750 mg de hierro #carboximaltosa separadas por una semana produjeron un 11% de hipofosfatemi…

Nov 19, 2022 · 4 shares · 127 followers View post →
Salva García Morillo PhD. MD.
@UCAMIraras · X

RT @salvadorpayan: En este estudio, 2 dosis de 750 mg de hierro #carboximaltosa separadas por una semana produjeron un 11% de hipofosfatemi…

Nov 19, 2022 · 4 shares · 1,060 followers View post →
Karan
@K424N · X

RT @salvadorpayan: En este estudio, 2 dosis de 750 mg de hierro #carboximaltosa separadas por una semana produjeron un 11% de hipofosfatemi…

Nov 19, 2022 · 4 shares · 688 followers View post →
Salvador Payán-Pernía
@salvadorpayan · X

En este estudio, 2 dosis de 750 mg de hierro #carboximaltosa separadas por una semana produjeron un 11% de hipofosfatemia grave (<1 mg/dl). Ojo al fósforo si dosis repetidas o síntomas: "Doctor, me pone hierro pero me canso más, no puedo con las piernas". https://t.co/iwfxfjuSAP https://t.co/YnyrQoFwUG

Nov 19, 2022 · 18 likes · 4 shares · 2,777 followers View post →
Abu Ibrahim
@Muhamma14307109 · X

@PromiseAlharbi https://t.co/p5nhBoncvX

Jul 26, 2022 · 130 followers View post →
名前
@akkiii0830 · X

リンの低下が少ないかも? Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia Two Randomized Clinical Trials https://t.co/y0HOZAmzB9

Feb 10, 2022 · 246 followers View post →
Zoë Raos
@ZoeRaos · X

RT @luyimin2009: @drkeithsiau Great summary! To add: ferric carboxymaltose could acutely elevate iFGF23 to induce hypophosphatemia. https:/…

Jul 14, 2021 · 3 shares · 1,133 followers View post →
Kok Leong Diong
@kldiong · X

RT @luyimin2009: @drkeithsiau Great summary! To add: ferric carboxymaltose could acutely elevate iFGF23 to induce hypophosphatemia. https:/…

Jul 14, 2021 · 3 shares · 44 followers View post →
Hirotsugu Kitayama
@HirotsuguKitay1 · X

RT @luyimin2009: @drkeithsiau Great summary! To add: ferric carboxymaltose could acutely elevate iFGF23 to induce hypophosphatemia. https:/…

Jul 13, 2021 · 3 shares · 172 followers View post →
ylu
@luyimin2009 · X

@drkeithsiau Great summary! To add: ferric carboxymaltose could acutely elevate iFGF23 to induce hypophosphatemia. https://t.co/YMd5Mdk6cK

Jul 13, 2021 · 5 likes · 3 shares · 262 followers View post →
KristopherMaday PA-C
@PA_Maday · X

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia https://t.co/VqBhwMXkCV https://t.co/jrCGPzoD8x

Mar 2, 2021 · 2 likes · 1 share · 2,458 followers View post →
UC Davis Nephrology
@UCDNephrology · X

RT @NWiegley: Great job #nephtwitter! Yes, Hypophosphatemia is the answer. ✨ Ferric carboxymaltose causes increase in FGF-23 levels ➡️ pho…

Nov 10, 2020 · 3 shares · 1,399 followers View post →
Zainab Obaidi
@zainabo87 · X

RT @NWiegley: Great job #nephtwitter! Yes, Hypophosphatemia is the answer. ✨ Ferric carboxymaltose causes increase in FGF-23 levels ➡️ pho…

Nov 10, 2020 · 3 shares · 2,128 followers View post →
Nasim Wiegley, MD, FASN
@NWiegley · X

Great job #nephtwitter! Yes, Hypophosphatemia is the answer. ✨ Ferric carboxymaltose causes increase in FGF-23 levels ➡️ phosphaturic hormone leading to kidney phos excretion ✨ @TheSkeletonKG case 9 addresses this perfectly! https://t.co/9EEoEKvUU5 https://t.co/eg3dJtZvrK https://t.co/3YUrUY2pAp

Nov 10, 2020 · 9 likes · 3 shares · 2,717 followers View post →
James Uprichard
@doctoruprichard · X

Wolf et al. No differences in efficacy between #ferinject and #monofer, but there are differences in #hypophosphataemia https://t.co/SuJcQCksay

Nov 10, 2020 · 2 likes · 469 followers View post →
Anitha Vijayan
@VijayanMD · X

@hswapnil Did they look at serum phosphorus? Carboxymaltose has much higher risk for hypophosphatemia. #Kidneywk https://t.co/7plW0WAZUz

Oct 22, 2020 · 1 like · 1 share · 5,338 followers View post →
Almansour
@malmansour81 · X

RT @VijayanMD: @kidney_boy Great case @TheSkeletonKG! Have had a few cases including severe hypophos with osteomalacia after regular ferric…

Aug 1, 2020 · 3 shares · 211 followers View post →
Kartik Kalra MD,FNKF,FASN
@kkalra_22 · X

RT @VijayanMD: @kidney_boy Great case @TheSkeletonKG! Have had a few cases including severe hypophos with osteomalacia after regular ferric…

Jun 17, 2020 · 3 shares · 3,225 followers View post →
TheSkeletonKeyGroup
@TheSkeletonKG · X

RT @VijayanMD: @kidney_boy Great case @TheSkeletonKG! Have had a few cases including severe hypophos with osteomalacia after regular ferric…

Jun 17, 2020 · 3 shares · 3,190 followers View post →
Anitha Vijayan
@VijayanMD · X

@kidney_boy Great case @TheSkeletonKG! Have had a few cases including severe hypophos with osteomalacia after regular ferric carboxymaltose infusions over yrs. Not a high incidence with other iron preparations.This paper shows almost 75% incidence with ferr carbmalt. https://t.co/7plW0WAZUz

Jun 17, 2020 · 9 likes · 3 shares · 5,338 followers View post →
Nurse-R
@RIMOCALISH · X

静脈注射での鉄剤補充による、低リン血症の比較 https://t.co/YR3vTTcOPc

Feb 18, 2020 · 433 followers View post →
Sara Asecas
@SaraKeru · X

RT @DukeKidney: Myles Wolf and colleagues in @JAMA_current Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in I…

Feb 6, 2020 · 2 shares · 156 followers View post →
Jochen Reiser MD PhD
@JochenReiser · X

RT @DukeKidney: Myles Wolf and colleagues in @JAMA_current Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in I…

Feb 6, 2020 · 2 shares · 4,665 followers View post →
Duke Kidney
@DukeKidney · X

Myles Wolf and colleagues in @JAMA_current Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: 2 RCTs https://t.co/1Dx0Gl4HTE

Feb 6, 2020 · 14 likes · 2 shares · 5,518 followers View post →
Chile717
@Chile7171 · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 682 followers View post →
renalRCTs
@renalRCTs · X

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials. https://t.co/WH3pXJedHa

Feb 5, 2020 · 39 followers View post →
Rafeeq
@rafeeq_rm · X

RT @GIdietitian: Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinic…

Feb 5, 2020 · 8 shares · 1,185 followers View post →
RONAK GANDHI
@drronakmgandhi · X

RT @GIdietitian: Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinic…

Feb 5, 2020 · 8 shares · 260 followers View post →
Charlotte Rutter (& on BlueSky)
@Charl0tteRutter · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 2,380 followers View post →
Isaura R. Penin
@irodriguezpenin · X

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia https://t.co/atphhlM8m8

Feb 5, 2020 · 623 followers View post →
Dr.Epelde
@DrEpelde · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 17 followers View post →
⚕️Med Reposting
@Angel_EsparzaOn · X

RT @GIdietitian: Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinic…

Feb 5, 2020 · 8 shares · 81 followers View post →
LLZ Consulting
@llzconsulting · X

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia. https://t.co/t8Fwbn8dZd

Feb 5, 2020 · 270 followers View post →
Dr. Joshuan J. Barboza
@joshuanbarbozam · X

RT @GIdietitian: Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinic…

Feb 5, 2020 · 8 shares · 10,044 followers View post →
JAMA Internal Medicine
@JAMAInternalMed · X

RT @GIdietitian: Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinic…

Feb 5, 2020 · 8 shares · 108,262 followers View post →
JAMA
@JAMA_current · X

RT @GIdietitian: Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinic…

Feb 5, 2020 · 8 shares · 488,377 followers View post →
Aiggy 애이지
@doaeiji · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 835 followers View post →
Ashwini Menon
@Ashwini_MenonRD · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 30 followers View post →
Frank
@franklinamaya · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 37 followers View post →
IBDCNC
@charismaew · X

RT @GIdietitian: Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinic…

Feb 5, 2020 · 8 shares · 908 followers View post →
Dana Alsugeir | دانه الصقير
@DanaAlSugeir · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 773 followers View post →
dytsemih
@dytsmh · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 688 followers View post →
nicki ruddock
@nicki_ruddock · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 560 followers View post →
Nutrition Doc
@Leicnut · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 20,343 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 5, 2020 · 24 shares · 5,445 followers View post →
Adela
@adelapoite · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 4, 2020 · 24 shares · 1,242 followers View post →
Kelly Issokson MS RD LDN (she/her)
@GIdietitian · X

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials | Clinical Pharmacy and Pharmacology | ⁦@JAMA_current⁩ https://t.co/VWdzlgRUUj

Feb 4, 2020 · 30 likes · 8 shares · 4,503 followers View post →
Fernando Gomollón
@fgomollon · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 4, 2020 · 24 shares · 8,547 followers View post →
Iván
@Dockat16 · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 4, 2020 · 24 shares · 86 followers View post →
Jordi Guardiola
@JordiGuardiolac · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 4, 2020 · 24 shares · 1,153 followers View post →
SANDRAJOHNSTON
@sandra04850184 · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 4, 2020 · 24 shares · 950 followers View post →
J. Caro
@jcarocd · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 4, 2020 · 24 shares · 343 followers View post →
Pub Health Monitor
@monitor_PH · X

RT @JAMA_current: Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose)…

Feb 4, 2020 · 24 shares · 1,825 followers View post →
JAMA
@JAMA_current · X

Because IV iron can induce hypophosphatemia, 2 RCTs compared the effects of iron isomaltoside (AKA ferric derisomaltose) vs ferric carboxymaltose and report the former resulted in lower hypophosphatemia over 35 days https://t.co/UKyHy81oq1 #VisualAbstract

Feb 4, 2020 · 46 likes · 24 shares · 488,377 followers View post →
Souma Lab_Duke
@LabSouma · X

Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia https://t.co/de2kqv9uEV

Feb 4, 2020 · 375 followers View post →
Souma Lab_Duke
@LabSouma · X

From our chief. Congrats on your exciting discovery! https://t.co/OhWoSoix5u

Feb 4, 2020 · 375 followers View post →