January 2020 PMID 32038233

Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and   Organ Culture.

Xianyan Chen, Ben Liu, Ying Li, Le Han, Xin Tang, Wenjia Deng, Wei Lai, Miaojian Wan

Mentions

27
Peak: 12 in Mar 2023
across 3 sources since Feb 2020

Extended reach

1,085,812
potential audience

Total likes

29,013

Video views

948,879

Mentions per month

Feb 2020 – Dec 2025

Where it's discussed

  • X / Twitter17 posts
  • YouTube6 videos
  • News4 articles

AI synopsis

What people are saying

The posts reflect strong interest and support, often citing specific details such as DHT's dose-dependent effects on hair follicles and signaling pathways, exemplified by mentions of different DHT concentrations and their impact. The tone varies from scientific to casual, with some users sharing videos and asking questions, indicating both engagement and a recognition of the study's significance.

AgreementModerate agreement

Most discussions acknowledge and support the scientific findings that DHT influences hair growth via the Wnt/β-catenin pathway, with some emphasizing the dose-dependent effects.

InterestHigh interest

The posts demonstrate high interest, with many referencing specific mechanisms, implications for hair growth, and related questions, indicating curiosity about the research.

EngagementModerate engagement

The discussions show moderate engagement through elaborations on biological processes, potential health impacts, and further explanations or videos, though some comments are superficial.

ImpactModerate impact

The collective commentary suggests the research has a meaningful influence on understanding hair growth and potential treatments, as many posts consider its relevance and practical implications.

Abstract in brief

  • Dihydrotestosterone (DHT) is a potent androgen that influences hair growth by interacting with the Wnt/β-catenin pathway, affecting hair follicle (HF) activity in humans and mice.
  • The study found that different DHT concentrations have varying effects: low levels (10 mol/L) promote hair growth and increase Wnt/β-catenin signaling, while higher levels inhibit growth and decrease pathway activity, with manipulation of the pathway (using inhibitors or activators) further confirming its role.
  • These findings suggest that DHT regulates region-specific hair growth through the Wnt/β-catenin pathway, implying potential targets for hair growth treatments.]

Top posts

Most liked on X and Bluesky
SciShow
@SciShow · X

It can be alarming when thick, dark hair pops up on your body seemingly out of nowhere. But that hair was actually there already, it just looked a little different. https://t.co/tYZUi2M2M6 https://t.co/Vrk4w8AIEF

Mar 17, 2023 · 12 likes · 3 shares · 115,755 followers View post →
bubu
@bubunilla · X

@datadeletedac @PilarSoyYo30 @Xue_yu_ @sstvrgirl_ La testosterona puede influir en la caída del pelo, pero no es la testosterona en sí la que la provoca directamente, sino una de sus formas derivadas: la dihidrotestosterona (DHT). https://t.co/n7ZvNVLMlr https://t.co/ELDTMaYO61

May 11, 2025 · 3 likes · 4,617 followers View post →
Frontiers - Pharmacology and Toxicology
@FrontPharmacol · X

New Research: Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture https://t.co/BX8NzVkEFs #pharmacology

Feb 5, 2020 · 1 like · 6,106 followers View post →
Shipwreck
@markthesnark2 · X

https://t.co/l5FJRrAB1i How do you make a hormone Pull her hair

Mar 18, 2023 · 1 like · 3,685 followers View post →
permabera
@Minointerista · X

@haidut dose dependent DHT effect on HDPCs has been confirmed with this study from 2020 : https://t.co/IUPR4n0CWs high concentrations inhibit hair growth, but there is a specific dose where DHT promotes hair growth (10-7 mol/L)

Mar 25, 2024 · 1 like · 274 followers View post →
La Fleur Des Pavés
@FleursDesPaves · X

@Katsunan3000 https://t.co/X93aNNaEM9

Mar 18, 2023 · 1 like · 214 followers View post →

All mentions

Origins of Thick Dark Hair and Hormonal Influences

This video explores the appearance of new thick, dark hair due to hormonal changes or natural processes, emphasizing how body odour reflects reproductive fitness through hormonal levels, particularly oestradiol and…

SciShow · Mar 17, 2023 831,416 views
Anti-Jimacus
@jimacus27477 · X

https://t.co/X48Mq88HBR Differential response in mouse hair follicles to varying levels of DHT. 1uM DHT induces shortening of hair shaft, changes in hair morphology, reduction in B-catenin signaling, reduced hair growth. 100nM DHT induces opposite. 10nM DHT has no effect.

Jul 27, 2025 View post →
bubu
@bubunilla · X

@datadeletedac @PilarSoyYo30 @Xue_yu_ @sstvrgirl_ La testosterona puede influir en la caída del pelo, pero no es la testosterona en sí la que la provoca directamente, sino una de sus formas derivadas: la dihidrotestosterona (DHT). https://t.co/n7ZvNVLMlr https://t.co/ELDTMaYO61

May 11, 2025 · 3 likes · 4,617 followers View post →
permabera
@Minointerista · X

@haidut dose dependent DHT effect on HDPCs has been confirmed with this study from 2020 : https://t.co/IUPR4n0CWs high concentrations inhibit hair growth, but there is a specific dose where DHT promotes hair growth (10-7 mol/L)

Mar 25, 2024 · 1 like · 274 followers View post →
Kevin
@kevdawgrob · X

@Lightwaves_9 @PrincessOfMeat Matty is basically right, but here’s a vid if you want to know more about how peach fuzz turns into thicker hair. https://t.co/vgsrpDUUMx

May 29, 2023 · 1 like · 183 followers View post →
Crap Zap (Sabrina)
@CrapZap · X

Liked on YouTube: Where Did That One Thick, Dark Hair Come From? https://t.co/HWekojv8J2

Apr 9, 2023 · 290 followers View post →
Albert Zweistein
@al_zweistein · X

Where Did That One Thick, Dark Hair Come From? https://t.co/SbmDDKMQwr via @YouTube "vellus hair / terminal hair" vellus hair follicle + androgen → terminal hair (←

Mar 20, 2023 · 206 followers View post →
La Fleur Des Pavés
@FleursDesPaves · X

@Katsunan3000 https://t.co/X93aNNaEM9

Mar 18, 2023 · 1 like · 214 followers View post →
Shipwreck
@markthesnark2 · X

https://t.co/l5FJRrAB1i How do you make a hormone Pull her hair

Mar 18, 2023 · 1 like · 3,685 followers View post →
Peter Azak
@thepha · X

Just Liked on YouTube: Where Did That One Thick, Dark Hair Come From? https://t.co/S0b4YuhE2B

Mar 17, 2023 · 345 followers View post →
Kitty
@kittybravofan · X

Where Did That One Thick, Dark Hair Come From? https://t.co/YFcJi0Abei via @YouTube

Mar 17, 2023 · 722 followers View post →
Nizam
@Nyzms · X

Where Did That One Thick, Dark Hair Come From? https://t.co/n0C6yQYD14

Mar 17, 2023 · 526 followers View post →
Parody Aaron Scivener Haunted Winged Wolf Tao Wese
@Eintsein1980 · X

RT @SciShow: It can be alarming when thick, dark hair pops up on your body seemingly out of nowhere. But that hair was actually there alrea…

Mar 17, 2023 · 3 shares · 624 followers View post →
Johannes Lüke
@JohannesSLueke · X

New video by SciShow: Where Did That One Thick, Dark Hair Come From? https://t.co/fvud3CwOPq

Mar 17, 2023 · 83 followers View post →
Kimberly Purcell
@KimberlyLetsGo · X

Where Did That One Thick, Dark Hair Come From? https://t.co/HyID2R0Usf via @YouTube This is the bane of lots of women.

Mar 17, 2023 · 3,200 followers View post →
Dai
@Dai5tr0y3r · X

RT @SciShow: It can be alarming when thick, dark hair pops up on your body seemingly out of nowhere. But that hair was actually there alrea…

Mar 17, 2023 · 3 shares · 87 followers View post →
SciShow
@SciShow · X

It can be alarming when thick, dark hair pops up on your body seemingly out of nowhere. But that hair was actually there already, it just looked a little different. https://t.co/tYZUi2M2M6 https://t.co/Vrk4w8AIEF

Mar 17, 2023 · 12 likes · 3 shares · 115,755 followers View post →
Frontiers - Pharmacology and Toxicology
@FrontPharmacol · X

New Research: Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture https://t.co/BX8NzVkEFs #pharmacology

Feb 5, 2020 · 1 like · 6,106 followers View post →