November 1988 PMID 3207614

Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.

D Stamatiadis, M C Bulteau-Portois, I Mowszowicz

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Mentions

Peak: 1 in Jun 2020

across 3 sources since Jun 2020

Extended reach

73,531

potential audience

Total likes

1,581

Video views

70,220

Mentions per month

Jun 2020 – Jan 2025

Where it's discussed

X / Twitter5 posts
YouTube3 videos
News2 articles

AI synopsis

What people are saying

The discussions reflect a strong interest in the clinical and practical implications of the research, exemplified by comments such as 'INTERESTING STUDY ALERT' and mentions of the study being 'similar to finasteride,' which indicates engagement with potential real-world applications and mechanisms. The tone varies from curiosity to recognition of the study's significance, contributing to a generally positive view of its possible impact on treatments for androgen-related skin conditions.

AgreementModerate agreement

Most discussions acknowledge the significance of zinc and azelaic acid's inhibitory effects, with some referencing the study as promising or noteworthy.

InterestHigh interest

Social discussions show high interest, especially highlighted by phrases like 'INTERESTING STUDY ALERT' and references to further research, showing curiosity and engagement.

EngagementModerate engagement

Several posts link the study to practical implications, comparing zinc to finasteride, and citing references, indicating active interest and engagement with the topic.

ImpactModerate impact

Participants perceive the findings as potentially influential for skin treatments and alternative therapies, emphasizing the relevance of the research.

Abstract in brief

Zinc sulphate and azelaic acid both strongly inhibit 5 alpha-reductase activity in human skin, with zinc showing complete inhibition at high concentrations and azelaic acid at lower concentrations.
An additive effect was observed when combining the two inhibitors, especially at low concentrations that are ineffective alone, and vitamin B6 enhances zinc's inhibitory effect, indicating different underlying mechanisms.
These findings suggest that a combination of zinc sulphate and azelaic acid could potentially be used as an effective treatment for androgen-related skin conditions, pending confirmation of their effectiveness in vivo.]

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All mentions

Possible Hair Loss Treatments Better Than Finasteride and Dutasteride

This video explores new potential treatments for hair loss by analyzing the inhibition of 5 alpha-reductase using zinc sulphate and azelaic acid, which may offer effective alternatives or supplements to existing…

Haircafe · Jan 21, 2025 26,691 views

Understanding DHT Scalp Itch and Treatment Options

Steroid 5-alpha-reductase deficiency is a genetic disorder causing male pseudohermaphroditism, leading to ambiguous genitalia at birth. During puberty, virilization occurs but with low dihydrotestosterone levels…

Haircafe · Jun 19, 2023 23,901 views

The Impact of Vitamins and Minerals on Hair Loss Treatment Effectiveness

Micronutrients like vitamins and minerals are crucial for healthy hair growth and may influence hair loss. Deficiencies in nutrients such as zinc, iron, vitamins A, B, C, D, and E can be linked to nonscarring alopecia…

Haircafe · Apr 6, 2022 19,628 views

كاشف Exposed

@showmerealyou · X

Oct 26, 2024 · 865 followers View post →

Michael Ruiz

@mdr5256 · X

@nattyextremist @Primal_Health1 https://t.co/AQw2hpGF9x What about this study

Apr 29, 2024 · 244 followers View post →

Alaa Sati

@AlaaSattii · X

Ref : 1-https://t.co/WO7lC5ecd2 PMC4120804/ 2- https://t.co/00QRIS8itO 3-https://t.co/Zg2PJSNV6M

Jun 11, 2021 · 3 likes · 1,358 followers View post →

NootropicReddit

@NootropicReddit · X

Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid (1988) via /r/Nootropics https://t.co/MPtIB1FgPW

Mar 16, 2021 · 791 followers View post →

Prepare Your Hair

@prepareyourhair · X

INTERESTING STUDY ALERT: Zinc was shown to work similarly to finasteride in its ability to block 5-alpha reductase: the enzyme responsible for converting testosterone into DHT. https://t.co/k9Zbbr15Yu

Jun 26, 2020 · 54 followers View post →