The overall tone reflects curiosity and support for the research, with posts citing examples like the longer duration of psilocybin’s effects and questioning ketamine’s therapeutic value, showing active engagement and recognition of its potential impact in mental health treatment.
AgreementModerate agreement
Most discussions support the findings, emphasizing that psychedelics like psilocybin and LSD have longer-lasting antidepressant effects compared to ketamine.
InterestHigh interest
Posts show high interest, referencing specific studies, long-term effects, and debates about the mechanisms, revealing active engagement with the subject.
EngagementModerate engagement
Some posts delve into scientific details, biological implications, and comparisons, indicating moderate to deep engagement.
ImpactHigh impact
The discussions highlight the potential importance of these findings for mental health treatments, suggesting they could influence future research and therapy approaches.
Abstract in brief
Psilocybin and LSD produce long-lasting antidepressant-like effects in rats, whereas ketamine only has short-term effects, suggesting that traditional psychedelics may offer more durable treatment benefits.
The study indicates that the fast-acting antidepressant effects of psilocybin, LSD, and ketamine may share similar biological mechanisms, but their duration differs significantly.
Importantly, the research suggests that a profound subjective experience may not be essential for the antidepressant effects of psychedelics, challenging some previous assumptions about their therapeutic action.]
According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this argument, this study supports the antidepressant effects of #psychedelics in rats and argues that these effects are biological in nature.
https://t.co/KFxTVLIN6y
Mar 13, 2020 · 31 likes · 10 shares · 60,074 followersView post →
JA
Jeff Atwood
@codinghorror · X
"Psychedelics ... Produce Persistent Antidepressant-like Effects in a Rodent Experimental System"
May 3, 2020 · 28 likes · 5 shares · 264,575 followersView post →
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Psychedelics Today
@PsydelicsToday · X
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/b1moE3UgxP
Mar 7, 2020 · 24 likes · 3 shares · 41,624 followersView post →
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DanceSafe
@DanceSafe · X
Ketamine and #psilocybin: both effective for treating depression, in different ways. https://t.co/OrC9EB4i3D https://t.co/OJk5bHLB5R
Psilocybin shows antidepressant-like effect in the WKY rat, a genetic model of depression. We found no effect in the FSL model, so I'm naturally skeptical, and maybe a little biased.. I look forward to reading this! #psilocybin #psychedelics https://t.co/EsYT3eDGdx
Mar 7, 2020 · 9 likes · 5 shares · 232 followersView post →
ME
Manoj Doss not exist
@ManojDoss · X
@GiantBalls5 Sure, but studies like these show an antidepressant-like effect:
https://t.co/VMIIoLQnvb
https://t.co/ySvxcVDYBL
Jun 28, 2022 · 8 likes · 6,086 followersView post →
Psychedelics like psilocybin and LSD produce long-lasting antidepressant effects in rats, unlike ketamine which offers short-term relief. The study suggests durable benefits from traditional psychedelics and questions…
This review discusses the use of psychedelics in mental health treatment, highlighting significant improvements in mood and depression symptoms observed in recent studies, especially in mood disorder patients. The…
RT @dawso007: Open Access:
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System f…
Oct 24, 2025 · 4 shares · 125 followersView post →
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Frank Armstrong
@frankarmstrong2 · X
RT @dawso007: Open Access:
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System f…
Oct 24, 2025 · 4 shares · 1,675 followersView post →
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CopperKettle
@Artyom_Yekat · X
RT @dawso007: Open Access:
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System f…
Oct 23, 2025 · 4 shares · 382 followersView post →
GD
George Dawson
@dawso007 · X
Open Access:
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression | ACS Chemical Neuroscience https://t.co/DSQTnO3yo3
Oct 23, 2025 · 7 likes · 4 shares · 7,819 followersView post →
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Simple
@SimonSimplicio · X
psilocybin was always more promising
https://t.co/f7EBILSvKk https://t.co/RkjcRNS3xn
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects #InRodents. Would you believe a self-reported depression score that was obtained from a rodent? https://t.co/pWlvo4hF3H
@ManojDoss @lab_nichols Doing behavior only 24 hours after psychedelics probably isn't great and less relevant to people. We care about long term effects, not drug
"afterglow". The assays are sensitive to biological noise, so any kind of lingering drug effects can disrupt them
https://t.co/IiykVloL0v
@amp6 It's super interesting but I wish this included to what extent integration and psychotherapy were included post dose. Ketamine is promising but also has its pitfalls in terms of remission https://t.co/mmwfMuLHmE
Nov 10, 2021 · 1 like · 4,773 followersView post →
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bwuisess
@bwuisess · X
I feel like this isn't real.... I mean ketamine... really? I am pretty sure ketamine can't help with depression... I just found a whole article about how ketamine is one of the few psychedelics that doesn't help with mental illnesses https://t.co/HciHlxJOkf
#Psychedelics, but Not #Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression 1/5 https://t.co/ImrxWqrx5V
Jun 25, 2021 · 1 share · 2,056 followersView post →
PN
Psilo.net
@NetPsilo · X
Single-dose administration of LSD and psilocybin produce persistent “anti-depressant like effects” in a rodent model of depression
#psychedelics
https://t.co/VvYpyca2Yz
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/yal1QNvVdu
Dec 20, 2020 · 2 likes · 7,819 followersView post →
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UltimApe
@ultimape · X
"Our results indicate that classic psychedelics may have therapeutic efficacy that is more persistent than that of ketamine, and also suggest that a subjective existential experience may not be necessary for therapeutic effects."
https://t.co/rQ5Wz8co2J https://t.co/YkusEeHqxI
RT @ichiipsy: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study…
Oct 30, 2020 · 2 shares · 538 followersView post →
IG
informed consent (is almost never given)
@iatrogenic_harm · X
RT @Altostrata: One of the more pathetically misguided aspects of #psychiatric research: Forced swim test again used as a model for #antide…
Oct 28, 2020 · 2 shares · 1,391 followersView post →
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Bert
@HenryRunamucker · X
RT @Altostrata: One of the more pathetically misguided aspects of #psychiatric research: Forced swim test again used as a model for #antide…
Oct 28, 2020 · 2 shares · 2,141 followersView post →
KD
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X
One of the more pathetically misguided aspects of #psychiatric research: Forced swim test again used as a model for #antidepressant action. Vigorous paddling supposedly means the rat is feeling perkier, potential adverse effects be damned.
https://t.co/ds6OLY6mFD
Oct 27, 2020 · 5 likes · 2 shares · 6,597 followersView post →
いバ
いっちー@バーチャル精神科医
@ichiipsy · X
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression
https://t.co/8RQCbtmumu
Oct 27, 2020 · 4 likes · 2 shares · 80,020 followersView post →
RJ
Riia Järvenpää
@riiajarvenpaa · X
@APulkkis Tuli vaan mieleen kun etsin viitettä ihan toiseen juttuun ja tää artikkeli tuli vastaan. https://t.co/SI8yy8211y
Oct 16, 2020 · 1 like · 4,173 followersView post →
BP
Bunk Police
@BunkPolice · X
RT @DanceSafe: Ketamine and #psilocybin: both effective for treating depression, in different ways. https://t.co/OrC9EB4i3D https://t.co/OJ…
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/Es9IgBXNYH
"Psychedelics ... Produce Persistent Antidepressant-like Effects in a Rodent Experimental System"
May 3, 2020 · 28 likes · 5 shares · 264,575 followersView post →
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Blackdoriart
@blackdoriart · X
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/5yZAtaKuwT
El LSD y la psilocibina (encontrada en los hongos mágicos) presentan efectos antidepresivos con duración de seis o más meses, tras una o dos dosis.
La ketamina no lo hace. Su efecto es de corta duración.
Esto se sabe en humanos y se ha probado en ratas. https://t.co/6kiUxIxVcE
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/ahKxsyzPMT
#depression #psychedelic
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/UzSjBup6w2
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 15, 2020 · 10 shares · 5,136 followersView post →
PS
Psychedelic Support
@psysupnet · X
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 14, 2020 · 10 shares · 1,394 followersView post →
RC
Reilly Capps
@ReillyCapps · X
Simplest graphic ever in a scientific paper about #psilocybin.
https://t.co/q5U0xSBWzJ https://t.co/jG2AOiHjh1
Mar 14, 2020 · 2 likes · 3,781 followersView post →
LT
Lawrence Turner
@Athbheochan · X
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 14, 2020 · 10 shares · 163 followersView post →
CV
Caroline Vigneron
@CaroVigneron · X
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 14, 2020 · 10 shares · 332 followersView post →
KK
Kari Kosmos
@KariKosmos · X
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 13, 2020 · 10 shares · 217 followersView post →
BB
Blind Willie #BLM
@willsmithyyp · X
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 13, 2020 · 10 shares · 354 followersView post →
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SIC
@sictwit · X
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 13, 2020 · 10 shares · 3,711 followersView post →
MB
Michel Blanc
@Blanc07Michel · X
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 13, 2020 · 10 shares · 1,665 followersView post →
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psYplectic
@psy_plectic · X
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 13, 2020 · 10 shares · 2,338 followersView post →
XB
Xamanismo Coletivo Brasileiro
@eliasulrich · X
"Our results indicate that classic #psychedelics may have therapeutic efficacy that is more persistent than that of #ketamine, and also suggest that a subjective existential experience may not be necessary for therapeutic effects."
https://t.co/EFwPyJwYj3
RT @BeckleyResearch: According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this…
Mar 13, 2020 · 10 shares · 507 followersView post →
BR
Beckley Foundation | Psychedelic Research
@BeckleyResearch · X
According to modern science, rats do not have a sense of self & are incapable of existential #anxiety. Following this argument, this study supports the antidepressant effects of #psychedelics in rats and argues that these effects are biological in nature.
https://t.co/KFxTVLIN6y
Mar 13, 2020 · 31 likes · 10 shares · 60,074 followersView post →
M
MNSociety
@MnSociety · X
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/C68j4XmhYM
More Persistent antidepressant effects of psilocybin vs ketamine preclinically. Looking forward to the clinical head to head study! https://t.co/chypO0d78A
Super interesting - in rats, the antidepressant effect of psilocybin is context dependent (stress post-PSI means less antidepressant effect). The psychodynamic dimension of the exp. may be correlated with improved health, but not causal.
https://t.co/EdiNdQVDxz
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 8, 2020 · 32 shares · 237 followersView post →
GT
Gohsuke Takama
@gohsuket · X
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression | ACS Chemical Neuroscience - https://t.co/zuDlH33CV4
#Psychedelics, but Not #Ketamine, Produce Persistent #Antidepressant-like Effects in a #Rodent Experimental System for the Study of #Depression
https://t.co/1qdZ5CYWyU
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression
https://t.co/aqhKA8s9ao
Mar 7, 2020 · 6 likes · 2 shares · 11,700 followersView post →
RT @OskarJefsen: Psilocybin shows antidepressant-like effect in the WKY rat, a genetic model of depression. We found no effect in the FSL m…
Mar 7, 2020 · 5 shares · 1,069 followersView post →
MA
Micah G. Allen
@micahgallen · X
RT @OskarJefsen: Psilocybin shows antidepressant-like effect in the WKY rat, a genetic model of depression. We found no effect in the FSL m…
Mar 7, 2020 · 5 shares · 23,338 followersView post →
MB
Michel Blanc
@Blanc07Michel · X
RT @OskarJefsen: Psilocybin shows antidepressant-like effect in the WKY rat, a genetic model of depression. We found no effect in the FSL m…
Mar 7, 2020 · 5 shares · 1,665 followersView post →
OJ
Oskar Jefsen
@OskarJefsen · X
Psilocybin shows antidepressant-like effect in the WKY rat, a genetic model of depression. We found no effect in the FSL model, so I'm naturally skeptical, and maybe a little biased.. I look forward to reading this! #psilocybin #psychedelics https://t.co/EsYT3eDGdx
Mar 7, 2020 · 9 likes · 5 shares · 232 followersView post →
RT @PsydelicsToday: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the…
Mar 7, 2020 · 3 shares · 144,217 followersView post →
GK
GranX #jarfi #veelvraat #jarfr #katschemakensis
@GrandmaTheGrey · X
RT @PsydelicsToday: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the…
Mar 7, 2020 · 3 shares · 2,391 followersView post →
PT
Psychedelics Today
@PsydelicsToday · X
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/b1moE3UgxP
Mar 7, 2020 · 24 likes · 3 shares · 41,624 followersView post →
LJ
Luke Jelen
@LukeJelen · X
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/iAhg4t3Xfa
Mar 7, 2020 · 5 likes · 1,012 followersView post →
XA
x_annie3592
@x_annie3592 · X
The 15-year-old me says, “I told you so.” The 48-year-old me laughs knowingly. I stinking love science. https://t.co/hB7T1VS09h
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 302 followersView post →
CG
Cecilia Giron
@mceciliagiron · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 310 followersView post →
AA
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X
[ASAP] Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression https://t.co/70F26q9EAG
Mar 5, 2020 · 3 likes · 1 share · 4,002 followersView post →
AH
Ahmed El Hady
@zamakany · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 2,808 followersView post →
LA
Lucassen lab University of Amsterdam
@LucassenPJ · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 1,473 followersView post →
SC
Sandra Corvi
@CorviSandra · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 121 followersView post →
NW
Noelia Weisstaub
@noeliaweisstaub · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 435 followersView post →
A關
Alex Kwan 關進晞
@kwanalexc · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 5,875 followersView post →
JR
Jose Maria Restrepo
@chemarestrepo · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 255 followersView post →
TP
Thomas Pfeiffer
@th_pfeiffer · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 527 followersView post →
SF
Sashaina Fanibunda
@SashainaEF · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Mar 5, 2020 · 32 shares · 664 followersView post →
RM
Richard McCarty
@VUMcCarty · X
RT @zenbrainest: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Stu…
Psilocybin in Neuropsychiatry A Review of Its Phar | PDF | Psilocybin ...
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doi:10.1021/acschemneuro.9b00493. 10.1098/rsif.2014.0873. 73. Higgins GA, Carroll NK, Brown M, et al. Low doses of psilocybin and 54. Barrett FS, Krimmel SR ...
Psychedelics Essay Final Final | PDF | Hallucinogen | Psilocybin
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... 10.1021/acschemneuro.9b00493. Rougemont-Bücking, Ansgar, et al. “Comparing Mental Health across Distinct Groups of Users. of Psychedelics, MDMA ...