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ACS Synth Biol April 2020 PMID 32163268

Balancing Cell Populations Endowed with a Synthetic Toggle Switch Adaptive Pulsatile Feedback Control.

Agostino Guarino, Davide Fiore, Davide Salzano, Mario di Bernardo

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Mentions

12
Peak: 4 in Apr 2020
across 2 sources since Nov 2019

Extended reach

12,418
potential audience

Total likes

30

Video views

192

Mentions per month

Nov 2019 – Sep 2022

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions show high enthusiasm, with posts highlighting the innovative approach of using pulsatile feedback control and referencing the paper as a key development in synthetic biology, such as calling it a 'benchmark problem' or 'game changer.' The tone and word choices emphasize excitement and recognize the work's importance, reflecting a generally positive perception and engagement level.

AgreementModerate agreement

Most discussions recognize the significance of the research in advancing control strategies in synthetic biology, supporting its positive impact.

InterestHigh interest

The posts display strong interest, with many discussing the innovative control methods and their potential applications.

EngagementModerate engagement

Several comments reference specific techniques and previous research, indicating active engagement with the content.

ImpactModerate impact

The community perceives the work as potentially influential, though it is still emerging as a fundamental advancement.

Abstract in brief

  • This text discusses how synthetic biology aims to control populations of cells using a genetic toggle switch, with recent research showing that periodic forcing can keep cells in an undifferentiated state.
  • The authors introduce feedback control strategies that dynamically adjust the amplitude and duty cycle of pulsatile inputs, making the balancing of cell populations more robust against biological uncertainties like stochastic effects, growth, and diffusion.
  • They demonstrate through experiments and simulations that their feedback approach improves stability and performance compared to previous methods, highlighting its potential for practical implementation despite some limitations.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Mario di Bernardo
@mdiberna · X

Balancing cell populations via adaptive pulsatile feedback control. Our latest paper with @AgoGuarino92 @DavideSalzano94 @dvd_fiore on control in synthetic biology now out on @ACSSynBio @Syn_Biology @synbio_papers @SynBio https://t.co/7tOepRkhoR

Apr 17, 2020 · 20 likes · 3 shares · 1,942 followers View post →
Mario di Bernardo
@mdiberna · X

“The problem of controlling cells with a genetic toggle switch has been recently highlighted as a benchmark problem in #syntheticbiology .” @dvd_fiore @AgoGuarino92 and @DavideSalzano94 @ACSSynBio @CSSIEEE @cosybio

Nov 12, 2020 · 8 likes · 3 shares · 1,942 followers View post →
synbiopapers
@synbio_papers · X

[ASAP] Balancing Cell Populations Endowed with a Synthetic Toggle Switch via Adaptive Pulsatile Feedback Control https://t.co/jX8a7G8iLS https://t.co/pqj3E7JOii

Mar 20, 2020 · 2 likes · 4,047 followers View post →
bioRxiv Published
@biorxiv_pubd · X

Balancing cell populations endowed with a synthetic toggle switch via adaptive pulsatile feedback control published as: https://t.co/pQKY7OJ8x3 @acssynbio #biorxiv

Sep 19, 2022 · 2,909 followers View post →
Alexander Darlington
@apsduk · X

RT @mdiberna: “The problem of controlling cells with a genetic toggle switch has been recently highlighted as a benchmark problem in #synth…

Nov 12, 2020 · 3 shares · 918 followers View post →
Sara Napolitano
@SaraNapolitano5 · X

RT @mdiberna: Balancing cell populations via adaptive pulsatile feedback control. Our latest paper with @AgoGuarino92 @DavideSalzano94 @dvd…

Apr 17, 2020 · 3 shares · 155 followers View post →

All mentions

bioRxiv Published
@biorxiv_pubd · X

Balancing cell populations endowed with a synthetic toggle switch via adaptive pulsatile feedback control published as: https://t.co/pQKY7OJ8x3 @acssynbio #biorxiv

Sep 19, 2022 · 2,909 followers View post →
Davide Salzano
@DavideSalzano94 · X

RT @mdiberna: “The problem of controlling cells with a genetic toggle switch has been recently highlighted as a benchmark problem in #synth…

Nov 12, 2020 · 3 shares · 91 followers View post →
Davide Fiore
@dvd_fiore · X

RT @mdiberna: “The problem of controlling cells with a genetic toggle switch has been recently highlighted as a benchmark problem in #synth…

Nov 12, 2020 · 3 shares · 42 followers View post →
Alexander Darlington
@apsduk · X

RT @mdiberna: “The problem of controlling cells with a genetic toggle switch has been recently highlighted as a benchmark problem in #synth…

Nov 12, 2020 · 3 shares · 918 followers View post →
Mario di Bernardo
@mdiberna · X

“The problem of controlling cells with a genetic toggle switch has been recently highlighted as a benchmark problem in #syntheticbiology .” @dvd_fiore @AgoGuarino92 and @DavideSalzano94 @ACSSynBio @CSSIEEE @cosybio

Nov 12, 2020 · 8 likes · 3 shares · 1,942 followers View post →
Sara Napolitano
@SaraNapolitano5 · X

RT @mdiberna: Balancing cell populations via adaptive pulsatile feedback control. Our latest paper with @AgoGuarino92 @DavideSalzano94 @dvd…

Apr 17, 2020 · 3 shares · 155 followers View post →
Davide Salzano
@DavideSalzano94 · X

RT @mdiberna: Balancing cell populations via adaptive pulsatile feedback control. Our latest paper with @AgoGuarino92 @DavideSalzano94 @dvd…

Apr 17, 2020 · 3 shares · 91 followers View post →
Davide Fiore
@dvd_fiore · X

RT @mdiberna: Balancing cell populations via adaptive pulsatile feedback control. Our latest paper with @AgoGuarino92 @DavideSalzano94 @dvd…

Apr 17, 2020 · 3 shares · 42 followers View post →
Mario di Bernardo
@mdiberna · X

Balancing cell populations via adaptive pulsatile feedback control. Our latest paper with @AgoGuarino92 @DavideSalzano94 @dvd_fiore on control in synthetic biology now out on @ACSSynBio @Syn_Biology @synbio_papers @SynBio https://t.co/7tOepRkhoR

Apr 17, 2020 · 20 likes · 3 shares · 1,942 followers View post →
synbiopapers
@synbio_papers · X

[ASAP] Balancing Cell Populations Endowed with a Synthetic Toggle Switch via Adaptive Pulsatile Feedback Control https://t.co/jX8a7G8iLS https://t.co/pqj3E7JOii

Mar 20, 2020 · 2 likes · 4,047 followers View post →