Front Med April 2020 PMID 32170560

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection.

Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han

Mentions

72
Peak: 30 in Mar 2020
across 6 sources since Mar 2020

Extended reach

277,678
potential audience

Total likes

888

Video views

78,252

Mentions per month

Mar 2020 – Nov 2022

Where it's discussed

  • X / Twitter51 posts
  • Facebook14 posts
  • News3 articles
  • YouTube2 videos
  • Bluesky1 posts
  • Blogs1 articles

AI synopsis

What people are saying

The group of social discussions emphasizes the critical findings of the publication, citing specific organs like the lungs, heart, and kidneys, and highlighting how ACE2 receptor expression increases vulnerability. The tone and language, such as 'high risk' and 'vulnerable,' reflect a serious, impactful understanding of the research's consequences for disease prognosis and treatment strategies.

AgreementStrong agreement

Most discussions reinforce the article's findings, emphasizing the organs identified as vulnerable to COVID-19 based on ACE2 receptor expression.

InterestHigh interest

Discussion participants show high curiosity, referencing specific results like the high risk to lungs and kidneys, indicating engagement with the study's implications.

EngagementHigh engagement

Many comments delve into technical aspects of the data and mention detailed organ risk profiles, demonstrating deep analysis and active involvement.

ImpactHigh impact

The discussions highlight the significance of the research in understanding COVID-19 vulnerability, with phrases like 'potential risk' and 'risk map' illustrating its importance.

Abstract in brief

  • The study uses single-cell RNA sequencing data to analyze ACE2 receptor expression across different human organs, revealing which organs and specific cell types are most vulnerable to 2019nCoV (COVID-19) infection.
  • It confirms that the lungs, heart, kidneys, and digestive organs like the esophagus and ileum are at higher risk, with particular cell types such as alveolar cells and kidney tubule cells being more susceptible.
  • The findings help create a risk map of how and where 2019nCoV might invade the body, supporting further research into how the virus causes disease and spreads within different organs.

Top posts

Most liked on X and Bluesky
研究者「」@1copyからのRT-PCR
@uwemon · X

ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection | SpringerLink https://t.co/mWJ6DGuRFk

Oct 13, 2020 · 13 likes · 9 shares · 6,896 followers View post →
Rock Mada
@RackMada · X

@SyndromeK1 זה נכון! בעוד כמה איברים יש ביטוי של הרצפטור, כולל כליות, לב ואפילו שלפוחית השתן. האם הדבקה שם תמנע מהווירוס להגיע לריאות? אני לא יודע. הנה המאמר:https://t.co/DrecWWVdRS

Mar 29, 2020 · 9 likes · 36,560 followers View post →
SIP
@SIPediatri · X

Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua proteina “spike”, esporrebbe tali organi a maggiori rischi di compromissioni funzionali, soprattutto in caso di viremie. https://t.co/pYihL46bjB https://t.co/l93uXpLudt

Mar 16, 2020 · 4 likes · 4 shares · 1,318 followers View post →
Rocco Russo
@RocRus1 · X

Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua proteina “spike”, esporrebbe tali organi a maggiori rischi di compromissioni funzionali, soprattutto in caso di viremie. https://t.co/tIYELV4wAt https://t.co/AssWLslzXe

Mar 15, 2020 · 4 likes · 4 shares · 517 followers View post →
Arenas
@jearlugo · X

4/

May 15, 2020 · 2 likes · 5,673 followers View post →
The Grand Teuton
@flulrich · X

@jeffgiesea it's not yet understood - and would indeed be helpful meanwhile, this paper shows different risk profiles for organs based on ACE2 expression. most at risk: lung, heart, esophagus, kidney, ileum and bladder (though they haven't checked the entire body) https://t.co/tY3lSUl5y7

Mar 18, 2020 · 2 likes · 1,762 followers View post →

All mentions

How COVID-19 Infects Human Organs and Cells

This video explains how the COVID-19 coronavirus spreads via droplets and targets human cells with ACE2 receptors, affecting the lungs, heart, kidneys, and digestive organs. It highlights the vulnerabilities of specific…

TomoNews US · Apr 3, 2020 62,310 views
Ragna
@RagoutFin · X

@leseerlaubnis Wie findest du das hier? https://t.co/1d4fuEHvSp #CovidIsNotOver

Nov 30, 2022 · 873 followers View post →
Blackie56
@Blackie566 · X

@SHomburg Zou, X., Chen, K., Zou, J., Han, P., Hao, J., and Han, Z. (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med 14, 185-192.

Oct 18, 2020 · 47 followers View post →
GB
@GBfe06 · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 329 followers View post →
しるこサンド桜
@Olga88351025 · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 253 followers View post →
延喜
@r_braford · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 420 followers View post →
IWJ_KB_SPTR
@IWJ_KB_SPTR · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 349 followers View post →
内田
@uchida_kawasaki · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 1,928 followers View post →
真田 正夫/サタン(世も末)
@sanadian_dadd · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 524 followers View post →
平岡久司
@hisashi_0225 · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 771 followers View post →
兼水(kenzui)
@lamohkun · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 732 followers View post →
赤井キツネ/∃
@Rockow653 · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 2,090 followers View post →
Hiroshi Makita Ph.D. 誰が日本のコロナ禍を悪化させたのか?扶桑社8/18発売中
@BB45_Colorado · X

RT @uwemon: ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potenti…

Oct 13, 2020 · 9 shares · 55,893 followers View post →
研究者「」@1copyからのRT-PCR
@uwemon · X

ACE2発現レベルから新型コロナウイルスに感染するリスクのある臓器についての文献 >Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection | SpringerLink https://t.co/mWJ6DGuRFk

Oct 13, 2020 · 13 likes · 9 shares · 6,896 followers View post →
Sunshuenng
@WealthBlog_Ng · X

#ACE2 expression reveals risk of [lung, heart, esophagus, kidney, bladder, and ileum] and type II alveolar cells (AT2), myocardial cells, ileum and esophagus epithelial cells, and bladder urothelial cells] are vulnerable to 2019-nCoV infection. #COVIDー19 https://t.co/HweLnfOR5M

May 23, 2020 · 20 followers View post →
@COVID_Evidence
@COVID_Evidence · X

Core Pubmed: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection.: Related Articles Single-cell RNA-seq data analysis… https://t.co/yoxUtejUQe #coronavirus #SARS_CoV_2 #covid19

May 16, 2020 · 2,115 followers View post →
Arenas
@jearlugo · X

4/

May 15, 2020 · 2 likes · 5,673 followers View post →
Prof Simon Carley
@emmanchester.bsky.social · Bluesky

2. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection https://link.springer.com/article/10.1007/s11684-020-0754-0

Apr 14, 2020 · 1 share View post →
Simon Carley
@EMManchester · X

2. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection https://t.co/5dfoS6cTYy

Apr 14, 2020 · 28,241 followers View post →
Dr. Paul Peter Tak
@paulpetertak · X

@InvestorSwan @sciencescanner @AppleHelix The average proportion of ACE2-positive AT2 cells is approximately 1% with 1% standard derivation. The respiratory track is thus regarded as high risk. Front. Med. https://t.co/VFL2CO46mH

Apr 8, 2020 · 1,830 followers View post →
Nightgammer
@Nitegammer_ · X

Coronavirus animation: How COVID19 attacks the body - TomoNews - YouTube https://t.co/kwttdRR7aP

Apr 4, 2020 · 1,658 followers View post →
哇係灰熊啦⛽️tw
@icaretw · X

https://t.co/XkM06ot1zK

Apr 3, 2020 · 95 followers View post →
Creepypasta Slenderverse Fan
@Masky_Jay_Hoody · X

https://t.co/dhGwyHjWS3

Apr 3, 2020 · 2,016 followers View post →
Rock Mada
@RackMada · X

@SyndromeK1 זה נכון! בעוד כמה איברים יש ביטוי של הרצפטור, כולל כליות, לב ואפילו שלפוחית השתן. האם הדבקה שם תמנע מהווירוס להגיע לריאות? אני לא יודע. הנה המאמר:https://t.co/DrecWWVdRS

Mar 29, 2020 · 9 likes · 36,560 followers View post →
meteora
@Meteorapersa · X

RT @SIPediatri: Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua p…

Mar 27, 2020 · 4 shares · 401 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @sgivan: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerab…

Mar 24, 2020 · 1 share · 3,822 followers View post →
Scott Givan
@sgivan · X

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection https://t.co/9hqUyAZkWw #COVID19 #Bioinformatics

Mar 24, 2020 · 1 share · 769 followers View post →
Margherita Fronte
@mafronte · X

RT @RocRus1: Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua prot…

Mar 24, 2020 · 4 shares · 11,136 followers View post →
The Grand Teuton
@flulrich · X

@jeffgiesea it's not yet understood - and would indeed be helpful meanwhile, this paper shows different risk profiles for organs based on ACE2 expression. most at risk: lung, heart, esophagus, kidney, ileum and bladder (though they haven't checked the entire body) https://t.co/tY3lSUl5y7

Mar 18, 2020 · 2 likes · 1,762 followers View post →
Domenica Taruscio
@DTaruscio · X

RT @SIPediatri: Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua p…

Mar 18, 2020 · 4 shares · 2,551 followers View post →
Comasia Raguso
@cosetteraguso · X

RT @RocRus1: Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua prot…

Mar 17, 2020 · 4 shares · 127 followers View post →
Pere Joan Sala
@Fradbius · X

RT @didaclopez: "Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and il…

Mar 17, 2020 · 1 share · 250 followers View post →
didaclopez
@didaclopez · X

"Through scRNA-seq data analyses, we identified the organs at risk, such as lung, heart, esophagus, kidney, bladder, and ileum" https://t.co/NfFJvOpPup

Mar 17, 2020 · 1 share · 3,435 followers View post →
HealthHumanitiesLab_ISS
@HHLab_ISS · X

RT @SIPediatri: Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua p…

Mar 17, 2020 · 4 shares · 588 followers View post →
the paper link
@the_paper_link · X

Trend up+23: *Zou X* et al (Front Med) __Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection__ https://t.co/O25uswa29u

Mar 17, 2020 · 136 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @researchphilia:

Mar 17, 2020 · 1 share · 3,822 followers View post →
Researchphilia
@researchphilia · X

Mar 17, 2020 · 1 share · 481 followers View post →
Farmacología
@Farmaco_curso · X

De parte de la Dra. Mori: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection https://t.co/T3EG7ZF8GY Tomado de: https://t.co/dUGOjhCHwD

Mar 17, 2020 · 40 followers View post →
the paper link
@the_paper_link · X

Trend up+12: *Zou X* et al (Front Med) __Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection__ https://t.co/O25uswa29u

Mar 17, 2020 · 136 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @the_paper_link: Trend up+19: *Zou X* et al (Front Med) __Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the…

Mar 16, 2020 · 1 share · 3,822 followers View post →
the paper link
@the_paper_link · X

Trend up+19: *Zou X* et al (Front Med) __Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection__ https://t.co/O25uswa29u

Mar 16, 2020 · 1 share · 136 followers View post →
flavio quarantiello
@flavioquara · X

RT @SIPediatri: Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua p…

Mar 16, 2020 · 4 shares · 301 followers View post →
SIP
@SIPediatri · X

Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua proteina “spike”, esporrebbe tali organi a maggiori rischi di compromissioni funzionali, soprattutto in caso di viremie. https://t.co/pYihL46bjB https://t.co/l93uXpLudt

Mar 16, 2020 · 4 likes · 4 shares · 1,318 followers View post →
the paper link
@the_paper_link · X

Trend up+29: *Zou X* et al (Front Med) __Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection__ https://t.co/O25uswa29u

Mar 15, 2020 · 136 followers View post →
the paper link
@the_paper_link · X

Trend up+41: *Zou X* et al (Front Med) __Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection__ https://t.co/O25uswa29u

Mar 15, 2020 · 136 followers View post →
the paper link
@the_paper_link · X

Trend new: *Zou X* et al (Front Med) __Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection__ https://t.co/O25uswa29u

Mar 15, 2020 · 136 followers View post →
jena
@jenaPlissken000 · X

RT @RocRus1: Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua prot…

Mar 15, 2020 · 4 shares · 60 followers View post →
Daniele Banfi
@danielebanfi83 · X

RT @RocRus1: Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua prot…

Mar 15, 2020 · 4 shares · 5,658 followers View post →
Rocco Russo
@RocRus1 · X

Il livello di espressione del recettore ACE2 su determinati organi, permettendo il legale del #COVID19 attraverso la sua proteina “spike”, esporrebbe tali organi a maggiori rischi di compromissioni funzionali, soprattutto in caso di viremie. https://t.co/tIYELV4wAt https://t.co/AssWLslzXe

Mar 15, 2020 · 4 likes · 4 shares · 517 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @PapersPe: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulner…

Mar 15, 2020 · 1 share · 3,822 followers View post →
placenta_PE_papers
@PapersPe · X

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. https://t.co/ukZRZaJkka

Mar 15, 2020 · 1 share · 8 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @PaperbirdsH: New article: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different hum…

Mar 15, 2020 · 1 share · 3,822 followers View post →
NFTdose
@PaperbirdsH · X

New article: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. https://t.co/NyyMcJtF52 #coronavirus #COVID19 #2019ncov

Mar 15, 2020 · 1 like · 1 share · 301 followers View post →
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doi: 10.1007/s11684-020-0754-0. [Epub ahead of print] Wang P, Anderson N, Pan Y, Poon L, Charlton C, Zelyas N, Persing D, Rhoads D, Babcock H.The SARS-CoV-2 ...

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Med. https://doi. org/10.1007/s11684-020-0754-0 · تصوير کی تفصیل دستیاب نہیں ہے۔

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Tomado de: Front. Med. https://doi. org/10.1007/s11684-020-0754-0 · 没有照片描述。

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org/10.1007/s11684-020-0754-0 · Ingen bildebeskrivelse er tilgjengelig.

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https://doi.org/10.1007/s11684-020-0754-0 · Нема опис за фотографијата.

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... RNA-seq). Tomado de: Front. Med. https://doi. org/10.1007/s11684-020-0754-0 · No photo description available.

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org/10.1007/s11684-020-0754-0 · फ़ोटो के बारे में कोई जानकारी नहीं दी गई है.

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Med. https://doi. org/10.1007/s11684-020-0754-0 · Nėra nuotraukos aprašo.

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Angiotensin-Converting Enzyme Inhibitor / Angiotensin II Receptor Blocker in COVID-19: a Double-edged Sword or a Myth Kunal Bikram Shaha1, ...

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