Nat Genet April 2020 PMID 32231276

Minimal phenotyping yields genome-wide association signals of low specificity for major depression.

Na Cai, Joana A Revez, Mark J Adams, Till F M Andlauer, Gerome Breen, Enda M Byrne, Toni-Kim Clarke, Andreas J Forstner, Hans J Grabe, Steven P Hamilton, Douglas F Levinson, Cathryn M Lewis, Glyn Lewis, Nicholas G Martin, Yuri Milaneschi

Mentions

28
Peak: 8 in Mar 2020
across 3 sources since Mar 2020

Extended reach

215,206
potential audience

Total likes

42

Video views

1,223

Mentions per month

Mar 2020 – Jul 2025

Where it's discussed

  • X / Twitter23 posts
  • YouTube3 videos
  • News2 articles

AI synopsis

What people are saying

The group expresses cautious agreement with the article, as seen in references to additional research and methodological critiques, such as mentions of other papers by Jonathan Flint and the importance of large sample sizes, which reflect a thoughtful and engaged attitude towards the implications of the research findings.

AgreementModerate agreement

Most discussions acknowledge the limitations of minimal phenotyping, showing a consensus that it leads to less specific genetic signals for major depression.

InterestModerate interest

Participants demonstrate moderate curiosity, referencing related papers and engaging with the topic through social discussions and sharing articles.

EngagementModerate engagement

Posts include references to methods, other studies, and implications, indicating a reasonable level of engagement and critical thinking.

ImpactModerate impact

The discussions highlight the significance of measurement methods for genetic research, suggesting the findings could influence future studies and approaches in the field.

Abstract in brief

  • Minimal phenotyping, which uses only a few self-reported items to identify disease cases in genomewide association studies (GWAS), results in less specific and less heritable genetic signals for major depression compared to strictly defined major depressive disorder (MDD).
  • Studies show that GWAS based on minimal phenotyping tend to identify genetic loci that are not specific to MDD and share genetic overlap with other conditions, leading to less precise insights into the genetics of depression.
  • While minimal phenotyping can produce highly predictive polygenic risk scores, their accuracy mainly depends on large sample sizes, not on being specifically tailored to MDD, which may bias understanding of the disorder’s genetic pathways.

Top posts

Most liked on X and Bluesky
Nature Genetics
@NatureGenet · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression (Cai et al.) https://t.co/HwjHCf0pYj https://t.co/KeM6pMzTeW

Mar 30, 2020 · 11 likes · 3 shares · 128,324 followers View post →
Helmholtz Munich | @HelmholtzMunich
@HelmholtzMunich · X

Mar 31, 2020 · 6 likes · 10,086 followers View post →
Isabell Brikell
@IsabellBrikell · X

A good reminder in the depression session at #WCPG2020. Need for large N in GWAS does not make quality of measurement irrelevant! Minimal phenotyping yields genome-wide association signals of low specificity for major depression https://t.co/XXd70bkCTs

Oct 21, 2020 · 4 likes · 339 followers View post →
Amir Sariaslan
@AmirSariaslan · X

"Minimal phenotyping yields genome-wide association signals of low specificity for major depression" https://t.co/MoUH20rRKZ cc @EikoFried

Apr 2, 2020 · 3 likes · 1 share · 20,312 followers View post →
BioDecoded
@BioDecoded · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression | Nature Genetics https://t.co/d3RfpJppDr #GWAS https://t.co/dLsUhxodXQ

May 6, 2020 · 2 likes · 8,902 followers View post →
Anand Gururajan
@anandgururajan · X

'Minimal phenotyping yields genome-wide association signals of low specificity for major depression' in @NatureGenet #majordepression #GWAS https://t.co/caV0TDg7ka

Apr 6, 2020 · 2 likes · 1 share · 1,757 followers View post →

All mentions

Verena Zuber
@VerenaZuber · X

→ Confounding and non-specific genetic associations in the original genome-wide association study https://t.co/cUvtrm8VRI → The high levels of symptom-level and diagnostic overlap between major depressive disorder and other psychiatric disorders https://t.co/PQCX2E9mYt 10/

Jun 24, 2024 · 1 like · 630 followers View post →
Diego Forero MD, PhD
@daforerog · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression https://t.co/B9LxNxI5Yk

Feb 7, 2023 · 1 like · 1,596 followers View post →
Robert W. Williams
@robwilliamsiii · X

There is another paper by Jonathan Flint @jonathan_flint1 on this subject, casting shadow on “depression” hits—correctly in my view. https://t.co/zT2TDR8DQ5 https://t.co/Gkr6IkY2ZE

Apr 4, 2022 · 1,203 followers View post →
Todd Lencz
@ToddLencz · X

@doctorveera I’d like to see other papers like this one: https://t.co/bL1ZShLBpW

Jan 3, 2021 · 1 like · 717 followers View post →
UCL Discovery
@ucl_discovery · X

Open Access UCL Research: Minimal phenotyping yields genome-wide association signals of low specificity for major depression https://t.co/KNEo4uIjWc

Dec 11, 2020 · 2,528 followers View post →
Isabell Brikell
@IsabellBrikell · X

A good reminder in the depression session at #WCPG2020. Need for large N in GWAS does not make quality of measurement irrelevant! Minimal phenotyping yields genome-wide association signals of low specificity for major depression https://t.co/XXd70bkCTs

Oct 21, 2020 · 4 likes · 339 followers View post →
James Kerwin
@JamesKerwin9 · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression https://t.co/jz2E5lbeE8

Sep 29, 2020 · 144 followers View post →
InWhites
@EthnicScientist · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression #InWhites https://t.co/cYcFVPvkTA

Jun 19, 2020 · 218 followers View post →
BioDecoded
@BioDecoded · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression | Nature Genetics https://t.co/d3RfpJppDr #GWAS https://t.co/dLsUhxodXQ

May 6, 2020 · 2 likes · 8,902 followers View post →
PubMedCurator
@PubMedCurator · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression. https://t.co/dpaaYBsTsZ

Apr 22, 2020 · 137 followers View post →
Anthony Hannan
@anthonyjhannan · X

RT @anandgururajan: 'Minimal phenotyping yields genome-wide association signals of low specificity for major depression' in @NatureGenet #m…

Apr 6, 2020 · 1 share · 4,548 followers View post →
Anand Gururajan
@anandgururajan · X

'Minimal phenotyping yields genome-wide association signals of low specificity for major depression' in @NatureGenet #majordepression #GWAS https://t.co/caV0TDg7ka

Apr 6, 2020 · 2 likes · 1 share · 1,757 followers View post →
BioDecoded
@BioDecoded · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression | Nature Genetics https://t.co/d3RfpJppDr #GWAS https://t.co/7lbTY65bli

Apr 5, 2020 · 8,902 followers View post →
zuxfoucault
@zuxfoucault · X

RT @AmirSariaslan: "Minimal phenotyping yields genome-wide association signals of low specificity for major depression" https://t.co/MoUH20…

Apr 3, 2020 · 1 share · 574 followers View post →
Amir Sariaslan
@AmirSariaslan · X

"Minimal phenotyping yields genome-wide association signals of low specificity for major depression" https://t.co/MoUH20rRKZ cc @EikoFried

Apr 2, 2020 · 3 likes · 1 share · 20,312 followers View post →
ENCODE Project
@ENCODE_NIH · X

RT @NatureGenet: Minimal phenotyping yields genome-wide association signals of low specificity for major depression (Cai et al.) https://t.…

Mar 31, 2020 · 3 shares · 10,614 followers View post →
Stefano Berto, PhD
@StefanoBerto83 · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression | Nature Genetics https://t.co/2PaMVACdSF

Mar 31, 2020 · 7,748 followers View post →
Na Cai
@caina89 · X

RT @NatureGenet: Minimal phenotyping yields genome-wide association signals of low specificity for major depression (Cai et al.) https://t.…

Mar 31, 2020 · 3 shares · 2,128 followers View post →
Helmholtz Munich | @HelmholtzMunich
@HelmholtzMunich · X

Mar 31, 2020 · 6 likes · 10,086 followers View post →
M Herrera-Rivero
@HerreraR_biomed · X

RT @NatureGenet: Minimal phenotyping yields genome-wide association signals of low specificity for major depression (Cai et al.) https://t.…

Mar 31, 2020 · 3 shares · 181 followers View post →
Janet Piñero
@Janis3_14159 · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression https://t.co/wpWan8yGbW

Mar 30, 2020 · 1 like · 768 followers View post →
Diego Forero MD, PhD
@daforerog · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression https://t.co/B9LxNxI5Yk

Mar 30, 2020 · 1,596 followers View post →
Nature Genetics
@NatureGenet · X

Minimal phenotyping yields genome-wide association signals of low specificity for major depression (Cai et al.) https://t.co/HwjHCf0pYj https://t.co/KeM6pMzTeW

Mar 30, 2020 · 11 likes · 3 shares · 128,324 followers View post →