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Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways.
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Apr 2020 – Jul 2025Where it's discussed
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What people are saying
The discussions highlighted critical aspects of the article, such as how low lean muscle mass and beta cell dysfunction contribute to the high prevalence of diabetes in South Asians. Phrases like 'need broad public health messaging' and 'a novel perspective' illustrate a sense of urgency and relevance, while the tone varies from persuasive to informative, demonstrating the range of opinions within the community.
Many discussions support the article's hypothesis, acknowledging the unique biological factors affecting South Asians, although some express skepticism based on different interpretations of the data.
Contributors show high interest, frequently referencing related studies and background information regarding diabetes risk and the mechanisms at play.
Participants dive into the article's points but vary in their depth of discussion; some posts provide significant context while others remain surface level.
A strong sentiment exists regarding the article's potential to influence public health discussions and research directions in addressing diabetes among South Asians.
Abstract in brief
- South Asians exhibit a higher prevalence of type 2 diabetes even with lower body mass index (BMI), suggesting unique metabolic challenges in this population.
- Emerging studies indicate that South Asians might have a reduced capacity to secrete insulin, leading to vulnerabilities under unhealthy lifestyle conditions rather than solely relying on insulin resistance as the main cause.
- A combination of factors such as lower muscle mass and a tendency for fat accumulation in the liver and muscles may exacerbate insulin action disruption, signaling the need for more research into these specific mechanisms impacting South Asian populations.
Top posts
Most liked on X and BlueskyUp front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvnarayan14 @alka_kanaya @EmoryRollins @UCSF https://t.co/3J87LxN3o3 #editorspicks https://t.co/EDdZdIzICT
Sugestão de leituras para o thread. https://t.co/IUrcjEH3so
A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvnarayan14 @alka_kanaya @EmoryRollins @UCSF https://t.co/yoo7THGi51 https://t.co/j8kwwjnc5w
https://t.co/XUR0B2Ed6w
Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liver (#fattyliver) & muscle. #Insulinresistance probably plays minor role. @DiabetologiaJnl @EASDelearning @kamleshkhunti @drmohanv https://t.co/ElInQQMhzo
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Impact of British Colonization on Health in India
This video explores how British colonization has resulted in significant health issues in India, including a heightened risk of type 2 diabetes. South Asians display a unique metabolic profile, suggesting a need for…
Insulin Resistance and Type 2 Diabetes in South Asians Explained
This is incorrect. There is scientific evidence to show that Indians are more vulnerable to diabetes than other races, also evidence connecting it to centuries of deprivation. Here are 3 papers: 1. https://t.co/H6BXuSnHZB 2. https://t.co/T1rORngc9d 3. https://t.co/CprMR6Yjfu https://t.co/UUcni2UJrz
@ocnerth https://t.co/sbwujND8RS Ah see some of the stuff here too, not a smoking gun either but this isn't totally out my ass.
@DrDeepMD Many papers support this: https://t.co/27NZSFV4Yj https://t.co/AnUUJRnCvt https://t.co/M5p6Dtsv9x https://t.co/zMVLZhZAch
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
RT @shinigamind: @Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
@Non240020041905 https://t.co/1X3GeQeR6X https://t.co/ZDUddrEzZv https://t.co/dvKfsEzBkx
@gmohan64 @DharavSolanki @theliverdr there's research into South Asians being prone to type 2 diabetes https://t.co/BMPjNOxlOX and @guardian put up this video https://t.co/vChWn89RkM
@ArnoldRhino @bharat1596954 @GemsOfINDOLOGY https://t.co/nhFaQndQDG https://t.co/LJOwHz2Y08 https://t.co/ZchoiCnBbv Read them they are not Russia Funded News Portal, one is Nature, another is USA website.
RT @kmvnarayan14: @egdrc @EmoryUniversity @EmoryRollins @guardian We @alka_kanaya posit islet cells of the pancreas have been compromise…
RT @kmvnarayan14: @egdrc @EmoryUniversity @EmoryRollins @guardian We @alka_kanaya posit islet cells of the pancreas have been compromise…
@egdrc @EmoryUniversity @EmoryRollins @guardian We @alka_kanaya posit islet cells of the pancreas have been compromised, in addition to impaired insulin action. https://t.co/aVrBl46jmU How British colonialism increased #diabetes in south Asians https://t.co/aD8c5YkYQd
@jamalna82341410 @BrownJHM @DelthiaRicks @d_s_thakur @DalrympleWill @suchetadalal @Teensthack @salilkallianpur @drkeithsiau @IMAIndiaOrg @PriyankaPulla @Banjotkaur @RPrasad12 @ChandnaHimani @KavitaDatt Here is a much more plausible explanation by @EmoryUniversity Prof @kmvnarayan14 et al https://t.co/DDu9gQVbbG
Sugestão de leituras para o thread. https://t.co/IUrcjEH3so
@vivekagnihotri This article attributes unusually high rates of diabetes among south asians and people of south asian descent to: 1. Reduced Beta cell function (which releases insulin) 2. Low lean muscle mass (due to passive lifestyle / deficiency) https://t.co/Ab5D85yTyG
@davidbelle_ @rachelmantock https://t.co/MA9F1MqtA3
RT @jamalawan42: https://t.co/XUR0B2Ed6w
@thefoodlearner https://t.co/6ttmJOW9rn
RT @jamalawan42: https://t.co/XUR0B2Ed6w
https://t.co/XUR0B2Ed6w
@KamathGurudutt @latajag @1shankarsharma https://t.co/oofqu3E5eW When work was harder the diet was not as big a problem. Now working inside and light duty causes disease. I have been studying and treating this for nearly 20 years.
@WilliamGrobman https://t.co/fCyYdq83i4 https://t.co/EP4L44suZ9
RT @kojija: 【インスリン機能が弱いアジア人】 ベータ細胞機能が弱い 筋肉量が少ない→インスリン作用が低い 進化的な理由は何だろうか? 中東の小麦農耕文化に満足せず、東へ南へ肉と魚を追いかけて移住したから? https://t.co/w6SiQcKwpL ht…
RT @kojija: 【インスリン機能が弱いアジア人】 ベータ細胞機能が弱い 筋肉量が少ない→インスリン作用が低い 進化的な理由は何だろうか? 中東の小麦農耕文化に満足せず、東へ南へ肉と魚を追いかけて移住したから? https://t.co/w6SiQcKwpL ht…
【インスリン機能が弱いアジア人】 ベータ細胞機能が弱い 筋肉量が少ない→インスリン作用が低い 進化的な理由は何だろうか? 中東の小麦農耕文化に満足せず、東へ南へ肉と魚を追いかけて移住したから? https://t.co/w6SiQcKwpL https://t.co/79ONrQqyhC
@Roshan_Karia PS - Asians include Pakistanis, Bangladeshis etc and the ‘higher earning’ ‘stressed’ Indian are only small part of the group. Diabetes more prevalent in Asians is not coz of stressful lifestyle. It’s more molecular than that: https://t.co/zYd8aHjbPa
RT @alka_kanaya: @AnkurKalraMD @ShariqShamimMD @doconmoney @DrAnkitKPatel @DrMarthaGulati @iamritu @purviparwani @KoushikReddyMD @JayMathew…
RT @alka_kanaya: @AnkurKalraMD @ShariqShamimMD @doconmoney @DrAnkitKPatel @DrMarthaGulati @iamritu @purviparwani @KoushikReddyMD @JayMathew…
@AnkurKalraMD @ShariqShamimMD @doconmoney @DrAnkitKPatel @DrMarthaGulati @iamritu @purviparwani @KoushikReddyMD @JayMathewsMD @RealKushAgrawal @Uqayyum123 Several culprits: a combination of higher liver fat (more of a problem than visceral fat in South Asians), low lean mass, and beta cell dysfunction, some evolutionarily determined @kmvnarayan14 https://t.co/zUmsVLMDnl
RT @GuruAnaerobic: 'Why are South Asians prone to T2D? - March 2020 - Reduced beta cell mass and/or function, impairing insulin secretion…
RT @GuruAnaerobic: 'Why are South Asians prone to T2D? - March 2020 - Reduced beta cell mass and/or function, impairing insulin secretion…
RT @GuruAnaerobic: 'Why are South Asians prone to T2D? - March 2020 - Reduced beta cell mass and/or function, impairing insulin secretion…
'Why are South Asians prone to T2D? - March 2020 - Reduced beta cell mass and/or function, impairing insulin secretion - low lean muscle mass -> reduced insulin action. - propensity to ectopic fat deposition in the liver&muscle, impairing insulin action https://t.co/AsfN8gnihX
RT @alka_kanaya: Devastating models for #diabetes risk in India. Need broad #PublicHealth messaging of nutrition/exercise/weight loss, and…
Devastating models for #diabetes risk in India. Need broad #PublicHealth messaging of nutrition/exercise/weight loss, and studies to investigate other novel methods of prevention: https://t.co/zUmsVLMDnl https://t.co/UZgTK3H0gA
RT @kmvnarayan14: Recent alarming data on lifetime risk of #diabetes in #SouthAsians published in @DiabetologiaJnl shine the focus on the q…
Recent alarming data on lifetime risk of #diabetes in #SouthAsians published in @DiabetologiaJnl shine the focus on the question why this population is at high risk at low body weights. https://t.co/KBSh5F6kfC @alka_kanaya @WHO @NIDDKgov @NIMHD @nih_nhlbi @egdrc @IntDiabetesFed
4 in 10 men and 1 in 2 women in urban South Asia, considered under- or normal-weight at age 20, will develop diabetes in their lifetime. Obesity and adiposity does not explain this. https://t.co/KBSh5FnVEc https://t.co/Jfu2LqHeTY
RT @alka_kanaya: A perspective by @kmvnarayan14 and me: Why are #SouthAsians prone to #diabetes? A hypothesis @NIDDKgov @nih_nhlbi @u…
Great paper from MASALA study. Further advances the hypothesis for why South Asians are at high risk of type 2 diabetes (Hepatic fat important). https://t.co/LmEnET41Px https://t.co/wHcA8GxJ23 https://t.co/wZOYknuF8y
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
RT @alka_kanaya: A perspective by @kmvnarayan14 and me: Why are #SouthAsians prone to #diabetes? A hypothesis @NIDDKgov @nih_nhlbi @u…
RT @alka_kanaya: A perspective by @kmvnarayan14 and me: Why are #SouthAsians prone to #diabetes? A hypothesis @NIDDKgov @nih_nhlbi @u…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
RT @PowellJose: Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscl…
Important review on #SouthAsians & ⬆️ diabetes risk (despite lower BMI). Multiple mechanisms: ⬇️ beta cell fxn, lean muscle (genes) ⬆️ ectopic fat deposit (diet/lifestyle) Need more research on interventions (resistance/HIIT training)
Increased risk of #diabetes in #southasian people https://t.co/tzNK6Ysbyl https://t.co/J2kNtMvzuD
RT @drstak70: Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liv…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
A great read on why South Asians are more prone to diabetes https://t.co/yZ1V5MVjgv https://t.co/a9L6Nuqxh4
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
RT @profsmarshall: Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes…
Up front and free to read in June's @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvnarayan14 @alka_kanaya @EmoryRollins @UCSF https://t.co/3J87LxN3o3 #editorspicks https://t.co/EDdZdIzICT
RT @drstak70: Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liv…
RT @drstak70: Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liv…
RT @drstak70: Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liv…
RT @drstak70: Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liv…
RT @drstak70: Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liv…
RT @drstak70: Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liv…
RT @drstak70: Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liv…
Why south-asians are more prone to T2 #Diabetes? *reduced beta cell function *low muscle mass *ectopic fat deposition in liver (#fattyliver) & muscle. #Insulinresistance probably plays minor role. @DiabetologiaJnl @EASDelearning @kamleshkhunti @drmohanv https://t.co/ElInQQMhzo
RT @EmoryRollins: Rollins professor @kmvnarayan14 co-authored a review in a recent issue of @DiabetologiaJnl which hypothesizes that lower…
Rollins professor @kmvnarayan14 co-authored a review in a recent issue of @DiabetologiaJnl which hypothesizes that lower lean muscle mass and ectopic fat deposition might drive the abnormally high prevalence of #diabetes among South Asians. Learn more: https://t.co/tsA7cRCOCS https://t.co/jJzn2Hp7Zt
Why are #SouthAsians prone to #type2diabetes? A hypothesis based on underexplored pathways https://t.co/fiXKsmk8EX https://t.co/0hvshtiTcI
南アジア人はBMIが低くても2型糖尿病の有病率が高い。その考えられるメカニズムは: インスリン分泌能力が低いため、不健康な生活習慣への耐性が低い 平均的に筋肉量が少なく、異所性肝脂肪蓄積や細胞内脂肪沈着がインスリン作用の障害を引き起こす可能性 https://t.co/OYqjRfHruZ
high diabetes susceptibility in South Asians woul be evolutionarily through reduced beta cell function and impaired insulin action owing to low lean mass, which would be further accentuated by ectopic fat deposition in the liver and muscle https://t.co/UECCXjoKZE
In a recently published issue of @DiabetologiaJnl, @rollinsHDGH professor @kmvnarayan14 and @alka_kanaya authored an article which examined possible reasons behind the inordinately high prevalence of type 2 #diabetes among South Asians. Learn more: https://t.co/Ar4EEvFMhf @egdrc https://t.co/m5cMs2kBi4
RT @suryasath: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways | SpringerLink https://t.co/UW5h…
RT @suryasath: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways | SpringerLink https://t.co/UW5h…
RT @suryasath: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways | SpringerLink https://t.co/UW5h…
Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways | SpringerLink https://t.co/UW5hfQcAhZ
RT @kmvnarayan14: Just published our article "Why are South Asians prone to type 2 diabetes? .." with #Springer https://t.co/0K46lGWEYi via…
Just published our article "Why are South Asians prone to type 2 diabetes? .." with #Springer https://t.co/0K46lGWEYi via @SN_Authors
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
Why do South Asians have a higher prevalence of type 2 #diabetes? In this recently published article, Rollins' @kmvnarayan14 and @UCSF's @alka_kanaya hypothesize that this atypical susceptibility could be linked to low muscle mass and ectopic fat: https://t.co/oXcpdzMYGH @egdrc https://t.co/35q7Z4JEok
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
RT @DiabetologiaJnl: A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvn…
A novel perspective: Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways @kmvnarayan14 @alka_kanaya @EmoryRollins @UCSF https://t.co/yoo7THGi51 https://t.co/j8kwwjnc5w
Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways. - PubMed - NCBI https://t.co/5yucwkOHC9
Non-COVID-Why are #SouthAsians prone to #type2diabetes? A hypothesis based on underexplored pathways https://t.co/QJ0oubxgF1
RT @kamleshkhunti: Why are South Asians prone to T2 diabetes? A hypothesis https://t.co/A9iW37Iz96 @DSNforumUK @youngdiab @ABCDiab @Am…
RT @kamleshkhunti: Why are South Asians prone to T2 diabetes? A hypothesis https://t.co/A9iW37Iz96 @DSNforumUK @youngdiab @ABCDiab @Am…
Interesting read : Why are South Asians prone to T2 diabetes? A hypothesis https://t.co/vxhlZqZS0A @SouthAsianHF @Ahmed742Iqbal @m_alikaramat @DeepaPa46002748 @zeenat49806942 @documi https://t.co/53YfD84zml
RT @kamleshkhunti: Why are South Asians prone to T2 diabetes? A hypothesis https://t.co/A9iW37Iz96 @DSNforumUK @youngdiab @ABCDiab @Am…
RT @kamleshkhunti: Why are South Asians prone to T2 diabetes? A hypothesis https://t.co/A9iW37Iz96 @DSNforumUK @youngdiab @ABCDiab @Am…