PubHawk
April 2020 PMID 32246132

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer.

Alex H Wagner, Brian Walsh, Georgia Mayfield, David Tamborero, Dmitriy Sonkin, Kilannin Krysiak, Jordi Deu-Pons, Ryan P Duren, Jianjiong Gao, Julie McMurry, Sara Patterson, Catherine Del Vecchio Fitz, Beth A Pitel, Ozman U Sezerman, Kyle Ellrott

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Mentions

51
Peak: 41 in Apr 2020
across 4 sources since Apr 2020

Extended reach

436,790
potential audience

Total likes

98

Video views

969

Mentions per month

Apr 2020 – May 2021

Where it's discussed

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  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

Several discussions highlight the article’s emphasis on unifying different cancer variant databases to enhance clinical decision-making. Phrases like 'improved overlap and consistency' and references to the launch of a 'public web tool' reflect a focus on practical advancements. The tone varies from supportive recognition of the harmonization effort to curiosity about its real-world impact, depicting a generally positive but measured outlook.

AgreementModerate agreement

Most discussions acknowledge the importance of creating a unified resource to improve cancer variant interpretation, showing moderate support for the publication's goals.

InterestHigh interest

The posts display high curiosity, often emphasizing the significance of the meta-knowledgebase through words like 'harmonized' and 'improved,' indicating strong engagement with the topic.

EngagementModerate engagement

Participants reference specific aspects such as the creation of a public web tool and the challenge of inconsistencies between databases, demonstrating thoughtful involvement.

ImpactModerate impact

The overall tone suggests that users see potential for meaningful influence in clinical practice, though some remain cautiously optimistic rather than outright revolutionary.

Abstract in brief

  • Precision oncology depends on precise identification and understanding of genomic variants to tailor cancer care effectively.
  • A study revealed significant differences among six major cancer variant databases, making it harder for clinicians to agree on the importance of specific variants.
  • The researchers created a unified meta-knowledgebase that improved overlap and consistency between these resources, leading to a better match of patient data to clinically relevant interpretations, and they launched a public web tool for exploring these interpretations.
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Nature Genetics
@NatureGenet · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://t.co/xjW2Z3inig https://t.co/E9aYwaeOi0

Apr 3, 2020 · 43 likes · 15 shares · 128,305 followers View post →
Dr. Iván R. González
@Dr_Ivanoncologo · X

@NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 5, 2020 · 36 likes · 18 shares · 4,202 followers View post →
BioDecoded
@BioDecoded · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer | Nature Genetics https://t.co/YWO8uKMpbd #bioinformatics https://t.co/n0qlULLte5

Apr 8, 2020 · 5 likes · 8,896 followers View post →
Jason H. Moore, PhD
@moorejh · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer - Nature Genetics https://t.co/Iyl9nBHoxA #cancer #genomics #bioinformatics https://t.co/9eOfTbHbIH

May 20, 2020 · 1 like · 1 share · 34,218 followers View post →
BibliotecaHUVH
@BibliotecaHUVH · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer https://t.co/vUEMT2aspb #hvhebron #onco [Text complet] @NatureGenet

Apr 6, 2020 · 1 like · 1 share · 2,313 followers View post →
Nature Genetics
@NatureGenet · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 128,305 followers View post →

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priya joseph
@ayirpelle · X

RT @moorejh: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer - Nature Genetics https://t.…

May 20, 2020 · 1 share · 4,906 followers View post →
Jason H. Moore, PhD
@moorejh · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer - Nature Genetics https://t.co/Iyl9nBHoxA #cancer #genomics #bioinformatics https://t.co/9eOfTbHbIH

May 20, 2020 · 1 like · 1 share · 34,218 followers View post →
BioDecoded
@BioDecoded · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer | Nature Genetics https://t.co/YWO8uKMpbd #Bioinformatics https://t.co/dpcsFPMdVa

May 8, 2020 · 8,896 followers View post →
Momo-mama
@Momotaro_mama_k · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 21, 2020 · 18 shares · 175 followers View post →
Marwa Abdelazeem
@masrayagdn · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 16, 2020 · 18 shares · 35 followers View post →
Sushmita Roy @sroyyors.bsky.social,genomic.social
@sroyyors · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer https://t.co/n79zUbf7e1

Apr 9, 2020 · 1,269 followers View post →
BioDecoded
@BioDecoded · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer | Nature Genetics https://t.co/YWO8uKMpbd #bioinformatics https://t.co/n0qlULLte5

Apr 8, 2020 · 5 likes · 8,896 followers View post →
McDonnell Genome Institute, WashU Medicine
@GenomeInstitute · X

A Harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer https://t.co/OOvPP5HG13

Apr 8, 2020 · 17,872 followers View post →
Zhandong Liu
@ZhandongLiu · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 7, 2020 · 18 shares · 254 followers View post →
Hernan Dopazo
@hernandopazo · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 795 followers View post →
Nahaa E. Alsubaie
@N1h11 · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 6, 2020 · 15 shares · 135 followers View post →
David Russler-Germain, MD/PhD
@dgermain21 · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 3,666 followers View post →
Janet Piñero
@Janis3_14159 · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 6, 2020 · 15 shares · 768 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 1,325 followers View post →
Robert West, PhD ✝️
@westr · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 19,325 followers View post →
Terry Hébert
@THebertMcGill · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 2,187 followers View post →
Jitendra K Meena
@jitendrakmeena · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 122 followers View post →
Lei Li
@LeiLi_bioinfo · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 643 followers View post →
PharmaPosition
@PharmaPosition · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 1,089 followers View post →
Ashok R. Dinasarapu Ph.D
@adinasarapu · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 243 followers View post →
Roel Verhaak
@roelverhaak · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 5,035 followers View post →
Philippe Froguel
@philippefroguel · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 5,023 followers View post →
Christian LLC
@lacks22 · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 420 followers View post →
Nature Genetics
@NatureGenet · X

RT @Dr_Ivanoncologo: @NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 6, 2020 · 18 shares · 128,305 followers View post →
Saludteca
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RT @BibliotecaHUVH: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer https://t.co/vUEMT2as…

Apr 6, 2020 · 1 share · 1,999 followers View post →
BibliotecaHUVH
@BibliotecaHUVH · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer https://t.co/vUEMT2aspb #hvhebron #onco [Text complet] @NatureGenet

Apr 6, 2020 · 1 like · 1 share · 2,313 followers View post →
Dr. Iván R. González
@Dr_Ivanoncologo · X

@NatureGenet | A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in #cancer |

Apr 5, 2020 · 36 likes · 18 shares · 4,202 followers View post →
Biotexcel
@Biotexcel · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer - https://t.co/G46xlHW5oo

Apr 5, 2020 · 1,651 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer https://t.co/igulJxUjtm

Apr 5, 2020 · 31,603 followers View post →
John M Hancock
@JohnMHancock · X

RT @jsantoyo: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer. https://t.co/VqwCTIstm1

Apr 4, 2020 · 1 share · 1,129 followers View post →
Javier Santoyo
@jsantoyo · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer. https://t.co/VqwCTIstm1

Apr 4, 2020 · 1 share · 6,128 followers View post →
Art Teerasak
@artteristic · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 4, 2020 · 15 shares · 44 followers View post →
Yuan
@Yuan98309894 · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 4, 2020 · 15 shares · 11 followers View post →
Susan Jones
@Su_Jo10 · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 4, 2020 · 15 shares · 19 followers View post →
Carolina Jaramillo Oquendo
@Carolinaj215 · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 4, 2020 · 15 shares · 124 followers View post →
Na Cai
@caina89 · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 4, 2020 · 15 shares · 2,126 followers View post →
Yuqin
@yuqincai · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 3, 2020 · 15 shares · 265 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 3, 2020 · 15 shares · 1,325 followers View post →
Louella Vasquez
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RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 3, 2020 · 15 shares · 42 followers View post →
Cancer at Nature Portfolio
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RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

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Leng Han
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RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 3, 2020 · 15 shares · 1,116 followers View post →
ColdKingdom
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RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 3, 2020 · 15 shares · 140 followers View post →
Gian Marco Franceschini
@GMFranceschini · X

RT @NatureGenet: A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://…

Apr 3, 2020 · 15 shares · 544 followers View post →
Nature Genetics
@NatureGenet · X

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer (Wagner et al.) https://t.co/xjW2Z3inig https://t.co/E9aYwaeOi0

Apr 3, 2020 · 43 likes · 15 shares · 128,305 followers View post →