PubHawk
Nutr J April 2020 PMID 32284053

Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial.

Nallely Bueno-Hernández, Marcela Esquivel-Velázquez, Raúl Alcántara-Suárez, Angélica Y Gómez-Arauz, Aranza J Espinosa-Flores, Karen L de León-Barrera, Viridiana M Mendoza-Martínez, Gabriela A Sánchez Medina, Mireya León-Hernández, Alejandra Ruiz-Barranco, Galileo Escobedo, Guillermo Meléndez

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Mentions

104
Peak: 17 in Apr 2020
across 6 sources since Apr 2020

Extended reach

507,766
potential audience

Total likes

809

Video views

15,674

Mentions per month

Apr 2020 – Dec 2025

Where it's discussed

  • X / Twitter32 posts
  • TikTok28 posts
  • Reddit22 posts
  • Facebook16 posts
  • YouTube3 videos
  • News3 articles

AI synopsis

What people are saying

The collective discussions express a supportive stance about the study's implications, exemplified by phrases like 'a lot of research suggests,' 'another reason to avoid,' and mentions of insulin resistance; the tone is analytical and concerned, reflecting an interest in the potential health risks associated with chronic sucralose use.

AgreementModerate agreement

Many discussions highlight the potential negative effects of sucralose on insulin levels, indicating general support or acknowledgment of the study's findings.

InterestHigh interest

The majority of discussions show high curiosity and concern, especially when referencing the health implications of artificial sweeteners.

EngagementModerate engagement

Users debate, cite scientific articles, and question the safety of sucralose, demonstrating a moderate level of detailed engagement.

ImpactModerate impact

The discussions suggest that the study influences opinions about sweetness substitutes and health risks, though it's not universally regarded as groundbreaking.

Abstract in brief

  • The study found that 10 weeks of consuming sucralose significantly increased serum insulin and blood glucose levels during a glucose tolerance test in healthy young adults, especially in the group that consumed 48 mg.
  • Consumption of sucralose led to higher insulin concentrations at multiple time points and an increased area under the curve (AUC) for insulin, indicating altered insulin response.
  • These results suggest that even in healthy individuals, chronic sucralose intake may impact insulin and glucose metabolism, raising concerns about its safety and metabolic effects.
Read the full abstract

Top posts

Most liked on X and Bluesky
AConcernedParent
@AConcernedPare2 · X

@blythy1989 @fjgwey @vanillaopinions https://t.co/lXsJEaiwqM There are hundreds of articles on artificial sweeteners and insulin resistance - here's just one.

Jul 10, 2024 · 21 likes · 12,339 followers View post →
The Real Dr. Steven Horvitz
@IMWHorvitz · X

Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial | Nutrition Journal | Full Text -Anyone surprised?? https://t.co/BldEAA7j2k

Apr 14, 2020 · 21 likes · 5 shares · 10,100 followers View post →
DoctorTro
@DoctorTro · X

I have ZERO issue with the use of NNS especially for people with diabetes who consume significant sugar, great swap But your assertions are half truths Poor OGTT/insulin results https://t.co/kDX97lqKTb *Possible* effects on hunger & intake https://t.co/KzIbtR9Aye Many more… https://t.co/P9uvqs0zT6

Mar 17, 2022 · 8 likes · 162,729 followers View post →
Marit Kolby
@MaritKolby · X

No calories, no problem? Low doses of sucralose can elicit insulin release. https://t.co/4gCSbRZvpg

Oct 21, 2020 · 7 likes · 2 shares · 4,833 followers View post →
Hélène du .P Menagé (Fernández)
@Helene_G_du_P_M · X

@_WHarry_ @BGellard @matt_barrie @spectatorindex There is actually a lot of research (mostly non-profit government funded by the EU and EMA) that suggests artificial sweeteners induce a strong insulin response, which decreases your insulin sensitivity making you pre-diabetic: https://t.co/wyD915yBHz https://t.co/kr1dU94r1E

Jun 29, 2023 · 5 likes · 1,883 followers View post →
Nallely Bueno
@NalleBH5 · X

@incmnszmx ¿Qué hay de todos los efectos adversos que se han reportado en la literatura? incluso publicados por su institución, le dejo información de artículos científicos que es de donde deberían salir sus recomendaciones. https://t.co/sHplT4UxXg https://t.co/EdXwVwfc1o

Feb 11, 2022 · 5 likes · 201 followers View post →

All mentions

MORTIFAGO NARANJA DEL GORDO DAN
@_AleCapdevila · X

@michaelgraayyy https://t.co/bq6X1sMKzO.

Aug 28, 2025 · 2 likes · 1,281 followers View post →
Artur Mücke
@ArturMucke · X

Aug 2, 2025 · 38 followers View post →
Q U E E N
@dimeperra · X

@AriesTerron Y a ti que te gusta mucho citar artículos, pero no leerlos, aquí te dejo unos para que te sigas haciendo pndjo recomendándole a la gente que trague refresco. https://t.co/R14ajiEHqb https://t.co/R14ajiEHqb

Jan 10, 2025 · 19,995 followers View post →
T
@Tuluminati888 · X

@AlexJLeaf Certainly. Here are a few to start: 1. https://t.co/5d8dLaccHk 2.https://t.co/7FIVmjochH 3.https://t.co/AY7VlfwiGb 4.https://t.co/2nDqkGdC5J 5.https://t.co/CBhLZipPpY

Dec 16, 2024 · 4,859 followers View post →
Alex Beecher
@ARBeecher · X

@B_Holmer Depends on the sweetener somewhat, see this study re sucralose: https://t.co/Y374jeyXIn But regardless, compounds without calories aren’t the big problem with any poor diet.

Dec 15, 2024 · 1 like · 155 followers View post →
AConcernedParent
@AConcernedPare2 · X

@blythy1989 @fjgwey @vanillaopinions https://t.co/lXsJEaiwqM There are hundreds of articles on artificial sweeteners and insulin resistance - here's just one.

Jul 10, 2024 · 21 likes · 12,339 followers View post →
The Couch Potato Coach
@BenCPCoach · X

And it appears to make insulin resistance worse. https://t.co/9t5XTLgIeT https://t.co/3h8XoGjdcK https://t.co/qcYEYghnlP

May 8, 2024 · 2 likes · 172 followers View post →
Hélène du .P Menagé (Fernández)
@Helene_G_du_P_M · X

@_WHarry_ @BGellard @matt_barrie @spectatorindex There is actually a lot of research (mostly non-profit government funded by the EU and EMA) that suggests artificial sweeteners induce a strong insulin response, which decreases your insulin sensitivity making you pre-diabetic: https://t.co/wyD915yBHz https://t.co/kr1dU94r1E

Jun 29, 2023 · 5 likes · 1,883 followers View post →
Dr. Ben Braddock
@GraduatedBen · X

@rshorts22 https://t.co/C9gKwBTP11

Oct 17, 2022 · 140,569 followers View post →
DoctorTro
@DoctorTro · X

I have ZERO issue with the use of NNS especially for people with diabetes who consume significant sugar, great swap But your assertions are half truths Poor OGTT/insulin results https://t.co/kDX97lqKTb *Possible* effects on hunger & intake https://t.co/KzIbtR9Aye Many more… https://t.co/P9uvqs0zT6

Mar 17, 2022 · 8 likes · 162,729 followers View post →
Nallely Bueno
@NalleBH5 · X

@incmnszmx ¿Qué hay de todos los efectos adversos que se han reportado en la literatura? incluso publicados por su institución, le dejo información de artículos científicos que es de donde deberían salir sus recomendaciones. https://t.co/sHplT4UxXg https://t.co/EdXwVwfc1o

Feb 11, 2022 · 5 likes · 201 followers View post →
Madnedz
@madnedz · X

@nut_nuggies @DifficultNerd @oldTrumpTweetz https://t.co/aBXan7fRak

Jan 19, 2022 · 11 followers View post →
Marit Kolby
@MaritKolby · X

@gerdosi @ggkuhnle @ErnMedBlog @NutriNetSante Thanks, Gabor. In this study, they didn't dind glucose tolerance was affected. However, in a recent study, sucralose led to insulin secretion and lowered glucuse tolerance. IMO, these compounds are not well enough tested. https://t.co/Amz9eC8LmA

Oct 29, 2020 · 1 like · 4,833 followers View post →
René Alfonso
@ReneAlfon_zoo · X

RT @zinocker: No calories, no problem? Low doses of sucralose can elicit insulin release. https://t.co/4gCSbRZvpg

Oct 21, 2020 · 2 shares · 414 followers View post →
Aris Christodoulou
@ArisChristod · X

RT @zinocker: No calories, no problem? Low doses of sucralose can elicit insulin release. https://t.co/4gCSbRZvpg

Oct 21, 2020 · 2 shares · 1,265 followers View post →
Marit Kolby
@MaritKolby · X

No calories, no problem? Low doses of sucralose can elicit insulin release. https://t.co/4gCSbRZvpg

Oct 21, 2020 · 7 likes · 2 shares · 4,833 followers View post →
Avishkar Sabharwal, M.D. | The Immigrant Doctor
@TheImmigrantDr · X

Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial | Nutrition Journal | Full Text https://t.co/gkomrEkpS1

Apr 23, 2020 · 542 followers View post →
Fanny Paris
@Actunutrition · X

Chronic #sucralose consumption induces elevation of serum #insulin in #young #healthy adults: a randomized, double blind, controlled trial https://t.co/RoXVtuMkEW

Apr 22, 2020 · 1,245 followers View post →
Alex González
@tabris76 · X

RT @garyruskin: Yet another reason to avoid #sucralose/@Splenda: Chronic sucralose consumption induces elevation of serum insulin in young…

Apr 16, 2020 · 3 shares · 25 followers View post →
Helen F-H
@contempl_activ · X

RT @IMWHorvitz: Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, contr…

Apr 16, 2020 · 5 shares · 1,389 followers View post →
Marion Holman
@holmanm · X

RT @IMWHorvitz: Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, contr…

Apr 16, 2020 · 5 shares · 44,632 followers View post →
Roxanna Moya
@MoyaRoxanna · X

RT @IMWHorvitz: Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, contr…

Apr 15, 2020 · 5 shares · 55 followers View post →
Campbell Glover
@CampbellGlover · X

RT @DanielBerglind: Sucralose consumption may affect insulin and glucose responses in non-insulin resistant healthy young adults: https://t…

Apr 15, 2020 · 1 share · 69 followers View post →
I Wonder
@cultivatediq · X

RT @garyruskin: Yet another reason to avoid #sucralose/@Splenda: Chronic sucralose consumption induces elevation of serum insulin in young…

Apr 15, 2020 · 3 shares · 1,097 followers View post →
Gary Ruskin
@garyruskin · X

Yet another reason to avoid #sucralose/@Splenda: Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial. Via Nutrition Journal https://t.co/5ViFB3H1b1

Apr 15, 2020 · 2 likes · 3 shares · 22,216 followers View post →
Daniel Berglind, PhD
@DanielBerglind · X

Sucralose consumption may affect insulin and glucose responses in non-insulin resistant healthy young adults: https://t.co/JQfimVCzZT

Apr 15, 2020 · 3 likes · 1 share · 7,898 followers View post →
Tommy Reilly ⛰
@gnurizen · X

RT @IMWHorvitz: Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, contr…

Apr 14, 2020 · 5 shares · 130 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

10 wk sucralose (artificial #sweetener) increased blood #sugar and #insulin in healthy adults https://t.co/ZZ0gcJZA9E

Apr 14, 2020 · 8,788 followers View post →
J P Fanton
@HealthyFellow · X

Chronic #sucralose consumption induces elevation of serum #insulin in young #healthy adults: A randomized, double blind, controlled trial Attn: ⁦@Domenico_Sergi9⁩ ⁦@foundmyfitness⁩ ⁦@FatEmperor⁩ ⁦@livinlowcarbman⁩ ⁦@robbwolf⁩ https://t.co/PEXqsxshZg

Apr 14, 2020 · 4 likes · 1 share · 26,006 followers View post →
Maurício Lima
@dj_surfista · X

O consumo crônico de #sucralose induz elevação da insulina sérica em adultos jovens e saudáveis. #sweeteners #insulin #lowcarb #keto #zerocarb #nutrition #nutrição #endocrinology #endocrinologia https://t.co/UGbBeY0BPl

Apr 14, 2020 · 2 likes · 747 followers View post →
DiscoStew
@DiscoStew66 · X

RT @IMWHorvitz: Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, contr…

Apr 14, 2020 · 5 shares · 10,791 followers View post →
The Real Dr. Steven Horvitz
@IMWHorvitz · X

Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial | Nutrition Journal | Full Text -Anyone surprised?? https://t.co/BldEAA7j2k

Apr 14, 2020 · 21 likes · 5 shares · 10,100 followers View post →
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The issues with artificial sweeteners (sucralose) : r/nutrition
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https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5. However I'm sure there's several studies that also show to have ...

Aug 17, 2023 View →
Is sucralose safe for people living with diabetes?
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https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5; Diabetes meal planning. (2023). https://www.cdc.gov/diabetes ...

Jul 14, 2023 View →
15 Ways To Lower Your Blood Sugar, Naturally
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doi: 10.1186/s12937-020-00549-5. World Health Organization. WHO ... doi: 10.1186/s12902-022-01209-x. Pittas AG, Kawahara T, Jorde R ...

Jul 13, 2023 View →
Bryter sockerfri sirap fastan? : r/intermittentfasting
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https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5 · https://academic.oup.com/ajcn/article/97/3/517/4571511?login=false.

Jan 17, 2023 View →
Rikottaako ohut siirappi paastosi? : r/intermittentfasting
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https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5 · https://academic.oup.com/ajcn/article/97/3/517/4571511?login=false.

Jan 17, 2023 View →
Skinny сиропы прерывают голодание? : r/intermittentfasting
Reddit

https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5 · https://academic.oup.com/ajcn/article/97/3/517/4571511?login=false.

Jan 17, 2023 View →
Bryter skinny syrups fasten din? : r/intermittentfasting
Reddit

https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5 · https://academic.oup.com/ajcn/article/97/3/517/4571511?login=false.

Jan 17, 2023 View →
스키니 시럽이 단식 깨는 거임? : r/intermittentfasting
Reddit

com/articles/10.1186/s12937-020-00549-5 · https://academic.oup.com/ajcn/article/97/3/517/4571511?login=false · https://bjsm.bmj.com/content/50/8 ...

Jan 17, 2023 View →
Is skinny syrups break your fasting? : r/intermittentfasting
Reddit

https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5 · https://academic.oup.com/ajcn/article/97/3/517/4571511?login=false.

Jan 17, 2023 View →
瘦身糖浆会打破你的禁食吗？ : r/intermittentfasting
Reddit

com/articles/10.1186/s12937-020-00549-5 · https://academic.oup.com/ajcn/article/97/3/517/4571511?login=false · https://bjsm.bmj.com/content/50/8 ...

Jan 17, 2023 View →
Έχετε καμιά καλή σκόνη για κέτο σέικ με λίγες θερμίδες, σαν την ...
Reddit

... 10.1186/s12937-020-00549-5 · BigTexan1492. • πριν από 3 έτη. Λοιπόν, τα μαθηματικά λένε ΟΧΙ. Χρησιμοποιώ Isopure επειδή οι περισσότερες γεύσεις ...

Oct 28, 2022 View →
Any good keto low calorie shake powders, like Herbalife but low carb?
Reddit

... .com/ajcn/article/108/3/485/5095505 · https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5 · BigTexan1492. • 3y ago.

Oct 27, 2022 View →
Do any of you find artificial sweeteners and or sugar alcohols a ...
Reddit

... 10.1186/s12937-020-00549-5. "Artificial sweeteners induce glucose intolerance by altering the gut microbiota" https://pubmed.ncbi.nlm.nih.gov ...

Aug 28, 2022 View →
Are those 0 calorie 0 sugar 0 carb coffee syrups better than sugar ...
Reddit

https://nutritionj.biomedcentral.com/articles/10.1186/s12937-020-00549-5 · https://academic.oup.com/ajcn/article/108/3/485/5095505. It seems ...

Nov 8, 2021 View →
Hi. I'm new to all this and have loads of questions but, for now I'd like ...
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com/articles/10.1186/s12937-020-00549-5 • Healthline Explains CPIR from Artificial Sweeteners Healthline article on sucralose triggering ...

Oct 1, 2021 View →
Is cane sugar the worst offender?
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com/articles/10.1186/s12937-020-00549-5 • Healthline Explains CPIR from Artificial Sweeteners Healthline article on sucralose triggering ...

Nov 8, 2020 View →
Artificial sweetener ingredient supply chain issues
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Nutr J. 2020 Apr 13;19(1): 32. doi: 10.1186/s12937-020-00549-5. PMID: 32284053; PMCID: PMC7155288. Gail Schmidt and 108 others ·

Oct 26, 2020 View →
**I MADE A SNACK PACK FOR VLAD BUT HE STILL WON'T DRINK ...
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doi: 10.1186/s12937-020-00549-5. PMID: 32284053; PMCID: PMC7155288.

Apr 20, 2020 View →
How to know if a sweetener stalls weight loss?
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com/articles/10.1186/s12937-020-00549-5 • Healthline Explains CPIR from Artificial Sweeteners Healthline article on sucralose triggering ...

Jan 12, 2020 View →
How bad is sucralose? I work long hours and use an energy drink ...
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com/articles/10.1186/s12937-020-00549-5 • Healthline Explains CPIR from Artificial Sweeteners Healthline article on sucralose triggering ...

Aug 16, 2019 View →
What are the differences between regular coffee and keto coffee?
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Nutr J. 2020 Apr 13;19(1): 32. doi: 10.1186/s12937-020-00549-5. PMID: 32284053; PMCID: PMC7155288. Haley Knebel and 175 others ·

Aug 1, 2019 View →
Compelling animal research that failed to translate to humans
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Nutr J. 2020 Apr 13;19(1): 32. doi: 10.1186/s12937-020-00549-5. PMID: 32284053; PMCID: PMC7155288. Haley Knebel and 175 others ·

Feb 16, 2019 View →