@macroliter See also mutator pol mutants. If it were advantageous for the virus to generate diversity, it can do it all on its own https://t.co/WE7fAzsLtF
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant.
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Apr 2020 – Jun 2025Where it's discussed
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X / Twitter94 posts
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News20 articles
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YouTube6 videos
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Facebook3 posts
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AI synopsis
What people are saying
In the digital discussions, users often reference key points such as the mutagenic nature of SARS-CoV-2 and the implications of RNA-dependent RNA polymerase mutations. Words like 'interesting', 'concerns', and 'many mutations found' illustrate a mix of intrigue and caution regarding the virus's evolution. The tone remains predominantly analytical, with users emphasizing scientific details, which aligns with the overall sentiment of concern yet fascination regarding the virus's adaptability.
Many discussions reflect a general consensus about the significance of the article's findings, though there are some differing opinions.
A high level of curiosity is evident in the discussions, with many users expressing a desire to learn more about the implications of the mutation findings.
Most posts show moderate engagement, with individuals referencing specific scientific concepts, though some discussions are rather surface level.
Participants perceive the publication as having a potentially high impact on understanding SARS-CoV-2 mutations and their consequences.
Abstract in brief
- SARS-CoV-2 is a highly mutable RNA coronavirus responsible for COVID-19, with its mutation rate allowing it to escape host immunity and develop resistance to treatments.
- Researchers analyzed 220 genomic sequences from different countries and identified 8 new mutations, with specific mutations showing regional prevalence in Europe and North America.
- The study indicates the ongoing evolution of SARS-CoV-2, highlighting the importance of studying the role of mutations in the virus's RNA-dependent RNA polymerase (RdRp) in its adaptability and resistance.
Top posts
Most liked on X and Bluesky@LuxorSabatini @M_B_Med @alevarone @MauroV1968 @RobertoBurioni @AngeloBraga2 https://t.co/uUQe93cLCa https://t.co/fllYK7ZHmi https://t.co/bXvABO9wGU https://t.co/0KCbodQerw)%20%5B17%5D https://t.co/iKIPWLEx6K https://t.co/Sr3kD6YW7j https://t.co/uUQe93cLCa https://t.co/LHlIOkaOxA https://t.co/KfMpvUPzbM https://t.co/0jfWhXS6gS ecc ecc ecc
Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant likely has lower replication fidelity https://t.co/sqln8apvj4 Here's the phylogenic pattern. NB revertants back to ancestral P quickly mutate back to L https://t.co/ggoLx5G76i
@Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as well as
@Kevin_McKernan https://t.co/VjZ31bXK8w
The SARS-CoV-2 genomes from European and North American patients with #COVID19 present an increase in mutation frequency compared to Asia. https://t.co/R2d38jXd9e https://t.co/rjT32xWWua
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Understanding the New COVID-19 Strain and Its Implications
A new variant of the SARS-CoV-2 virus is causing an increase in cases in southeast England. This video explains what a new strain means, how variants arise, and discusses the broader genomic and geographic distribution…
New Insights on SARS-CoV-2 Mutations and Drug Resistance
SARS-CoV-2, the virus behind COVID-19, exhibits a high mutation rate that enables it to escape host immunity. This study analyzes 220 genomic sequences revealing 8 novel mutations, with significant implications for…
Novel SARS-CoV-2 Mutations and Their Implications for COVID-19
SARS-CoV-2 is highly mutable, impacting its resistance to treatments. This video examines recent research identifying 8 new mutations from 220 genomic sequences, highlighting the virus's evolution and the significance…
SARS-CoV-2 Mutation Hot Spots and RNA Polymerase Variants
SARS-CoV-2, the virus responsible for COVID-19, is highly mutable. This study analyzes 220 genomic sequences, revealing 8 new mutations prevalent in Europe and North America, emphasizing the need to understand…
SARS-CoV-2 Mutation Patterns and RNA Polymerase Variants
SARS-CoV-2 is a highly mutable RNA coronavirus responsible for COVID-19. Recent research identified 8 new mutations from 220 genomic sequences, demonstrating the virus's adaptability and resistance. This highlights the…
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase v... | RTCL.TV
RT @SeekingTruth4us: @Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as…
RT @SeekingTruth4us: @Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as…
RT @SeekingTruth4us: @Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as…
RT @SeekingTruth4us: @Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as…
@Johanne31785773 @JimFergusonUK YES-was known before EUA that #SARSCoV2 is highly mutagenic https://t.co/2yjyduiCro as well as
RT @dreamgbutterfly: Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/klBw5Su20o
@Daoyu15 @lissnup @KeithEv84928885 @breakfast_dogs IMO, it is a problem of selective infection by countries faced globally. https://t.co/kbvyV5ApP4
@thirdeyemafia @yessss44941792 "Virus mutagenic capability depends upon several factors, including the fidelity of viral enzymes that replicate nucleic acids, as SARS-CoV-2 RNA dependent RNA polymerase (RdRp)." https://t.co/vZKoYzMpK5
RT @DrHannahGale: @Kevin_McKernan https://t.co/VjZ31bXK8w
RT @DrHannahGale: @Kevin_McKernan https://t.co/VjZ31bXK8w
@Kevin_McKernan https://t.co/VjZ31bXK8w
RT @statesdj: @macroliter See also mutator pol mutants. If it were advantageous for the virus to generate diversity, it can do it all on it…
RT @statesdj: @macroliter See also mutator pol mutants. If it were advantageous for the virus to generate diversity, it can do it all on it…
@macroliter See also mutator pol mutants. If it were advantageous for the virus to generate diversity, it can do it all on its own https://t.co/WE7fAzsLtF
@SchreiberStuart @michaelzlin SARS-CoV-2 polymerase makes ~an error/genome copy. COVID cases cough out millions of mutated progeny all the time, and there are mutator pol mutants that increase the error rate. Using nucleoside analogs isn’t going to add significantly more diversity https://t.co/WE7fAzsLtF
@CurlyJungleJake SARS-CoV-2 polymerase makes ~an error/genome copy. COVID cases already cough out millions of progeny with every base in the genome mutated, and there are mutator mutants that increase polymerase error rate. Virus doesn’t need help to generate diversity https://t.co/WE7fAzsLtF
@Luxathe336 @HeathenSassy https://t.co/wc8tJWLpn7
@FlaviusEye @Bhedin7 @SaskLass @Walmart @WalmartCanada They say they sequence some suspected delta. The virus has never been electron microscoped as far as I can find. It's been sequenced and in January 2020 there was already numerous mutations. This is an Apr. 2020 paper about mutations up to March, 2020. https://t.co/XWEpZsXEKQ
RT @dreamgbutterfly: Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/klBw5Su20o
RT @stefaniaconti: @LuxorSabatini @M_B_Med @alevarone @MauroV1968 @RobertoBurioni @AngeloBraga2 https://t.co/uUQe93cLCa https://t.co/fllYK7…
@Raphque @JanJambon Als LEGO niet goed genoeg is voor meneer. https://t.co/ibkPHIrYlx Lees een beetje over fenotypische plasticiteit en waarom het gaat over de hoeveelheid virus op de wereld zo rap mogelijk zo laag mogelijk krijgen. Een volgende mutatie verhoogt sterfte.
@hjelle_brian This is interesting https://t.co/6czXiC2eiq
$MRK Molnupiravir targets SARSCoV2 RNA Polymerase https://t.co/UB88cP8iaY Which makes it prone to variant mutation - its P3 on Wild type virus is not applicable to Delta Variant https://t.co/KL55twIufO $ADMP Tempol hits Replicase - very stable - applies to Delta.
https://t.co/u7RrzmM2K2
RT @stefaniaconti: @LuxorSabatini @M_B_Med @alevarone @MauroV1968 @RobertoBurioni @AngeloBraga2 https://t.co/uUQe93cLCa https://t.co/fllYK7…
@LuxorSabatini @M_B_Med @alevarone @MauroV1968 @RobertoBurioni @AngeloBraga2 https://t.co/uUQe93cLCa https://t.co/fllYK7ZHmi https://t.co/bXvABO9wGU https://t.co/0KCbodQerw)%20%5B17%5D https://t.co/iKIPWLEx6K https://t.co/Sr3kD6YW7j https://t.co/uUQe93cLCa https://t.co/LHlIOkaOxA https://t.co/KfMpvUPzbM https://t.co/0jfWhXS6gS ecc ecc ecc
@MLevitt_NP2013 Thanks for the Structural Biology PNAS paper. I read it and it is very interesting. A recent variant emerged with a polymerase mutation. Also, I'd also like to know how cov2's RBD has changed in stability in interaction with human ACE2 over time https://t.co/JISgMewGaR
@jpelunico @INFORMADORCHILE @ALERTADESISMO https://t.co/rQGZeEtMU4 https://t.co/duxAjXLPOL https://t.co/20iQEhSskd https://t.co/FW871xTYxw
RT @Nic_Trevi: Qui lo studio https://t.co/T8ckTyKl37
Qui lo studio https://t.co/T8ckTyKl37
RT @cesarcuadra: Lamentablemente, esto NO es cierto. Se han encontrado mutaciones en todos los genes del SARS-CoV-2, hay muchos reportes al…
Lamentablemente, esto NO es cierto. Se han encontrado mutaciones en todos los genes del SARS-CoV-2, hay muchos reportes al respecto en medline. Por ejemplo este: mutacion en el gen de la RdRP https://t.co/bPxkOWlIff https://t.co/2zFkfMRglF
@CliveWismayer coronaviruses are known for their rapid mutability , but here's a scientific paper from April 2020 mentioning 220 variants of the "Wuhan seafood market pneumonia virus" logged Dec19 to March20. https://t.co/CUxifCGsxe
@CliveWismayer Just in case this is serious, here's an example. April 2020, science world all over the mutations. https://t.co/X8xV38wto5
Sars from the bottom up https://t.co/tHJ11g7sOF
@gsgs2 Don’t like this table at all. Why are all the mutations in Europe? #b117 https://t.co/IOyaujbflV https://t.co/ofROA1Ex3g
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/klBw5Su20o
@peterre76976220 @MLevitt_NP2013 W.H.O. didn't know this? See: https://t.co/z8Pt1oP9aV 4/20/13 and "Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant" https://t.co/Ac6IBoQREv
RT @elray67: Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant…
RT @MonaRahalkar: https://t.co/ZjqlEcuAcP
https://t.co/ZjqlEcuAcP
Over time, different #virus strains in the same host end up inhibiting each other to diminish lethality and increase spread. Mutations in NSP create a equilibrium in infection/death. #SARSCoV2 #covid19 https://t.co/5qcP47ofAf
Emerging SARS-CoV-2 mutation hot Open Access Journal of Translational Medicine spots include a novel RNA-dependent-RNA polymerase variant https://t.co/YC4ES4YSTA
Sars https://t.co/yIWflFYxcO
@CentristAllWay @debhodges1413 Here is a study on variants: These findings suggest that the virus is evolving and European, North American and Asian strains might coexist, each of them characterized by a different mutation pattern. https://t.co/svF4EoeaPT
@Shanbeleeleh @Mahooolak با توجه به این مقاله، ساخت واکسن باید خیلی سخت باشه. https://t.co/Vsrdp60eOw
@meteorologo777 Il virus é mutato, c'é un'ampia bibliografia che lo dimostra https://t.co/H0kbNwraZn l'affermazione contestata da alcuni virologi riguarda l'attenuazione della carica virale. Attualmente esiste un lavoro solido effettuato da ricercatori cinesi https://t.co/A7qbZWXltI
Sars https://t.co/HJRclGdglv
Sars https://t.co/8yWOHjD9AI
@KielyNeil @MaxChesnes You are right. If a person isolates themself, they will not contract the virus, however isolation is not sustainable. This virus is going nowhere and its mutation rate will most likely render a vaccine useless. Have you ever had a cold before? https://t.co/0N98MBTDLr
@mcrankshaft2 @JojoLmt @mandaobserver @JhendersonJames Incorrect: https://t.co/rSkjkaW1yw
Sars https://t.co/itY5NSL1Q8
Sars from the bottom up https://t.co/5bunork6BA
Last but not least Sars 8 https://t.co/5bunork6BA
RT @Atomoxetina: FUENTE: Pachetti, M., Marini, B., Benedetti, F. et al. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-depende…
FUENTE: Pachetti, M., Marini, B., Benedetti, F. et al. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. J Transl Med 18, 179 (2020). https://t.co/q9NhAlTFJe
Sars 2 Name II https://t.co/YXzvzwBIrE
Sars 2 Name II https://t.co/ssMtFF2m5C
RT @elray67: Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant…
@peripatetical Thanks heaps. It appears 2018/19 samples not tested rather used as controls? may explain the low sensitivity? Also "all +ve samples had SARS-CoV-2 .. conducted.. assay for the.. RdRp gene"....some debate about non silent mutations(pos 14408) on this.? https://t.co/3znCwKNqwh
Sars 2 https://t.co/ksfSszWKtz
Sars 2 https://t.co/WW3A0WPj1E
@pinkzebracross @MLevitt_NP2013 in most countries isolates were found, i think, but you ask for published papers: Mutation Hotspots https://t.co/w7o9kezDb9 Italy : https://t.co/GF4XN4IQWW Europe https://t.co/huk1gxnX4A Iceland https://t.co/uhJsdZRUJa
I spoke to someone who claimed they were a physician that said “this Virus (CoV-SARS-2) doesn’t mutate like the flu, the media is just playing this up” https://t.co/O0DfNbydGv
@luigi_warren @BillyBostickson @_coltseavers @paleovanguard @relluminati1 @R_H_Ebright @Harvard2H There is at least one mutation already described in the RdRp region of SARS-CoV-2. https://t.co/n45xhFd1wE https://t.co/x5KwmZ8WFy
RT @FerSuarezMD: Aqui el gráfico comparativo, abajo el enlace al artículo https://t.co/mQsh7SC10X https://t.co/qErDLewaBx
RT @FerSuarezMD: Aqui el gráfico comparativo, abajo el enlace al artículo https://t.co/mQsh7SC10X https://t.co/qErDLewaBx
Mutations in the S protein of SARS-CoV-2 raises concerns about the efficacy of a S protein-based vaccine (https://t.co/plTjUgZaib - https://t.co/R2d38jXd9e). Moving one step ahead of SARS-CoV-2, researchers suggest identification of potential human ACE2 receptor blockers https://t.co/ge1S4rZwMt
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. https://t.co/xYWi5ur7mu Pachetti M, Marini B, Benedetti F, Giudici F, Mauro E, Storici P, Masciovecchio C, Angeletti S, Ciccozzi M, Gallo RC, Zella D, Ippodrino R.
@_atanas_ SARS-CoV-2 mutates much slower than seasonal Flu (https://t.co/kUx9SjrkjO) and SARS (https://t.co/plTjUgZaib). The SARS-CoV-2 genomes from European and North American patients with #COVID19 present an increase in mutation frequency compared to Asia. https://t.co/R2d38jXd9e https://t.co/wggu2NjuHt
The SARS-CoV-2 genomes from European and North American patients with #COVID19 present an increase in mutation frequency compared to Asia. https://t.co/R2d38jXd9e https://t.co/rjT32xWWua
@aciscokid @DianeRo25123293 @ClimateAudit @johnrobertsFox @nerdhaspower Actually, many mutations have already been detected in SARS-CoV-2, even in the RdRp region. And many more go undetected, of course. Anyway, that was not the point of this thread, so I rest my case. https://t.co/n45xhFd1wE https://t.co/x5KwmZ8WFy
RT @mbalsevich: @tomasmateobal Cuando dice que no mutó, ¿se refiere a mutaciones que prevengan una vacuna? Porque mutaciones nuevas se está…
RT @mbalsevich: @tomasmateobal Cuando dice que no mutó, ¿se refiere a mutaciones que prevengan una vacuna? Porque mutaciones nuevas se está…
@tomasmateobal Cuando dice que no mutó, ¿se refiere a mutaciones que prevengan una vacuna? Porque mutaciones nuevas se están publicando en varias fuentes que creo respetables: https://t.co/RNzs9FkrEg
@monsefderraji @Vadeboncoeur_Al https://t.co/hcuOJQdEQ0
RT @vuduquebec: Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. - PubMed - NCBI https://t.co/N…
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. - PubMed - NCBI https://t.co/NWsp4DWunw
#SARSCoV2 Ha presentado mutaciones en muy poco tiempo, lo que sugiere que muy probablemente cada continente tendrá comportamientos diferentes de la enfermedad por #COVID__19 así como sus propios tratamientos efectivos. https://t.co/KKsw6LAFaX https://t.co/k7watnwmT3
@mariogarciacrv Solo el tiempo lo dirá, el Sars-cov2 ha tenido mutaciones en muy poco tiempo.. además, las pandemias se han caracterizado por su fluctuación y duración, siempre en oleadas... dentro de un mismo país coexistirán los 3 escenarios dependiendo de la región. https://t.co/KKsw6LAFaX https://t.co/NWAT6Fsqbe
RT @DrRebeccaO: @TwigletM @aconvict @nextstrain @GISAID @mrcunitgambia @NSWHealth @qldhealthnews @VictorianCHO @GregHuntMP @healthgovau @am…
@TwigletM @aconvict @nextstrain @GISAID @mrcunitgambia @NSWHealth @qldhealthnews @VictorianCHO @GregHuntMP @healthgovau @ama_media @RACGP #SARSCoV2 #COVID19 China US Canada Australia UK Germany France Japan Italy Switzerland Singapore Luxembourg Netherlands Spain Portugal Sweden Czech Republic Thailand India Cambodia Hong Kong Finland Singapore Ireland In Eurozone pos14408 increased mutation https://t.co/KYRirHqhxH https://t.co/vipCr8EahB
SARS-COV2 is mutating like it's doing the #renegadechallenge. Immunity from one strain does not guarantee immunity from another and vaccines developed for the UK might not work for Spanish patients. https://t.co/cvOv39COiM https://t.co/uDxGjiNHrt
Virüs aşılarım bazılarının önüne geçmiş bile yarışta hayırlısı.. Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant | Journal of Translational Medicine | Full Text https://t.co/wKGXofuhzW
@BillHanage Does your comment mean that this article is nonsense? https://t.co/PgsOak3ytt
RT @elray67: Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant…
Just trying to learn more about COVID-19 and bumped into this paper https://t.co/0QdTY5IvvR. - does anyone have data on #COVID19 mutants? Thank you.
RT @elray67: Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant…
RT @elray67: Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant…
Decided to look at position 14408, in ORF1b, the RdRp; substitution here associated w/more genomic substititions---this mutant likely has lower replication fidelity https://t.co/sqln8apvj4 Here's the phylogenic pattern. NB revertants back to ancestral P quickly mutate back to L https://t.co/ggoLx5G76i
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/OEkFa3fAfo
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant | Research Square https://t.co/Ja7ROjeCrJ
RT @AngelAzpeitia: Emerging #SARS_COV_2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/gPEh7kaMXN
Emerging #SARS_COV_2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant https://t.co/gPEh7kaMXN