Biomolecules April 2020 PMID 32365524

Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment.

Eun Seong Hwang, Seon Beom Song

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Mentions

Peak: 2 in May 2020

across 3 sources since May 2020

Extended reach

62,125

potential audience

Total likes

Video views

531

Mentions per month

May 2020 – Feb 2024

Where it's discussed

X / Twitter13 posts
News4 articles
YouTube1 videos

AI synopsis

What people are saying

The discussions show high interest with phrases like 'important safety concerns' and 'potential long-term risks,' and agreement is evident in statements supporting further research. While some users delve into mechanisms like DNA methylation, the overall engagement remains moderate, with a few posts suggesting these findings could influence supplement guidelines or future studies, reflecting a perceived but cautious impact.

AgreementModerate agreement

Most discussions acknowledge the potential risks highlighted in the publication, showing general agreement with the need for caution in high-dose NAM use.

InterestHigh interest

The social discussions demonstrate high curiosity and concern about the safety implications, reflecting strong interest in the topic.

EngagementModerate engagement

Posts often refer to specific mechanisms and express personal opinions or questions, indicating a moderate level of detailed engagement.

ImpactModerate impact

Some posts highlight how the findings might influence supplement use and future research, suggesting a modest perceived impact.

Abstract in brief

High doses of nicotinamide (NAM) may have negative effects by interfering with key cellular processes such as DNA repair, energy metabolism, and DNA/protein methylation, potentially leading to changes in gene expression and cellular function.
Although current usage levels of NAM are considered safe, chronic intake of high doses raises concerns about epigenetic alterations and long-term health risks, requiring further research to understand these mechanisms.
The review emphasizes the need for future studies to establish safer dosing guidelines and better assess the long-term safety of NAM, especially as its popularity as a supplement increases for disease treatment and longevity.

Read the full abstract

All mentions

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Mind Your Science!

@MindYourSci · X

RT @agingdoc1: Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment (2020) https://t.co/sHKd9E61rG

Feb 26, 2024 · 1 share · 133 followers View post →

Agingdoc

@agingdoc1 · X

Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment (2020) https://t.co/sHKd9E61rG

Feb 25, 2024 · 3 likes · 1 share · 41,424 followers View post →

Lainer

@Lainer · X

Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment https://t.co/8wWpGq5K6g

Jan 20, 2023 · 128 followers View post →

Ford Stone

@fordston1 · X

@BradStanfieldMD Review of NAM supplementation: Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment— https://t.co/G1bsiT7ETO

Nov 11, 2022 · 82 followers View post →

Rene Sugar

@renesugar · X

Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment https://t.co/Or3bi3XRHD https://t.co/5HiJdqL452

Mar 12, 2022 · 3,960 followers View post →

Rene Sugar

@renesugar · X

Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment https://t.co/KTetGSft8u

Feb 26, 2022 · 3,960 followers View post →

François Booream

@BooraemFrancois · X

Sep 2, 2021 · 718 followers View post →

Biomolecules MDPI

@Biomol_MDPI · X

#EditorsChoice Welcome to read "Possible #AdverseEffects of High-Dose #Nicotinamide: Mechanisms and #Safety Assessment", by Eun Seong Hwang, Seon Beom Song @USeoul The article

Aug 29, 2021 · 1,599 followers View post →

まる

@maru5657 · X

Mar 10, 2021 · 2 likes · 3,829 followers View post →

Biomolecules MDPI

@Biomol_MDPI · X

#EditorsChoice Welcome to read "Possible #AdverseEffects of High-Dose #Nicotinamide: Mechanisms and #Safety Assessment", by Eun Seong Hwang, Seon Beom Song @USeoul The article

Jan 26, 2021 · 1,599 followers View post →

BiohackersRadio

@BiohackersRadio · X

Possible Adverse Effects of High-Dose #Nicotinamide: Mechanisms and Safety Assessment #NMN https://t.co/1Lb3wUfFah

Dec 20, 2020 · 108 followers View post →

Transcriptomes

@transcriptomes · X

Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment. https://t.co/UiU7EA6N3z

May 6, 2020 · 1,809 followers View post →

Kelly A. Hogan Ph.D.

@Loose_Lab_Rat · X

Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment https://t.co/DcdVtl6Vms

May 6, 2020 · 2,241 followers View post →