Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metabolic rhythms in old age. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/n6MW6lMLTC
NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging.
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May 2020 – May 2025Where it's discussed
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X / Twitter102 posts
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Facebook3 posts
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News2 articles
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YouTube1 videos
AI synopsis
What people are saying
The discussions emphasize the importance of NAD+ in regulating circadian rhythms and combating aging, with multiple mentions of how NAD+ enhances energy and sleep. For instance, one post mentions a personal experience with NAD+ supplementation and its positive effects on sleep, illustrating the personal relevance of the research. The tone is mostly positive and enthusiastic, with phrases like 'exciting new collaboration' and references to specific researchers, which underscores the collective support and anticipation for future research in this field.
The overwhelming majority of discussions express strong support for the findings presented in the publication.
Participants display a high level of curiosity and urgency around the topic of NAD+ and its implications for aging and circadian rhythms.
Many posts involve in-depth discussions and references to the research methods and their potential broader impact, indicating deep engagement with the material.
Respondents generally perceive the findings as groundbreaking, highlighting a significant potential impact on health and aging.
Abstract in brief
- NAD supplementation with nicotinamide riboside (NR) can reverse age-related disruptions in circadian rhythms and metabolic pathways by targeting the clock repressor PER2.
- NR enhances the binding of the BMAL1 protein to DNA, which is crucial for regulating circadian clock genes, through a process of deacetylation of PER2.
- In older mice, restoring NAD levels with NR not only revitalizes circadian rhythms but also improves metabolic functions, highlighting the relationship between NAD metabolism and the molecular clock in aging.
Top posts
Most liked on X and BlueskyNAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
Bass lab strikes again! NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging: Molecular Cell https://t.co/s5XCTlPCdy
Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17SP3Ae
Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showing how #nicotinamideriboside restores youthful daily activity & sleep cycles to old mice. #NAD system disturbed with age & can be repaired https://t.co/xXNx5T2yf7
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging (2020) Daniel Levine, @clara_peek , @JoeBass91471540 & coauthors. https://t.co/KN3AqlvETM https://t.co/2MmCRNojyZ
All mentions
NAD+ Supplementation's Role in Aging and Circadian Rhythm Restoration
NAD levels decline is associated with aging and circadian disruption. This video explores how supplementation with nicotinamide riboside (NR) can reverse age-related disruptions in circadian rhythms and enhance…
https://t.co/OZtGYDzXuz
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/TSckRKxIXW
Supplementing NAD+ levels, circadian rhythm and aging. https://t.co/CPKrg9Kbbx
RT @agingdoc1: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging (2020) Daniel Levine, @clara_peek…
RT @agingdoc1: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging (2020) Daniel Levine, @clara_peek…
RT @agingdoc1: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging (2020) Daniel Levine, @clara_peek…
RT @agingdoc1: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging (2020) Daniel Levine, @clara_peek…
RT @agingdoc1: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging (2020) Daniel Levine, @clara_peek…
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging (2020) Daniel Levine, @clara_peek , @JoeBass91471540 & coauthors. https://t.co/KN3AqlvETM https://t.co/2MmCRNojyZ
NAD+ is used to produce energy & is needed to help regulate sleep/wake cycles. Evidence indicates a decline in circadian activity is a hallmark of aging. Increasing NAD+ can help reprogram metabolic pathways & circadian clock that decline with age. https://t.co/rvS90qtHxk
@lqtang you could also look into supplementing with NAD+/NMN/NR. NAD+ declines in the brain as we age, meaning sleep can get dysregulated. This might sound a bit ✨woo✨ but it's what's working for me. https://t.co/vfC2CEFLKs
@jenistyping preface this with I don't know your age (I'm 35!), but I recently found out about NAD+ — it's an enzyme that decreases as you age and can impact energy and sleep. I've been trying it for 2 months and it seems to actually help: https://t.co/vfC2CEXn92
NAD + Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/LsFXnmqZXr https://t.co/ev3fKAQQ7D https://t.co/Sw8Uba3Nwd
@1971capital @Hongma123 @davidasinclair @ScienceMagazine @npure3 @foundmyfitness Also a very interesting recent paper (if nothing else these B3/derivatives may actually be potent sleep compounds: ) NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. 2020 https://t.co/1S7E2xqiwp
improved circadian activity in older mice with NR with Joe Bass & team https://t.co/xXNx5SKWQx /3
The longevity associated deacetylase SIRT1 interacts with the clock somehow...SIRT1 requires NAD+, which declines with age. The Bass lab find that NAD+ leads to deacetylation of PER to regulate the clock, with effects on aging! https://t.co/CmJ71H4Sa4
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @MolecularCell: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/b3D1q5pCrC
RT @MolecularCell: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/b3D1q5pCrC
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/b3D1q5pCrC
RT @EleanorSheekey: My summary of a recent @MolecularCell paper --> Supplementing NAD+ levels, circadian rhythm and aging. https://t.co/SWQ…
My summary of a recent @MolecularCell paper --> Supplementing NAD+ levels, circadian rhythm and aging. https://t.co/SWQUhF4xcx via @YouTube #biochemistry #scicomm #NAD
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. https://t.co/cfAC456bpZ
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging - ScienceDirect https://t.co/7PZo61faej
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
#aginghighlights #TheAgingField NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/iNbqBd9Z1T
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @CircadianClocks: Bass lab strikes again! NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging: Mo…
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging: Molecular Cell https://t.co/YSukwhDkoA
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @CharlesMBrenner: Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showi…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @CharlesMBrenner: Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showi…
RT @CharlesMBrenner: Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showi…
RT @CircadianClocks: Bass lab strikes again! NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging: Mo…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @CircadianClocks: Bass lab strikes again! NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging: Mo…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @CharlesMBrenner: Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showi…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @CircadianClocks: Bass lab strikes again! NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging: Mo…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @CircadianClocks: Bass lab strikes again! NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging: Mo…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
Bass lab strikes again! NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging: Molecular Cell https://t.co/s5XCTlPCdy
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @CharlesMBrenner: Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showi…
RT @CharlesMBrenner: Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showi…
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/zSQ0KrNuEz
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @CharlesMBrenner: Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showi…
Exciting new @MolecularCell collaboration w Joe Bass's group @NorthwesternMed especially Dan Levine & Clara Peek showing how #nicotinamideriboside restores youthful daily activity & sleep cycles to old mice. #NAD system disturbed with age & can be repaired https://t.co/xXNx5T2yf7
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
NAD+ controls circadian reprogramming through PER2 nuclear translocation to counter aging https://t.co/YdnrtOpsHZ … https://t.co/yAx7GjZiVV
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @JoeBass91471540: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/Fajb0KMKsj
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/o5B1vFV0ZP
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/3kNA420uPK
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
RT @clara_peek: Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metab…
Happy to share this paper on how NAD+ controls global circadian transcription and improves circadian oscillations and metabolic rhythms in old age. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/n6MW6lMLTC
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
RT @MolecularCell: Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17…
Online Now: NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging https://t.co/kHm17SP3Ae