Front Genet April 2020 PMID 32373156

A Preliminary Study to Investigate the Genetic Background of Longevity Based on Whole-Genome Sequence Data of Two Methuselah Dogs.

Dávid Jónás, Sára Sándor, Kitti Tátrai, Balázs Egyed, Enikö Kubinyi

Download social card

Mentions

52
Peak: 17 in Apr 2020
across 6 sources since Mar 2017

Extended reach

878,642
potential audience

Total likes

174

Video views

33,713

Mentions per month

Mar 2017 – Dec 2025

Where it's discussed

  • X / Twitter30 posts
  • News9 articles
  • Facebook7 posts
  • YouTube4 videos
  • LinkedIn1 posts
  • Blogs1 articles

AI synopsis

What people are saying

The discussions demonstrate strong interest in the genetic aspects of aging, with posts explicitly mentioning unique gene variants and their possible role in prolonging lifespan, indicating a mix of curiosity and support. The tone ranges from casual remarks about dogs living long lives to more technical comments on gene transcription and immune response, reflecting moderate engagement with some depth, but with an overall consensus that this research could influence future aging studies.

AgreementModerate agreement

Most discussions acknowledge the significance of genetic research on longevity, especially highlighting the uniqueness of ancient dogs' genomes.

InterestHigh interest

Posts show high curiosity about the genetic findings and their implications for aging and potential parallels in humans.

EngagementModerate engagement

Many posts reference specific genetic findings and the study's methodology, indicating a moderate level of detailed engagement.

ImpactModerate impact

While there's excitement about the potential of such research, many discussions are preliminary and suggest further research is needed before broad impact is realized.

Abstract in brief

  • This study investigates the genetic factors behind extreme aging by analyzing the whole-genome sequences of two very old dogs, aged 22 and 27 years, which is much longer than the average dog lifespan.
  • Researchers identified over 800,000 new genetic variations (SNPs), many of which are in non-coding regions, and some found in genes related to immune response, nervous system, and gene regulation, suggesting these areas may influence longevity.
  • The findings point to specific genetic pathways that could be linked to extreme lifespan risk and highlight the potential importance of gene transcription regulation, which warrants further research to confirm its role in aging in both dogs and humans.

Top posts

Most liked on X and Bluesky
Andrew Mayne
@AndrewMayne · X

And now I can add “Methuselah Dogs” to my list of odd but potentially useful ideas for storytelling… https://t.co/MOtAwPKt9E

Feb 10, 2021 · 16 likes · 684,626 followers View post →
Eniko Kubinyi
@KubinyiEniko · X

As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one such as the famous Augie? Please contact me. https://t.co/XMhQ3LWR9E *Genetics of #Methuselah dogs: https://t.co/p8D22zzKiz

Jun 28, 2020 · 15 likes · 10 shares · 1,574 followers View post →
Family Dog Project
@FamDogProject · X

Our new research identified gene variants unique to two Methuselah dogs (aged 22 and 27 years) which could not be found in 850 dogs of average age. The genome of the oldest old “Methuselahs” is enriched with gene variants that can elongate lifespan. https://t.co/Tc66fbZjc0

Apr 16, 2020 · 9 likes · 4 shares · 4,394 followers View post →
Rosa Porcel
@bioamara · X

Aquí el paper publicado en Frontiers https://t.co/zsR7V4XrA4

Apr 19, 2020 · 6 likes · 1 share · 21,013 followers View post →
Dogs Trust's Canine Behaviour & Research Teams
@DTScholars · X

#DNADay Did you know that @FamDogProject examined DNA of two old “Methuselah” dogs (22 & 27yrs!) and identified unique gene variants which didn't exist in DNA of 850 average dogs suggesting they have DNA enriched with genes that can elongate lifspan

Apr 26, 2020 · 6 likes · 2 shares · 3,961 followers View post →
Dogs Trust's Canine Behaviour & Research Teams
@DTScholars · X

We're taking part in the @RoyalSocBio #BiologyWeek2020! Today they're looking at healthy ageing

Oct 5, 2020 · 5 likes · 3 shares · 3,961 followers View post →

All mentions

Andrew Mayne
@AndrewMayne · X

And now I can add “Methuselah Dogs” to my list of odd but potentially useful ideas for storytelling… https://t.co/MOtAwPKt9E

Feb 10, 2021 · 16 likes · 684,626 followers View post →
Carlos E Alvarez
@CarlosEAlvare17 · X

RT @DTScholars: We're taking part in the @RoyalSocBio #BiologyWeek2020! Today they're looking at healthy ageing

Oct 5, 2020 · 3 shares · 1,170 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

RT @DTScholars: We're taking part in the @RoyalSocBio #BiologyWeek2020! Today they're looking at healthy ageing

Oct 5, 2020 · 3 shares · 16,747 followers View post →
OneWelfare
@SaraGarstecka · X

RT @DTScholars: We're taking part in the @RoyalSocBio #BiologyWeek2020! Today they're looking at healthy ageing

Oct 5, 2020 · 3 shares · 622 followers View post →
Dogs Trust's Canine Behaviour & Research Teams
@DTScholars · X

We're taking part in the @RoyalSocBio #BiologyWeek2020! Today they're looking at healthy ageing

Oct 5, 2020 · 5 likes · 3 shares · 3,961 followers View post →
CREEB Roehampton
@CREEBroehampton · X

RT @KubinyiEniko: As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one su…

Jun 29, 2020 · 10 shares · 705 followers View post →
Kristiina Torp
@KristiinaTorp · X

RT @KubinyiEniko: As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one su…

Jun 29, 2020 · 10 shares · 152 followers View post →
Andrea Sommese, Ph.D.
@andrea_sommese · X

RT @KubinyiEniko: As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one su…

Jun 28, 2020 · 10 shares · 1,294 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

RT @KubinyiEniko: As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one su…

Jun 28, 2020 · 10 shares · 16,747 followers View post →
Holly Root-Gutteridge
@holly_howls · X

RT @KubinyiEniko: As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one su…

Jun 28, 2020 · 10 shares · 1,013 followers View post →
Dog Cognition SE
@DogCognitionSE · X

RT @KubinyiEniko: As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one su…

Jun 28, 2020 · 10 shares · 7,003 followers View post →
Dr Zazie Todd (PhD)
@CompAnimalPsych · X

RT @KubinyiEniko: As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one su…

Jun 28, 2020 · 10 shares · 13,165 followers View post →
Eniko Kubinyi
@KubinyiEniko · X

As a follow-up on our recent study*, we aim at collecting DNA from dogs older than 20 years. Do you happen to know one such as the famous Augie? Please contact me. https://t.co/XMhQ3LWR9E *Genetics of #Methuselah dogs: https://t.co/p8D22zzKiz

Jun 28, 2020 · 15 likes · 10 shares · 1,574 followers View post →
Family Dog Project
@FamDogProject · X

FDP research about the genetics of extremely old dogs (22&27†) sin the Canine Corner blog by Stanley Coren https://t.co/4sA73MuRIB original study: https://t.co/Tc66fbHHNq

Jun 2, 2020 · 1 share · 4,394 followers View post →
Stefano Cattaneo DVM
@Albinovet · X

a preliminary study to investigate the genetic background of #longevity based on whole-genome sequence data of 2 Methuselah dogs. Most novel mutations were related to gene transcription/translation, to immune response& the nervous system in general https://t.co/3NCtWb70CZ https://t.co/ZcEezj1Usd

May 12, 2020 · 2,714 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

RT @DTScholars: #DNADay Did you know that @FamDogProject examined DNA of two old “Methuselah” dogs (22 & 27yrs!) and identified unique gene…

Apr 26, 2020 · 2 shares · 16,747 followers View post →
Dr Katrina Holland
@katrinaholland · X

RT @DTScholars: #DNADay Did you know that @FamDogProject examined DNA of two old “Methuselah” dogs (22 & 27yrs!) and identified unique gene…

Apr 26, 2020 · 2 shares · 1,011 followers View post →
Dogs Trust's Canine Behaviour & Research Teams
@DTScholars · X

#DNADay Did you know that @FamDogProject examined DNA of two old “Methuselah” dogs (22 & 27yrs!) and identified unique gene variants which didn't exist in DNA of 850 average dogs suggesting they have DNA enriched with genes that can elongate lifspan

Apr 26, 2020 · 6 likes · 2 shares · 3,961 followers View post →
Marcia... #EmergingTech #URFutureTech
@MFuturetech · X

RT @FrontGenetics: New Research: A Preliminary Study to Investigate the Genetic Background of Longevity Based on Whole-Genome Sequence Data…

Apr 25, 2020 · 1 share · 705 followers View post →
Frontiers - Genetics
@FrontGenetics · X

New Research: A Preliminary Study to Investigate the Genetic Background of Longevity Based on Whole-Genome Sequence Data of Two Methuselah Dogs: Aging is the largest risk factor in many diseases and mortality alike. As the elderly population is… https://t.co/myL3HgzNlQ #Genetics

Apr 25, 2020 · 1 like · 1 share · 5,391 followers View post →
Etolia· Etología Vet
@Etologiamalaga · X

A Preliminary Study to Investigate the Genetic Background of Longevity Based on Whole-Genome Sequence Data of Two Methuselah Dogs https://t.co/Qo8yM5D42m

Apr 21, 2020 · 1,617 followers View post →
gorogoro: purr&roll! Nutrición
@gorogoropurroll · X

RT @bioamara: Aquí el paper publicado en Frontiers https://t.co/zsR7V4XrA4

Apr 19, 2020 · 1 share · 266 followers View post →
José Luis Ricón Fernández de la Puente
@ArtirKel · X

@celinehalioua https://t.co/QKeVAnikDU #longlivedpuppers

Apr 19, 2020 · 22,835 followers View post →
Rosa Porcel
@bioamara · X

Aquí el paper publicado en Frontiers https://t.co/zsR7V4XrA4

Apr 19, 2020 · 6 likes · 1 share · 21,013 followers View post →
LUX RERUM REI LUCIS
@luxrerum · X

A dog's life may be awful ... long. https://t.co/S9xhOEuEXF

Apr 19, 2020 · 297 followers View post →
Christoph Jung
@Chr_Jung · X

RT @FamDogProject: Our new research identified gene variants unique to two Methuselah dogs (aged 22 and 27 years) which could not be found…

Apr 16, 2020 · 4 shares · 748 followers View post →
Dr. Chris Blazina
@DrChrisBlazina · X

RT @FamDogProject: Our new research identified gene variants unique to two Methuselah dogs (aged 22 and 27 years) which could not be found…

Apr 16, 2020 · 4 shares · 4,898 followers View post →
RajashreeKhalap
@RajashreeKhalap · X

RT @FamDogProject: Our new research identified gene variants unique to two Methuselah dogs (aged 22 and 27 years) which could not be found…

Apr 16, 2020 · 4 shares · 1,086 followers View post →
へちまこ7
@Chicoli07 · X

RT @FamDogProject: Our new research identified gene variants unique to two Methuselah dogs (aged 22 and 27 years) which could not be found…

Apr 16, 2020 · 4 shares · 3,648 followers View post →
Family Dog Project
@FamDogProject · X

Our new research identified gene variants unique to two Methuselah dogs (aged 22 and 27 years) which could not be found in 850 dogs of average age. The genome of the oldest old “Methuselahs” is enriched with gene variants that can elongate lifespan. https://t.co/Tc66fbZjc0

Apr 16, 2020 · 9 likes · 4 shares · 4,394 followers View post →
(Methods in Molecular Biology, 2672) Tony Heitkam, Sònia Garcia ...
News

https://doi.org/10.3389/fpls. 737–748. https://doi.org/10.1002/cyto.a. 2020.00315 ... https://doi.org/10.3389/fgene.2019.01315 ation tools for tissue exploration.

Jan 12, 2026 View →
Psychoneuroendocrinology, P. 106295, 2023 | PDF | Leptin | Eating
News

gene expression (Koh et al., 2016, for review). The latter effect is ... https:// (1) https://doi.org/10.1111/nmo.13717. doi.org/10.3389/fpsyt.2020.00315.

Jan 12, 2026 View →
Diagnosis, Treatment, And Management of Rickets. Italian ...
News

gene (11), polyostotic fibrous dysplasia (PFD) due to gain-of-. Frontiers ... doi: 10.3389/fped.2020.00315 116:2062–72. doi: 10.1172/JCI29449 22. Roizen ...

Jan 12, 2026 View →
Said et al. - 2023 | PDF | Biomaterial | Tissue Engineering
News

(RNA) systems to regulate gene expression at the fracture site [200–202]. ... doi:10.3389/fchem.2020.00315. [119] Y. Luo, A. Elumalai, A. Humayun ...

Dec 16, 2025 View →
KRÁTKY PREHĽAD O INDIKÁCIÁCH VYSOKÝCH DÁVOK ...
Facebook

... Gene Polymorphisms Modify the Response to Vitamin D ... 10.3389/fped.2020.00315 o Biasucci G, Donini V, Cannalire G. Rickets ...

Dec 8, 2025 View →
Michal - Facebook
Facebook

... Gene Polymorphisms Modify the Response to Vitamin D ... 10.3389/fped.2020.00315 o Biasucci G, Donini V, Cannalire G. Rickets ...

Dec 8, 2025 View →
MÝTY VS. FAKTY O PNEUMOKOKOVEJ VAKCÍNE PREVNAR 7 ...
Facebook

Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to ... doi: 10.3389/fped.2020.00315 o Biasucci G, Donini V, Cannalire G.

Nov 23, 2025 View →
Vitamin D Deficiency and Resistance in Long - Term Illnesses | PDF ...
News

arthritis: relation to disease activity and functional 12; 8:315. doi: 10.3389/fped.. 2020.00315. disability. Egypt Rheumatol Rehabil 47, 44 ( ...

Nov 5, 2025 View →
Understanding the ECS and its role in psychiatry | Maheshram ...
LinkedIn

... 10.3389/fpsyt.2020.00315/full#B221 · Like · Reply ... gene that profoundly affects individuals and families around the world. ... Errors in a gene ...

Mar 17, 2025 View →
Cognitive Ageing in Dogs | EVOLOR | Project | Results | H2020 ...
News

DOI: 10.3389/fgene.2020.00315. Assistance and Therapy Dogs Are Better Problem Solvers Than Both Trained and Untrained Family Dogs (opens in ...

Sep 6, 2024 View →
VITAMIN-D RESISTANT RICKETS.ppt educationx | PPTX
News

PATHOPHYSIOLOGY • Defective gene is called PHEX because it is a phosphate-regulating gene with ... 10.3389/fped.2020.00315. Pediatric nephrology ...

Apr 25, 2024 View →
Michal - MEMENTO: ODBORNÍČKA NA MZ SR, KTORÁ PREŽIJE ...
Facebook

Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to ... doi: 10.3389/fped.2020.00315 o Biasucci G, Donini V, Cannalire G.

Jul 25, 2023 View →
Why Do Some Dogs Have Extremely Long Lifespans? | Psychology ...
Blogs

Frontiers in Genetics, 11, 315, DOI=10.3389/fgene.2020.00315. More references. Share on Facebook Share. Share on X Tweet. Share ...

May 15, 2020 View →
Michal Piják, MD - Personalised Evolutionary Nutrition - V HUMNE ...
Facebook

doi: 10.3389/fped.2020.00315 o Biasucci G, Donini V, Cannalire G. Rickets Types and Treatment with Vitamin D and Analogues. Nutrients. 2024 ...

May 12, 2020 View →
Los perros más longevos del mundo esconden un secreto en sus ...
News

... 10.3389/fgene.2020.00315. Mostrar comentarios. {"allowComment":"allowed","articleId":"5ef7fe62-82f7-11ea-8b7d-960a2175428d ...

Apr 20, 2020 View →
Dos perros superlongevos revelan genes únicos
News

Frontiers in Genetics 16 de abril de 2020 doi: 10.3389/fgene.2020.00315. Más sobre este tema: sinc. Publicidad. SINC. Gadgets · Móviles · Redes ...

Apr 19, 2020 View →
Michal Piják, MD - Personalised Evolutionary Nutrition - THE ...
Facebook

doi: 10.3389/fped.2020.00315 o Biasucci G, Donini V, Cannalire G. Rickets Types and Treatment with Vitamin D and Analogues. Nutrients. 2024 ...

Jul 24, 2015 View →
Michal Piják, MD - Personalised Evolutionary Nutrition - Pijak MR ...
Facebook

Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to ... doi: 10.3389/fped.2020.00315 o Biasucci G, Donini V, Cannalire G.

Jun 21, 2014 View →