ACS Chem Neurosci June 2020 PMID 32379417

Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.

Katarzyna Bilinska, Patrycja Jakubowska, Christopher S Von Bartheld, Rafal Butowt

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Mentions

115

Peak: 71 in Jul 2020

across 4 sources since May 2020

Extended reach

719,834

potential audience

Total likes

10,088

Video views

443,433

Mentions per month

May 2020 – Nov 2021

Where it's discussed

X / Twitter107 posts
News5 articles
YouTube2 videos
Blogs1 articles

AI synopsis

What people are saying

The social discussions predominantly support the study's findings, with examples like references to the expression of ACE2 and TMPRSS2 in support cells, and users commenting on how this explains symptoms like anosmia. The tone emphasizes validation and curiosity, reflecting a strong interest but moderate engagement that focuses on scientific understanding rather than action.

AgreementModerate agreement

Most discussions recognize the validity of the study, with users referencing the confirmation of ACE2 and TMPRSS2 expression in olfactory support cells and their potential link to COVID-19 symptoms.

InterestHigh interest

Posts show high interest, as many discuss the mechanisms of virus entry and the connection to symptoms like loss of smell, indicating engagement with the scientific content.

EngagementHigh engagement

Some posts reference specific cellular details and implications, showing deep engagement with the research and its broader context.

ImpactModerate impact

While some consider the findings significant for understanding COVID-19 symptoms, the overall impact appears moderate, mainly informing ongoing scientific and public health discussions rather than immediate policy changes.

Abstract in brief

The study investigated how the COVID-19 virus enters cells in the olfactory epithelium and found that ACE2 and TMPRSS2, which are crucial for viral entry, are mainly expressed in sustentacular cells rather than olfactory neurons.
This suggests that the virus may infect support cells in the olfactory system, which could lead to loss of smell in COVID-19 patients.
Additionally, the expression of these entry proteins increases with age in mice, possibly explaining why older individuals are more vulnerable to COVID-19.]

Read the full abstract

All mentions

Understanding Why COVID-19 Causes Multiple Symptoms

COVID-19 affects more than just respiratory functions. The virus enters cells through ACE2 and TMPRSS2 proteins, mainly found in support cells of the olfactory system, which may explain loss of smell and severity…

SciShow · Jul 9, 2020 399,326 views

Analysis of SARS-CoV-2 Entry Proteins in the Olfactory Epithelium

This study investigates how COVID-19 virus enters cells in the olfactory epithelium, finding that ACE2 and TMPRSS2 are mainly expressed in sustentacular support cells, possibly leading to loss of smell and higher…

Доктор Степанов · Nov 10, 2021 44,108 views

sara.art

@saraart4 · X

RT @Smackenziekerr: This confirms data from the study in May 2020 of Butwot of the expression of input protein of SARS-COV2, ACE2 and TMPRS…

Sep 4, 2021 · 2 shares · 8,491 followers View post →

Theflowernurse

@theflowernurse · X

RT @Smackenziekerr: This confirms data from the study in May 2020 of Butwot of the expression of input protein of SARS-COV2, ACE2 and TMPRS…

Sep 4, 2021 · 2 shares · 8,289 followers View post →

MacKenzie

@Smackenziekerr · X

RT @Smackenziekerr: This confirms data from the study in May 2020 of Butwot of the expression of input protein of SARS-COV2, ACE2 and TMPRS…

Sep 4, 2021 · 2 shares · 7,187 followers View post →

MacKenzie

@Smackenziekerr · X

Aug 31, 2021 · 6 likes · 2 shares · 7,187 followers View post →

Isatou Sarr

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Jul 26, 2021 · 41 followers View post →

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Mar 13, 2021 · 1,347 followers View post →

James V. Kohl

@microRNApro · X

The Democrats racism is exposed each time they fail to link ethnic differences in ACE2 receptors to differences in susceptibility and patient outcomes. See: https://t.co/i0ssqM0ANM

Nov 25, 2020 · 1 like · 2,573 followers View post →

Kelly French

@kfrench581 · X

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Nov 18, 2020 · 212 followers View post →

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Sep 5, 2020 · 1 like · 361 followers View post →

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Aug 15, 2020 · 238 followers View post →

ice9

@__ice9 · X

@JohnBeachTX @colinbro COVID-19 anosmia is caused by olfactory epithelial damage. https://t.co/axmLfgFBCH https://t.co/UUZeHMiBUG https://t.co/6CprpYDlly From virus.

Jul 29, 2020 · 1 like · 7,961 followers View post →

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Jul 19, 2020 · 274 followers View post →

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Rationist4

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Jul 13, 2020 · 6,612 followers View post →

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Jul 13, 2020 · 304 followers View post →

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Nathan SP (நாதன்)

@nathan_sp21 · X

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Jul 13, 2020 · 912 followers View post →

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Jul 12, 2020 · 53 followers View post →

Shahil Juggernath

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Jul 12, 2020 · 2,793 followers View post →

Rineez Ahmed

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Jul 12, 2020 · 295 followers View post →

musicov197

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Jul 12, 2020 · 1,219 followers View post →

AFXM.COM

@AFXM · X

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Jul 12, 2020 · 147 followers View post →

Jon Ridinger

@jonridinger · X

RT @SciShow: We think of COVID-19 as a respiratory disease. But it can cause symptoms outside our lungs - many of which can be tied to the…

Jul 11, 2020 · 16 shares · 376 followers View post →

venkaT

@TweetzofV · X

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Jul 11, 2020 · 3 shares · 426 followers View post →

Antonio G

@carabidos · X

Jul 11, 2020 · 213 followers View post →

Narayanan

@narayanank1980 · X

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Jul 11, 2020 · 3 shares · 15 followers View post →

Satheesh Kumar

@saysatheesh · X

RT @pulavar_tharumi: கொரோனா வைரசு எப்படி உடலின் பல பாகங்களை தாக்குகிறது?

Jul 11, 2020 · 3 shares · 15,819 followers View post →

புலவர் தருமி

@pulavar_tharumi · X

கொரோனா வைரசு எப்படி உடலின் பல பாகங்களை தாக்குகிறது?

Jul 11, 2020 · 7 likes · 3 shares · 7,785 followers View post →

Jay rajamanickam

@jayrajamanickam · X

Why Does COVID-19 Have So Many Symptoms? https://t.co/9oOyNdbaoE

Jul 11, 2020 · 17 followers View post →

Haley Keller

@haleymkeller · X

Why Does COVID-19 Have So Many Symptoms? https://t.co/qOZRP0bfV7

Jul 10, 2020 · 1 like · 488 followers View post →

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@MarkSmith75z · X

RT @YesCT: @AnnaForFlorida I don't think they are putting effort into understanding how the virus works. I wish they would value learning a…

Jul 10, 2020 · 1 share · 111 followers View post →

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@AhmadYounis15 · X

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Jul 10, 2020 · 1 share · 1,009 followers View post →

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@cgiAlexis · X

Useful brief on #COVID19 mechanisms from a fairly reputable source with links https://t.co/Tv8rLHYEZ0

Jul 10, 2020 · 2,494 followers View post →

kot z twarzą jest też na tej innej stronie

@kot_z_twarza · X

RT @ArachneOfficial: Why Does COVID-19 Have So Many Symptoms? https://t.co/jpbdPxMRml przez @YouTube Streszczenie filmu z drobnymi koment…

Jul 10, 2020 · 1 share · 5,166 followers View post →

Sifu mort, M.D.

@ArachneOfficial · X

Jul 10, 2020 · 3 likes · 1 share · 1,916 followers View post →

Thomas Anderson

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Jul 10, 2020 · 1 like · 71 followers View post →

iscab.saptocondro

@saptocondro · X

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Jul 10, 2020 · 578 followers View post →

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Jul 10, 2020 · 16 shares · 190 followers View post →

Cathy YesCT

@YesCT · X

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Jul 10, 2020 · 1 like · 1 share · 2,011 followers View post →

Entropy

@__allprod__ · X

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Jul 10, 2020 · 728 followers View post →

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Jul 9, 2020 · 118 followers View post →

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Jul 9, 2020 · 4 likes · 36 followers View post →

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RT @SciShow: We think of COVID-19 as a respiratory disease. But it can cause symptoms outside our lungs - many of which can be tied to the…

Jul 9, 2020 · 16 shares · 337 followers View post →

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@bingorage · X

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Jul 9, 2020 · 242 followers View post →

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RT @SciShow: We think of COVID-19 as a respiratory disease. But it can cause symptoms outside our lungs - many of which can be tied to the…

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@falcos2012 · X

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@rangerwinslow · X

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@darcy_shapiro · X

RT @SciShow: We think of COVID-19 as a respiratory disease. But it can cause symptoms outside our lungs - many of which can be tied to the…

Jul 9, 2020 · 16 shares · 1,496 followers View post →

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@NerdyChristie · X

RT @SciShow: We think of COVID-19 as a respiratory disease. But it can cause symptoms outside our lungs - many of which can be tied to the…

Jul 9, 2020 · 16 shares · 17,720 followers View post →

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@Pnzer6 · X

RT @SciShow: We think of COVID-19 as a respiratory disease. But it can cause symptoms outside our lungs - many of which can be tied to the…

Jul 9, 2020 · 16 shares · 25 followers View post →

M-Boogie

@soulquarist · X

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Jul 9, 2020 · 16 shares · 19 followers View post →

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@EyesPeril · X

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@zydecopolka · X

RT @SciShow: We think of COVID-19 as a respiratory disease. But it can cause symptoms outside our lungs - many of which can be tied to the…

Jul 9, 2020 · 16 shares · 128 followers View post →

Melodie Weller, PhD

@MeloWeller · X

Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age https://t.co/wtREm65dWs

Jun 26, 2020 · 1 like · 615 followers View post →

Miguel Ángel Sogorb

@MASogorb · X

El motivo de la pérdida de olfato en algunos casos de COVID-19 https://t.co/X7OEyhIYpZ Más información: Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. https://t.co/8OP8jrX9Hz

May 23, 2020 · 158 followers View post →

Nancy Lapid

@NancyLapid · X

May 20, 2020 · 21 likes · 15 shares · 5,422 followers View post →

Ariel Cerda Rojas

@arielo_cerda · X

Un artículo (https://t.co/TxcjZ2XDwz) exploró las causas de la perdida de olfato en pacientes infectados con #SARSCoV2 utilizando un modelo de ratón. Al estudiar células del epitelio olfativo descubrieron que ACE2 y TMPRSS2 se expresan en las células sustentaculares del epitelio. https://t.co/2kh1BWWyrk

May 15, 2020 · 1 like · 671 followers View post →

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May 13, 2020 · 1 share · 32 followers View post →

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May 13, 2020 · 2 likes · 1 share · 1,200 followers View post →