Front Cell Neurosci April 2020 PMID 32390802

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases.

Adam Armada-Moreira, Joana I Gomes, Carolina Campos Pina, Oksana K Savchak, Joana Gonçalves-Ribeiro, Nádia Rei, Sara Pinto, Tatiana P Morais, Robertta Silva Martins, Filipa F Ribeiro, Ana M Sebastião, Vincenzo Crunelli, Sandra H Vaz

Mentions

77
Peak: 42 in Aug 2023
across 3 sources since Apr 2020

Extended reach

392,802
potential audience

Total likes

501

Video views

6,620

Mentions per month

Apr 2020 – Apr 2025

Where it's discussed

  • X / Twitter62 posts
  • YouTube13 videos
  • News2 articles

AI synopsis

What people are saying

The overall tone reflects strong agreement, especially where posters emphasize excitotoxicity's role in neurodegenerative diseases, with phrases like 'great comprehensive review' and calls to 'look deeper into these mechanisms.' The use of technical terms such as 'ROS,' 'neuroplasticity,' and 'synaptic failure' shows active engagement, while the acknowledgment of excitotoxicity as a contributor rather than the sole cause underscores its relevance in ongoing research discussions.

AgreementModerate agreement

Most posts acknowledge the importance of excitotoxicity and its link to neurodegenerative diseases, showing general agreement with the publication's focus.

InterestHigh interest

Posts display high interest by highlighting the complexity of neurotoxic processes and praising the review as comprehensive.

EngagementModerate engagement

Discussions include references to molecular mechanisms like calcium control and mitochondrial dysfunction, indicating moderate engagement.

ImpactModerate impact

The shared content and praise suggest the publication could influence ongoing neuroscience research and understanding of neurodegeneration.

Abstract in brief

  • Excitotoxicity occurs when excessive glutamate activates brain receptors, leading to neuron damage and death, with astrocytes normally regulating glutamate levels to prevent this.
  • The process involves disruptions in glutamate and calcium metabolism, malfunction of transporters and receptors (especially NMDARs), and is linked to mitochondrial dysfunction, oxidative stress, and neuronal injury.
  • This phenomenon plays a central role in neurodegenerative diseases such as Alzheimer's, ALS, and epilepsy, with overactivation of NMDARs causing harmful calcium influx and subsequent cellular damage.

Top posts

Most liked on X and Bluesky
January Littlejohn
@JanuaryDoNoHarm · X

10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell death, which then leads to neurodegenerative diseases https://t.co/dlRp8Z8poJ.

Aug 2, 2023 · 417 likes · 44 shares · 28,608 followers View post →
Frontiers - Neuroscience
@FrontNeurosci · X

New Research: Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases: Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the… https://t.co/ZoaAwpB3Y3 #neuroscience

May 6, 2020 · 15 likes · 6 shares · 81,038 followers View post →
Estoy con la verdad
@Watchandwait123 · X

10/ La excitotoxicidad del glutamato puede iniciar "una cascada de neurotoxicidad", lo que lleva a la pérdida de la función neuronal y la muerte celular, lo que luego conduce a enfermedades neurodegenerativas https://t.co/1HPIfZboJx.

Aug 3, 2023 · 15 likes · 2 shares · 2,971 followers View post →
Sandra H. Vaz
@SandraHVaz1 · X

Our last review on excitotoxicity in neurodegenerative diseases @FrontNeurosci Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases https://t.co/pJjxXBE7Xf

May 14, 2020 · 7 likes · 3 shares · 131 followers View post →
Ireland Stand Up
@IrelandStandUp · X

https://t.co/wA31m0TFbO https://t.co/zRzaaG5P5p

Aug 3, 2023 · 3 likes · 1 share · 2,897 followers View post →
Greg Mushen
@gregmushen · X

Neurodegeneration Neurons lose calcium control. Mitochondria can’t buffer it → excitotoxicity, ROS, synaptic failure. Note: this is not the sole cause, but a contributor. PMID: 35078537, https://t.co/T1IW30m2P6

Apr 16, 2025 · 2 likes · 29,402 followers View post →

All mentions

Marie
@re1_marie · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Apr 30, 2025 · 44 shares · 2,514 followers View post →
Greg Mushen
@gregmushen · X

Neurodegeneration Neurons lose calcium control. Mitochondria can’t buffer it → excitotoxicity, ROS, synaptic failure. Note: this is not the sole cause, but a contributor. PMID: 35078537, https://t.co/T1IW30m2P6

Apr 16, 2025 · 2 likes · 29,402 followers View post →
Park Ranger
@netminnow · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Dec 4, 2024 · 44 shares · 6,871 followers View post →
JorgiPorgi
@JPorgi · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Oct 29, 2024 · 44 shares · 457 followers View post →
Diana Villiers
@DianaVilliers1 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Oct 29, 2024 · 44 shares · 1,864 followers View post →
Dr. Jessica Giddens DNP (nurse)
@DrJGiddensRN · X

https://t.co/3hIKOtRnCG --- behold the beauty of #excitotoxicity and #neuroplasticity #neuroscience

Mar 8, 2024 · 2,751 followers View post →
Inky Dorman
@DormanInky · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Feb 21, 2024 · 44 shares · 50 followers View post →
Frankie
@Fr4nkie_Spence · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Dec 3, 2023 · 44 shares · 2,408 followers View post →
BEEPEACE
@lauramarsh70 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Dec 3, 2023 · 44 shares View post →
Jason Bourne The1st
@Jason_Bourne634 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Dec 3, 2023 · 44 shares · 512 followers View post →
(((Julia Williams)))
@JCCWilliams · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 22, 2023 · 44 shares · 3,855 followers View post →
Scott Norman Rosenth
@ScottNorman53 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 15, 2023 · 44 shares · 23 followers View post →
God Zilla
@TrumpsterTrash · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 15, 2023 · 44 shares · 6,816 followers View post →
Juana Gómez Serrano
@YoJuanaytu · X

RT @Watchandwait123: 10/ La excitotoxicidad del glutamato puede iniciar "una cascada de neurotoxicidad", lo que lleva a la pérdida de la fu…

Aug 4, 2023 · 2 shares · 3,301 followers View post →
Alan Whelan
@AlanWhelan17 · X

RT @IrelandStandUp: https://t.co/wA31m0TFbO

Aug 4, 2023 · 1 share · 1,026 followers View post →
En1bu1
@en1bu1 · X

RT @Watchandwait123: 10/ La excitotoxicidad del glutamato puede iniciar "una cascada de neurotoxicidad", lo que lleva a la pérdida de la fu…

Aug 4, 2023 · 2 shares · 2,119 followers View post →
Individious
@Individious · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 187 followers View post →
Parents with Inconvenient Truths about Trans
@pittparents · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 15,016 followers View post →
Terri Lewis
@terriblewis1 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 3,068 followers View post →
Ireland Stand Up
@IrelandStandUp · X

https://t.co/wA31m0TFbO https://t.co/zRzaaG5P5p

Aug 3, 2023 · 3 likes · 1 share · 2,897 followers View post →
GenX Deplorable Scientist
@piggylou73 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 891 followers View post →
Patricia Hardman #AdultHumanFemale #SexIsImmutable
@TriciaFrasman · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 3,456 followers View post →
Zena Woodley
@PrincessofWails · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 9,283 followers View post →
Tara Taylor
@coldcoqui · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 395 followers View post →
Hellacoptermom
@dennissimmoo · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 61 followers View post →
Carole Targett
@CaroleTargett · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 230 followers View post →
3 Libras Magdelena
@30ACTruth · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 17,018 followers View post →
Mamabear
@Mamabea02597983 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 990 followers View post →
Brave
@defiaye · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 13,249 followers View post →
Cool Clear Waters
@Coolclearwaters · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 699 followers View post →
CAT2027
@FITA2027 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 599 followers View post →
Marta
@sra_danvers · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 3,145 followers View post →
IndyAsapScot
@IndyAsapScot · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 7,231 followers View post →
Vinyl Witch
@Aflgirl126 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 18,687 followers View post →
LesleySemmens
@LesleySemmens · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 11,994 followers View post →
WeeVal
@wee_val · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 879 followers View post →
OnThe₿lockch₳in
@MagnaMater83 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 839 followers View post →
Ann Sinnott
@AnnMSinnott · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 10,993 followers View post →
Estoy con la verdad
@Watchandwait123 · X

10/ La excitotoxicidad del glutamato puede iniciar "una cascada de neurotoxicidad", lo que lleva a la pérdida de la función neuronal y la muerte celular, lo que luego conduce a enfermedades neurodegenerativas https://t.co/1HPIfZboJx.

Aug 3, 2023 · 15 likes · 2 shares · 2,971 followers View post →
Patrick
@STILLTish · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 46,309 followers View post →
Rohbo
@rohbo1 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 639 followers View post →
Minx
@WyrdGrl · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 3,605 followers View post →
PHughes Feminism- Radical Notion Women are Human
@PHughes74470229 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 4,317 followers View post →
quelizinha
@quelizinha · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 3,957 followers View post →
Ireland Stand Up
@IrelandStandUp · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 2,897 followers View post →
Pau #XX ✊
@anacum3 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 7,242 followers View post →
AcheJ
@AcheJ6 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 2,546 followers View post →
TheVoividaWannabe
@annalovestravel · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 3, 2023 · 44 shares · 49 followers View post →
Diana Villiers
@DianaVilliers1 · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 2, 2023 · 44 shares · 1,864 followers View post →
UniquelyDefined
@DefinedUniquely · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 2, 2023 · 44 shares · 3,608 followers View post →
Women & Girls aren't worthless or worth less
@TruthNotTrend · X

RT @JanuaryDoNoHarm: 10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell…

Aug 2, 2023 · 44 shares · 189 followers View post →
January Littlejohn
@JanuaryDoNoHarm · X

10/ Glutamate excitotoxicity can start "a cascade of neurotoxicity,” leading to the loss of neuronal function and cell death, which then leads to neurodegenerative diseases https://t.co/dlRp8Z8poJ.

Aug 2, 2023 · 417 likes · 44 shares · 28,608 followers View post →
EU-GliaPhD
@EUGliaPhD · X

RT @SandraHVaz1: Our last review on excitotoxicity in neurodegenerative diseases @FrontNeurosci Going the Extra (Synaptic) Mile: Excitotox…

May 15, 2020 · 3 shares · 180 followers View post →
Vanessa Henriques
@nessajhenriques · X

RT @SandraHVaz1: Our last review on excitotoxicity in neurodegenerative diseases @FrontNeurosci Going the Extra (Synaptic) Mile: Excitotox…

May 15, 2020 · 3 shares · 191 followers View post →
João F Oliveira
@Joao_F_Oliveira · X

RT @SandraHVaz1: Our last review on excitotoxicity in neurodegenerative diseases @FrontNeurosci Going the Extra (Synaptic) Mile: Excitotox…

May 14, 2020 · 3 shares · 1,136 followers View post →
Sandra H. Vaz
@SandraHVaz1 · X

Our last review on excitotoxicity in neurodegenerative diseases @FrontNeurosci Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases https://t.co/pJjxXBE7Xf

May 14, 2020 · 7 likes · 3 shares · 131 followers View post →
Layla Starr
@laylainlab · X

https://t.co/23avcz46si A great comprehensive review on excitotoxicity!

May 12, 2020 · 1 like · 261 followers View post →
MUSC Department of Neuroscience
@neuro_MUSC · X

RT @FrontNeurosci: New Research: Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases: Excitotoxic…

May 8, 2020 · 6 shares · 1,098 followers View post →
iBraiN Inserm Lab
@iBrain_Inserm · X

RT @FrontNeurosci: New Research: Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases: Excitotoxic…

May 7, 2020 · 6 shares · 1,713 followers View post →
Ariakas Enoreth
@Aenoreth · X

RT @FrontNeurosci: New Research: Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases: Excitotoxic…

May 7, 2020 · 6 shares · 1,005 followers View post →
Frontiers - Neuroscience
@FrontNeurosci · X

New Research: Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases: Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the… https://t.co/ZoaAwpB3Y3 #neuroscience

May 6, 2020 · 15 likes · 6 shares · 81,038 followers View post →
Tiago Fernandes
@TGF_fernandes · X

Congratulations Sandra on your newly published @FrontiersIn article: https://t.co/lkmOmAbANZ

Apr 24, 2020 · 1 like · 807 followers View post →