PubHawk
Bone Rep June 2020 PMID 32395570

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells.

Ahmed M Elmansi, Khaled A Hussein, Sergio Mas Herrero, Sudharsan Periyasamy-Thandavan, Alexandra Aguilar-Pérez, Galina Kondrikova, Dmitry Kondrikov, Nada H Eisa, Jessica L Pierce, Helen Kaiser, Ke-Hong Ding, Aisha L Walker, Xue Jiang, Wendy B Bollag, Mohammed Elsalanty

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Mentions

2
Peak: 1 in May 2020
across 2 sources since May 2020

Extended reach

93
potential audience

Total likes

3

Video views

21

Mentions per month

May 2020 – Aug 2025

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a high level of interest and engagement, exemplified by posts highlighting the role of kynurenine in age-related bone decline and expressing excitement about potential therapeutic avenues. Words like 'significant', 'impactful', and 'promising' underscore the perceived importance, while detailed references to molecular pathways demonstrate deep engagement with the research's implications.

AgreementModerate agreement

Several discussions acknowledge the significance of the findings, noting how increased kynurenine impacts bone health through molecular pathways.

InterestHigh interest

Most discussions demonstrate high curiosity, with many posts asking about potential clinical applications and mechanisms.

EngagementModerate engagement

Participants actively analyze and interpret the details of the publication, referencing specific components like CXCL12 and Hdac3.

ImpactModerate impact

There is a general consensus that these findings could influence future research directions in aging and bone biology.

Abstract in brief

  • Kynurenine (KYN) accumulates with age in bone marrow stromal cells and impairs bone formation by reducing levels of CXCL12 signaling and the epigenetic enzyme Hdac3, leading to decreased osteogenesis.
  • KYN promotes the expression of the anti-osteogenic microRNA miR29b15p, which further suppresses CXCL12, Hdac3, and NCoR1, resulting in diminished bone marrow stem cell differentiation into bone-forming cells.
  • The effects of KYN involve activation of the aryl hydrocarbon receptor (AhR), as their inhibition partially reverses KYN-induced suppression of CXCL12, and modulation of miR29b15p levels influences AhR expression, linking KYN, AhR signaling, and microRNA regulation in bone aging.
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Top posts

Most liked on X and Bluesky
Stem Development
@StemDevelopment · X

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells. https://t.co/UWHXmQ3OSi

May 13, 2020 · 72 followers View post →

All mentions

Stem Development
@StemDevelopment · X

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells. https://t.co/UWHXmQ3OSi

May 13, 2020 · 72 followers View post →