May 2020 PMID 32471470

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer.

Yoo-Ah Kim, Damian Wojtowicz, Rebecca Sarto Basso, Itay Sason, Welles Robinson, Dorit S Hochbaum, Mark D M Leiserson, Roded Sharan, Fabio Vadin, Teresa M Przytycka

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Mentions

16
Peak: 4 in Mar 2019
across 2 sources since Mar 2019

Extended reach

160,614
potential audience

Total likes

20

Video views

978

Mentions per month

Mar 2019 – Sep 2023

Where it's discussed

  • X / Twitter14 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a positive reception emphasizing the novel insights into mutational processes using network-based approaches, with words like 'elucidate' and hashtags indicating a focus on bioinformatics and bioRxiv as platforms for significant scientific advancements. The tone suggests appreciation for the research’s contribution to understanding breast cancer mutations and pathways.

AgreementModerate agreement

Most discussions recognize the value of network-based methods in revealing mutational differences in breast cancer, indicating general agreement on the significance of the research.

InterestModerate interest

The discussions show interest mostly through references to technical aspects and the potential of these approaches, though some posts are quite brief.

EngagementHigh engagement

Several participants delve into methodological implications, discussing how the approach sheds light on mutation pathways, demonstrating deep engagement.

ImpactModerate impact

The emphasis on understanding mutation mechanisms and the multiple mentions of potential for influence suggest moderate to high perceived impact.

Abstract in brief

  • The study explores how different mutational processes in breast cancer, like APOBEC activity and clocklike signatures, can be distinguished based on genetic and expression data using a network-based approach.
  • It investigates which biological pathways are linked to these mutational signatures and whether genetic alterations in these pathways drive specific mutational patterns.
  • The findings reveal that the APOBEC-related mutations and age-related signatures are caused by different mechanisms, with some mutations related to cell cycle activity and others not, highlighting the diverse origins of these mutational signatures.

Top posts

Most liked on X and Bluesky
Gang Wu
@wufgang · X

Learn tumor evolution from passenger mutations, Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer https://t.co/Cp3rjJVeNh

May 11, 2019 · 2 likes · 263 followers View post →
mutational signatures twitbot
@mutSignatures · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/ykWlXpTxxf

Oct 7, 2020 · 2 likes · 251 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer https://t.co/6HdFp39a8c #biorxiv_bioinfo

Mar 5, 2019 · 1 like · 18,096 followers View post →
mutational signatures twitbot
@mutSignatures · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/ykWlXpTxxf

Jul 14, 2020 · 1 like · 251 followers View post →
BioNetPapers
@bionet_papers · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/TnoS2AJJba

May 31, 2020 · 1 like · 221 followers View post →
bioRxiv
@biorxivpreprint · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer https://t.co/RuBx7r4gJC #bioRxiv

Mar 5, 2019 · 137,003 followers View post →

All mentions

J. Harry Caufield
@harry_caufield · X

TP: can see the interaction between mutation and molecular pathways re: breast cancer - see https://t.co/31vY5KROxj #NetBio #ISMB2022

Jul 12, 2022 · 275 followers View post →
mutational signatures twitbot
@mutSignatures · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/ykWlXpTxxf

Oct 31, 2020 · 251 followers View post →
mutational signatures twitbot
@mutSignatures · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/ykWlXpTxxf

Oct 7, 2020 · 2 likes · 251 followers View post →
mutational signatures twitbot
@mutSignatures · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/ykWlXpTxxf

Sep 15, 2020 · 251 followers View post →
mutational signatures twitbot
@mutSignatures · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/ykWlXpTxxf

Aug 12, 2020 · 251 followers View post →
mutational signatures twitbot
@mutSignatures · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/ykWlXpTxxf

Jul 14, 2020 · 1 like · 251 followers View post →
mutational signatures twitbot
@mutSignatures · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/ykWlXpTxxf

Jun 19, 2020 · 251 followers View post →
BioNetPapers
@bionet_papers · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer. https://t.co/TnoS2AJJba

May 31, 2020 · 1 like · 221 followers View post →
Raunak Shrestha, PhD
@raunakms · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer https://t.co/UxeLMXbIBf

May 30, 2020 · 1,172 followers View post →
Gang Wu
@wufgang · X

Learn tumor evolution from passenger mutations, Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer https://t.co/Cp3rjJVeNh

May 11, 2019 · 2 likes · 263 followers View post →
bxv_bioinf
@bxv_bioinf · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer https://t.co/BaTfCcWsjM

Mar 5, 2019 · 491 followers View post →
Helio Rocha
@_elioRocha · X

#bioRxiv Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer #bioinfo https://t.co/BBFEIhu5ne

Mar 5, 2019 · 609 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer https://t.co/6HdFp39a8c #biorxiv_bioinfo

Mar 5, 2019 · 1 like · 18,096 followers View post →
bioRxiv
@biorxivpreprint · X

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer https://t.co/RuBx7r4gJC #bioRxiv

Mar 5, 2019 · 137,003 followers View post →