March 2021 PMID 32508823

Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines.

Lynda Coughlan

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Mentions

99
Peak: 14 in Aug 2020
across 4 sources since Jun 2020

Extended reach

436,690
potential audience

Total likes

1,020

Video views

64,502

Mentions per month

Jun 2020 – May 2024

Where it's discussed

  • X / Twitter69 posts
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AI synopsis

What people are saying

Anonymous discussions highlight the understanding of adenoviral vectors’ mechanisms, with comments like, 'This is the best explanation for how the adenovirus delivery system works...' and references to specific vaccine designs, signaling active interest in the topic. The tone of respect and usage of phrases like 'excellent review' or 'very complete' contribute to a sentiment that sees the publication as a valuable resource in the field.

AgreementModerate agreement

Most discussions express a supportive or neutral stance towards the publication's insights on adenoviral vectors.

InterestHigh interest

There is a clear curiosity about the mechanisms of adenoviral vectors, indicating a high level of engagement with the topic.

EngagementModerate engagement

While several comments show basic understanding, deeper analysis is limited, suggesting moderate engagement.

ImpactHigh impact

The publication is viewed as influential, particularly in understanding vaccine mechanisms and their implications in public health.

Abstract in brief

  • Nonreplicating adenoviral vectors are a promising and safe vaccine platform that elicits strong immune responses, particularly through CD8 T cells and humoral immunity.
  • Despite their advantages, there's a complex hierarchy of immunogenic potency among different adenoviral vectors, which restricts the use of certain vectors that might otherwise be effective.
  • Ongoing research aims to understand the mechanisms behind these immunogenicity differences, including factors like vaccine antigen expression duration and the balance of innate immune signaling.

Top posts

Most liked on X and Bluesky
Devan Sinha
@DevanSinha · X

Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH 19/ https://t.co/oYOnlbkMVO

May 23, 2021 · 50 likes · 11 shares · 5,634 followers View post →
Michael Lin, MD PhD
@michaelzlin · X

Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presenting cells https://t.co/JfQuk8nKSq https://t.co/qaXEUj8Jkm

Jul 19, 2022 · 34 likes · 2 shares · 28,031 followers View post →
Dr. Krusty, MD
@Krusty_M_D · X

Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5

Jun 6, 2021 · 26 likes · 4 shares · 19,383 followers View post →
Devan Sinha
@DevanSinha · X

@AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers on how even non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH

Feb 22, 2021 · 21 likes · 5 shares · 5,634 followers View post →
Michael Lin, MD PhD
@michaelzlin · X

Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to protein or killed virus, not RNA. Regardless once lymphocytes are activated, they will live much longer than Ad or RNA can express. https://t.co/zgBlcvlrJn

Apr 13, 2021 · 11 likes · 3 shares · 28,031 followers View post →
IDI-UCV
@IdiUcv · X

Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8 https://t.co/XNt0ms2zmZ

Aug 22, 2020 · 11 likes · 14 shares · 2,953 followers View post →

All mentions

SIRENITA
@JojoSirenita · X

RT @michaelzlin: Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presen…

Jul 19, 2022 · 2 shares · 723 followers View post →
Gerald Commissiong
@G_Commish · X

RT @michaelzlin: Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presen…

Jul 19, 2022 · 2 shares · 5,325 followers View post →
Michael Lin, MD PhD
@michaelzlin · X

Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presenting cells https://t.co/JfQuk8nKSq https://t.co/qaXEUj8Jkm

Jul 19, 2022 · 34 likes · 2 shares · 28,031 followers View post →
m m ganesh
@mmganeshsalem · X

@speakshoutroar @drsanjaykrai https://t.co/NPlHfOmn8A mechanism of action of astrazenecca( covishield)

Dec 30, 2021 · 111 followers View post →
m m ganesh
@mmganeshsalem · X

RT @mmganeshsalem: @nicefiddler https://t.co/hONoWOqEHQ adeno virus vector .( vector means transport vehicle.) It transports spike protein…

Dec 30, 2021 · 1 share · 111 followers View post →
m m ganesh
@mmganeshsalem · X

@nicefiddler https://t.co/hONoWOqEHQ adeno virus vector .( vector means transport vehicle.) It transports spike protein gene ! of RNA sars virus.

Dec 30, 2021 · 1 like · 1 share · 111 followers View post →
Isatou Sarr
@IsatouSarr4 · X

Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines https://t.co/GYSZ7xZVZq

Dec 16, 2021 · 1 like · 33 followers View post →
Bio-brain_2035
@2035Bio · X

@maddstone1 @RNAiAnalyst https://t.co/Zf6RRU5Tng

Jul 15, 2021 · 274 followers View post →
Leo Ojeda
@LeoOjed27350204 · X

RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5

Jun 7, 2021 · 4 shares · 1,741 followers View post →
Clau
@clawwdy · X

RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5

Jun 7, 2021 · 4 shares · 3,868 followers View post →
Ro
@SPHIX_1 · X

RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5

Jun 7, 2021 · 4 shares · 577 followers View post →
briza♥
@dulcealmendras · X

RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5

Jun 6, 2021 · 4 shares · 2,962 followers View post →
Dr. Krusty, MD
@Krusty_M_D · X

Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5

Jun 6, 2021 · 26 likes · 4 shares · 19,383 followers View post →
Dr. Krusty, MD
@Krusty_M_D · X

@eljesusargento estoy todavía releyéndolo. Más tarde hago un mini hilo. https://t.co/4iuAzZwnmN

Jun 6, 2021 · 2 likes · 19,383 followers View post →
TigrecitoTriste
@TigrecitoTriste · X

RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…

May 29, 2021 · 5 shares · 564 followers View post →
Balaji R
@berliner_bee · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 27, 2021 · 11 shares · 480 followers View post →
Marvin
@moonwalkerwizzz · X

This is the best explanation for how the adenovirus delivery system works and how it stimulates immune response in humans I could find. Very complete. https://t.co/qjVkypNzwF

May 25, 2021 · 172 followers View post →
Sourav Singh
@MrSouravSingh · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 25, 2021 · 11 shares · 236 followers View post →
GustavoMarques
@gustavogarretRJ · X

RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…

May 25, 2021 · 5 shares · 45 followers View post →
Dr Kevin Purcell @kevinpurcell.bsky.social
@kevinpurcell · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 24, 2021 · 11 shares · 1,503 followers View post →
Mary Branscombe
@marypcbuk · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 24, 2021 · 11 shares · 11,409 followers View post →
Bassaces
@Bassaces1 · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 24, 2021 · 11 shares · 2,599 followers View post →
siddharthgpf
@siddharthgpf · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 24, 2021 · 11 shares · 2,464 followers View post →
Iram Sattar MBE
@DrIramSattar · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 24, 2021 · 11 shares · 824 followers View post →
Denys Bennett - @denysbennett.bsky.social
@denysbennett · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 24, 2021 · 11 shares · 762 followers View post →
Sangeeta Motiani
@sangmotiani · X

RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…

May 24, 2021 · 5 shares · 285 followers View post →
Tracy Chou
@triketora · X

RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…

May 23, 2021 · 11 shares · 108,901 followers View post →
Devan Sinha
@DevanSinha · X

Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH 19/ https://t.co/oYOnlbkMVO

May 23, 2021 · 50 likes · 11 shares · 5,634 followers View post →
nestor
@ndchiariello · X

@cingolani_oscar por lo que veo como un obdservador ignorante de estos temas es que hace tiempo se estudia lo que en Brasil comentan y lo deben tener en cuenta cualquier fabricante de vacuna que opte por esa tecnologia para evitarlo https://t.co/ZTHU8sySsP

Apr 30, 2021 · 91 followers View post →
Alfer
@Alfonso_aer · X

RT @lalbert75: @jorgeb_2021 @peterprincipio Éste artículo sobre como un vector de adenovirus no replicante puede continuar persistiendo y e…

Apr 21, 2021 · 2 shares · 3,188 followers View post →
Luis Santamaría
@lalbert75 · X

@jorgeb_2021 @peterprincipio Éste artículo sobre como un vector de adenovirus no replicante puede continuar persistiendo y estimulando el sistema inmunológico, especialmente células T, puede interesarle. No se va a quedar a medio vacunar, el sistema inmunológico no funciona así https://t.co/milJjMKKZ9

Apr 21, 2021 · 5 likes · 2 shares · 3,569 followers View post →
julioyuste
@julioyuste · X

RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…

Apr 14, 2021 · 5 shares · 771 followers View post →
Jb
@RideSoulSurf · X

RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…

Apr 14, 2021 · 3 shares · 243 followers View post →
Anita #cleanindoorair
@AnitaN1007 · X

RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…

Apr 14, 2021 · 3 shares · 567 followers View post →
Mandakhnaran Davaadorj
@mngmanda · X

RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…

Apr 14, 2021 · 3 shares · 1,528 followers View post →
Michael Lin, MD PhD
@michaelzlin · X

Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to protein or killed virus, not RNA. Regardless once lymphocytes are activated, they will live much longer than Ad or RNA can express. https://t.co/zgBlcvlrJn

Apr 13, 2021 · 11 likes · 3 shares · 28,031 followers View post →
IJR
@Pajarote99 · X

@JPabloReisch Mijo eso wue midieron ahí, no es la única forma en la que la vacuna induce inmunidad. https://t.co/CB9UQFgFxH

Apr 3, 2021 · 1 like · 14 followers View post →
IJR
@Pajarote99 · X

@edalgomezn @bacigalupe @micronauta @elaval @rafaelg_fisica @Censelio @nbody6 @PolarBearby Solo considera nivel de anticuerpos... pero... https://t.co/CB9UQFgFxH

Mar 23, 2021 · 14 followers View post →
Luis Santamaría
@lalbert75 · X

@jorgeb_2021 Por eso es tan interesante el mecanismo de una vacuna como OX/AZ. Hay artículos científicos detallados sobre cómo incluso el vector de adenovirus no replicante puede continuar persistiendo y estimulando el sistema inmunológico. Especialmente células T. https://t.co/milJjMKKZ9

Mar 21, 2021 · 3 likes · 1 share · 3,569 followers View post →
Asa Hidmark
@Nymne · X

@f_jalalvand du har helt rätt Adenovirusvektorer aktiverar TLR. Agnes vet inte vad hon prator om https://t.co/OzeS9baaDK

Mar 16, 2021 · 5,976 followers View post →
Uk Neuro
@Ukneuro · X

@ibrahimimam2000 @AgneStraukiene https://t.co/zgmzgyxR4H

Feb 27, 2021 · 237 followers View post →
Dr. Lynda Coughlan
@Virusnerdette · X

@ProtEngineer @chiara_rapi Agreed on some CAR usage, but also some as-yet unknown receptor(s). Uptake by muscle cells at injection site, some uptake in dLNs by APCs, including DCs. More info here: https://t.co/law69WLgub & https://t.co/sFKeOFpufJ

Feb 26, 2021 · 2 likes · 3,196 followers View post →
Devan Sinha
@DevanSinha · X

@AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers on how even non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH

Feb 22, 2021 · 21 likes · 5 shares · 5,634 followers View post →
Noelia López Montero
@NoeliaLopezMon · X

@LouDeFrogg @Cs_Madrid Efectivamente, y para ser correctos, no es el adenovirus el que entra en el núcleo, sino su ADN. A diferencia de otros, como los retrovirus, no se integran en el ADN genómico celular. Si está interesada en conocer su mecanismo de acción: https://t.co/e5kYMGuzS6

Feb 8, 2021 · 1,481 followers View post →
DomTheBoss
@uberrimaefidei1 · X

RT @Virusnerdette: @__philipn__ In summary, it's complicated. There is a hierarchy of immunogenicity. Multiple factors likely contribute to…

Jan 30, 2021 · 1 share · 625 followers View post →
Dr. Lynda Coughlan
@Virusnerdette · X

@__philipn__ In summary, it's complicated. There is a hierarchy of immunogenicity. Multiple factors likely contribute to differences https://t.co/mpMTLaVpIf

Jan 29, 2021 · 5 likes · 1 share · 3,196 followers View post →
Venkat
@Venkat24indian · X

@surnell @Prasannasimha @Swamy39 This is a good review on adenoviral vectors if you are interested to understand why testing in an indian context is important https://t.co/eDO7mF0EZ5

Jan 3, 2021 · 205 followers View post →
Jeffrey A. Hirschfield, MD
@DrHirschfield · X

@DrEricDing Data uncertainty regarding Oxford's coronavirus vaccine, MORE

Dec 4, 2020 · 11,949 followers View post →
Andrei Zvelindovsky
@zvelindovsky · X

Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines https://t.co/9pKid7aYlV

Nov 5, 2020 · 325 followers View post →
Rdlfo Guttiérrez
@RodolfoGutierre · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 24, 2020 · 14 shares · 705 followers View post →
Ilusion Romero
@IlusionR · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 1,501 followers View post →
Periodoncia UCV
@PeriodonciaUCV · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 449 followers View post →
Diana
@Dprincz · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 91 followers View post →
orquidea rodriguez
@orquileo · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 184 followers View post →
Michael Mijares
@michaelfarmacia · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 636 followers View post →
Yalalu. America Lupi
@yalalu · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 680 followers View post →
Dr Rigoberto Marcano: Médico internista
@rigotordoc · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 26,211 followers View post →
Alexis H. García Piñero
@alexis_garcia27 · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 1,550 followers View post →
IDI-UCV
@IdiUcv · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 2,953 followers View post →
Juan B. De Sanctis
@DesanctisJuan · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 317 followers View post →
L. Griselda V.P.M.
@crazylourdes · X

RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…

Aug 23, 2020 · 14 shares · 242 followers View post →
IDI-UCV
@IdiUcv · X

Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8 https://t.co/XNt0ms2zmZ

Aug 22, 2020 · 11 likes · 14 shares · 2,953 followers View post →
daniel de Moselle
@Daniel57500 · X

Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines https://t.co/TAkE8lrz2c

Aug 13, 2020 · 896 followers View post →
Dr. Lynda Coughlan
@Virusnerdette · X

RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…

Jun 30, 2020 · 6 shares · 3,196 followers View post →
Ariakas Enoreth
@Aenoreth · X

RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…

Jun 24, 2020 · 6 shares · 1,006 followers View post →
Meme_Guru2020
@MGuru2020 · X

RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…

Jun 23, 2020 · 6 shares · 715 followers View post →
David Ochayon
@DOchayon · X

RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…

Jun 23, 2020 · 6 shares · 288 followers View post →
Jorge Rosas
@guruesmx · X

RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…

Jun 23, 2020 · 6 shares · 136 followers View post →
Frontiers - Immunology
@FrontImmunol · X

New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-replicating Ad vectors possess several… https://t.co/dcVfStvjl1 #immunology

Jun 23, 2020 · 4 likes · 6 shares · 33,760 followers View post →