Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH 19/ https://t.co/oYOnlbkMVO
Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines.
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Jun 2020 – May 2024Where it's discussed
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What people are saying
Anonymous discussions highlight the understanding of adenoviral vectors’ mechanisms, with comments like, 'This is the best explanation for how the adenovirus delivery system works...' and references to specific vaccine designs, signaling active interest in the topic. The tone of respect and usage of phrases like 'excellent review' or 'very complete' contribute to a sentiment that sees the publication as a valuable resource in the field.
Most discussions express a supportive or neutral stance towards the publication's insights on adenoviral vectors.
There is a clear curiosity about the mechanisms of adenoviral vectors, indicating a high level of engagement with the topic.
While several comments show basic understanding, deeper analysis is limited, suggesting moderate engagement.
The publication is viewed as influential, particularly in understanding vaccine mechanisms and their implications in public health.
Abstract in brief
- Nonreplicating adenoviral vectors are a promising and safe vaccine platform that elicits strong immune responses, particularly through CD8 T cells and humoral immunity.
- Despite their advantages, there's a complex hierarchy of immunogenic potency among different adenoviral vectors, which restricts the use of certain vectors that might otherwise be effective.
- Ongoing research aims to understand the mechanisms behind these immunogenicity differences, including factors like vaccine antigen expression duration and the balance of innate immune signaling.
Top posts
Most liked on X and BlueskyAnother nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presenting cells https://t.co/JfQuk8nKSq https://t.co/qaXEUj8Jkm
Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
@AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers on how even non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH
Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to protein or killed virus, not RNA. Regardless once lymphocytes are activated, they will live much longer than Ad or RNA can express. https://t.co/zgBlcvlrJn
Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8 https://t.co/XNt0ms2zmZ
All mentions
How Oxford-AstraZeneca's COVID-19 vaccine work - Adenovirus vector vaccine mechanism of action
Understanding Adenoviral Vector Vaccines and Immune Response
Nonreplicating adenoviral vectors are a promising vaccine platform that elicits strong immune responses. This video explores how these vaccines generate antibodies and the factors influencing their immunogenicity…
RT @michaelzlin: Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presen…
RT @michaelzlin: Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presen…
Another nitpick: most antigen is synthesized in myocytes after the intramuscular injection, not directly by antigen-presenting cells https://t.co/JfQuk8nKSq https://t.co/qaXEUj8Jkm
@speakshoutroar @drsanjaykrai https://t.co/NPlHfOmn8A mechanism of action of astrazenecca( covishield)
RT @mmganeshsalem: @nicefiddler https://t.co/hONoWOqEHQ adeno virus vector .( vector means transport vehicle.) It transports spike protein…
@nicefiddler https://t.co/hONoWOqEHQ adeno virus vector .( vector means transport vehicle.) It transports spike protein gene ! of RNA sars virus.
Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines https://t.co/GYSZ7xZVZq
@maddstone1 @RNAiAnalyst https://t.co/Zf6RRU5Tng
RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
RT @JSchmukler: Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
Esta es una excelente review sobre las vacunas con vector adenoviral (como AZ, Janssen y Sputnik) https://t.co/age6Emgwb5
@eljesusargento estoy todavía releyéndolo. Más tarde hago un mini hilo. https://t.co/4iuAzZwnmN
RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
This is the best explanation for how the adenovirus delivery system works and how it stimulates immune response in humans I could find. Very complete. https://t.co/qjVkypNzwF
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…
RT @DevanSinha: Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate…
Ox/AZ vax mechanism is comparatively slow release. Non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH 19/ https://t.co/oYOnlbkMVO
@cingolani_oscar por lo que veo como un obdservador ignorante de estos temas es que hace tiempo se estudia lo que en Brasil comentan y lo deben tener en cuenta cualquier fabricante de vacuna que opte por esa tecnologia para evitarlo https://t.co/ZTHU8sySsP
RT @lalbert75: @jorgeb_2021 @peterprincipio Éste artículo sobre como un vector de adenovirus no replicante puede continuar persistiendo y e…
@jorgeb_2021 @peterprincipio Éste artículo sobre como un vector de adenovirus no replicante puede continuar persistiendo y estimulando el sistema inmunológico, especialmente células T, puede interesarle. No se va a quedar a medio vacunar, el sistema inmunológico no funciona así https://t.co/milJjMKKZ9
RT @DevanSinha: @AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers…
RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…
RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…
RT @michaelzlin: Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to p…
Review of Ad-based vaccine mechanisms below. Asserts that Ad allow enduring antigen presentation, but that's compared to protein or killed virus, not RNA. Regardless once lymphocytes are activated, they will live much longer than Ad or RNA can express. https://t.co/zgBlcvlrJn
@JPabloReisch Mijo eso wue midieron ahí, no es la única forma en la que la vacuna induce inmunidad. https://t.co/CB9UQFgFxH
@edalgomezn @bacigalupe @micronauta @elaval @rafaelg_fisica @Censelio @nbody6 @PolarBearby Solo considera nivel de anticuerpos... pero... https://t.co/CB9UQFgFxH
@jorgeb_2021 Por eso es tan interesante el mecanismo de una vacuna como OX/AZ. Hay artículos científicos detallados sobre cómo incluso el vector de adenovirus no replicante puede continuar persistiendo y estimulando el sistema inmunológico. Especialmente células T. https://t.co/milJjMKKZ9
@f_jalalvand du har helt rätt Adenovirusvektorer aktiverar TLR. Agnes vet inte vad hon prator om https://t.co/OzeS9baaDK
@ibrahimimam2000 @AgneStraukiene https://t.co/zgmzgyxR4H
@ProtEngineer @chiara_rapi Agreed on some CAR usage, but also some as-yet unknown receptor(s). Uptake by muscle cells at injection site, some uptake in dLNs by APCs, including DCs. More info here: https://t.co/law69WLgub & https://t.co/sFKeOFpufJ
@AntellPhilippa NYT overview of ChAdOx1 mechanism (source of pics): https://t.co/dwMI7SBLXc More detailed science papers on how even non-replicating adenovirus vector can continue to persist and stimulate immune system: https://t.co/tjbuy9Q8Hu Especially T-cells: https://t.co/crHu4fv3XH
@LouDeFrogg @Cs_Madrid Efectivamente, y para ser correctos, no es el adenovirus el que entra en el núcleo, sino su ADN. A diferencia de otros, como los retrovirus, no se integran en el ADN genómico celular. Si está interesada en conocer su mecanismo de acción: https://t.co/e5kYMGuzS6
RT @Virusnerdette: @__philipn__ In summary, it's complicated. There is a hierarchy of immunogenicity. Multiple factors likely contribute to…
@__philipn__ In summary, it's complicated. There is a hierarchy of immunogenicity. Multiple factors likely contribute to differences https://t.co/mpMTLaVpIf
@surnell @Prasannasimha @Swamy39 This is a good review on adenoviral vectors if you are interested to understand why testing in an indian context is important https://t.co/eDO7mF0EZ5
@DrEricDing Data uncertainty regarding Oxford's coronavirus vaccine, MORE
Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines https://t.co/9pKid7aYlV
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
RT @IdiUcv: Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8…
Factores que contribuyen a la inmunogenicidad de las vacunas con vectores adenovirales no replicantes. https://t.co/EOGBsIeei8 https://t.co/XNt0ms2zmZ
Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines https://t.co/TAkE8lrz2c
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
RT @FrontImmunol: New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral…
New Research: Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines: Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-replicating Ad vectors possess several… https://t.co/dcVfStvjl1 #immunology