Hypertension July 2020 PMID 32520619

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.

Vienna E Brunt, Rachel A Gioscia-Ryan, Abigail G Casso, Nicholas S VanDongen, Brian P Ziemba, Zachary J Sapinsley, James J Richey, Melanie C Zigler, Andrew P Neilson, Kevin P Davy, Douglas R Seals

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Mentions

48
Peak: 15 in Jul 2020
across 6 sources since Jun 2020

Extended reach

331,848
potential audience

Total likes

2,288

Video views

177,531

Mentions per month

Jun 2020 – Sep 2020

Where it's discussed

  • X / Twitter21 posts
  • News14 articles
  • Blogs6 articles
  • Reddit3 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Overall, the group shows a balanced perspective, with many acknowledging the research's potential implications, such as links between gut bacteria and vascular health, supported by phrases like 'damage our arteries' and 'promotes age-related stress.' While some discussions reflect skepticism with statements like 'the jury is still out,' the tone remains engaged and curious, demonstrating recognition of the importance of the findings without complete certainty.

AgreementModerate agreement

Most discussions acknowledge the findings and seem to support the idea that TMAO is linked to vascular aging, though some remain cautious, emphasizing the need for more evidence.

InterestModerate interest

The discussions show a moderate level of curiosity, with mentions of related research and potential health implications, indicating genuine interest.

EngagementModerate engagement

Participants reference specific studies, comment on the mechanisms, and share personal or related experiences, reflecting a moderate level of engagement.

ImpactNeutral impact

The discussions recognize the significance of the research, but many also highlight ongoing debates and future research needs, indicating a neutral impact level.

Abstract in brief

  • The study finds that trimethylamineN-oxide (TMAO), a metabolite generated by gut bacteria, increases with age in both humans and mice, and higher levels are linked to impaired blood vessel function and increased oxidative stress.
  • In mice, supplementing with TMAO causes aging-like damage to blood vessels, reducing their ability to dilate properly, increasing oxidative stress markers, and impairing nitric oxide signaling; these effects can be reversed with antioxidants.
  • In humans, middle-aged and older adults with higher TMAO levels show greater signs of oxidative stress in their endothelial cells, but antioxidant treatments can improve blood vessel function, suggesting TMAO plays a role in age-related vascular decline.

Top posts

Most liked on X and Bluesky
Vienna Brunt
@viennabrunt · X

Results of my F32 fellowship were published online in @HyperAHA yesterday | Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans https://t.co/I93UdzIC5u @kdinbburg @Abigail_Casso

Jun 11, 2020 · 25 likes · 4 shares · 310 followers View post →
humanOS.me
@humanOS_me · X

TMAO promotes age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans. https://t.co/SUF559BGRr https://t.co/3FEFWjRLHq

Jul 16, 2020 · 4 likes · 9,654 followers View post →
Mike Eisenhart
@mikeeisenhart · X

Yep. Something like that. https://t.co/ULtUAalYBU https://t.co/scZ423hvKZ

Jul 14, 2020 · 3 likes · 3,446 followers View post →
Simon Hill MSc, BSc
@theproof · X

⁦@AviBittMD⁩ some more TMAO data for you https://t.co/A0JQyohB8j

Jul 2, 2020 · 2 likes · 34,258 followers View post →
Microbiome Articles
@microbe_article · X

Trimethylamine-n-oxide promotes age-related vascular oxidative stress and endothelial dysfunction in mice and health... - Brunt VE et al. - https://t.co/LGNCKxOTnz #microbiome

Jun 11, 2020 · 1 like · 7,156 followers View post →
FMO3 Metabolic Malodor (mostly sulfides + TMAU ?)
@systemicBO · X

TMAO - CVD Uni of Boulder Colorado study Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans https://t.co/eKJCMTGgmW https://t.co/iPSY4aGGyA https://t.co/HOzJfP1p6B seems to agree with Hazen lab theory

Jul 4, 2020 · 1 like · 1 share · 126 followers View post →

All mentions

Agingdoc
@agingdoc1 · X

On the other hand, the jury is still out. Opposing evidence presented here: https://t.co/M0YmghzXHz We need to careful to to overweigh any one publication and always err on the side of caution ( for example, also in lipidology debates).

Sep 20, 2020 · 41,947 followers View post →
Agingdoc
@agingdoc1 · X

@bioMioSoftware @nick_krontiris @PrimaryCarePAC @MatthewJDalby Just remember, much of this is theory, and the jury is still out. The ultimate verdict may go either way. For example, just published: https://t.co/M0YmghzXHz

Sep 20, 2020 · 41,947 followers View post →
humanOS.me
@humanOS_me · X

TMAO promotes age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans. https://t.co/SUF559BGRr https://t.co/3FEFWjRLHq

Jul 16, 2020 · 4 likes · 9,654 followers View post →
Mike Eisenhart
@mikeeisenhart · X

Yep. Something like that. https://t.co/ULtUAalYBU https://t.co/scZ423hvKZ

Jul 14, 2020 · 3 likes · 3,446 followers View post →
Copyright © 2025 Claudia Ghimel "Владимир Путин"
@VPutin_biz · X

Já ho snad už ani nemam, nízký tlak :-)) https://t.co/ykYMgxzGFP prostřednictvím @YouTube

Jul 7, 2020 · 1,256 followers View post →
Evan Allen
@EAllen0417 · X

@ScepticalDoctor Yes. And in cell culture. https://t.co/82yb7Uscs3 https://t.co/20sh2eWGhM

Jul 6, 2020 · 2,800 followers View post →
Scible
@TheScible · X

A compound produced in the #gut when we eat #redmeat damages our arteries and may play a key role in boosting the risk of #heartdisease as we get older, according to new research. Reference: https://t.co/EAi1fcJ9jM https://t.co/l1mkfZhQCk

Jul 6, 2020 · 80 followers View post →
yuhao100
@chenyuhao0001 · X

Hypertension:肠道微生物产生的化合物会损伤动脉,进而增加患心脏病的风险。 https://t.co/hm8zCkXmR8

Jul 5, 2020 · 9 followers View post →
FMO3 Metabolic Malodor (mostly sulfides + TMAU ?)
@systemicBO · X

TMAO - CVD Uni of Boulder Colorado study Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans https://t.co/eKJCMTGgmW https://t.co/iPSY4aGGyA https://t.co/HOzJfP1p6B seems to agree with Hazen lab theory

Jul 4, 2020 · 1 like · 1 share · 126 followers View post →
Simon Hill MSc, BSc
@theproof · X

⁦@AviBittMD⁩ some more TMAO data for you https://t.co/A0JQyohB8j

Jul 2, 2020 · 2 likes · 34,258 followers View post →
Alejandro Frank
@AlejandroFrank · X

RT @GMFHx: Are gut bacteria linked to the ageing of arteries? TMAO produced in the gut when we eat red meat damages our arteries and may pl…

Jul 1, 2020 · 8 shares · 2,676 followers View post →
Salesianos Argentina
@salesianoarg1 · X

RT @GMFHx: Are gut bacteria linked to the ageing of arteries? TMAO produced in the gut when we eat red meat damages our arteries and may pl…

Jul 1, 2020 · 8 shares · 606 followers View post →
María Celeste
@MCelestelj · X

RT @GMFHx: Are gut bacteria linked to the ageing of arteries? TMAO produced in the gut when we eat red meat damages our arteries and may pl…

Jul 1, 2020 · 8 shares · 67 followers View post →
ImmunoLatinXs "Científicos Comunicando Ciencia"
@ImmunoLatinXs · X

RT @GMFHx: Are gut bacteria linked to the ageing of arteries? TMAO produced in the gut when we eat red meat damages our arteries and may pl…

Jul 1, 2020 · 8 shares · 1,561 followers View post →
Sinan Yuruker
@sinanyuruker · X

TMAO is related to ageing of blood vessels https://t.co/cvV2PUhNuH

Jul 1, 2020 · 18 followers View post →
Chris Pugh
@CJAPugh · X

RT @viennabrunt: Results of my F32 fellowship were published online in @HyperAHA yesterday | Trimethylamine-N-Oxide Promotes Age-Related Va…

Jun 11, 2020 · 4 shares · 1,020 followers View post →
CUBoulderIPHY
@CUBoulderIPHY · X

RT @viennabrunt: Results of my F32 fellowship were published online in @HyperAHA yesterday | Trimethylamine-N-Oxide Promotes Age-Related Va…

Jun 11, 2020 · 4 shares · 379 followers View post →
Tadej Debevec
@DebevecTadej · X

RT @viennabrunt: Results of my F32 fellowship were published online in @HyperAHA yesterday | Trimethylamine-N-Oxide Promotes Age-Related Va…

Jun 11, 2020 · 4 shares · 3,794 followers View post →
Vienna Brunt
@viennabrunt · X

Results of my F32 fellowship were published online in @HyperAHA yesterday | Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans https://t.co/I93UdzIC5u @kdinbburg @Abigail_Casso

Jun 11, 2020 · 25 likes · 4 shares · 310 followers View post →
Symbiosis papers
@Symbiosispapers · X

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans. https://t.co/b5pvD911hG

Jun 11, 2020 · 1,109 followers View post →
Microbiome Articles
@microbe_article · X

Trimethylamine-n-oxide promotes age-related vascular oxidative stress and endothelial dysfunction in mice and health... - Brunt VE et al. - https://t.co/LGNCKxOTnz #microbiome

Jun 11, 2020 · 1 like · 7,156 followers View post →