Dev Med Child Neurol September 2020 PMID 32542675

Definition and diagnosis of cerebral palsy in genetic studies: a systematic review.

Ryan Pham, Ben W Mol, Jozef Gecz, Alastair H MacLennan, Suzanna C MacLennan, Mark A Corbett, Clare L van Eyk, Dani L Webber, Lyle J Palmer, Jesia G Berry

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Mentions

19
Peak: 8 in Aug 2020
across 3 sources since Aug 2020

Extended reach

20,019
potential audience

Total likes

28

Video views

1,599

Mentions per month

Aug 2020 – Apr 2025

Where it's discussed

  • X / Twitter14 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone underscores a consensus on the necessity of detailed diagnostic criteria and standardized reporting, as seen in statements like 'simply noting a diagnosis of CP is not enough' and calls for uniform definitions, implying the review's findings could considerably influence future research and clinical practice.

AgreementModerate agreement

Most discussions emphasize the importance of standardizing the definition and diagnosis of cerebral palsy, indicating moderate to strong agreement with the review's findings.

InterestHigh interest

The posts show high interest, focusing on improving research standards and treatment implications, with multiple references to the need for precise definitions.

EngagementModerate engagement

Participants engage actively by referencing specific aspects like case documentation, diagnostic criteria, and potential therapies, demonstrating meaningful involvement.

ImpactModerate impact

The discussions suggest that the review could influence research practices and clinical approaches, emphasizing the significance of standardized definitions for advancing knowledge and treatment.

Abstract in brief

  • This systematic review examined 57 genetic studies of cerebral palsy (CP) published between 1990 and 2019 to assess how well they defined CP and reported case details, with only 32% following international guidelines.
  • Many studies lacked complete or clear descriptions of how they diagnosed and classified CP, making it difficult to compare findings or ensure accurate diagnosis across research.
  • The review highlights the need for better adherence to standardized guidelines, like those from SCPE, to improve the quality, consistency, and usefulness of genetic research in CP, ultimately aiding gene discovery efforts.]

Top posts

Most liked on X and Bluesky
Bhooma Aravamuthan MD DPhil
@drbhooma · X

Could not agree more. We need to uniformly apply #cerebralpalsy consensus definitions to do any meaningful research...or provide appropriate patient care. https://t.co/qyy0CDlIOp

Aug 3, 2020 · 6 likes · 1 share · 1,627 followers View post →
Mac Keith Press
@mackeithpress · X

How should #cerebralpalsy be defined to conduct useful #genetic research? @bwmol @GeczSquadGoals @neurogeneration @PalmerLyle https://t.co/M92MjjL41i

Aug 10, 2020 · 5 likes · 3 shares · 2,062 followers View post →
Bernard Dan
@ProfBernardDan · X

The authors of this #systematicreview of #genetic studies of #cerebralpalsy urge researchers to report in detail the case definition and ascertainment method to aid standardization of diagnostic criteria, minimize study heterogeneity and enable comparisons https://t.co/Grm4fraz3Z https://t.co/WUM1yZMzqv

Nov 26, 2020 · 4 likes · 2 shares · 1,704 followers View post →
Bernard Dan
@ProfBernardDan · X

@Marilynpaedsahp @EACDtweet https://t.co/Grm4fraz3Z https://t.co/zTzsJEHQIO https://t.co/2onxEbp7Qb "When molecular/cellular mechanisms that lead to CP are understood, this knowledge can be used to develop effective new therapies seeking to control symptoms and treat the fundamental pathophysiology of CP"

Nov 27, 2020 · 1 like · 1,704 followers View post →
Mac Keith Press
@mackeithpress · X

#DMCN podcast Definition and diagnosis of #cerebralpalsy in #genetic studies: a #SystematicReview https://t.co/k4ynZSjY0a

Aug 20, 2020 · 2 shares · 2,062 followers View post →
Mac Keith Press
@mackeithpress · X

RT @ProfBernardDan: The authors of this #systematicreview of #genetic studies of #cerebralpalsy urge researchers to report in detail the ca…

Nov 27, 2020 · 2 shares · 2,062 followers View post →

All mentions

Ann-Marie Halligan
@amkhalligan · X

RT @ProfBernardDan: The authors of this #systematicreview of #genetic studies of #cerebralpalsy urge researchers to report in detail the ca…

Nov 28, 2020 · 2 shares · 314 followers View post →
Bernard Dan
@ProfBernardDan · X

@Marilynpaedsahp @EACDtweet https://t.co/Grm4fraz3Z https://t.co/zTzsJEHQIO https://t.co/2onxEbp7Qb "When molecular/cellular mechanisms that lead to CP are understood, this knowledge can be used to develop effective new therapies seeking to control symptoms and treat the fundamental pathophysiology of CP"

Nov 27, 2020 · 1 like · 1,704 followers View post →
Mac Keith Press
@mackeithpress · X

RT @ProfBernardDan: The authors of this #systematicreview of #genetic studies of #cerebralpalsy urge researchers to report in detail the ca…

Nov 27, 2020 · 2 shares · 2,062 followers View post →
Bernard Dan
@ProfBernardDan · X

The authors of this #systematicreview of #genetic studies of #cerebralpalsy urge researchers to report in detail the case definition and ascertainment method to aid standardization of diagnostic criteria, minimize study heterogeneity and enable comparisons https://t.co/Grm4fraz3Z https://t.co/WUM1yZMzqv

Nov 26, 2020 · 4 likes · 2 shares · 1,704 followers View post →
dystobot (broken)
@dystobot_broken · X

RT @drbhooma: What should be the standard for defining CP in research articles looking at etiologies? Great paper on this : https://t.co/qy…

Sep 25, 2020 · 1 share · 682 followers View post →
Bhooma Aravamuthan MD DPhil
@drbhooma · X

What should be the standard for defining CP in research articles looking at etiologies? Great paper on this : https://t.co/qyy0CD47WR In short, simply noting a dx of CP is not enough - should have clear documentation of non-progressive motor disability + spasticty/#dystonia/etc.

Sep 25, 2020 · 1 share · 1,627 followers View post →
Mac Keith Press
@mackeithpress · X

RT @mackeithpress: #DMCN podcast Definition and diagnosis of #cerebralpalsy in #genetic studies: a #SystematicReview https://t.co/k4ynZS…

Sep 11, 2020 · 2 shares · 2,062 followers View post →
Mac Keith Press
@mackeithpress · X

#DMCN podcast Definition and diagnosis of #cerebralpalsy in #genetic studies: a #SystematicReview https://t.co/k4ynZSjY0a

Aug 20, 2020 · 2 shares · 2,062 followers View post →
Ann-Marie Halligan
@amkhalligan · X

RT @mackeithpress: How should #cerebralpalsy be defined to conduct useful #genetic research? @bwmol @GeczSquadGoals @neurogeneration @Pal…

Aug 13, 2020 · 3 shares · 314 followers View post →
SCPE
@SCPEtweets · X

RT @mackeithpress: How should #cerebralpalsy be defined to conduct useful #genetic research? @bwmol @GeczSquadGoals @neurogeneration @Pal…

Aug 11, 2020 · 3 shares · 404 followers View post →
Kero
@Kero14971951 · X

RT @mackeithpress: How should #cerebralpalsy be defined to conduct useful #genetic research? @bwmol @GeczSquadGoals @neurogeneration @Pal…

Aug 10, 2020 · 3 shares · 96 followers View post →
Mac Keith Press
@mackeithpress · X

How should #cerebralpalsy be defined to conduct useful #genetic research? @bwmol @GeczSquadGoals @neurogeneration @PalmerLyle https://t.co/M92MjjL41i

Aug 10, 2020 · 5 likes · 3 shares · 2,062 followers View post →
C. Roy Lin, MD, MPH, FAAN
@RoyCLinMD · X

RT @drbhooma: Could not agree more. We need to uniformly apply #cerebralpalsy consensus definitions to do any meaningful research...or prov…

Aug 3, 2020 · 1 share · 1,618 followers View post →
Bhooma Aravamuthan MD DPhil
@drbhooma · X

Could not agree more. We need to uniformly apply #cerebralpalsy consensus definitions to do any meaningful research...or provide appropriate patient care. https://t.co/qyy0CDlIOp

Aug 3, 2020 · 6 likes · 1 share · 1,627 followers View post →
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