Res Pract Thromb Haemost May 2020 PMID 32548560

Inhibition of thrombin generation 12 hours after intake of direct oral anticoagulants.

Michael Metze, Christian Pfrepper, Tristan Klöter, Stephan Stöbe, Roland Siegemund, Thomas Siegemund, Elvira Edel, Ulrich Laufs, Sirak Petros

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Mentions

6
Peak: 3 in Apr 2020
across 2 sources since Apr 2020

Extended reach

13,759
potential audience

Total likes

16

Video views

1,415

Mentions per month

Apr 2020 – Feb 2023

Where it's discussed

  • X / Twitter4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The comments highlight key findings, such as the sustained inhibition of thrombin generation 12 hours after medication intake, especially noting differences in effects among rivaroxaban, edoxaban, and apixaban. Words like 'shows' and phrases referencing specific drugs underscore a factual tone, while interest in the clinical impact indicates moderate engagement with the study's implications.

AgreementModerate agreement

Most posts acknowledge the importance of the study, with some explicitly supporting its findings about the prolonged effect of DOACs.

InterestHigh interest

Discussions show high curiosity about the research, especially regarding differences among various anticoagulants.

EngagementModerate engagement

Posts briefly mention the study results but don't deeply analyze implications, indicating moderate engagement.

ImpactModerate impact

The focus on clinical effects suggests some recognition of the study's relevance, but the influence on practice isn't explicitly discussed.

Abstract in brief

  • The study investigates the residual effects of direct oral anticoagulants (DOACs) on thrombin generation 12 hours post-intake, which is crucial during emergencies like bleeding or surgery.
  • Four types of DOACs (apixaban, edoxaban, rivaroxaban, and dabigatran) were tested on 80 patients, comparing their blood samples before and after medication, and against a control group of blood donors.
  • Results showed that all DOACs significantly decreased thrombin generation parameters and prolonged lag time compared to baseline and the healthy control, indicating ongoing antithrombotic activity that may impact clinical decisions in urgent situations.

Top posts

Most liked on X and Bluesky
RPTH
@RPTHjournal · X

New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs compared to baseline. The effect is more pronounced in #rivaroxaban and #edoxaban compared to #apixaban. https://t.co/d7q6Jjc8eo https://t.co/5qbOSYKFvf

Apr 27, 2020 · 6 likes · 3 shares · 10,890 followers View post →
Snehal Bhatt
@SnayCardsPharmD · X

RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…

Apr 27, 2020 · 3 shares · 892 followers View post →
Dr. M. Bernardo
@mbernardo321 · X

RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…

Apr 27, 2020 · 3 shares · 349 followers View post →
OlgaDunaeva
@DunyaOlga · X

RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…

May 27, 2020 · 3 shares · 190 followers View post →

All mentions

OlgaDunaeva
@DunyaOlga · X

RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…

May 27, 2020 · 3 shares · 190 followers View post →
Snehal Bhatt
@SnayCardsPharmD · X

RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…

Apr 27, 2020 · 3 shares · 892 followers View post →
Dr. M. Bernardo
@mbernardo321 · X

RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…

Apr 27, 2020 · 3 shares · 349 followers View post →
RPTH
@RPTHjournal · X

New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs compared to baseline. The effect is more pronounced in #rivaroxaban and #edoxaban compared to #apixaban. https://t.co/d7q6Jjc8eo https://t.co/5qbOSYKFvf

Apr 27, 2020 · 6 likes · 3 shares · 10,890 followers View post →