New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs compared to baseline. The effect is more pronounced in #rivaroxaban and #edoxaban compared to #apixaban. https://t.co/d7q6Jjc8eo https://t.co/5qbOSYKFvf
Inhibition of thrombin generation 12 hours after intake of direct oral anticoagulants.
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Apr 2020 – Feb 2023Where it's discussed
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X / Twitter4 posts
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YouTube2 videos
AI synopsis
What people are saying
The comments highlight key findings, such as the sustained inhibition of thrombin generation 12 hours after medication intake, especially noting differences in effects among rivaroxaban, edoxaban, and apixaban. Words like 'shows' and phrases referencing specific drugs underscore a factual tone, while interest in the clinical impact indicates moderate engagement with the study's implications.
Most posts acknowledge the importance of the study, with some explicitly supporting its findings about the prolonged effect of DOACs.
Discussions show high curiosity about the research, especially regarding differences among various anticoagulants.
Posts briefly mention the study results but don't deeply analyze implications, indicating moderate engagement.
The focus on clinical effects suggests some recognition of the study's relevance, but the influence on practice isn't explicitly discussed.
Abstract in brief
- The study investigates the residual effects of direct oral anticoagulants (DOACs) on thrombin generation 12 hours post-intake, which is crucial during emergencies like bleeding or surgery.
- Four types of DOACs (apixaban, edoxaban, rivaroxaban, and dabigatran) were tested on 80 patients, comparing their blood samples before and after medication, and against a control group of blood donors.
- Results showed that all DOACs significantly decreased thrombin generation parameters and prolonged lag time compared to baseline and the healthy control, indicating ongoing antithrombotic activity that may impact clinical decisions in urgent situations.
Top posts
Most liked on X and BlueskyRT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…
RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…
RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…
All mentions
Understanding Thrombin Generation and Its Clinical Significance
This episode explains thrombin generation, its measurement, and standardization efforts. Presented by Audrey Carlo, Ccile Hourquet, and special guest Marisa Ninivaggi from Synapse Research Institute, focusing on the…
Understanding Thrombin Generation in Hemostasis and Coagulation Analysis
Presented by Audrey Carlo and Ccile Hourquet, this episode features Xavier Teuma discussing what thrombin generation is. Thrombin generation assays are essential for evaluating the hemostatic system and their…
RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…
RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…
RT @RPTHjournal: New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs…
New #RPTH article from @michaelmetze shows thrombin generation is significantly inhibited 12 hours after intake of #DOACs compared to baseline. The effect is more pronounced in #rivaroxaban and #edoxaban compared to #apixaban. https://t.co/d7q6Jjc8eo https://t.co/5qbOSYKFvf