PubHawk
July 2020 PMID 32579880

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.

Liuliu Yang, Yuling Han, Benjamin E Nilsson-Payant, Vikas Gupta, Pengfei Wang, Xiaohua Duan, Xuming Tang, Jiajun Zhu, Zeping Zhao, Fabrice Jaffré, Tuo Zhang, Tae Wan Kim, Oliver Harschnitz, David Redmond, Sean Houghton

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Mentions

87
Peak: 38 in Jun 2020
across 5 sources since Jun 2020

Extended reach

391,865
potential audience

Total likes

130

Video views

705

Mentions per month

Jun 2020 – Jun 2022

Where it's discussed

  • X / Twitter50 posts
  • News22 articles
  • Blogs9 articles
  • Facebook4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone emphasizes the innovative use of human pluripotent stem cells to study virus behavior across tissues, with posts referencing technical details and related research, which demonstrates both high interest and active engagement. Words like 'model', 'platform', and mentions of 'significant findings' convey the perceived importance of the study for understanding and potentially treating COVID-19.

AgreementModerate agreement

Most discussions support the importance and potential of the platform described in the publication, indicating general alignment on its relevance.

InterestHigh interest

Posts show high interest, mentioning specific aspects like tissue tropism and the use of organoids to model SARS-CoV-2 infection.

EngagementModerate engagement

Participants reference methods, cite related studies, and express eagerness to understand the research, reflecting active engagement.

ImpactModerate impact

Several social discussions highlight the significance of this research in advancing COVID-19 understanding, suggesting moderate impact.

Abstract in brief

  • The study introduces a platform using human pluripotent stem cells (hPSCs) and organoids to investigate SARS-CoV-2 infection across various human tissues, including the pancreas, liver, heart, and brain.
  • Researchers found that pancreatic beta cells and liver organoids are highly susceptible to the virus, which mirrors clinical observations linking COVID-19 to diabetes and liver issues.
  • The platform helps understand how SARS-CoV-2 triggers immune responses, such as chemokine production, in different tissues, providing valuable insights for studying COVID-19 disease mechanisms and potential treatments.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Cell Stem Cell
@CellStemCell · X

New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/W32YlF1WQt

Jun 19, 2020 · 78 likes · 26 shares · 58,561 followers View post →
Benjamin Nilsson-Payant
@BenjaminNilsson · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/g7c9svLz7m

Jun 19, 2020 · 11 likes · 1 share · 879 followers View post →
Chinese American Diabetes Association
@CADA_diabetes · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/HytBpSmQrB Fighting with COVID-19 by CADA member Dr. Shuibing Chen @WeillCornell

Jun 20, 2020 · 8 likes · 4 shares · 364 followers View post →
Billy Bostickson
@BillyBostickson · X

@Daoyu15 But citation *1* does not say that: https://t.co/ccMOocuPLM

May 2, 2021 · 4 likes · 18,449 followers View post →
مركز الأبحاث
@KFSHRC_Research · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/2pxNmC4gHD https://t.co/TOS9zcDUPT

Jun 30, 2020 · 3 likes · 2 shares · 71,801 followers View post →
Erin C. Sanders, MSN, WHNP (She/Her)
@ErinSandersNP · X

@WesElyMD @PulmCrit @nickmmark @HUMANIZALAUCI @SCCM @gsmartinmd @Paul_Wischmeyer @laxswamy @EM_RESUS @efan75 @OtisBRickman Unfortunately, @WesElyMD I have not seen a a lot of data on pancreas re path. There was one study from China in May that was only in Chinese, and then this lab cell study in June: https://t.co/w6ft1yFDvh

Dec 6, 2020 · 1 like · 18,597 followers View post →

All mentions

Jeff Keelan
@jeff_keelan · X

@Neisha_36 https://t.co/ffZuLYsCAL An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells https://t.co/XBAZBeirMQ A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Jun 14, 2022 · 1,966 followers View post →
JuanPe
@PerezPpaa · X

@P1m2P3 @ulises37 Las pruebas de laboratorio de cultivos de supuesto Sars cov 2. ¿Como comprueban el avance de infección? Con PCR. Con el mismo margen de error que el que no distingue de gripe. ¿Y como seleccionan las células infectadas? Con PCR. https://t.co/rs4y03lkt7

Jul 26, 2021 · 72 followers View post →
Eduard Centeno
@segol60 · X

RT @AngelAzpeitia: A Human Pluripotent Stem Cell-based Platform to Study #SARSCoV2 Tropism and Model Virus Infection in Human Cells and Org…

Jun 9, 2021 · 2 shares · 408 followers View post →
ScienceStop
@B0tSci · X

RT @AngelAzpeitia: A Human Pluripotent Stem Cell-based Platform to Study #SARSCoV2 Tropism and Model Virus Infection in Human Cells and Org…

Jun 9, 2021 · 2 shares · 4,072 followers View post →
Angel Azpeitia
@AngelAzpeitia · X

A Human Pluripotent Stem Cell-based Platform to Study #SARSCoV2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/U17HB290Hl

Jun 9, 2021 · 1 like · 2 shares · 1,474 followers View post →
Billy Bostickson
@BillyBostickson · X

@Daoyu15 But citation *1* does not say that: https://t.co/ccMOocuPLM

May 2, 2021 · 4 likes · 18,449 followers View post →
Rio Sugimura
@rio_sugimura · X

Today's read 8 A #Human #Pluripotent Stem Cell-based Platform to Study #SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and #Organoids @CellStemCell https://t.co/f9azuZDhwu

Jan 12, 2021 · 3,164 followers View post →
Erin C. Sanders, MSN, WHNP (She/Her)
@ErinSandersNP · X

@WesElyMD @PulmCrit @nickmmark @HUMANIZALAUCI @SCCM @gsmartinmd @Paul_Wischmeyer @laxswamy @EM_RESUS @efan75 @OtisBRickman Unfortunately, @WesElyMD I have not seen a a lot of data on pancreas re path. There was one study from China in May that was only in Chinese, and then this lab cell study in June: https://t.co/w6ft1yFDvh

Dec 6, 2020 · 1 like · 18,597 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/wfGFLc0Y02 #Endocrinology #Endo

Oct 21, 2020 · 1 like · 5,041 followers View post →
akarilmiah
@akarilmiah · X

sumber: 2. Yang, L. et al. (2020) ‘A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids’, Cell Stem Cell, 27(1), pp. 125-136.e7. doi: 10.1016/j.stem.2020.06.015. cari ilmu sampai ke akarnya!

Sep 18, 2020 · 1 like · 7 followers View post →
Krishan Maggon
@kkmaggon · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids - ScienceDirect https://t.co/7nTdIScLWW https://t.co/EgUg6aAsbk

Aug 2, 2020 · 1,001 followers View post →
NeuroStemCells
@NeuroStemCell · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. https://t.co/eMFLFB6NwD

Jul 15, 2020 · 1 like · 536 followers View post →
Cell Stem Cell
@CellStemCell · X

@ChenShuibing & Co show that hPSCs can model #COVID19 & #SARSCoV2 tissue tropism in their recent paper- "A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids" https://t.co/QPfTuiH3Xy

Jul 2, 2020 · 58,561 followers View post →
HBA_100
@HBA_100 · X

RT @KFSHRC_Research: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and…

Jun 30, 2020 · 2 shares · 38,973 followers View post →
ملتقى علوم الاحياء
@Biology1802 · X

RT @KFSHRC_Research: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and…

Jun 30, 2020 · 2 shares · 54,585 followers View post →
مركز الأبحاث
@KFSHRC_Research · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/2pxNmC4gHD https://t.co/TOS9zcDUPT

Jun 30, 2020 · 3 likes · 2 shares · 71,801 followers View post →
Dr xiaosun
@diligencesun · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/NXLOd8VNth I got it

Jun 29, 2020 · 5 followers View post →
john morley
@drjohnmorley · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropi... https://t.co/fSQ5clkZCZ

Jun 27, 2020 · 8,310 followers View post →
the paper link
@the_paper_link · X

RT @the_paper_link: Trend up+34: *Yang L* et al (Cell Stem Cell) __A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism…

Jun 26, 2020 · 1 share · 137 followers View post →
the paper link
@the_paper_link · X

Trend up+34: *Yang L* et al (Cell Stem Cell) __A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids__ https://t.co/I105iGiDbX

Jun 26, 2020 · 1 share · 137 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. https://t.co/v30mSnvQlN #pancreaticcancer #oncology https://t.co/uEb9HP1AvV

Jun 25, 2020 · 891 followers View post →
Wenke Feng
@wenke_feng · X

RT @CADA_diabetes: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Or…

Jun 21, 2020 · 4 shares · 80 followers View post →
The Immunocompatibility Group
@Liptrott_Group · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 21, 2020 · 26 shares · 399 followers View post →
Xianming Wang
@wxm24554364 · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 21, 2020 · 26 shares · 226 followers View post →
Panglab@Rutgers
@zppang · X

RT @CADA_diabetes: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Or…

Jun 21, 2020 · 4 shares · 589 followers View post →
Dr. Yong Xu
@DrYongXu1 · X

RT @CADA_diabetes: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Or…

Jun 21, 2020 · 4 shares · 816 followers View post →
Longlong (Lucas) Tu
@longlong_tu · X

RT @CADA_diabetes: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Or…

Jun 21, 2020 · 4 shares · 101 followers View post →
Chinese American Diabetes Association
@CADA_diabetes · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/HytBpSmQrB Fighting with COVID-19 by CADA member Dr. Shuibing Chen @WeillCornell

Jun 20, 2020 · 8 likes · 4 shares · 364 followers View post →
Mikio Shiba, MD, PhD, FACC
@general_mikio · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 53 followers View post →
Fidalgostemlab
@fidalgostemlab · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 225 followers View post →
Histology
@histocasino · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 3,331 followers View post →
AnMoL S
@AnMoLS42776977 · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 218 followers View post →
Jade
@JingZha51775470 · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 4 followers View post →
RIYAZ
@RIYAZ53105015 · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 19 followers View post →
eastvillagetwt
@eastvillagetwt · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 2,453 followers View post →
Merry Lab
@MerryLabNotts · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 1,743 followers View post →
Dr. Aviseka
@aviseka · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 2,458 followers View post →
Dylan Liabeuf
@LiabeufDylan · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 612 followers View post →
Faraahh
@Farahahmed7 · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 73 followers View post →
David Van Valen
@davidvanvalen · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 3,146 followers View post →
Ryuichiro Nakato (中戸 隆一郎)
@RyuichiroNakato · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 901 followers View post →
Olivier Elemento
@ElementoLab · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 6,248 followers View post →
Zaniar Ghazizadeh
@xaniarg · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 750 followers View post →
Sudha Warrier
@SudhaRW · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 28 followers View post →
Karim
@khmadcha · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 52 followers View post →
Norio Nakatsuji
@norionakatsuji · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 15,690 followers View post →
Daniel Rawle
@daniel_rawle · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 20, 2020 · 26 shares · 324 followers View post →
Xiaokun Shu
@ShuLab2010 · X

RT @CellStemCell: New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and M…

Jun 19, 2020 · 26 shares · 1,365 followers View post →
Benjamin Nilsson-Payant
@BenjaminNilsson · X

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/g7c9svLz7m

Jun 19, 2020 · 11 likes · 1 share · 879 followers View post →
Cell Stem Cell
@CellStemCell · X

New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids https://t.co/W32YlF1WQt

Jun 19, 2020 · 78 likes · 26 shares · 58,561 followers View post →