Nat Nanotechnol August 2020 PMID 32601450

Role of nanoscale antigen organization on B-cell activation probed using DNA origami.

Rémi Veneziano, Tyson J Moyer, Matthew B Stone, Eike-Christian Wamhoff, Benjamin J Read, Sayak Mukherjee, Tyson R Shepherd, Jayajit Das, William R Schief, Darrell J Irvine, Mark Bathe

Mentions

56
Peak: 8 in Jul 2020
across 4 sources since Feb 2020

Extended reach

276,368
potential audience

Total likes

52

Video views

3,567

Mentions per month

Feb 2020 – Sep 2024

Where it's discussed

  • X / Twitter27 posts
  • News20 articles
  • YouTube5 videos
  • Blogs4 articles

AI synopsis

What people are saying

The discussions express strong interest by emphasizing the potential for improved vaccine efficacy through nanoscale antigen arrangement, with phrases like 'Vaccine efficacy can be increased' and 'optimal B-cell signaling.' The tone varies from informative to enthusiastic, especially with posts referencing the study's influence on vaccine design and nanotechnology, illustrating both high engagement and acknowledgment of the scientific impact.

AgreementModerate agreement

Most discussions acknowledge the importance and relevance of the research, with some explicitly supporting the study's focus on nanoscale antigen organization and B-cell activation.

InterestHigh interest

The discussions display high interest, frequently highlighting the significance of the findings for vaccine development and nanotechnology, with phrases like 'vaccine efficacy can be increased' and 'new illustration.'

EngagementHigh engagement

Many posts delve into specifics about the methods, such as DNA origami and nanoscale parameters, indicating deep engagement with the scientific content.

ImpactModerate impact

Comments reflect an understanding that this research could influence future vaccine strategies and nanomedicine, implying a notable impact, although some posts are mainly informational rather than advocacy or application-focused.

Abstract in brief

  • Vaccine efficacy can be improved by arranging multiple immunogens on virus-like nanoparticles, but the details of how factors like antigen copy number and spacing influence B-cell activation are not fully understood.
  • A study investigated the impact of these nanoscale parameters using the HIV-1 glycoprotein-120 on DNA origami nanoparticles, focusing on B-cell activation in a lab setting.
  • The findings showed that optimal B-cell signaling occurs with five well-spaced antigens on a 40-nm nanoparticle, and that both increased spacing (up to 25-30 nm) and scaffold rigidity are crucial for effective B-cell responses.

Top posts

Most liked on X and Bluesky
Ella Marushchenko
@Ella_Maru · X

New illustration!Role of nanoscale antigen organization on B-cell activation probed using DNA origami Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like nanoparticles to enhance B-cell activation. Read more https://t.co/Sv6fu4z6Fr #sciart https://t.co/fQSd847Qqj

Nov 10, 2020 · 36 likes · 5 shares · 46,547 followers View post →
Nature Nanotechnology
@NatureNano · X

New content online: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/1RmSrtrp2I

Jun 29, 2020 · 7 likes · 5 shares · 40,613 followers View post →
MIT.nano
@mit_nano · X

Prof. @bathe_mark from @MITdeptofBE will present "Role of Nanoscale Antigen Organization on B-Cell Activation Probed Using DNA Origami" next Monday, July 20! More details below. #nanoscience #nanoscale #nanotechnology #nanomedicine #engineering https://t.co/fpYXh7rSJO

Jul 15, 2020 · 5 likes · 4 shares · 3,841 followers View post →
bioRxiv
@biorxivpreprint · X

Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/zTZNc4vTIr #bioRxiv

Feb 18, 2020 · 1 like · 2 shares · 136,859 followers View post →
bioRxiv Immunology
@biorxiv_immuno · X

Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/T22KINnwW2 #biorxiv_immuno

Feb 18, 2020 · 1 like · 10,586 followers View post →
Joost Snijder
@joostsnijder · X

Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/otUOWpNoHZ

Jul 1, 2020 · 1 like · 1,366 followers View post →

All mentions

Cards of the Crone
@CardsCrone · X

DNA

Sep 7, 2024 · 1 like · 442 followers View post →
Wolfgang's tensor
@Tensorwg006 · X

RT @Ella_Maru: New illustration!Role of nanoscale antigen organization on B-cell activation probed using DNA origami Vaccine efficacy can b…

Dec 28, 2021 · 5 shares · 159 followers View post →
Prometheus
@PrometheusClstr · X

New article: Role of nanoscale antigen organization on B-cell activation probed using DNA origami. https://t.co/kakSkNc1a9

Dec 26, 2020 · 32 followers View post →
Angry Rabbit
@angelsvenice · X

RT @Ella_Maru: New illustration!Role of nanoscale antigen organization on B-cell activation probed using DNA origami Vaccine efficacy can b…

Nov 11, 2020 · 5 shares · 327 followers View post →
John McLaughlin
@je_mclaughlin · X

RT @Ella_Maru: New illustration!Role of nanoscale antigen organization on B-cell activation probed using DNA origami Vaccine efficacy can b…

Nov 10, 2020 · 5 shares · 3,930 followers View post →
Eva Rose Balog
@ProfBalog · X

RT @Ella_Maru: New illustration!Role of nanoscale antigen organization on B-cell activation probed using DNA origami Vaccine efficacy can b…

Nov 10, 2020 · 5 shares · 420 followers View post →
Frank Boehm
@cellrepair777 · X

RT @Ella_Maru: New illustration!Role of nanoscale antigen organization on B-cell activation probed using DNA origami Vaccine efficacy can b…

Nov 10, 2020 · 5 shares · 1,371 followers View post →
Ella Marushchenko
@Ella_Maru · X

New illustration!Role of nanoscale antigen organization on B-cell activation probed using DNA origami Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like nanoparticles to enhance B-cell activation. Read more https://t.co/Sv6fu4z6Fr #sciart https://t.co/fQSd847Qqj

Nov 10, 2020 · 36 likes · 5 shares · 46,547 followers View post →
nano-Events
@Nano_Events · X

20 Marble Center Distinguished Seminar with Dr. Mark Bathe (MIT) Role of Nanoscale Antigen Organization on B-Cell Activation Probed using DNA Origami https://t.co/IV3VAU70RP

Jul 24, 2020 · 1,865 followers View post →
MIT Device Realization Lab
@mitdevicereal · X

RT @mit_nano: Prof. @bathe_mark from @MITdeptofBE will present "Role of Nanoscale Antigen Organization on B-Cell Activation Probed Using DN…

Jul 16, 2020 · 4 shares · 99 followers View post →
MIT Dept of BE
@MITdeptofBE · X

RT @mit_nano: Prof. @bathe_mark from @MITdeptofBE will present "Role of Nanoscale Antigen Organization on B-Cell Activation Probed Using DN…

Jul 15, 2020 · 4 shares · 9,282 followers View post →
Marble Center for Cancer Nanomedicine
@KI_Nanomedicine · X

RT @mit_nano: Prof. @bathe_mark from @MITdeptofBE will present "Role of Nanoscale Antigen Organization on B-Cell Activation Probed Using DN…

Jul 15, 2020 · 4 shares · 777 followers View post →
MIT.nano
@mit_nano · X

Prof. @bathe_mark from @MITdeptofBE will present "Role of Nanoscale Antigen Organization on B-Cell Activation Probed Using DNA Origami" next Monday, July 20! More details below. #nanoscience #nanoscale #nanotechnology #nanomedicine #engineering https://t.co/fpYXh7rSJO

Jul 15, 2020 · 5 likes · 4 shares · 3,841 followers View post →
Dr.med. Bernd Kynast
@DrKynast · X

RT @NatureNano: New content online: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/1RmSr…

Jul 6, 2020 · 5 shares · 3,020 followers View post →
Renaissance Man
@2dedostesta · X

Irvine and Bathe are senior authors of the team’s published study in Nature Nanotechnology, which is titled, “Role of nanoscale antigen organization on B-cell activation probed using DNA origami.” The paper’s lead authors are former MIT postdocs Rémi Veneziano & Tyson Moyer.

Jul 4, 2020 · 219 followers View post →
Joost Snijder
@joostsnijder · X

Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/otUOWpNoHZ

Jul 1, 2020 · 1 like · 1,366 followers View post →
la lumière de ma vie
@scientistmike35 · X

RT @NatureNano: New content online: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/1RmSr…

Jun 30, 2020 · 5 shares · 1,517 followers View post →
The Chow Lab
@thechowlab · X

RT @NatureNano: New content online: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/1RmSr…

Jun 29, 2020 · 5 shares · 5,800 followers View post →
Tyson Moyer
@MoyerTyson · X

RT @NatureNano: New content online: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/1RmSr…

Jun 29, 2020 · 5 shares · 25 followers View post →
Gary Beane
@pollinus66 · X

RT @NatureNano: New content online: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/1RmSr…

Jun 29, 2020 · 5 shares · 2,026 followers View post →
MSOCNanochemistry.bsky.social
@MNanochemistry · X

Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/5Dn29EPC2f

Jun 29, 2020 · 634 followers View post →
Nature Nanotechnology
@NatureNano · X

New content online: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/1RmSrtrp2I

Jun 29, 2020 · 7 likes · 5 shares · 40,613 followers View post →
Tyson Moyer
@MoyerTyson · X

RT @biorxivpreprint: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/zTZNc4vTIr #bioRxiv

Feb 25, 2020 · 2 shares · 25 followers View post →
bxv_imm
@bxv_imm · X

Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/fTx3W25pGg

Feb 18, 2020 · 440 followers View post →
Dan Ellis
@DanLikeProteins · X

RT @biorxivpreprint: Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/zTZNc4vTIr #bioRxiv

Feb 18, 2020 · 2 shares · 417 followers View post →
bioRxiv Immunology
@biorxiv_immuno · X

Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/T22KINnwW2 #biorxiv_immuno

Feb 18, 2020 · 1 like · 10,586 followers View post →
bioRxiv
@biorxivpreprint · X

Role of nanoscale antigen organization on B-cell activation probed using DNA origami https://t.co/zTZNc4vTIr #bioRxiv

Feb 18, 2020 · 1 like · 2 shares · 136,859 followers View post →