PubHawk
July 2020 PMID 32668216

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.

Andrea J Pruijssers, Amelia S George, Alexandra Schäfer, Sarah R Leist, Lisa E Gralinksi, Kenneth H Dinnon, Boyd L Yount, Maria L Agostini, Laura J Stevens, James D Chappell, Xiaotao Lu, Tia M Hughes, Kendra Gully, David R Martinez, Ariane J Brown

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Mentions

97
Peak: 15 in Jul 2020
across 5 sources since Jul 2020

Extended reach

227,414
potential audience

Total likes

115

Video views

1,559

Mentions per month

Jul 2020 – Jun 2025

Where it's discussed

  • X / Twitter43 posts
  • News42 articles
  • Blogs8 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions demonstrate a high level of interest and consensus on remdesivir’s promising results, exemplified by mentions of its effectiveness in human lung cells and animal models. Words like 'supports' and 'further confirms' highlight the perceived importance and potential impact of this research, reflected in both detailed scientific references and enthusiastic tone.

AgreementStrong agreement

The majority of discussions clearly acknowledge the positive findings regarding remdesivir's effectiveness against SARS-CoV-2, with some emphasizing its potential as a treatment option.

InterestHigh interest

Participants display strong curiosity by highlighting specific details of the research, such as its efficiency in human lung cells and mice models, indicating high relevance and engagement with the subject.

EngagementModerate engagement

Many discussions reference detailed scientific aspects, including the mechanisms of action and research collaborations, showing a level of deep engagement, although some posts are more brief or supportive.

ImpactHigh impact

The tone and content suggest that the community perceives this research as highly impactful, with phrases that imply significant potential for clinical application, and references to support from prominent institutions and researchers.

Abstract in brief

  • Remdesivir (RDV) effectively inhibits SARS-CoV-2 replication in human lung cells and airway tissues, showing stronger activity in these human models compared to Vero E6 cells.
  • Researchers created a chimeric virus in mice containing the SARS-CoV-2 RNA polymerase to test remdesivir's in vivo efficacy, where RDV reduced lung viral load and improved lung function.
  • These findings support the potential of remdesivir as a promising treatment for COVID-19, warranting further clinical investigation.
Read the full abstract

Top posts

Most liked on X and Bluesky
Cell Reports
@CellReports · X

Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice https://t.co/w35LiIMdNb

Jul 31, 2020 · 63 likes · 20 shares · 141,478 followers View post →
FrauHodl
@FrauHodl · X

@AnwaltUlbrich "Perfektes" Umfeld: Mark Denison von der Vanderbilt University Zitat: Mark Denison led the team that developed the Remdesivir drug to treat COVID-19. July 21, 2020 Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase https://t.co/JZ3Hl347DD

Jun 25, 2024 · 9 likes · 3 shares · 17,876 followers View post →
Arun
@arunschirps · X

@jhas5 @KindeandTrue @keverington @lissnup @tommy_cleary @gdemaneuf @CharlesRixey @CentristXtreme @capitolsheila @zhiyanle @Muller_Lab @FoolsMultiply @Daoyu15 @Byron_Wan @BillyBostickson @franciscodeasis @GMWatch @MonaRahalkar @quay_dr @TheSeeker268 @mattwridley @ianbirrell @SharriMarkson @Tantalite @joshrogin @AGHuff @samhusseini From this Jul 2020 publication https://t.co/5s3fHJ5VBq Authors include Ralph S Baric, PLUS Gilead Sciences makers of Veklury which was granted EUA on May 1, 2020 https://t.co/0uvUC5zzD8

Dec 21, 2021 · 5 likes · 1 share · 692 followers View post →
Steve Alexander
@mqzspa · X

"Remdesivir [https://t.co/t3Aa9UR4Oq] inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice" https://t.co/NoyeEaGBFE

Jul 10, 2020 · 4 likes · 3 shares · 944 followers View post →
BitSonicoin
@BitSonicoin · X

@Jikkyleaks @Melchizedek1972 I could sound as a broken disc, but: https://t.co/E693P53UHL Look for one usual suspect here: https://t.co/XKalkkK7ki And one of his pupils end working at Merck: https://t.co/yMpOMvhYtJ https://t.co/auPZEytzRL https://t.co/2rUHhs8PxR

Jul 23, 2023 · 4 likes · 413 followers View post →
Javier Mancilla Galindo
@Javimangal · X

Los estudios pre-clínicos sugieren que sí sirve, pero en esos estudios se dio extremadamente temprano: 12 horas post-infección en macacos: https://t.co/QQeN92Q869 24 horas post-infección en modelo murino: https://t.co/F6Ee6YuGIf

Oct 9, 2020 · 1 like · 3,523 followers View post →

All mentions

Bina Greene
@BinaGreene · X

RT @FrauHodl: @AnwaltUlbrich "Perfektes" Umfeld: Mark Denison von der Vanderbilt University Zitat: Mark Denison led the team that develope…

Jun 15, 2025 · 3 shares · 3,441 followers View post →
Sonnie
@Sonniesonnen · X

RT @FrauHodl: @AnwaltUlbrich "Perfektes" Umfeld: Mark Denison von der Vanderbilt University Zitat: Mark Denison led the team that develope…

Jun 25, 2024 · 3 shares · 550 followers View post →
TheBestChris
@1ChrisTheBest · X

RT @FrauHodl: @AnwaltUlbrich "Perfektes" Umfeld: Mark Denison von der Vanderbilt University Zitat: Mark Denison led the team that develope…

Jun 25, 2024 · 3 shares · 261 followers View post →
FrauHodl
@FrauHodl · X

@AnwaltUlbrich "Perfektes" Umfeld: Mark Denison von der Vanderbilt University Zitat: Mark Denison led the team that developed the Remdesivir drug to treat COVID-19. July 21, 2020 Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase https://t.co/JZ3Hl347DD

Jun 25, 2024 · 9 likes · 3 shares · 17,876 followers View post →
BitSonicoin
@BitSonicoin · X

@Jikkyleaks @Melchizedek1972 I could sound as a broken disc, but: https://t.co/E693P53UHL Look for one usual suspect here: https://t.co/XKalkkK7ki And one of his pupils end working at Merck: https://t.co/yMpOMvhYtJ https://t.co/auPZEytzRL https://t.co/2rUHhs8PxR

Jul 23, 2023 · 4 likes · 413 followers View post →
Obama2028 (Blue Check)
@PaxNostrum · X

RT @biorxiv_pubd: Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymeras…

Apr 23, 2023 · 1 share · 9,152 followers View post →
bioRxiv Published
@biorxiv_pubd · X

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. published as: https://t.co/sLrmXYaM8D @cellreports #biorxiv

Apr 19, 2023 · 1 like · 1 share · 2,905 followers View post →
Muller Lab
@Muller_Lab · X

RT @victoriacyanide: Similar to what has been observed with #remdesivir, authors show correlation between formation of intracellular 3'dATP…

Dec 1, 2022 · 1 share · 1,432 followers View post →
Victoria Yan
@victoriacyanide · X

Similar to what has been observed with #remdesivir, authors show correlation between formation of intracellular 3'dATP and cytotoxicity (LC50) in 4 cancer cell lines in vitro. 2/3 https://t.co/DOUmM45k0p https://t.co/3EL6pCyzz4 https://t.co/ZUAByckiVF

Dec 1, 2022 · 1 like · 1 share · 1,508 followers View post →
Arun
@arunschirps · X

@jhas5 @KindeandTrue @keverington @lissnup @tommy_cleary @gdemaneuf @CharlesRixey @CentristXtreme @capitolsheila @zhiyanle @Muller_Lab @FoolsMultiply @Daoyu15 @Byron_Wan @BillyBostickson @franciscodeasis @GMWatch @MonaRahalkar @quay_dr @TheSeeker268 @mattwridley @ianbirrell @SharriMarkson @Tantalite @joshrogin @AGHuff @samhusseini From this Jul 2020 publication https://t.co/5s3fHJ5VBq Authors include Ralph S Baric, PLUS Gilead Sciences makers of Veklury which was granted EUA on May 1, 2020 https://t.co/0uvUC5zzD8

Dec 21, 2021 · 5 likes · 1 share · 692 followers View post →
Isatou Sarr
@IsatouSarr4 · X

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice https://t.co/83Oo5crbif

Dec 1, 2021 · 1 like · 33 followers View post →
Isatou Sarr
@IsatouSarr4 · X

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice https://t.co/Iqx8ijQagf

Dec 1, 2021 · 1 like · 33 followers View post →
filippo masini
@filimasini · X

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase ... https://t.co/wmrkzAn1G4

Nov 1, 2020 · 771 followers View post →
Javier Mancilla Galindo
@Javimangal · X

Los estudios pre-clínicos sugieren que sí sirve, pero en esos estudios se dio extremadamente temprano: 12 horas post-infección en macacos: https://t.co/QQeN92Q869 24 horas post-infección en modelo murino: https://t.co/F6Ee6YuGIf

Oct 9, 2020 · 1 like · 3,523 followers View post →
Don
@poorcanuck · X

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice: Cell Reports https://t.co/06ShyMvR3D

Sep 20, 2020 · 619 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

https://t.co/Vtqw2W5OHS Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice https://t.co/SuuSqDtwN9

Aug 16, 2020 · 876 followers View post →
Charleux
@__________75009 · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 2, 2020 · 20 shares · 89 followers View post →
fishnets_andsex
@fishnets_andsex · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 2, 2020 · 20 shares · 193 followers View post →
Andy
@Andypzvi · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 337 followers View post →
CientificasEC
@CientificasEC · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 13,585 followers View post →
Bhavani Shankar Sahu.
@urssahu · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 1,360 followers View post →
Keith Brooker
@KeithBrooker5 · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 1,027 followers View post →
AIM
@aimnism · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 333 followers View post →
Dr. Claire McCarthy (she/her)
@cemccarthy02 · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 1,997 followers View post →
Abhijit Debnath
@TheAbhijitDN · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 271 followers View post →
f
@fdoesthings · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 564 followers View post →
Germomics
@Germomics · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 287 followers View post →
Emilie
@paintsandsings · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Aug 1, 2020 · 20 shares · 1,937 followers View post →
Hoang Tong
@HoangvTong · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Jul 31, 2020 · 20 shares · 21 followers View post →
Jorge I. Castillo-Quan, MD, PhD
@CastilloQuan_JI · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Jul 31, 2020 · 20 shares · 2,052 followers View post →
Lilibeth Pacheco
@LilibethPache14 · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Jul 31, 2020 · 20 shares · 191 followers View post →
JuanCarlosGR
@JUANK20011 · X

RT @CellReports: Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice…

Jul 31, 2020 · 20 shares · 5 followers View post →
Cell Reports
@CellReports · X

Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice https://t.co/w35LiIMdNb

Jul 31, 2020 · 63 likes · 20 shares · 141,478 followers View post →
NobuoMaita
@nob_mai · X

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice https://t.co/91AIlQOJGQ

Jul 21, 2020 · 1,071 followers View post →
Lucinda Morais
@lucindaplugada · X

(comprovações importantes) Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice https://t.co/0e662tzW7Y

Jul 17, 2020 · 1 like · 105 followers View post →
あきた
@kachimakeakita · X

(Cited from “Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice”, by Andrea J. Pruijssers, et al, Cell Reports (2020), https://t.co/zqGw27o2VA)

Jul 17, 2020 · 4 followers View post →
VU Chemical Biology
@VICB_Vanderbilt · X

Another co-authored paper by Mark Denison further supports the use of remdesivir for the treatment of COVID-19: https://t.co/MAMw0CMP4o @CellReports @CellPressNews @CellCellPress @VUMCResearch @VUMC_Vaccines @VanderbiltU

Jul 16, 2020 · 1,518 followers View post →
Saludteca
@Saludteca · X

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice https://t.co/6zgznVSxMo #AyudaBiblioteca https://t.co/A6SBds3sBz

Jul 15, 2020 · 1,999 followers View post →
Dr. Juan A. Gilabert
@Juanan_Gilabert · X

RT @mqzspa: "Remdesivir [https://t.co/t3Aa9UR4Oq] inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 R…

Jul 13, 2020 · 3 shares · 104 followers View post →
GuidetoPharmacology
@GuidetoPHARM · X

RT @mqzspa: "Remdesivir [https://t.co/t3Aa9UR4Oq] inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 R…

Jul 13, 2020 · 3 shares · 5,479 followers View post →
Saoirse E.O'Sullivan
@ScienceSaoirse · X

RT @mqzspa: "Remdesivir [https://t.co/t3Aa9UR4Oq] inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 R…

Jul 11, 2020 · 3 shares · 2,259 followers View post →
Steve Alexander
@mqzspa · X

"Remdesivir [https://t.co/t3Aa9UR4Oq] inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice" https://t.co/NoyeEaGBFE

Jul 10, 2020 · 4 likes · 3 shares · 944 followers View post →
Andras Toth
@tothur · X

Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. - ScienceDirect https://t.co/rB9Hu5zVka

Jul 9, 2020 · 1,823 followers View post →