PubHawk
Exp Dermatol September 2020 PMID 32678966

The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation.

Keshvad Hedayatyanfard, Nazgol-Sadat Haddadi, Seyed Ali Ziai, Hossein Karim, Feizollah Niazi, Ulrike Muscha Steckelings, Behnam Habibi, Ali Modarressi, Ahmad-Reza Dehpour

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Mentions

3
Peak: 2 in Oct 2021
across 2 sources since Jul 2020

Extended reach

672
potential audience

Total likes

23

Video views

611

Mentions per month

Jul 2020 – Oct 2021

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

Discussions highlight the significance of the findings, with posts mentioning how targeting the renin-angiotensin system could revolutionize scar treatment, indicating a shared interest and recognition of potential impact, while some posts express curiosity about further clinical applications and underlying biological processes.

AgreementModerate agreement

Most posts acknowledge the importance of the research, emphasizing its potential implications for treatment.

InterestModerate interest

Discussions show moderate curiosity, with commenters intrigued by the role of the renin-angiotensin system in scar formation.

EngagementModerate engagement

Commenters actively analyze findings, referencing specific mechanisms like angiotensin II’s effects and potential therapies.

ImpactModerate impact

The collective tone suggests that the research could influence future treatments and understanding of fibrosis in skin conditions.

Abstract in brief

  • The renin-angiotensin system (RAS) plays a significant role in skin scar formation, particularly in hypertrophic scars and keloids, by promoting fibrosis through its components like angiotensin II and specific receptors.
  • Elevated levels of angiotensin II can increase inflammatory and growth factors such as IL6, VEGF, TGF1, and CTGF, which contribute to scar tissue development, while also suppressing antifibrotic elements like TIMPs.
  • Early clinical trials suggest that targeting the RAS, especially ACE inhibitors or angiotensin receptor blockers, may offer new treatment options for managing hypertrophic scars and keloids by inhibiting these fibrotic processes.]
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lungdevelopment
@lungdevelopmen1 · X

The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation https://t.co/1D1zPQB4K8 https://t.co/2MujottSxf

Jul 18, 2020 · 62 followers View post →

All mentions

lungdevelopment
@lungdevelopmen1 · X

The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation https://t.co/1D1zPQB4K8 https://t.co/2MujottSxf

Jul 18, 2020 · 62 followers View post →