September 2020 PMID 32682336

Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

Ralf Paus, Yuval Ramot, Robert S Kirsner, Marjana Tomic-Canic

Mentions

14
Peak: 2 in Jul 2020
across 4 sources since Jul 2020

Extended reach

22,161
potential audience

Total likes

378

Video views

12,743

Mentions per month

Jul 2020 – Feb 2025

Where it's discussed

  • X / Twitter5 posts
  • Reddit4 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions emphasize the promising nature of topical L-thyroxine as a 'Cinderella' hormone in skin therapy, with posts referencing its potential in wound healing and hair growth, and terms like 'waiting to dance' metaphorically underscore its overlooked but promising status. Word choices reflect excitement and curiosity, but the overall engagement remains moderate, indicating ongoing interest rather than deep exploration.

AgreementModerate agreement

Most discussions recognize the potential of topical L-thyroxine as a promising, yet underexplored, treatment in dermatology, indicating general support.

InterestHigh interest

The posts show high interest, highlighting the novelty and potential clinical importance of the hormone in skin therapy.

EngagementModerate engagement

While some discussions touch on specific concepts like wound healing and hair growth, they remain somewhat superficial, reflecting moderate engagement.

ImpactModerate impact

The mentions suggest this research could influence future dermatological treatments, but are still in early stages, so impact is moderate.

Abstract in brief

  • Topical L-thyroxine (T4) has potential as a dermatological treatment, especially for wound healing and hair growth, but has been largely overlooked compared to other hormone therapies like steroids and vitamin D.
  • There is substantial evidence from clinical studies, cell experiments, and skin culture research suggesting that thyroid hormone receptor signaling plays a significant role in skin physiology, including effects on hair follicles, pigmentation, energy metabolism, and tissue repair.
  • The authors advocate for further preclinical and clinical research into the use of topical T4, emphasizing its proven safety profile and potential as a cost-effective treatment for skin ulcers and hair loss conditions like telogen effluvium.]

Top posts

Most liked on X and Bluesky
ExpDermatol
@ExpDermatol · X

Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? #wound healing https://t.co/uC1PLSj5ba

Sep 3, 2020 · 1 like · 2 shares · 1,077 followers View post →
Warayuwadee A.
@dr_lookjeabnoi · X

RT @ExpDermatol: Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? #wound healing…

Oct 24, 2020 · 2 shares · 6,051 followers View post →
Edel O'Toole
@EdelOToole · X

RT @ExpDermatol: Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? #wound healing…

Sep 3, 2020 · 2 shares · 1,872 followers View post →
UpToPhate
@UpToPhate · X

Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? https://t.co/V3aBkurXtv

Jul 19, 2020 · 192 followers View post →

All mentions

Warayuwadee A.
@dr_lookjeabnoi · X

RT @ExpDermatol: Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? #wound healing…

Oct 24, 2020 · 2 shares · 6,051 followers View post →
Edel O'Toole
@EdelOToole · X

RT @ExpDermatol: Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? #wound healing…

Sep 3, 2020 · 2 shares · 1,872 followers View post →
ExpDermatol
@ExpDermatol · X

Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? #wound healing https://t.co/uC1PLSj5ba

Sep 3, 2020 · 1 like · 2 shares · 1,077 followers View post →
UpToPhate
@UpToPhate · X

Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? https://t.co/V3aBkurXtv

Jul 19, 2020 · 192 followers View post →
mitopapers
@mito_papers · X

Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? https://t.co/lifuegBkYP https://t.co/aQZtmQLinv

Jul 19, 2020 · 145 followers View post →
... 10.1111/febs.14175,86310 Nature Chemical Biology,14,2018,10.1038/s41589-018 ... 14156,89451 mSphere,5,2020,10.1128/msphere.00792-20,124139 Nature ...
News

... 10.1111/febs.14175,86310 Nature Chemical Biology,14,2018,10.1038/s41589-018 ... 14156,89451 mSphere,5,2020,10.1128/msphere.00792-20,124139 Nature ...

Dec 14, 2025 View →
rp | PDF | Extracellular Matrix | Wound Healing
News

https://doi.org/10.1111/jocd.14156 [11] Wong ... Experimental Dermatology, 31(8), 1124–1132. https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14570

Dec 14, 2025 View →
The Impact of Perceived Stress On The Hair Follicle | PDF | Stress ...
News

10.1111/exd.13288. Singh, B., Schoeb, T.R., Bajpai, P., Slominski, A., Singh ... 10.1038/nature14156. Fisher, D.E., Hsu, Y.-C., 2020. Hyperactivation ...

Dec 14, 2025 View →
Hair Loss Community Member using chemotherapy drugs to ...
Reddit

https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14156. "On this background, we argue that short-term topical T4 treatment deserves ...

Mar 3, 2024 View →
ICYMI HairDAO Funds First Research Study to Develop New Hair ...
Reddit

https://onlinelibrary.wiley.com/doi/10.1111/exd.14156. This study is a good choice. Not promising the world, but the relationship of thyroid ...

Jan 10, 2023 View →
ICYMI HairDAO Yeni Saç Dökülmesi Çözümü Geliştirmek İçin İlk ...
Reddit

https://onlinelibrary.wiley.com/doi/10.1111/exd.14156. Bu çalışma iyi bir seçim. Dünyayı vaat etmiyor ama tiroidin cilt ve saçla ilişkisinin ...

Jan 10, 2023 View →
Professor Sinclair Hair Loss Q&A Megathread - June 2022 : r ...
Reddit

... are some very high powered researchers investigating it. https://onlinelibrary.wiley.com/doi/10.1111/exd.14156 · julysrapunzel. • 4y ago.

May 30, 2022 View →