Sci Transl Med July 2020 PMID 32718993

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.

Maria V Selvadurai, Mitchell J Moon, Simon J Mountford, Xiao Ma, Zhaohua Zheng, Ian G Jennings, Natasha M Setiabakti, Rizani P Iman, Rose J Brazilek, Nurul Aisha Z Abidin, Gaëtan Chicanne, Sonia Severin, Alyce J Nicholls, Connie H Y Wong, Jean-Yves Rinckel

Download social card

Mentions

Peak: 27 in Jul 2020

across 4 sources since Jul 2020

Extended reach

110,851

potential audience

Total likes

124

Video views

1,554

Mentions per month

Jul 2020

All 27 dated mentions so far are from Jul 2020.

Where it's discussed

X / Twitter25 posts
News14 articles
YouTube2 videos
Facebook2 posts

AI synopsis

What people are saying

The discussions frequently praise the study's innovative approach to preventing dangerous blood clots without increasing bleeding risk, using enthusiastic language like 'breaking' and 'super important,' and referencing potential clinical benefits, which reflects both high interest and belief in the significance of the findings.

AgreementModerate agreement

Most discussions express strong support for the significance and novelty of the findings, emphasizing the importance of the new approach for preventing thrombosis without impairing normal clotting.

InterestHigh interest

Posts demonstrate high interest, highlighting the potential impact on cardiovascular treatment and discussing mechanisms involved, indicating engagement with the research's implications.

EngagementHigh engagement

Discussions include references to the research methods, the potential for safer medications, and reactions like 'breaking' and 'super important,' showing deep engagement with the topic.

ImpactHigh impact

User comments suggest the research could be a breakthrough, with mentions of 'game-changing' potential and the promise of safer therapies, underlining the high perceived impact.

Abstract in brief

The study explores a new way to prevent blood clots (thrombosis) without increasing bleeding risk by targeting a specific enzyme, PI3KC2, in platelets.
Inhibiting PI3KC2 enlarges platelet internal membranes but does not impair normal platelet functions like blood clotting during injury, yet it significantly reduces the formation of dangerous arterial clots in both laboratory and animal tests.
The anti-clotting effect is due to impaired platelet adhesion under high shear stress, suggesting that drugs targeting platelet internal membranes could offer safer and more effective treatments for preventing heart attacks and strokes.]

Read the full abstract

All mentions

Targeting Platelet Internal Membranes to Prevent Thrombosis in COVID-19

Associate Professor Justin Hamilton's recent research focuses on a compound targeting pathogenic clots. This innovative approach offers potential for safer thrombosis prevention, especially relevant for COVID-19-related…

Translational Medicine, Monash University · Jul 22, 2020 1,290 views

Targeting Platelet Enzyme to Prevent Dangerous Blood Clots Safely

Associate Professor Justin Hamilton and colleagues have published a paper in Science Translational Medicine on how platelets about to form pathogenic clots such as those in stroke and heart attack can be specifically…

Translational Medicine, Monash University · Jul 22, 2020 264 views

NieswandtLab

@NieswandtLab · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 26, 2020 · 16 shares · 687 followers View post →

Ariakas Enoreth

@Aenoreth · X

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation https://t.co/LxNm2lqN9W

Jul 24, 2020 · 1,006 followers View post →

ACBD

@ACBDresearch · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 23, 2020 · 16 shares · 671 followers View post →

Monash University Diabetes Department

@MonashDiabetes · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 23, 2020 · 16 shares · 483 followers View post →

Monash University STM Department of Immunology

@MonashImmunol · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 23, 2020 · 16 shares · 1,826 followers View post →

waqar dahri

@Dahri85Waqar · X

RT @rtjunejo: Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activ…

Jul 23, 2020 · 2 shares · 457 followers View post →

Ebru Erbay

@EbruErbayMDPhD · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 23, 2020 · 16 shares · 3,298 followers View post →

Lipidomics.at

@Ahrends15 · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 23, 2020 · 16 shares · 818 followers View post →

Sarwan Saleem

@sarwansaleem · X

RT @rtjunejo: Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activ…

Jul 23, 2020 · 2 shares · 312 followers View post →

Annals of Cardiovascular and Thoracic Surgery

@AndThoracic · X

RT @Hragy: Breaking!!! Super duper important! Read please if you are a CV specialist : Disrupting the platelet internal membrane via PI3K…

Jul 23, 2020 · 1 share · 290 followers View post →

Rehan Junejo

@RTJunejo · X

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation https://t.co/uuEE6UXDBq

Jul 23, 2020 · 3 likes · 2 shares · 281 followers View post →

Hany Ragy

@Hragy · X

Jul 23, 2020 · 1 share · 80,403 followers View post →

bender_lab

@bender_lab · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 23, 2020 · 16 shares · 768 followers View post →

Carsten Deppermann

@plateletcarsten · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 23, 2020 · 16 shares · 1,496 followers View post →

Anirban Sen Gupta

@JishnuSenGupta · X

Jul 22, 2020 · 3 likes · 3,790 followers View post →

Dr. Mitchell Moon

@MitchMoon1 · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 22, 2020 · 16 shares · 25 followers View post →

Rossjohn lab

@RossjohnLab · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 22, 2020 · 16 shares · 1,530 followers View post →

Prof Andrew Murphy

@AJMurph5 · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 22, 2020 · 16 shares · 2,498 followers View post →

renhao li

@renhao_li · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 22, 2020 · 16 shares · 407 followers View post →

Scott Cameron

@2Scottish · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 22, 2020 · 16 shares · 2,113 followers View post →

Marvin Nieman

@MarvNieman · X

RT @lab_hamilton: Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 22, 2020 · 16 shares · 546 followers View post →

Translational Medicine at Monash University

@MonashSTM · X

Jul 22, 2020 · 4,027 followers View post →

Hamilton Lab

@lab_hamilton · X

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation https://t.co/6gQqPZofCw

Jul 22, 2020 · 6 likes · 331 followers View post →

Hamilton Lab

@lab_hamilton · X

Aaaaaaaaand it's finally out! Check out our latest publication in Science Translational Medicine - out today!

Jul 22, 2020 · 99 likes · 16 shares · 331 followers View post →

Jason T Maynes

@DrDrJTMaynes · X

Pretty interesting novel target for anti-platelet therapy that reduces spon bleeding risk. Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation https://t.co/C4bMCjWkzm

Jul 22, 2020 · 407 followers View post →

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Targeting Platelet Internal Membranes to Prevent Thrombosis in COVID-19

Targeting Platelet Enzyme to Prevent Dangerous Blood Clots Safely