UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @GenomeMedicine
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein.
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Mar 2020 – Oct 2024Where it's discussed
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The overall tone shows a strong interest in the study's findings, with posts like 'signs for reversion' and 'evidence for a cell passage induced deletion' demonstrating active engagement. The tone is scientific and analytical, emphasizing the relevance of the in-frame deletion and its potential effects on viral infectivity and mutation, which underscores the perceived high impact of the research in understanding SARS-CoV-2 evolution.
Many discussions acknowledge the significance of the research, expressing support or neutral curiosity about its findings.
Posts show high interest, with several emphasizing the importance of the deletion in the spike protein and its implications for viral behavior.
Discussions include references to methodologies like mass spectrometry, indicating active engagement and a desire to understand the detailed technical aspects.
The collective tone suggests the research could influence future studies on virus mutations and vaccine design, highlighting its noteworthy potential impact.
Abstract in brief
- This study analyzed the genetic and protein makeup of SARS-CoV-2 to understand how the virus behaves in host cells.
- It discovered a 24 nucleotide deletion in the spike protein gene that removes a key furin cleavage site, which could impact how the virus infects cells.
- The findings suggest that SARS-CoV-2 can mutate in important regions, highlighting the need for careful monitoring of viral genomes during research and vaccine development.
Top posts
Most liked on X and BlueskyCharacterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that ... https://t.co/sGyJLD9V1U #bioRxiv
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site. https://t.co/Y5zanb7pI5
FCO interview with Andrew Davidson and David Matthews explaining how #SARSCoV2 is different and why understanding the viral genome is so important to inform development of #vaccines and therapeutics @CMMBristol @BrisRDIntl @GenomeMedicine https://t.co/PbzZSuVHwb https://t.co/fUPoq50YPd
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein @GenomeMedicine @CMMBristol https://t.co/1tZvCfpmA8
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site https://t.co/fLQeWI90Jj
All mentions
SARS-CoV-2 Transcriptome and Proteome Characterization Reveals Spike Protein Deletion
This study analyzed the genetic and protein makeup of SARS-CoV-2 to understand how the virus behaves in host cells. It discovered a 24 nucleotide deletion in the spike protein gene that removes a key furin cleavage…
SARS-CoV-2 Transcriptome and Proteome Analysis Reveals Spike Protein Deletion
SARS-CoV-2 Transcriptome and Proteome Characterization Reveals Spike Protein Mutations
This study analyzed the genetic and protein makeup of SARS-CoV-2 to understand how the virus behaves in host cells. It discovered a 24 nucleotide deletion in the spike protein gene, potentially affecting infection…
SARS-CoV-2 Transcriptome and Proteome Analysis Reveals Key Spike Protein Deletion
This study analyzed the genetic and protein makeup of SARS-CoV-2 to understand how the virus behaves in host cells. It discovered a 24 nucleotide deletion in the spike protein gene that removes a key furin cleavage…
SARS-CoV-2 Transcriptome and Proteome Analysis Reveals Spike Protein Mutation
@Virus_FOI_Lady @gavinepark @GovCanHealth Some reading, should cover you https://t.co/2dkh0wzBjU https://t.co/buC5fCYJXS https://t.co/u5EQmPRUlp https://t.co/QESoNjoOSL https://t.co/s9GO8Yo1eG
@jrmy_tu @monsterrit @Censored4sure You're being far too vague to be of any use. Let's get current and have a look at the evidence for sars cov2. Cross reference with Bradford Hill, you'll need the references https://t.co/2dkh0wA99s https://t.co/cVNWWVK5fV https://t.co/huAraH6RFD https://t.co/buC5fCZhNq
@breakfast_dogs @VBruttel @gadboit @humblesci @PatrickSSte @zhihuachen @acritschristoph @K_G_Andersen @MonaRahalkar The loops were shortened with the variants, here the FCS is deleted. Signs for reversion? https://t.co/kvIf4geO1y https://t.co/jJ6PRPSBCu
RT @JeffBrender: @Ayjchan Not in SARS-COV2 https://t.co/enxLdRRTWZ
@Ayjchan Not in SARS-COV2 https://t.co/enxLdRRTWZ
@TotalCytopath @LazarusLong13 @19joho @HickieMd @gorskon Unsurprisingly, no *evidence-based* answer was provided to this query: Would serial passage leave signs in the resulting SARS-CoV-2 sequence, as per different selection pressures in vitro + in non-human animals? https://t.co/6EgjQg0PpM https://t.co/MWpSoQtB1V https://t.co/jpFDNCEoo9
@TotalCytopath @HickieMd @gorskon Amazing this still needs to b explained to folks years later. https://t.co/gbmL8mTbAy https://t.co/MWpSoQtB1V https://t.co/NuiwSLfhEj https://t.co/FEM5hGn38j https://t.co/oZ2G8f0xuO https://t.co/neEZSXXIf0 https://t.co/PlCoiYy1yK
@umamaheshwarb @Gem_liz31 @firuzimehta https://t.co/CwrQQrSIGD
Cet ensemble de données transcriptomique et protéomique intégré est une ressource riche pour les équipes de recherche qui construisent une image de ce nouveau virus https://t.co/UetpdDujdb
RT @JamesKerwin9: Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the…
@kundan_official @CarterIancarter You can stop wasting people's time with the "serial passage in cell culture" conspiracy theory. https://t.co/vKnvBexP3S https://t.co/MWpSoQtB1V https://t.co/ImKBL1MVK4 https://t.co/dEQNNNDDYx https://t.co/j0ieRly9YL https://t.co/neEZSXXIf0 https://t.co/utcszhrOLu
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein | Genome Medicine | Full Text https://t.co/1xi439wppD
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion o… https://t.co/0BioZffAgT
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion o… https://t.co/0BioZeXYSj
@drjulie_b Oddly similar to kind of just a normal transcript profile of the genome: https://t.co/NhPYeaKpMu https://t.co/rcmkZ2vP5D https://t.co/3G08ICCTZw
RT @zzz_as_zzz: Full text https://t.co/TESHIjmsgF フリン開削点がVero細胞での培養で抜ける変異を確認。 ネズミへの感染実験でも明らかなように、Sarscov-2は、割と簡単に変異して宿主に対応する。 遺伝子の削除だけでなく…
RT @BristolUncover: FCO interview with Andrew Davidson and David Matthews explaining how #SARSCoV2 is different and why understanding the v…
FCO interview with Andrew Davidson and David Matthews explaining how #SARSCoV2 is different and why understanding the viral genome is so important to inform development of #vaccines and therapeutics @CMMBristol @BrisRDIntl @GenomeMedicine https://t.co/PbzZSuVHwb https://t.co/fUPoq50YPd
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein https://t.co/s6jKaLznJ0
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @zzz_as_zzz: Full text https://t.co/TESHIjmsgF フリン開削点がVero細胞での培養で抜ける変異を確認。 ネズミへの感染実験でも明らかなように、Sarscov-2は、割と簡単に変異して宿主に対応する。 遺伝子の削除だけでなく…
RT @zzz_as_zzz: また、この研究では、通常多くのコロナウイルスで非常に変異の少ないEタンパクの変異を確認。 Eタンパクは、変異がほぼ無い為に、PCRなどでもその部分を使ったりしている場合があるので、注意が必要とのこと。 再度論文リンク https://t.co…
RT @zzz_as_zzz: Full text https://t.co/TESHIjmsgF フリン開削点がVero細胞での培養で抜ける変異を確認。 ネズミへの感染実験でも明らかなように、Sarscov-2は、割と簡単に変異して宿主に対応する。 遺伝子の削除だけでなく…
RT @zzz_as_zzz: また、この研究では、通常多くのコロナウイルスで非常に変異の少ないEタンパクの変異を確認。 Eタンパクは、変異がほぼ無い為に、PCRなどでもその部分を使ったりしている場合があるので、注意が必要とのこと。 再度論文リンク https://t.co…
また、この研究では、通常多くのコロナウイルスで非常に変異の少ないEタンパクの変異を確認。 Eタンパクは、変異がほぼ無い為に、PCRなどでもその部分を使ったりしている場合があるので、注意が必要とのこと。 再度論文リンク https://t.co/TESHIjmsgF
Full text https://t.co/TESHIjmsgF フリン開削点がVero細胞での培養で抜ける変異を確認。 ネズミへの感染実験でも明らかなように、Sarscov-2は、割と簡単に変異して宿主に対応する。 遺伝子の削除だけでなく追加も起こる。 これらの影響を調査する為にも遺伝子解析が非常に重要だと思います。 https://t.co/sGue3ZnigZ
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein. https://t.co/ReLttgRrVu
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
RT @BristolUni: UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @…
UK’s first research paper using live SARS-CoV-2 virus by @CMMBristol Drs David Matthews & Andrew Davidson is published in @GenomeMedicine
RT @BristolUncover: Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of th…
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein @GenomeMedicine @CMMBristol https://t.co/1tZvCfpmA8
RT @virus_genome: Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the…
Characterisation of the transcriptome & proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein. Davidson, et al., doi: 10.1186/s13073-020-00763-0.
RT @virus_genome: Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the…
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induc... https://t.co/crH4bbkzl0
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein. https://t.co/ywfh5fPlCW https://t.co/Ln3NsGzs7v
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein. https://t.co/p7ZZCSKYyf
RT @TheSeeker268: Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the…
RT @Inmuno_UB: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry re…
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site. https://t.co/UfpTvoOBkM https://t.co/qWvJV1G1QR
RT @juan_vizcaino: 3)"Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem MS reveals ev…
3)"Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem MS reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site", #PXD018241, https://t.co/i8QSJ5BnsU
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem MS reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site @medrxivpreprint https://t.co/FBCBv2C3YB
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site https://t.co/fLQeWI90Jj
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site https://t.co/u3rDzC1wLt
#RNAseq Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing ... https://t.co/3q1QvPUgSl
RT @joostsnijder: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry…
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike gly... https://t.co/vcYpF37AfD #glycotime
RT @biorxivpreprint: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrome…
RT @joostsnijder: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry…
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cl... https://t.co/OL7YPCMCTm
RT @joostsnijder: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry…
RT @joostsnijder: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry…
New #SARSCoV preprint: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the fur... https://t.co/S64L4BsHsv
Contribute a rapid review or request one for "Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequen..." (https://t.co/S64L4BsHsv). "Add" or "Request" w/DOI (10.1101/2020.03.22.002204) at https://t.co/RnurTL3DyM @outbreaksci @PREreview_
New #COVID19 preprint: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the fur... https://t.co/S64L4BsHsv
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site. https://t.co/Y5zanb7pI5
RT @biorxiv_micrbio: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrome…
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site. | bioRxiv …
RT @biorxivpreprint: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrome…
#RNAseq Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing ... https://t.co/K7Ppd5mM0d
RT @biorxivpreprint: Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrome…
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals ... https://t.co/ucmZZnq2x4 #biorxiv_micrbio
Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that ... https://t.co/sGyJLD9V1U #bioRxiv