J Transl Med July 2020 PMID 32727475

A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease.

Sean Holden, Rebekah Maksoud, Natalie Eaton-Fitch, Hélène Cabanas, Donald Staines, Sonya Marshall-Gradisnik

Mentions

48
Peak: 19 in Jul 2020
across 5 sources since Jul 2020

Extended reach

88,194
potential audience

Total likes

73

Video views

681

Mentions per month

Jul 2020 – Feb 2025

Where it's discussed

  • X / Twitter34 posts
  • Facebook6 posts
  • News4 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Several posts highlight the inconsistency across studies and question whether mitochondrial abnormalities are truly linked to ME/CFS, using phrases like 'no good evidence' and 'difficult to establish with certainty,' which imply skepticism and cautious inquiry. The tone is generally neutral or slightly dismissive, emphasizing methodological issues and the limited current impact of the review on the understanding of the disease.

AgreementLow agreement

The majority of discussions express skepticism about the significance of mitochondrial dysfunction in ME/CFS, highlighting inconsistencies and the lack of definitive evidence, which indicates a cautious or dismissive stance.

InterestModerate interest

Posts show moderate curiosity, with some referencing related research and ongoing debates, suggesting that the topic is of some relevance but not deeply engaging for most.

EngagementNeutral engagement

Few comments delve into detailed analysis or critique of the methodologies and implications; many posts acknowledge the review but stop short of deep discussion.

ImpactNeutral impact

Overall, the discussions reflect a perception that the review does not currently revolutionize understanding or treatment of ME/CFS, indicating a neutral to negligible perceived impact.

Top posts

Most liked on X and Bluesky
Tom Kindlon
@TomKindlon · X

A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https://t.co/4zeGBcO5BL "It is difficult to establish the role of mitochondria in the pathomechanisms of ME/#CFS/SEID due to inconsistencies across the studies"

Jul 30, 2020 · 34 likes · 7 shares · 15,125 followers View post →
ME/CFS News
@MECFSNews · X

A review of mitochondrial abnormalities in #MECFS. 19 studies were included. Evidence of potentially disrupted mitochondrial pathways is difficult to establish with certainty due to the use of different sampling methodology. https://t.co/CvN0d8IVp7

Jul 30, 2020 · 21 likes · 6 shares · 14,441 followers View post →
Cyrus | Mastodon in bio
@CyruxiME · X

@renardtif https://t.co/63TKYBTSXW

Oct 8, 2021 · 2 likes · 1 share · 1,521 followers View post →
Frank Paul Mora
@InTime_49 · X

@healingfromlc Google AI read it and others and produced a rather lengthy overview. I couldn't get an image. This review is 2020 A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease https://t.co/Qj3GFkcDSP

Feb 19, 2025 · 2 likes · 1 share · 405 followers View post →
Crazie Daizee
@Crazie_Daizee · X

Justified #MEcfs complaint for decades is limited number of studies, underfunded/underpowered. BUT they found SOME consistencies across studies! Have they even checked for these markers in #LongCovid? Could they be used to test status and explain #PEM?

Aug 31, 2022 · 2 likes · 2 shares · 351 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

@CBMEgroup I’d then search the 34 papers that have cited the review since 2020 as a starting place for finding new relevant articles (link to all the papers that cited it here) https://t.co/0UCLmP07aM

May 17, 2024 · 1 like · 1 share · 16,584 followers View post →

All mentions

ONG PEM
@AsociacionPEM · X

RT @InTime_49: @healingfromlc Google AI read it and others and produced a rather lengthy overview. I couldn't get an image. This review is…

Feb 20, 2025 · 1 share · 1,577 followers View post →
Frank Paul Mora
@InTime_49 · X

@healingfromlc Google AI read it and others and produced a rather lengthy overview. I couldn't get an image. This review is 2020 A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease https://t.co/Qj3GFkcDSP

Feb 19, 2025 · 2 likes · 1 share · 405 followers View post →
Zachary Grin, PT, DPT
@ZacharyGrinDPT · X

@ellbail @ChronicallyTina @gar_mcguigan Several problems here: Mito diseases produce various objective signs of disease which are absent in ME/CFS. There’s no good evidence to support mitochondria are the problem: https://t.co/ojR9Y8lGoe Lactic acid causing muscle aches is a known myth: https://t.co/fUQ3heYgzk

Sep 15, 2024 · 1 like · 1,854 followers View post →
Cambridge ME group
@CBMEgroup · X

RT @Naomi_D_Harvey: @CBMEgroup I’d then search the 34 papers that have cited the review since 2020 as a starting place for finding new rele…

May 17, 2024 · 1 share · 1,514 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

@CBMEgroup I’d then search the 34 papers that have cited the review since 2020 as a starting place for finding new relevant articles (link to all the papers that cited it here) https://t.co/0UCLmP07aM

May 17, 2024 · 1 like · 1 share · 16,584 followers View post →
Ephemeral
@Ephemerallama · X

@benfire71 @OS51388957 @StraightStats @ID_Denmark Prevalence estimated around 1:4-5000 for mit diseases. 2-3% in fatigue-driven diagnoses is plausible given overlap in symptoms & potential link between chronic fatigue & mit mutations, but remains speculative https://t.co/g6UFl14ueP https://t.co/SJlWuTG4zt https://t.co/ydvzW9FGF7

Apr 25, 2024 · 1 like · 719 followers View post →
Bumb'y
@bumb_y · X

@kimgl1993 @MarximusOne https://t.co/YlU7XMg7eT https://t.co/QnvGaUy0ni Nimmt eure Gesundheit selbst in die Hand so weit es geht

Dec 10, 2023 · 981 followers View post →
KarenLesliePhysio
@karenphysiocouk · X

@plainAZtruth @mgtmccartney Some dysfunction in mitochondria has been found but it's inconsistent so far. Mitochondrial dysfunction can be found in other conditions that do not have PEM as defining characteristic so my guess is it's a component but not cause https://t.co/SqbDYlnSRT

Nov 27, 2022 · 1 like · 4,562 followers View post →
sharonogata
@sharonogata1 · X

RT @Crazie_Daizee: Justified #MEcfs complaint for decades is limited number of studies, underfunded/underpowered. BUT they found SOME consi…

Aug 31, 2022 · 2 shares · 482 followers View post →
Patricia Hyland Bowman
@bowman_hyland · X

RT @Crazie_Daizee: Justified #MEcfs complaint for decades is limited number of studies, underfunded/underpowered. BUT they found SOME consi…

Aug 31, 2022 · 2 shares · 153 followers View post →
Crazie Daizee
@Crazie_Daizee · X

Justified #MEcfs complaint for decades is limited number of studies, underfunded/underpowered. BUT they found SOME consistencies across studies! Have they even checked for these markers in #LongCovid? Could they be used to test status and explain #PEM?

Aug 31, 2022 · 2 likes · 2 shares · 351 followers View post →
thanh
@renardtif · X

RT @CyruxiME: @renardtif https://t.co/63TKYBTSXW

Oct 8, 2021 · 1 share · 616 followers View post →
Cyrus | Mastodon in bio
@CyruxiME · X

@renardtif https://t.co/63TKYBTSXW

Oct 8, 2021 · 2 likes · 1 share · 1,521 followers View post →
David
@Foreman1David · X

@JaneEMCallaghan If it’s this then you’ve got 11 CFS vs 9 controls https://t.co/tMEIDXbY1y needs to be read against https://t.co/txuOeGdDFi

Dec 16, 2020 · 2,115 followers View post →
MyJournals
@myjournals · X

Correction to: A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease https://t.co/7y5THnwdcB

Oct 27, 2020 · 557 followers View post →
Matt Jones
@Mattjones0203 · X

A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease https://t.co/s8uxowgeyQ

Jul 31, 2020 · 1,281 followers View post →
Marit Hjelsvold
@memhj · X

RT @TomKindlon: A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https:/…

Jul 31, 2020 · 7 shares · 557 followers View post →
Its ME Matina
@justask · X

RT @MECFSNews: A review of mitochondrial abnormalities in #MECFS. 19 studies were included. Evidence of potentially disrupted mitochondrial…

Jul 31, 2020 · 6 shares · 2,389 followers View post →
PenelopeJ McMillan
@PenelopeJaneMcM · X

RT @TomKindlon: A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https:/…

Jul 30, 2020 · 7 shares · 635 followers View post →
Gilda (Jill-duh)
@GildaFoster · X

RT @TomKindlon: A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https:/…

Jul 30, 2020 · 7 shares · 642 followers View post →
Kajsa
@catskajsa · X

RT @MECFSNews: A review of mitochondrial abnormalities in #MECFS. 19 studies were included. Evidence of potentially disrupted mitochondrial…

Jul 30, 2020 · 6 shares · 2,762 followers View post →
Millions Missing Finland
@FinlandMissing · X

RT @MECFSNews: A review of mitochondrial abnormalities in #MECFS. 19 studies were included. Evidence of potentially disrupted mitochondrial…

Jul 30, 2020 · 6 shares · 696 followers View post →
Irish ME/CFS Association
@IrishMECFSAssoc · X

RT @TomKindlon: A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https:/…

Jul 30, 2020 · 7 shares · 2,571 followers View post →
diddlytwoshoes
@diddlytwoshoes · X

RT @MECFSNews: A review of mitochondrial abnormalities in #MECFS. 19 studies were included. Evidence of potentially disrupted mitochondrial…

Jul 30, 2020 · 6 shares · 660 followers View post →
applewalks
@rebeccasears · X

RT @TomKindlon: A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https:/…

Jul 30, 2020 · 7 shares · 461 followers View post →
The Invisible | an IPR Zine | @IntuitivePublic
@IllAndInvisible · X

RT @MECFSNews: A review of mitochondrial abnormalities in #MECFS. 19 studies were included. Evidence of potentially disrupted mitochondrial…

Jul 30, 2020 · 6 shares · 168 followers View post →
More than fatigue
@mas_que_fatiga · X

RT @MECFSNews: A review of mitochondrial abnormalities in #MECFS. 19 studies were included. Evidence of potentially disrupted mitochondrial…

Jul 30, 2020 · 6 shares · 156 followers View post →
ME/CFS News
@MECFSNews · X

A review of mitochondrial abnormalities in #MECFS. 19 studies were included. Evidence of potentially disrupted mitochondrial pathways is difficult to establish with certainty due to the use of different sampling methodology. https://t.co/CvN0d8IVp7

Jul 30, 2020 · 21 likes · 6 shares · 14,441 followers View post →
Miren Joseba
@miren_joseba · X

RT @TomKindlon: A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https:/…

Jul 30, 2020 · 7 shares · 303 followers View post →
Millions Missing France
@MillionsMissgFr · X

RT @TomKindlon: A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https:/…

Jul 30, 2020 · 7 shares · 2,169 followers View post →
Marilyn Gavranovic
@marilyngavrano1 · X

RT @TomKindlon: A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https:/…

Jul 30, 2020 · 7 shares · 830 followers View post →
Tom Kindlon
@TomKindlon · X

A systematic review of mitochondrial abnormalities in #MyalgicEncephalomyelitis/#ChronicFatigueSyndrome/#SEID Free https://t.co/4zeGBcO5BL "It is difficult to establish the role of mitochondria in the pathomechanisms of ME/#CFS/SEID due to inconsistencies across the studies"

Jul 30, 2020 · 34 likes · 7 shares · 15,125 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @NorthGreyLitC: A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis… https://t.co/AlZJ0Fw84Q #JTransMed

Jul 30, 2020 · 1 share · 6,712 followers View post →
National Grey Lit Collection
@NorthGreyLitC · X

A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis… https://t.co/AlZJ0Fw84Q #JTransMed

Jul 30, 2020 · 1 like · 1 share · 726 followers View post →