Neurology October 2020 PMID 32727835

Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study.

Amit Bar-Or, Jonathan C Calkwood, Cathy Chognot, Joanna Evershed, Edward J Fox, Ann Herman, Marianna Manfrini, John McNamara, Derrick S Robertson, Daniela Stokmaier, Jeanette K Wendt, Kevin L Winthrop, Anthony Traboulsee

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Mentions

34
Peak: 12 in May 2021
across 4 sources since Jul 2020

Extended reach

41,972
potential audience

Total likes

92

Video views

7,880

Mentions per month

Jul 2020 – Feb 2024

Where it's discussed

  • X / Twitter23 posts
  • News5 articles
  • YouTube3 videos
  • Blogs3 articles

AI synopsis

What people are saying

The overall summaries highlight that while patients on ocrelizumab may have weaker vaccine responses, vaccination remains recommended; discussion includes mentions of specific vaccine response rates and clinical implications, emphasizing the importance and potential limitations of the findings, often using words like 'important,' 'noted,' and 'recommendation' to convey impact.

AgreementModerate agreement

Most discussions acknowledge the study’s findings, with many emphasizing the reduced vaccine responses observed in patients on ocrelizumab, yet generally agreeing on the importance of vaccination.

InterestModerate interest

Participants show moderate interest, often referencing specific vaccine responses and the study's implications, but some posts are brief or primarily news-sharing.

EngagementModerate engagement

There is a moderate level of engagement, with commenters citing details from the study, discussing clinical relevance, or sharing related research, but few delve deeply into methodology or broader impacts.

ImpactModerate impact

The collective tone suggests the study is influential in clinical decision-making, with posts mentioning vaccination strategies and potential adjustments in patient care, indicating a recognition of its meaningful impact.

Abstract in brief

  • The VELOCE study evaluated how ocrelizumab, a medication for multiple sclerosis, affects the immune response to vaccines, finding that patients on ocrelizumab had weaker responses to certain vaccines compared to those not on the drug.
  • Patients treated with ocrelizumab showed significantly reduced responses to tetanus, pneumococcal, and influenza vaccines, suggesting that their immune systems are less capable of producing protective antibodies while on this treatment.
  • Despite the decreased vaccine responses, it is still recommended to vaccinate patients on ocrelizumab, especially with seasonal influenza vaccines, because some level of protection can still be achieved even if the immune response is weaker.]

Top posts

Most liked on X and Bluesky
MSキャビン
@mscabin · X

MSニュース、日本では未承認だけど「オクレリズマブ治療中のワクチンの効果」終了。 Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study https://t.co/kP1JzNBYx5

Jan 14, 2021 · 3 likes · 1 share · 4,229 followers View post →
Dr. Brandon Beaber
@Brandon_Beaber · X

@hollysme Yes. This is specifically studied with Ocrevus in the VELOCE trial: https://t.co/N6ThphDOG0 For instance, "Positive response rate to [the pneumonia vaccine] at 4 weeks was 71.6% [with Ocrevus] and 100% in the control group"

Jan 11, 2021 · 2 likes · 1 share · 18,257 followers View post →
Professor_Bart
@bart_professor · X

RT @Brandon_Beaber: @hollysme Yes. This is specifically studied with Ocrevus in the VELOCE trial: https://t.co/N6ThphDOG0 For instance, "…

Jan 12, 2021 · 1 share · 2,095 followers View post →
Dataemia
@Dataemia · X

(Reader Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study) https://t.co/hS0wwT0Sv6

May 4, 2021 · 966 followers View post →
Dataemia
@Dataemia · X

(Author Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study) https://t.co/hizt6Jctre

May 3, 2021 · 966 followers View post →
Dataemia
@Dataemia · X

(Editors' Note: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study) https://t.co/g6r7dkd8JE

May 4, 2021 · 966 followers View post →

All mentions

Paperbirds_Neurology
@PaperbirdsN · X

New article: Author Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study https://t.co/M5tGbOmqjE #MS #multiplesclerosis #neurology https://t.co/RiEcGHgAIt

May 26, 2021 · 457 followers View post →
Paperbirds_Neurology
@PaperbirdsN · X

New article: Reader Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study https://t.co/bWuhUSYU1K #MS #multiplesclerosis #neurology https://t.co/jV6O83Fjn3

May 26, 2021 · 457 followers View post →
Paperbirds_Neurology
@PaperbirdsN · X

New article: Editors' Note: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study https://t.co/5Vz0KxRxdA #MS #multiplesclerosis #neurology https://t.co/s32hNENbUk

May 26, 2021 · 457 followers View post →
Dataemia
@Dataemia · X

(Reader Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study) https://t.co/hS0wwT0Sv6

May 4, 2021 · 966 followers View post →
Dataemia
@Dataemia · X

(Editors' Note: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study) https://t.co/g6r7dkd8JE

May 4, 2021 · 966 followers View post →
Dataemia
@Dataemia · X

(Author Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study) https://t.co/hizt6Jctre

May 3, 2021 · 966 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Editors' Note: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study - AAN Neurology via BrainSights for iOS https://t.co/FzjZY2ufLJ

May 3, 2021 · 313 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Author Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study - AAN Neurology via BrainSights for iOS https://t.co/qlSWJvndGD

May 3, 2021 · 313 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Reader Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study - AAN Neurology via BrainSights for iOS https://t.co/pGcWDMvFCI

May 3, 2021 · 313 followers View post →
Shiva Gopal Vasishta
@ShivaVasishta · X

Editors' Note: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study https://t.co/7UxavnBaNQ #neurology #doctors #medtwitter #medical #medicinenews #healthcare

May 3, 2021 · 335 followers View post →
Shiva Gopal Vasishta
@ShivaVasishta · X

Reader Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study https://t.co/Jd5QGFbgdP #neurology #doctors #medtwitter #medical #medicinenews #healthcare

May 3, 2021 · 335 followers View post →
Shiva Gopal Vasishta
@ShivaVasishta · X

Author Response: Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis: The VELOCE Study https://t.co/BJmcZemKch #neurology #doctors #medtwitter #medical #medicinenews #healthcare

May 3, 2021 · 335 followers View post →
Sabakokokeshi
@sabakokokeshi · X

RT @mscabin: MSニュース、日本では未承認だけど「オクレリズマブ治療中のワクチンの効果」終了。 Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The…

Jan 14, 2021 · 1 share · 314 followers View post →
MSキャビン
@mscabin · X

MSニュース、日本では未承認だけど「オクレリズマブ治療中のワクチンの効果」終了。 Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study https://t.co/kP1JzNBYx5

Jan 14, 2021 · 3 likes · 1 share · 4,229 followers View post →
Professor_Bart
@bart_professor · X

RT @Brandon_Beaber: @hollysme Yes. This is specifically studied with Ocrevus in the VELOCE trial: https://t.co/N6ThphDOG0 For instance, "…

Jan 12, 2021 · 1 share · 2,095 followers View post →
Dr. Brandon Beaber
@Brandon_Beaber · X

@hollysme Yes. This is specifically studied with Ocrevus in the VELOCE trial: https://t.co/N6ThphDOG0 For instance, "Positive response rate to [the pneumonia vaccine] at 4 weeks was 71.6% [with Ocrevus] and 100% in the control group"

Jan 11, 2021 · 2 likes · 1 share · 18,257 followers View post →
Neurology
@PracUpNeuro · X

Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis https://t.co/lc2P3O51qP #MultipleSclerosis

Nov 16, 2020 · 568 followers View post →
Neurology
@PracUpNeuro · X

Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis https://t.co/AqrJxg8RiB #neurology

Nov 13, 2020 · 568 followers View post →
Livia Sousa
@LiviaSo96444059 · X

Effect of Ocrelizumab on Vaccine Responses in Patients With Multiple Sclerosis https://t.co/jCwsaC6HT5 via @practiceupdate

Oct 23, 2020 · 116 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study - AAN Neurology via BrainSights for iOS https://t.co/R5Mk4u3DKU

Oct 5, 2020 · 313 followers View post →
Shiva Gopal Vasishta
@ShivaVasishta · X

Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study https://t.co/eb4fiJUUrp #neurology #doctors #medtwitter #medical #medicinenews #healthcare

Oct 5, 2020 · 335 followers View post →
Ghaniah Hassan-Smith
@Dr_GhaniahHS · X

Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study - PubMed https://t.co/xlxVfu3wRc

Aug 1, 2020 · 482 followers View post →
Ingentium Multiple Sclerosis
@ingentium_ms · X

Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study. https://t.co/bpGoWIVfsy https://t.co/0F7pj8ZCdx

Jul 31, 2020 · 596 followers View post →