The overall tone is highly engaged and supportive, with posts frequently citing specific mutations such as D614G and N439K, discussing their effects on infectivity and antibody resistance. The language used conveys both technical interest and concern, emphasizing the relevance for vaccine development and viral monitoring.
AgreementModerate agreement
Most discussions acknowledge the findings, with some emphasizing the significance of mutations like D614G and how they increase infectivity, showing general consensus.
InterestHigh interest
Participants display high engagement and curiosity, often referencing detailed mutations and their effects, indicating strong interest in the subject.
EngagementModerate engagement
Posts include scientific references, mentions of specific mutations, and discussions on vaccine implications, demonstrating active and thoughtful engagement.
ImpactHigh impact
Many posts highlight the importance and potential consequences of these mutations on viral behavior and public health, suggesting a perceived high impact.
Abstract in brief
The study examines how mutations and glycosylation changes in the SARS-CoV-2 spike protein affect the virus's infectivity and how well it can be neutralized by antibodies.
The D614G mutation, along with some other combined mutations, increases infectivity, while changes in the receptor binding domain can reduce infectivity or lead to resistance against neutralizing antibodies.
Alterations in glycosylation sites generally decrease infectivity, but some specific mutations, like N234Q, can make the virus more resistant to neutralization, which is important for vaccine and therapeutic development.]
Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralized within a +/- 3-fold range of wild type virus. The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity https://t.co/vuy8eNNFrg https://t.co/k4etLSplX5
Nov 5, 2020 · 42 likes · 12 shares · 1,574 followersView post →
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influenzer
@influenzer3 · X
RBD領域の変異で中和抗体から回避できるようですが、現時点では感染性低下につながっていると。
The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity
https://t.co/1K8fug1VW6
Jälleen uudessa Cell:ssä työ SARS-CoV-2:n muuntumisesta. Pinta-proteiinin mutaatiot näyttävät vaikuttavan infektiivisyyteen ja vasta-aineiden toimintaan.
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity https://t.co/cARDUrunhM
We will need to worry about a bunch of new mutations after the second wave in this #COVID19 in Europe and the rest of the world as the viral population is expanding collectively. Epidemiological control would be the key to avoid surprises or bad luck. https://t.co/9rkHU22PBG
Nov 6, 2020 · 9 likes · 2 shares · 1,252 followersView post →
G
GÖKMEN
@GKMNNMKG · X
alanı etkiler ve virüsün hedef hücrelere daha sıkı bir şekilde bağlanmasına yardımcı olur.
D-K ; https://t.co/ZvxzND5sPX
Feb 24, 2021 · 8 likes · 1 share · 5,206 followersView post →
The science behind how taking a leek helps your immune system kill SARS-CoV-2. Research shows eating leeks may enhance innate immunity to recognize and destroy the virus, supported by studies on plant lectins and immune…
Eating a leek a week may boost your immune system by increasing Mannose Binding Lectin levels, aiding in the fight against SARS-CoV-2. This video reviews scientific research on how leeks support innate immunity and…
@Unusual_Times @PeacockFlu @Mike_Honey_ @OmicsOmicsBlog @GuptaR_lab It's been around since mid 2020, here they found it would likely enhance infectivity when combined with the ever present D614G.
https://t.co/G2oKrgVPyV
@KielnotKiel @Bcrip84 @Crackerdoodled1 @DrHirschfield The spike protein remains unchanged? Where did you hear that one? “The spike protein of SARS-CoV-2 has been undergoing mutations and is highly glycosylated.” https://t.co/3dh17XfYr3
@james_krieger @elray67 @VirusesImmunity @rlevin4408 The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity - L452R markedly resistant to many mAbs - https://t.co/BT9bqiQ0Vg
Jan 31, 2021 · 1 like · 1 share · 2,161 followersView post →
戦改
戦争・原発・改憲反対！
@w_books6 · X
RT @keyaki1117: メモ
「The Impact of Mutations in SARS-CoV-2
Spike on Viral Infectivity and Antigenicity」(ウイルスの感染性と抗原性に及ぼす、新型コロナウイルスのスパイクたんぱく質…
Jan 20, 2021 · 6 shares · 806 followersView post →
氷
氷室隆
@qNcGqjcj68Vx8CS · X
RT @keyaki1117: メモ
「The Impact of Mutations in SARS-CoV-2
Spike on Viral Infectivity and Antigenicity」(ウイルスの感染性と抗原性に及ぼす、新型コロナウイルスのスパイクたんぱく質…
Jan 19, 2021 · 6 shares · 864 followersView post →
し京
しとらす＠京都
@citrus_kyoto · X
RT @keyaki1117: メモ
「The Impact of Mutations in SARS-CoV-2
Spike on Viral Infectivity and Antigenicity」(ウイルスの感染性と抗原性に及ぼす、新型コロナウイルスのスパイクたんぱく質…
Jan 19, 2021 · 6 shares · 1,352 followersView post →
太た
太郎(たろー)
@taro_010 · X
RT @keyaki1117: メモ
「The Impact of Mutations in SARS-CoV-2
Spike on Viral Infectivity and Antigenicity」(ウイルスの感染性と抗原性に及ぼす、新型コロナウイルスのスパイクたんぱく質…
RT @keyaki1117: メモ
「The Impact of Mutations in SARS-CoV-2
Spike on Viral Infectivity and Antigenicity」(ウイルスの感染性と抗原性に及ぼす、新型コロナウイルスのスパイクたんぱく質…
Jan 18, 2021 · 6 shares · 799 followersView post →
笹
笹山登生
@keyaki1117 · X
メモ
「The Impact of Mutations in SARS-CoV-2
Spike on Viral Infectivity and Antigenicity」(ウイルスの感染性と抗原性に及ぼす、新型コロナウイルスのスパイクたんぱく質部分での変異の影響について)
https://t.co/HVGqRTHio0
Jan 18, 2021 · 5 likes · 6 shares · 28,798 followersView post →
MA
Mads Albertsen
@MadsAlbertsen85 · X
RT @AKiversen: Detaljeret gennemgang af bl.a. N439K fra juli - den er ikke så bekymrende.
The Impact of Mutations in SARS-CoV-2 Spike on Vi…
Dec 23, 2020 · 1 share · 6,315 followersView post →
AI
Astrid Iversen
@AKiversen · X
Detaljeret gennemgang af bl.a. N439K fra juli - den er ikke så bekymrende.
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity https://t.co/19OlTrbigz
Dec 23, 2020 · 5 likes · 1 share · 1,052 followersView post →
DS
Dr. Mark Slifka
@MarkSlifka · X
@alfonzoPgr Yeah - here is a paper that tested >100 different mutants and they could all be neutralized. The story is this - if a virus mutates too much to evade antibodies, then it loses "fitness" for infecting the host. The virus has to balance these trade offs. https://t.co/vuy8eNNFrg
RT @john_jxw: We will need to worry about a bunch of new mutations after the second wave in this #COVID19 in Europe and the rest of the wo…
Nov 19, 2020 · 2 shares · 2,122 followersView post →
E
ERP
@mudito37664890 · X
80 variantes naturales y 26 mutantes de glicosilación-pico (S) de SARS-CoV-2 en términos de infectividad y antigenicidad pero el problema está en los visones.
https://t.co/QYabtmaEhZ
3/ A peer-reviewed publication has studied >100 mutations and found the major N439K mutation causes slightly weaker growth of virus but immune serum could still recognize the virus https://t.co/vuy8eNNFrg
Nov 7, 2020 · 2 likes · 1,574 followersView post →
R
Robertson
@robertson_lab · X
RT @john_jxw: We will need to worry about a bunch of new mutations after the second wave in this #COVID19 in Europe and the rest of the wo…
Nov 6, 2020 · 2 shares · 3,472 followersView post →
XJ
Xiaowei Jiang
@john_jxw · X
We will need to worry about a bunch of new mutations after the second wave in this #COVID19 in Europe and the rest of the world as the viral population is expanding collectively. Epidemiological control would be the key to avoid surprises or bad luck. https://t.co/9rkHU22PBG
Nov 6, 2020 · 9 likes · 2 shares · 1,252 followersView post →
DH
Dustin Hammond
@DustinHammond14 · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 1,577 followersView post →
MM
Myrna Minkoff
@MyrnaMinkoff4 · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 7,907 followersView post →
B
Burrs
@sadantnan · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 871 followersView post →
NS
Never Settle
@SettleNevermore · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 400 followersView post →
LS
Liberty Bell Society
@TLBSociety · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 1,238 followersView post →
PK
Phil Kerpen
@kerpen · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 127,073 followersView post →
CM
Constantly Done Man
@mwmjenard · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 472 followersView post →
CE
crcounts.eth
@crcounts · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 657 followersView post →
NU
NK Leb #UpdateTheVaccines
@NickytaLeb · X
RT @MartinJuhl2: Previous papers on subject
A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants https://t…
Nov 5, 2020 · 2 shares · 2,936 followersView post →
MJ
Martin Juhl
@MartinJuhl2 · X
Previous papers on subject
A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants https://t.co/QY8M65IRiX
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity https://t.co/b7GtyMAaeC
Ref @KasperKepp https://t.co/LyVWJwvkWi
Nov 5, 2020 · 6 likes · 2 shares · 1,859 followersView post →
DW
Don Wolt
@tlowdon · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 17,883 followersView post →
NU
NK Leb #UpdateTheVaccines
@NickytaLeb · X
RT @MarkSlifka: Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralize…
Nov 5, 2020 · 12 shares · 2,936 followersView post →
DS
Dr. Mark Slifka
@MarkSlifka · X
Just to put this into perspective, people have tested 106 mutated strains of SARS-CoV-2 and all of them could be neutralized within a +/- 3-fold range of wild type virus. The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity https://t.co/vuy8eNNFrg https://t.co/k4etLSplX5
Nov 5, 2020 · 42 likes · 12 shares · 1,574 followersView post →
E
ERP
@mudito37664890 · X
The Impact of Mutations in SARS-CoV-2 Spike on
Viral Infectivity and Antigenicity,
https://t.co/EA5sxDk5No
Jälleen uudessa Cell:ssä työ SARS-CoV-2:n muuntumisesta. Pinta-proteiinin mutaatiot näyttävät vaikuttavan infektiivisyyteen ja vasta-aineiden toimintaan.
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity...
Jälleen uudessa Cell:ssä työ SARS-CoV-2:n muuntumisesta. Pinta-proteiinin mutaatiot näyttävät vaikuttavan infektiivisyyteen ja vasta-aineiden toimintaan.
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity https://t.co/cARDUrunhM
@lumidek D614G, a mutation of the Covid-19 virus, is 10 times more infectious than the original variant https://t.co/P6qRhffJ8z and has therefore unsurprisingly prevailed by now. It seems to be far less deadly https://t.co/7JGlwev3Iv Via Czech TV https://t.co/rLKkpXKV03
Did you see "D614G, along with several variants containing both D614G and another amino acid change, were significantly more infectious." at https://t.co/8HMJC9x30A
変異のペースが速ければ、ワクチンが追い付くかどうか？
一部の型にしか効かないというHPVVのようになるかもよ？
カバー率が低ければ接種有無で死亡率に有意差がないかもしれないし
→
The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity https://t.co/K4kselsDG3
RBD領域の変異で中和抗体から回避できるようですが、現時点では感染性低下につながっていると。
The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity
https://t.co/1K8fug1VW6
Journal Pre-proof - "The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity"
Received Date: 8 June 2020
Revised Date: 7 July 2020
Accepted Date: 10 July 2020
https://t.co/GpMuAhs4TK
著者らの所属は中国食品药品检定研究院(National Institutes for Food and Drug Control)。
Li et al.: The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity, Cell(Published July 17, 2020)
https://t.co/IVaPKkTZqr
coronavirus is trying out its best survival and propagation suits
RT
The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity https://t.co/wsAWrhdCJF
... Cell, une étude conduite par des chercheurs du Massachusetts General ... 10.1016/j.virusres.2021.198345. Moreira FRR, Bonfim DM, Geddes VEV, et al ...
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