Acta Pharmacol Sin September 2020 PMID 32747721

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.

Yuan Huang, Chan Yang, Xin-Feng Xu, Wei Xu, Shu-Wen Liu

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AI synopsis

What people are saying

The overall tone reflects keen interest and support for the research, with posts referencing detailed structural aspects and potential clinical relevance, such as mentions of specific protein regions, noting the importance of understanding spike functionality for antiviral development.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, supporting its findings and potential applications.

InterestHigh interest

Participants show high curiosity about structural details and implications for therapies, indicating strong engagement with the topic.

EngagementModerate engagement

Posts reference several studies, mention specific regions of the spike protein, and discuss potential impacts, demonstrating active involvement.

ImpactModerate impact

The discussions suggest that the research could influence vaccine and drug development, highlighting its relevance to ongoing efforts against COVID-19.

Abstract in brief

The SARS-CoV-2 spike protein is crucial for the virus's ability to infect human cells, with its two parts (S1 and S2) responsible for receptor binding and membrane fusion, respectively.
The S1 subunit binds to the ACE2 receptor on human cells, while the S2 subunit facilitates the fusion of the viral and cell membranes, helping the virus enter the cell.
Recent research focuses on understanding the structure and function of the spike protein to develop antiviral drugs that can block its activity and prevent COVID-19 infection.]

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峰　宗太郎

@minesoh · X

SARS-CoV-2 のスパイクタンパク質についてはこのレビューが読みやすかったよ

Dec 26, 2020 · 69 likes · 6 shares · 71,310 followers View post →

Francis Villatoro

@emulenews · X

#ActaPharmacologicaSinica Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 https://t.co/haaqZsTF7N https://t.co/uyo2GUWeqL

Nov 9, 2020 · 10 likes · 5 shares · 45,148 followers View post →

James William Owens

@Willard1951 · X

@ammocrypta @mugger124 @Jamz129 @Andrewemcameron @bob_calder @jwickers @glinch72 @B_Bolshevik100 @IngersolRobert @25_cycle @Climatehope2 @Stephen90045069 @KCTaz @MATTP1949 @BrknMan @Anvndarnamn5 @Mark_A_Lunn @BridgetHolmstro @FChecker76 @flyonthewall182 @OfReason23 @DK25769559 @91996340e81d45a @Tragic4Libs @CallMeBlaise1 @JohnOz1900 @joetheatheistp @aSinister @fishyfish67 @richardwakelin3 @GregTruman4 @Jaisans @BubbasRanch @RelampagoBlanc2 @GeraldKutney @MikeDel21893959 @TheDisproof @DigitalPsyche @WeaponizedPatr1 @Birthday_Chris @Tangomitteckel @0Sundance @davidyoung13 @SimonGr41594862 @ClimateCatastr3 @swcrisis @RealMikeDelta1 @fcmfcs2019 Two papers that may be of interest 1. Basics of spike protein structure & function, note SP1 & SP2 regions Huang et al 2020 https://t.co/8J1DbEmHU2 2. SP regions of Ab binding and RCD involving variants, very good 3-D figures Zhou et al 2021 h

Mar 28, 2021 · 4 likes · 493 followers View post →

Show_TimeZ_

@Show_TimeZ_ · X

@IlNazionale Le ricerche citate sono: "SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies" pubblicata su PubMed nel 2021. "Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19" pubblicata su Nature nel

Jul 18, 2024 · 1 like · 1 share · 1,686 followers View post →

S. Bohn McCallister, #Heyoka #Magdalene #Lilth

@SBMcCallister · X

@EricSpracklen Natural immunity to a disease requires for it to be common place, like the flu. SARS is not the flu. https://t.co/eEEjwO0x9r Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 https://t.co/YSyxCpsb80

Oct 5, 2021 · 8,801 followers View post →

Cure Cancer Now

@CancerCureNow · X

Huang, Y., Yang, C., Xu, Xf. et al. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin 41, 1141–1149 (2020). https://t.co/LZMOnpkB3o

Jul 31, 2021 · 6,926 followers View post →

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This presentation explores the applications of US mRNA vaccines in China and their implications for developing a universal COVID vaccine. It emphasizes understanding the SARS-CoV-2 spike protein's structure to aid…

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VicG

@vicvgold1 · X

@_Foreteller_ @Uriy4ka Название статьи в вашем посте: статья опубликована гораздо позже, и на другую тему: Huang, et al. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin 41, 1141–1149 (2020). https://t.co/xIeKeiGdyL

May 6, 2025 · 39 followers View post →

我的责任

@zhangwe01730822 · X

RT @Signor__Nessuno: @IlNazionale Le ricerche citate sono: "SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies" pub…

Jul 19, 2024 · 1 share · 730 followers View post →

Show_TimeZ_

@Show_TimeZ_ · X

Jul 18, 2024 · 1 like · 1 share · 1,686 followers View post →

John Turmel

@KingofthePauper · X

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 https://t.co/QgLF7ebZDx Looking for size of spike protein: With a size of 180–200 kDa, length of SARS-CoV-2 S is 1273 aa Jct: What does kDa or aa mean?

Nov 30, 2021 · 373 followers View post →

John Turmel

@KingofthePauper · X

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug dev | Acta Pharmacologica Sinica https://t.co/QgLF7ebZDx Looking for size of spike protein: With a size of 180–200 kDa, length of SARS-CoV-2 S is 1273 aa Jct: What does kDa or aa mean?

Nov 30, 2021 · 373 followers View post →

FollowJesusTheMessiah

@NepheshChayyah7 · X

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 - PubMed https://t.co/YgHL9lHDDF need to no more of what it can do in the body....eg clotting ,trigger autoImmune etc

Nov 19, 2021 · 199 followers View post →

Laurentius

@q_laurentius · X

@AMontille Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 Twitters referenssystem bökar till det :(

Nov 17, 2021 View post →

S. Bohn McCallister, #Heyoka #Magdalene #Lilth

@SBMcCallister · X

Oct 5, 2021 · 8,801 followers View post →

Afi Ghazouani

@pharmad_281 · X

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 | Acta Pharmacologica Sinica https://t.co/qMsgiLPTFQ

Aug 23, 2021 · 264 followers View post →

Cure Cancer Now

@CancerCureNow · X

Jul 31, 2021 · 6,926 followers View post →

James William Owens

@Willard1951 · X

Mar 28, 2021 · 4 likes · 493 followers View post →

Health Science

@KStangebye · X

More on the structural and functional properties of SARS-CoV-2 spike protein https://t.co/vurHXU8h7h https://t.co/Ov7zo2UU9m

Mar 15, 2021 · 505 followers View post →

Kiyokiyo

@KiyoKiyoEngland · X

RT @minesoh: SARS-CoV-2 のスパイクタンパク質についてはこのレビューが読みやすかったよ

Dec 27, 2020 · 6 shares · 117 followers View post →

Yosenapar, PhD

@Yosenapar · X

RT @minesoh: SARS-CoV-2 のスパイクタンパク質についてはこのレビューが読みやすかったよ

Dec 26, 2020 · 6 shares · 209 followers View post →

峰　宗太郎

@minesoh · X

SARS-CoV-2 のスパイクタンパク質についてはこのレビューが読みやすかったよ

Dec 26, 2020 · 69 likes · 6 shares · 71,310 followers View post →

Anaveac

@Anavillalobos17 · X

RT @emulenews: #ActaPharmacologicaSinica Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug develop…

Nov 10, 2020 · 5 shares · 57 followers View post →

mjgarciag

@mjggodoy · X

RT @emulenews: #ActaPharmacologicaSinica Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug develop…

Nov 10, 2020 · 5 shares · 658 followers View post →

Bea Neo

@thira6 · X

RT @emulenews: #ActaPharmacologicaSinica Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug develop…

Nov 10, 2020 · 5 shares · 316 followers View post →

J.Celda

@motosporttt · X

RT @emulenews: #ActaPharmacologicaSinica Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug develop…

Nov 9, 2020 · 5 shares · 279 followers View post →

Francis Villatoro

@emulenews · X

#ActaPharmacologicaSinica Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 https://t.co/haaqZsTF7N https://t.co/uyo2GUWeqL

Nov 9, 2020 · 10 likes · 5 shares · 45,148 followers View post →