J Am Soc Nephrol October 2020 PMID 32817311

Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.

Miles D Witham, Jennifer S Lees, Myra White, Margaret Band, Samira Bell, Donna J Chantler, Ian Ford, Roberta L Fulton, Gwen Kennedy, Roberta C Littleford, Ian V McCrea, Deborah McGlynn, Maurizio Panarelli, Maximilian R Ralston, Elaine Rutherford

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Mentions

Peak: 10 in Aug 2020

across 3 sources since Aug 2020

Extended reach

1,216,625

potential audience

Total likes

21,796

Video views

1,110,242

Mentions per month

Aug 2020 – May 2025

Where it's discussed

X / Twitter20 posts
YouTube6 videos
Blogs2 articles

AI synopsis

What people are saying

The discussions demonstrate high interest and broad agreement that vitamin K2 supplementation does not improve vascular stiffness in CKD, exemplified by phrases like 'NO mejoró la velocidad de pulso' and 'falla', which clearly acknowledge the null findings. Words like 'otro ensayo clínico' and references to the trial as 'muy plausible' indicate engagement with the scientific process, though the tone remains somewhat clinical and skeptical about the supplement's effectiveness.

AgreementStrong agreement

Most discussions acknowledge that the trial found no significant benefit of vitamin K2 on vascular stiffness in CKD patients, showing broad consensus.

InterestHigh interest

The consistent focus on the trial results indicates a high level of interest in its implications for CKD treatment and vascular health.

EngagementModerate engagement

While many users discuss the study’s outcomes, the engagement appears primarily focused on sharing information rather than in-depth critical analysis.

ImpactModerate impact

The emphasis on the trial’s null results suggests some consideration of its impact on clinical practices, but overall, it may not fully shift current treatment paradigms.

Abstract in brief

The K4Kidneys trial tested whether taking vitamin K2 daily for a year could help reduce arterial stiffness and improve vascular health in people with moderate to severe CKD, but the study found no significant benefits.
The primary measure used to assess vascular stiffness, called carotid-femoral pulse wave velocity, showed no difference between those taking vitamin K2 and those given a placebo after 12 months.
A combined analysis with other studies also confirmed that vitamin K supplementation does not seem to help with vascular calcification or stiffness in patients with CKD.]

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All mentions

Vitamin K2 and Vascular Calcification in Hemodialysis Patients

This study examined whether vitamin K2 supplementation could slow vascular calcification in hemodialysis patients. After 18 months, there was no significant reduction in coronary artery calcification or other…

Dr. med. Ulrich Selz · Apr 16, 2025 287,201 views

The Effectiveness of Daily Vitamin K2 on Vascular Calcification

Vitamin K2 has numerous health benefits, especially its impact on blood vessels. Studies show K2 MK7 may halt artery calcification, but a recent trial found no significant benefit in reducing vascular calcification in…

Dr. med. Ulrich Selz · Apr 13, 2025 239,082 views

Vitamin K2 and Vascular Calcification in Hemodialysis Patients

This study examined whether vitamin K2 supplementation can reduce vascular calcification in hemodialysis patients. After 18 months, no significant differences in coronary artery calcification or cardiac outcomes were…

Dr. med. Ulrich Selz · Apr 14, 2025 237,392 views

Vitamin K2 and Vascular Calcification in Hemodialysis Patients

This video discusses a clinical trial examining the effect of vitamin K2 supplementation on vascular calcification in hemodialysis patients. Despite reducing markers of deficiency, it did not significantly impact…

Dr. med. Ulrich Selz · May 14, 2025 205,124 views

Vitamin K2 and Vascular Calcification in Hemodialysis Patients

This study examined whether vitamin K2 supplementation could slow vascular calcification in hemodialysis patients. Results showed no significant reduction in calcification scores or major cardiac events after 18 months…

Dr. med. Ulrich Selz · Apr 14, 2025 141,084 views

Exploring Vitamin K2: Effects on Bone and Heart Health

In this video, I dive deep into the science behind Vitamin K2 and its impact on bone health and heart health. I will unpack its key functions, including maintaining bone health and preventing arterial calcium buildup…

Tawnya Hansen · Jul 2, 2024 360 views

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