Microbiome August 2020 PMID 32819434

The gut microbiota regulates autism-like behavior by mediating vitamin B homeostasis in EphB6-deficient mice.

Ying Li, Zheng-Yi Luo, Yu-Ying Hu, Yue-Wei Bi, Jian-Ming Yang, Wen-Jun Zou, Yun-Long Song, Shi Li, Tong Shen, Shu-Ji Li, Lang Huang, Ai-Jun Zhou, Tian-Ming Gao, Jian-Ming Li

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Mentions

59
Peak: 22 in Aug 2020
across 5 sources since Aug 2020

Extended reach

700,153
potential audience

Total likes

15,447

Video views

497,072

Mentions per month

Aug 2020 – Apr 2025

Where it's discussed

  • X / Twitter48 posts
  • Facebook4 posts
  • Reddit3 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Discussions highlight the role of microbiota in autism, with examples like references to vitamin B6 metabolism and genetics such as EphB6 gene downregulation, using technical language and emphasizing potential therapeutic targets. The tone is analytical but also includes critical comments about the use of certain insecticides, which adds skepticism and a broader context to the scientific findings.

AgreementModerate agreement

Most discussions recognize the connection between the microbiota and autism-like behaviors, reflecting moderate agreement with the study’s implications.

InterestModerate interest

The focus on gut microbiota and vitamin B6 in autism triggers mild to moderate interest among participants.

EngagementNeutral engagement

While some comments delve into methods and implications, many are cursory, indicating a neutral level of engagement.

ImpactModerate impact

Participants see some significance in the study, especially with mentions of potential therapies and broader implications, but overall impact is measured.

Abstract in brief

  • The study shows that deleting the gene EphB6 in mice causes autism-like behaviors and disrupts their gut microbiota, linking genetics, gut health, and ASD.
  • Transplanting gut bacteria from EphB6-deficient mice to healthy mice triggers autism-like behaviors, while restoring normal bacteria helps reduce symptoms, highlighting the microbiota's role.
  • The disturbed microbiota affects vitamin B levels and dopamine, which in turn influence brain activity and the balance between excitation and inhibition in the brain's prefrontal cortex, contributing to ASD symptoms.

Top posts

Most liked on X and Bluesky
GutMicrobiota Health
@GMFHx · X

Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice show that one crucial mechanism by which the gut microbiota regulates autism-like behaviour is involving vitamin B6 metabolism https://t.co/e6iBdwedPp

Aug 24, 2020 · 28 likes · 14 shares · 35,554 followers View post →
GutMicrobiota Health
@GMFHx · X

A functional link has found between the gut microbiota and autism spectrum disorders. These findings in mice show that one crucial mechanism by which the gut microbiota regulates autism-like behaviour is involving vitamin B6 metabolism https://t.co/NkjUVipuKJ

Sep 25, 2020 · 27 likes · 16 shares · 35,554 followers View post →
InfinaLife
@InfinaLife · X

^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinant insecticide nanoparticles in the "COVID19 vaccine" - to induce autism as in this paper: https://t.co/tjLh6XIUK7

Nov 9, 2023 · 12 likes · 12 shares · 1,095 followers View post →
Ferreira Lab - Cocos Patogênicos e Microbiota
@LabCocos · X

Esse estudo sugere um novo modelo de TEA provando o papel da microbiota intestinal no autismo induzido por fator genético. Além disso, fornece uma nova visão sobre o eixo intestino-cérebro-microbiota. Por @MariClaGui https://t.co/fod7XICLUM

Oct 16, 2020 · 7 likes · 1 share · 607 followers View post →
Microbiome
@MicrobiomeJ · X

The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice https://t.co/kjuoG18DlD

Aug 21, 2020 · 3 likes · 3 shares · 20,430 followers View post →
Research Square
@researchsquare · X

It’s World #Autism Awareness Day. Currently, pharmacological treatments for autism spectrum disorder are limited, but a @MicrobiomeJ study reveals EphB6, a gene that helps regulate the gut microbiome, to be a promising target for future therapies: https://t.co/VOXAcJQsGF #WAAD https://t.co/kO2SoFStiv

Apr 2, 2021 · 1 like · 16,565 followers View post →

All mentions

InfinaLife
@InfinaLife · X

RT @NiasCin: ... "C57BL/6J mice were orally gavaged with antibiotics (ampicillin, vancomycin, neomycin, metronidazole)" https://t.co/tjL…

Apr 17, 2025 · 2 shares · 1,095 followers View post →
Robert
@RobertBarber64 · X

RT @NiasCin: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinant…

Feb 20, 2025 · 12 shares · 2,787 followers View post →
InfinaLife
@InfinaLife · X

RT @3L3X3R: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinant…

Jan 31, 2025 · 12 shares · 1,095 followers View post →
Jim Keightley
@Nitro3501969 · X

RT @3V3LV3: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinant…

Sep 6, 2024 · 12 shares · 5 followers View post →
Sophia Koltavary
@holypaprika23 · X

RT @B3EFI: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinant i…

Jul 20, 2024 · 12 shares · 215 followers View post →
InfinaLife
@InfinaLife · X

RT @B3EFI: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinant i…

Jul 20, 2024 · 12 shares · 1,095 followers View post →
InfinaLife
@InfinaLife · X

RT @PureB3EF: ... "C57BL/6J mice were orally gavaged with antibiotics (ampicillin, vancomycin, neomycin, metronidazole)" https://t.co/tj…

Jul 8, 2024 · 2 shares · 1,095 followers View post →
All’e’anna
@Alleanna14 · X

RT @PureB3EF: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinan…

Jun 28, 2024 · 12 shares · 1,002 followers View post →
MakeUSA_Great
@MakeUSA_Great · X

RT @PureB3EF: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinan…

Jun 24, 2024 · 12 shares · 4,544 followers View post →
HOM3OSTASIS.com
@GPR109A · X

RT @VitaminB3E: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombin…

Apr 28, 2024 · 12 shares · 724 followers View post →
InfinaLife
@InfinaLife · X

... "C57BL/6J mice were orally gavaged with antibiotics (ampicillin, vancomycin, neomycin, metronidazole)" https://t.co/tjLh6XIUK7

Mar 15, 2024 · 2 shares · 1,095 followers View post →
Becca Anne
@BellabamaAnne · X

RT @DmitryKatscom: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recom…

Mar 6, 2024 · 12 shares · 571 followers View post →
Змајица Биби ЕјАј@2025@Biliana BiBiShi Art
@BilianaBibishi · X

RT @DmitryKatscom: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recom…

Dec 18, 2023 · 12 shares · 1,240 followers View post →
Victoria
@victoria_c_u · X

RT @DmitryKatscom: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recom…

Dec 16, 2023 · 12 shares · 75 followers View post →
RGSJr
@BobSlater18 · X

RT @DmitryKatscom: ^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recom…

Dec 13, 2023 · 12 shares · 2,621 followers View post →
InfinaLife
@InfinaLife · X

^ They literally use these SAME EXACT insecticides from Strep- bacteria like neomycin in the MMR jab or ivermectin recombinant insecticide nanoparticles in the "COVID19 vaccine" - to induce autism as in this paper: https://t.co/tjLh6XIUK7

Nov 9, 2023 · 12 likes · 12 shares · 1,095 followers View post →
高等夢眠
@NobuKoba1988 · X

こないだASDマウスモデルにFMTすると自閉様行動が改善されるという論文を基礎配属の学生に紹介してもらったばかりである… https://t.co/U3lEub9hxo

Nov 14, 2021 · 1 like · 8,624 followers View post →
Research Square
@researchsquare · X

It’s World #Autism Awareness Day. Currently, pharmacological treatments for autism spectrum disorder are limited, but a @MicrobiomeJ study reveals EphB6, a gene that helps regulate the gut microbiome, to be a promising target for future therapies: https://t.co/VOXAcJQsGF #WAAD https://t.co/kO2SoFStiv

Apr 2, 2021 · 1 like · 16,565 followers View post →
John Yorski
@john_yorski · X

@RayTruant @NatureNews His assertions have been validated this year. You dont even care about the nature of thew subject, you are just here to harass bully and terrorize. You are the epitome of abuse and corruption in academia. https://t.co/zVweNEe9U2

Oct 27, 2020 · 24 followers View post →
AB Johnson
@Hijo_de_Juan · X

gut microbiota regulates ADD-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice https://t.co/ez6qxVtrXN

Oct 17, 2020 · 151 followers View post →
Eros
@ErosSowinski · X

RT @LabCocos: Esse estudo sugere um novo modelo de TEA provando o papel da microbiota intestinal no autismo induzido por fator genético. A…

Oct 16, 2020 · 1 share · 532 followers View post →
Ferreira Lab - Cocos Patogênicos e Microbiota
@LabCocos · X

Esse estudo sugere um novo modelo de TEA provando o papel da microbiota intestinal no autismo induzido por fator genético. Além disso, fornece uma nova visão sobre o eixo intestino-cérebro-microbiota. Por @MariClaGui https://t.co/fod7XICLUM

Oct 16, 2020 · 7 likes · 1 share · 607 followers View post →
Dr Paris Tavakoli
@TavakoliParis · X

The gut microbiota regulates autism-like behavior by mediating vitamin B 6 homeostasis in EphB6-deficient mice | Microbiome | Full Text https://t.co/Bst3YK2Ry9

Sep 27, 2020 · 238 followers View post →
Rene Sugar
@renesugar · X

RT @GMFHx: A functional link has found between the gut microbiota and autism spectrum disorders. These findings in mice show that one cruci…

Sep 25, 2020 · 16 shares · 3,972 followers View post →
I_am_Scottish
@EU_Remain_2017 · X

RT @GMFHx: A functional link has found between the gut microbiota and autism spectrum disorders. These findings in mice show that one cruci…

Sep 25, 2020 · 16 shares · 3,787 followers View post →
GutMicrobiota Health
@GMFHx · X

A functional link has found between the gut microbiota and autism spectrum disorders. These findings in mice show that one crucial mechanism by which the gut microbiota regulates autism-like behaviour is involving vitamin B6 metabolism https://t.co/NkjUVipuKJ

Sep 25, 2020 · 27 likes · 16 shares · 35,554 followers View post →
Retweetburner
@retweetburner · X

RT @alephh: Autism (=EPHB6 gene downregulated) - Delete EphB6 (mice) ➡️autism-like-behavior (ALB) ➡️bad microbiota (MB)➡️bad B6/dopamine➡️b…

Aug 30, 2020 · 1 share · 282 followers View post →
alephh
@alephh · X

Autism (=EPHB6 gene downregulated) - Delete EphB6 (mice) ➡️autism-like-behavior (ALB) ➡️bad microbiota (MB)➡️bad B6/dopamine➡️bad excitation/inhibition in medial prefrontal cortex - Move EphB6 MB to C57BL/6J mice➡️ALB - Move wild-type MB to EphB6➡️less ALB https://t.co/1DyA2e2Rpr

Aug 26, 2020 · 1 like · 1 share · 388 followers View post →
I_am_Scottish
@EU_Remain_2017 · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 25, 2020 · 14 shares · 3,787 followers View post →
Rosa Fasching
@rosinafasching · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 25, 2020 · 14 shares · 1,278 followers View post →
Dr. Nauf AlBendar | #DOHaD
@thewombeffect · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 25, 2020 · 14 shares · 617 followers View post →
Katie Guzzetta
@ktguzz · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 25, 2020 · 14 shares · 4,773 followers View post →
Neuropsicologo
@CHRISTIANGEL76 · X

La evidencia sugiere un vínculo entre la microbiota intestinal y los trastornos del TEA. hallazgos muestran que un mecanismo crucial por el cual la microbiota intestinal regula el comportamiento similar al #autismo es el metabolismo de la vitamina B6 https://t.co/ZKHmMqRaVF

Aug 25, 2020 · 295 followers View post →
AB Johnson
@Hijo_de_Juan · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 25, 2020 · 14 shares · 151 followers View post →
M. Lynn Cornish
@SisterSeaweed · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 25, 2020 · 14 shares · 4,341 followers View post →
John F. Cryan
@jfcryan · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 25, 2020 · 14 shares · 22,437 followers View post →
Ann Gregory, PhD
@gregory_annc · X

RT @MicrobiomeJ: The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice https://t.co…

Aug 25, 2020 · 3 shares · 1,593 followers View post →
Sportify-GlutenFree F&B
@SportifyG · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 25, 2020 · 14 shares · 432 followers View post →
Shreya Ghosh
@shrez07 · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 24, 2020 · 14 shares · 138 followers View post →
Benjamin Gold
@BenjamminGold · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 24, 2020 · 14 shares · 2,067 followers View post →
Salesianos Argentina
@salesianoarg1 · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 24, 2020 · 14 shares · 605 followers View post →
Backroom Spin
@backroomspin · X

RT @GMFHx: Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice sh…

Aug 24, 2020 · 14 shares · 1,371 followers View post →
GutMicrobiota Health
@GMFHx · X

Increasing evidence suggests a functional link between the gut microbiota and autism spectrum disorders. New findings in mice show that one crucial mechanism by which the gut microbiota regulates autism-like behaviour is involving vitamin B6 metabolism https://t.co/e6iBdwedPp

Aug 24, 2020 · 28 likes · 14 shares · 35,554 followers View post →
The Clarifi Test
@clarifiASD · X

New research finds more connections to the gut microbiota and #autism spectrum disorder! https://t.co/jpgufzFfcV

Aug 24, 2020 · 1 like · 372 followers View post →
Salesianos Argentina
@salesianoarg1 · X

RT @MicrobiomeJ: The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice https://t.co…

Aug 21, 2020 · 3 shares · 605 followers View post →
Microbiome Articles
@microbe_article · X

The gut microbiota regulates autism-like behavior by mediating vitamin b<sub>6</sub> homeostasis in ephb6-deficient mice. - Li Y et al. - https://t.co/xqnxj4YdK7 #microbiome

Aug 21, 2020 · 7,154 followers View post →
(D) (R) (I) Distancing
@StephaniePalosP · X

RT @MicrobiomeJ: The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice https://t.co…

Aug 21, 2020 · 3 shares · 3,188 followers View post →
Microbiome
@MicrobiomeJ · X

The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice https://t.co/kjuoG18DlD

Aug 21, 2020 · 3 likes · 3 shares · 20,430 followers View post →