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J Vet Intern Med September 2020 PMID 32856349

Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs.

Rachel Pilla, Frederic P Gaschen, James W Barr, Erin Olson, Julia Honneffer, Blake C Guard, Amanda B Blake, Dean Villanueva, Mohammad R Khattab, Mustafa K AlShawaqfeh, Jonathan A Lidbury, Jörg M Steiner, Jan S Suchodolski

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71
Peak: 8 in Sep 2020
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AI synopsis

What people are saying

The discussions demonstrate recognition of the study’s significance, citing examples such as mentions of the drug's four-week impact on the microbiome and calls for cautious use, with words like 'supporting a cautious approach' underscoring the perceived importance and potential influence of the findings.

AgreementModerate agreement

Most discussions agree that metronidazole has significant long-lasting effects on the gut microbiome, emphasizing caution in its use.

InterestModerate interest

Participants show moderate interest, commenting on specific findings like the four-week impact and potential health implications.

EngagementModerate engagement

Comments include references to the study, implications for veterinary practices, and calls for caution, indicating moderate depth of engagement.

ImpactModerate impact

The conversations highlight the importance of the research, with some discussing how it could influence prescribing habits and animal health protocols.

Abstract in brief

  • Metronidazole significantly alters the gut microbiome and metabolome in healthy dogs, causing decreases in beneficial bacteria and affecting bile acid and lactate levels.
  • These changes in the microbiome and metabolism do not fully recover within 4 weeks after stopping the drug, indicating long-lasting impacts.
  • Using a hydrolyzed protein diet alone does not cause these microbiome changes, suggesting that the antibiotic is the main factor affecting gut health in this context.
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Microbiome Articles
@microbe_article · X

Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. - Pilla R et al. - https://t.co/lcV5ofFXcw #microbiome

Aug 29, 2020 · 5 likes · 7,155 followers View post →
Dr. Celeste Allaband
@LabAllaband · X

@AJVROA Just because metronidazole is not genotoxic to PBMCs does not mean it can’t have detrimental effects on health. https://t.co/fGR7ivtWdG We should be a bit more cautious with its use, especially in puppies.

Nov 11, 2022 · 2 likes · 429 followers View post →
Victor Algra
@Victor_Algra · X

Jun 18, 2024 · 1 like · 2 shares · 1,562 followers View post →
MissioneVeterinario
@ProfVeterinario · X

Effects of #metronidazole on the fecal microbiome and metabolome in healthy dogs | #ECM #Veterinaria https://t.co/j50DuVoCdx

Sep 2, 2020 · 1 like · 915 followers View post →
jacamp98
@jacamp98 · X

RT @Victor_Algra:

Jun 24, 2024 · 2 shares · 6,722 followers View post →
DrRPalmquist
@DrPalmquist · X

Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs - Pilla - 2020 - Journal of Veterinary Internal Medicine - Wiley Online Library https://t.co/VhBssIi2S2

Oct 20, 2021 · 3,152 followers View post →

All mentions

jacamp98
@jacamp98 · X

RT @Victor_Algra:

Jun 24, 2024 · 2 shares · 6,722 followers View post →
Sweet Blasphemy
@SweetBlasphem13 · X

RT @Victor_Algra:

Jun 20, 2024 · 2 shares · 12 followers View post →
Victor Algra
@Victor_Algra · X

Jun 18, 2024 · 1 like · 2 shares · 1,562 followers View post →
Dr. Celeste Allaband
@LabAllaband · X

@AJVROA Just because metronidazole is not genotoxic to PBMCs does not mean it can’t have detrimental effects on health. https://t.co/fGR7ivtWdG We should be a bit more cautious with its use, especially in puppies.

Nov 11, 2022 · 2 likes · 429 followers View post →
DrRPalmquist
@DrPalmquist · X

Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs - Pilla - 2020 - Journal of Veterinary Internal Medicine - Wiley Online Library https://t.co/VhBssIi2S2

Oct 20, 2021 · 3,152 followers View post →
MissioneVeterinario
@ProfVeterinario · X

Effects of #metronidazole on the fecal microbiome and metabolome in healthy dogs | #ECM #Veterinaria https://t.co/j50DuVoCdx

Sep 2, 2020 · 1 like · 915 followers View post →
Stefano Cattaneo DVM
@Albinovet · X

effects of #metronidazole on the fecal microbiome and metabolome in healthy dogs. There is a a minimum 4‐week effect of metronidazole on fecal microbiome &metabolome, supporting a cautious approach to prescription of metronidazole in dogs. https://t.co/97YPlhQJBT https://t.co/CeTa8ad2vH

Aug 31, 2020 · 2,713 followers View post →
Symbiosis papers
@Symbiosispapers · X

Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. https://t.co/SDD2yk9PRE

Aug 29, 2020 · 1,104 followers View post →
Microbiome Articles
@microbe_article · X

Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. - Pilla R et al. - https://t.co/lcV5ofFXcw #microbiome

Aug 29, 2020 · 5 likes · 7,155 followers View post →
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