September 2020 PMID 32888407

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.

Jeremy S Abramson, M Lia Palomba, Leo I Gordon, Matthew A Lunning, Michael Wang, Jon Arnason, Amitkumar Mehta, Enkhtsetseg Purev, David G Maloney, Charalambos Andreadis, Alison Sehgal, Scott R Solomon, Nilanjan Ghosh, Tina M Albertson, Jacob Garcia

Mentions

39
Peak: 4 in Feb 2021
across 4 sources since Sep 2020

Extended reach

483,144
potential audience

Total likes

909

Video views

65,705

Mentions per month

Sep 2020 – Sep 2022

Where it's discussed

  • X / Twitter17 posts
  • News16 articles
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions emphasize the high response rates (e.g., 73% objective response, 53% complete response), and words like 'high', 'approved', and 'study' reflect a tone of achievement and significance. Participants incorporate professional insights, personal experiences, and references to approval processes, illustrating both interest and perceived impact of the therapy on lymphoma treatments.

AgreementModerate agreement

Most discussions recognize the positive outcomes and approval of LISocabtagene maraleucel, indicating general agreement with its clinical significance.

InterestHigh interest

Participants show high interest, highlighting the therapy's promising efficacy and real-world application across different settings.

EngagementModerate engagement

Users engage actively by sharing study results, personal connections, and professional insights, suggesting moderate but meaningful involvement.

ImpactHigh impact

The widespread mention and approval by authorities like the FDA suggest the therapy has a noteworthy impact on treatment options and future research.

Abstract in brief

  • The study evaluated the effectiveness and safety of lisocabtagene maraleucel, a CAR T-cell therapy targeting CD19, in treating adults with various types of relapsed or refractory large B-cell lymphomas across 14 US cancer centers.
  • Patients received different dose levels of the therapy, which involved a two-step infusion of CAR T cells, and the main focus was on safety, toxicities, and how well the tumor responded according to independent assessments.
  • Out of 344 patients who were processed for treatment, 269 received at least one dose of lisocabtagene maraleucel, with many having undergone multiple prior treatments, including a significant portion over age 65, indicating the therapy's use in heavily pretreated and older populations.]

Top posts

Most liked on X and Bluesky
Michael Wang, MD
@michaelwangmd · X

In this multicenter study we participated in, lisocabtagene maraleucel in R/R large B-cell lymphoma pts resulted in a high objective response rate and is currently used as a CAR T cell therapy for relapsed #mantlecelllymphoma in an ongoing clinical trial. https://t.co/Us6fHi1RFw

Jul 7, 2021 · 14 likes · 3 shares · 7,197 followers View post →
Michael Wang, MD
@michaelwangmd · X

The study by Jeremy Abramson et al showed Lisocabtagene maraleucel, an autologous, CD19-directed, CAR T-cell product for pts with R/R large B-cell lymphomas (TRANSCEND NHL 001). Of 256 pts included in efficacy-evaluable set, OR seen in 73% pts & CR in 53% https://t.co/Us6fHi1RFw

Oct 12, 2021 · 9 likes · 3 shares · 7,197 followers View post →
Vinay Prasad MD MPH
@VPrasadMDMPH · X

I was honored to have her on my show @Plenary_Session not just once https://t.co/qdsWibuKXc

May 27, 2021 · 8 likes · 312,475 followers View post →
The ASCO Post
@ASCOPost · X

.@US_FDA Approves Lisocabtagene Maraleucel for Patients With Relapsed or Refractory Large B-Cell Lymphoma https://t.co/2G4UHL89Ip @FDAOncology #lymsm #hematology

Feb 9, 2021 · 1 like · 2 shares · 61,815 followers View post →
Eric K. Singhi, MD
@lungoncdoc · X

4/ Dr. An discussed the results of the TRANSCEND NHL 001 study evaluating the autologous CD19-directed CAR T-cell agent liso-cel that resulted in ⬆️ response rates in pts w/ R/R large B-cell lymphomas

Nov 24, 2020 · 1 like · 6,043 followers View post →
Levine Cancer
@LevineCancer · X

Our CAR T research lead to authorship (Nilanjan Ghosh, MD, PhD) on the TRASNCEND CAR T study published in Lancet (2020): https://t.co/GuBaHb0r0M #CARTCellLCI #lymsm #mmsm

Oct 29, 2020 · 1 like · 1,812 followers View post →

All mentions

Vladislav Sergeev
@DrVladSergeev · X

RT @michaelwangmd: The study by Jeremy Abramson et al showed Lisocabtagene maraleucel, an autologous, CD19-directed, CAR T-cell product for…

Oct 13, 2021 · 3 shares · 285 followers View post →
Anna Sureda
@AnnaSureda5 · X

RT @michaelwangmd: The study by Jeremy Abramson et al showed Lisocabtagene maraleucel, an autologous, CD19-directed, CAR T-cell product for…

Oct 12, 2021 · 3 shares · 5,180 followers View post →
Santhosh Ambika
@RenoHemonc · X

RT @michaelwangmd: The study by Jeremy Abramson et al showed Lisocabtagene maraleucel, an autologous, CD19-directed, CAR T-cell product for…

Oct 12, 2021 · 3 shares · 4,013 followers View post →
Michael Wang, MD
@michaelwangmd · X

The study by Jeremy Abramson et al showed Lisocabtagene maraleucel, an autologous, CD19-directed, CAR T-cell product for pts with R/R large B-cell lymphomas (TRANSCEND NHL 001). Of 256 pts included in efficacy-evaluable set, OR seen in 73% pts & CR in 53% https://t.co/Us6fHi1RFw

Oct 12, 2021 · 9 likes · 3 shares · 7,197 followers View post →
Leng Han
@lenghan_bioinfo · X

RT @michaelwangmd: In this multicenter study we participated in, lisocabtagene maraleucel in R/R large B-cell lymphoma pts resulted in a hi…

Jul 7, 2021 · 3 shares · 1,116 followers View post →
Hematology Media Center (HMC)
@US_HMC · X

RT @michaelwangmd: In this multicenter study we participated in, lisocabtagene maraleucel in R/R large B-cell lymphoma pts resulted in a hi…

Jul 7, 2021 · 3 shares · 269 followers View post →
Michael Wang, MD
@michaelwangmd · X

In this multicenter study we participated in, lisocabtagene maraleucel in R/R large B-cell lymphoma pts resulted in a high objective response rate and is currently used as a CAR T cell therapy for relapsed #mantlecelllymphoma in an ongoing clinical trial. https://t.co/Us6fHi1RFw

Jul 7, 2021 · 14 likes · 3 shares · 7,197 followers View post →
Vinay Prasad MD MPH
@VPrasadMDMPH · X

I was honored to have her on my show @Plenary_Session not just once https://t.co/qdsWibuKXc

May 27, 2021 · 8 likes · 312,475 followers View post →
Ginger Riley ~Eternal Optimist~
@gingerly21 · X

RT @ASCOPost: .@US_FDA Approves Lisocabtagene Maraleucel for Patients With Relapsed or Refractory Large B-Cell Lymphoma https://t.co/2G4UHL…

Feb 9, 2021 · 2 shares · 252 followers View post →
Emmanuele
@Biotech2050 · X

RT @ASCOPost: .@US_FDA Approves Lisocabtagene Maraleucel for Patients With Relapsed or Refractory Large B-Cell Lymphoma https://t.co/2G4UHL…

Feb 9, 2021 · 2 shares · 6,270 followers View post →
The ASCO Post
@ASCOPost · X

.@US_FDA Approves Lisocabtagene Maraleucel for Patients With Relapsed or Refractory Large B-Cell Lymphoma https://t.co/2G4UHL89Ip @FDAOncology #lymsm #hematology

Feb 9, 2021 · 1 like · 2 shares · 61,815 followers View post →
Mihaela Munteanu, EdD
@lymphomastudy · X

FDA Approves Lisocabtagene Maraleucel for Patients With Relapsed or Refractory Large B-Cell Lymphoma - The ASCO Post https://t.co/7Q0ya6acjw

Feb 9, 2021 · 84 followers View post →
Eric K. Singhi, MD
@lungoncdoc · X

4/ Dr. An discussed the results of the TRANSCEND NHL 001 study evaluating the autologous CD19-directed CAR T-cell agent liso-cel that resulted in ⬆️ response rates in pts w/ R/R large B-cell lymphomas

Nov 24, 2020 · 1 like · 6,043 followers View post →
Levine Cancer
@LevineCancer · X

Our CAR T research lead to authorship (Nilanjan Ghosh, MD, PhD) on the TRASNCEND CAR T study published in Lancet (2020): https://t.co/GuBaHb0r0M #CARTCellLCI #lymsm #mmsm

Oct 29, 2020 · 1 like · 1,812 followers View post →
Lymphoma Papers
@Lymphoma_Papers · X

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study. #lymphoma #lymsm https://t.co/18UN2hG9hS

Sep 7, 2020 · 2,449 followers View post →
Tom Cochrane
@cochranereviews · X

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas… https://t.co/7Wwec7IFh1

Sep 7, 2020 · 19 followers View post →
Paperbirds_Hematology
@PaperbirdsM · X

New article: Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study. https://t.co/SRVft1tQU8 #FL #lymsm #hematology https://t.co/pSLnIC7IHp

Sep 6, 2020 · 910 followers View post →