September 2020 PMID 32917884

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor.

Jinsung Yang, Simon J L Petitjean, Melanie Koehler, Qingrong Zhang, Andra C Dumitru, Wenzhang Chen, Sylvie Derclaye, Stéphane P Vincent, Patrice Soumillion, David Alsteens

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Mentions

25
Peak: 6 in Sep 2020
across 3 sources since May 2020

Extended reach

24,037
potential audience

Total likes

34

Video views

587

Mentions per month

May 2020 – Dec 2023

Where it's discussed

  • X / Twitter20 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

This collection of discussions collectively emphasizes the importance of the research, with posts praising its innovative methods like force spectroscopy and linking findings to broader COVID-19 treatment efforts, using tone and word choices to convey both excitement and recognition of its significance.

AgreementModerate agreement

Most discussions reflect support and recognition of the significance of the research, with comments calling it 'important work' and acknowledging its potential impact.

InterestHigh interest

The majority of posts demonstrate high interest, referencing the article repeatedly and discussing its implications for COVID-19 treatment and vaccine development.

EngagementModerate engagement

Several social discussions involve detailed mentions of the methods used, such as atomic force microscopy, and consider the potential for therapeutic applications, indicating active engagement.

ImpactHigh impact

Many posts highlight the potential influence of the research on future treatments, vaccine strategies, and scientific understanding of the virus-receptor interaction, showing a perception of high impact.

Abstract in brief

  • The study explores how the SARS-CoV-2 spike glycoprotein binds to the human ACE2 receptor, which is crucial for the virus to enter cells, using atomic force microscopy to analyze the interaction on both cell models and living cells.
  • It identifies the receptor binding domain (RBD) of the spike protein as the main interface for binding to ACE2 and details the kinetic and thermodynamic properties of this interaction.
  • The research also tests potential inhibitor peptides that could block the virus from attaching to host cells, providing insights for developing new treatments against COVID-19.]

Top posts

Most liked on X and Bluesky
Carsten Schulte
@CarstenSchulte4 · X

Very cool and important work on molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor studied by AFM force spectroscopy @nBIO_lab : https://t.co/wNmRfIBiC9 @scita_lab @MJ_Humphries @JDHL18 @IPFdoc @BakalLabICR @grosse_lab

May 27, 2020 · 10 likes · 1 share · 1,525 followers View post →
INDICASAT-AIP
@indicasat · X

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor | Nature Communications https://t.co/SWZ8rhHtZK

Sep 11, 2020 · 7 likes · 3 shares · 6,287 followers View post →
Bhai SHAHAB
@Sid_blue · X

Hello Ma'am @kiranshaw @Bioconlimited this pandemic is not going to stop like this with oxygen and ventilators. Came across an interesting article at NATURE COMMUNICATIONS | (2020) 11:4541 | https://t.co/qB5bTovRt0 | https://t.co/INOEhkjslT about ACE2 derived peptide inhibitors

Apr 24, 2021 · 1 like · 27 followers View post →
Gisli Jenkins
@IPFdoc · X

RT @CarstenSchulte4: Very cool and important work on molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor studie…

May 27, 2020 · 1 share · 4,728 followers View post →
NanoTrac Technologies
@nanotrac · X

Author Correction: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor Nanoscience and technology @NatureNano #Nanoscience #Technology this is #Nature https://t.co/imeic0a6zy

May 14, 2021 · 1 share · 3,068 followers View post →
Ivonne Torres-Atencio
@negrita73bn · X

RT @indicasat: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor | Nature Communications https://t.co/SWZ8rhH…

Sep 12, 2020 · 3 shares · 2,378 followers View post →

All mentions

Tanya Carmona Daniels
@tanycar · X

@CarmeloTallasT @DrAlfredoTorre1 @HectorRossete

Mar 13, 2023 · 636 followers View post →
John Thomas White
@Johnthomaswhit · X

Listen you fucks https://t.co/v3UufyRbtb

Jun 30, 2022 · 85 followers View post →
John Thomas White
@Johnthomaswhit · X

Read https://t.co/v3UufyRbtb

May 22, 2022 · 85 followers View post →
John Thomas White
@Johnthomaswhit · X

Read https://t.co/v3UufyRbtb

May 19, 2022 · 85 followers View post →
John Thomas White
@Johnthomaswhit · X

RT @Johnthomaswhit: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor - PubMed https://t.co/sOzRxLr6cT

May 19, 2022 · 1 share · 85 followers View post →
John Thomas White
@Johnthomaswhit · X

RT @Johnthomaswhit: @ChinaNews01 partner with John to make vaccine this also works for Covid 19 https://t.co/v3UufyRbtb

May 19, 2022 · 1 share · 85 followers View post →
John Thomas White
@Johnthomaswhit · X

@ChinaNews01 partner with John to make vaccine this also works for Covid 19 https://t.co/v3UufyRbtb

Mar 31, 2022 · 1 share · 85 followers View post →
John Thomas White
@Johnthomaswhit · X

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor - PubMed https://t.co/sOzRxLr6cT

Mar 28, 2022 · 1 share · 85 followers View post →
Gary Beane
@pollinus66 · X

RT @nanotrac: Author Correction: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor Nanoscience and technology…

May 14, 2021 · 1 share · 2,014 followers View post →
NanoTrac Technologies
@nanotrac · X

Author Correction: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor Nanoscience and technology @NatureNano #Nanoscience #Technology this is #Nature https://t.co/imeic0a6zy

May 14, 2021 · 1 share · 3,068 followers View post →
Bhai SHAHAB
@Sid_blue · X

Hello Ma'am @kiranshaw @Bioconlimited this pandemic is not going to stop like this with oxygen and ventilators. Came across an interesting article at NATURE COMMUNICATIONS | (2020) 11:4541 | https://t.co/qB5bTovRt0 | https://t.co/INOEhkjslT about ACE2 derived peptide inhibitors

Apr 24, 2021 · 1 like · 27 followers View post →
COVID-X Program
@TheCovidX · X

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor https://t.co/XjXD6TEksG Funding & tenders via @EU_Commission #COVID19 #DATAvCOVID #TheCovidX #GameOn https://t.co/InxqtuICEf

Feb 24, 2021 · 952 followers View post →
micropapers
@micro_papers · X

NC/ Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor. https://t.co/LnQvF5xFrn

Sep 13, 2020 · 331 followers View post →
NFTdose
@PaperbirdsH · X

New article: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor. https://t.co/69mET2xvt6 #coronavirus #COVID19 #2019ncov

Sep 13, 2020 · 301 followers View post →
Ivonne Torres-Atencio
@negrita73bn · X

RT @indicasat: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor | Nature Communications https://t.co/SWZ8rhH…

Sep 12, 2020 · 3 shares · 2,378 followers View post →
rao jagannatha
@kjr5n2009 · X

RT @indicasat: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor | Nature Communications https://t.co/SWZ8rhH…

Sep 12, 2020 · 3 shares · 220 followers View post →
MANO.nieto de Emilia españolaza.
@manobarria · X

RT @indicasat: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor | Nature Communications https://t.co/SWZ8rhH…

Sep 11, 2020 · 3 shares · 319 followers View post →
INDICASAT-AIP
@indicasat · X

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor | Nature Communications https://t.co/SWZ8rhHtZK

Sep 11, 2020 · 7 likes · 3 shares · 6,287 followers View post →
Gisli Jenkins
@IPFdoc · X

RT @CarstenSchulte4: Very cool and important work on molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor studie…

May 27, 2020 · 1 share · 4,728 followers View post →
Carsten Schulte
@CarstenSchulte4 · X

Very cool and important work on molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor studied by AFM force spectroscopy @nBIO_lab : https://t.co/wNmRfIBiC9 @scita_lab @MJ_Humphries @JDHL18 @IPFdoc @BakalLabICR @grosse_lab

May 27, 2020 · 10 likes · 1 share · 1,525 followers View post →
Fairweather Et Al 2023 Covid 19 Myocarditis and Pericarditis | PDF ...
News

2017;91:e01347–1417. doi: 10.1038/s41467-020-18319-6 47. Rodrigues M, Fan J, Lyon C, Wan M, Hu Y. Role of extracellular vesicles in 27. Bailey AL, Dmytrenko ...

Dec 14, 2025 View →
References | PDF | Nitric Oxide Synthase | Endothelium
News

doi:10.1038/s41467-020-18319-6 66. ACE2 angiotensin converting enzyme 2 [Homo sapiens (human)] - Gene - NCBI. Accessed September 28, 2021. https://www.ncbi ...

Dec 14, 2025 View →
Deciphering virus-host interactions using correlated confocal-atomic ...
News

DOI: 10.1038/s41467-021-22380-0. Stepwise Enzymatic-Dependent ... DOI: 10.1038/s41467-020-18319-6. Atomic force microscopy applied to ...

Dec 8, 2023 View →