Hippocampus January 2021 PMID 32946184

Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice.

Christine Cincotta, Nathen J Murawski, Stephanie L Grella, Olivia McKissick, Emily Doucette, Steve Ramirez

Mentions

18
Peak: 3 in Sep 2020
across 4 sources since Jul 2020

Extended reach

237,286
potential audience

Total likes

36

Video views

173

Mentions per month

Jul 2020 – Jul 2021

Where it's discussed

  • X / Twitter9 posts
  • News6 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions mainly focus on the promising potential of neurobiological research in addiction treatment, with remarks like 'Can memory manipulation help treat alcohol addiction?' and expressions of excitement such as 'my first first-author paper is officially published.' The tone is enthusiastic and supportive, highlighting curiosity and the significance of the findings, which indicates a high level of interest and perceived impact.

AgreementModerate agreement

Most discussions express positive recognition and support for the research findings, viewing the study as promising especially for potential treatments.

InterestHigh interest

Users are highly interested, as evidenced by enthusiasm about its implications and curiosity about applications, demonstrated by phrases like 'find out' and questions about potential treatments.

EngagementModerate engagement

The conversations show moderate engagement, with some users sharing personal reactions or emphasizing the significance of the work, but lacking in detailed analysis.

ImpactModerate impact

Overall, the discussions suggest the publication could have a meaningful impact, particularly in the fields of addiction and neuroscience, though some comments are more enthusiastic than profound.

Abstract in brief

  • The study investigates how alcohol exposure and withdrawal affect fear extinction processes in mice, showing that alcohol impairs the ability to extinguish fear memories.
  • Researchers used optogenetics to repeatedly activate specific neurons involved in fear memory, which led to a reduction in fear responses, mimicking extinction, even in alcohol-exposed mice.
  • The results suggest that manipulating fear-related brain circuits can overcome alcohol-induced deficits in fear extinction, providing potential insights into treating addiction-related memory issues.

Top posts

Most liked on X and Bluesky
Pavlovian Society
@PavlovSociety · X

What happens when you chronically activate fear engrams in ethanol-exposed mice⁉️ Check out this paper from @c_cincotta, @nathenmurawski, @S_Grella, Olivia McKissick, @eadouce, & @okaysteve to find out! #FearConditioningFriday https://t.co/IQc2M6fXrB

Jul 16, 2021 · 15 likes · 3 shares · 1,923 followers View post →
Mo Costandi
@mocost · X

Can memory manipulation help treat alcohol addiction? https://t.co/5Br5mT87oX Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice https://t.co/IjftcdbPgu by @c_cincotta @nathenmurawski @S_Grella @eadouce & @okaysteve https://t.co/dpJFMhr2aG

Nov 21, 2020 · 8 likes · 32,772 followers View post →
bioRxiv
@biorxivpreprint · X

Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice https://t.co/xYhIVJlMLe #bioRxiv

Jul 2, 2020 · 1 like · 137,963 followers View post →
bioRxiv Neuroscience
@biorxiv_neursci · X

Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice https://t.co/0ztMImugDv #biorxiv_neursci

Jul 2, 2020 · 1 like · 60,300 followers View post →
Heidi Meyer
@heidithmeyer · X

RT @PavlovSociety: What happens when you chronically activate fear engrams in ethanol-exposed mice⁉️ Check out this paper from @c_cincotta,…

Jul 16, 2021 · 3 shares · 1,669 followers View post →
Rosaura Brisuela @roswitta.bsky.social
@Roswitamind · X

RT @c_cincotta: !!!!! my first first-author paper is officially published brb crying !!!!! Time for some sappiness - this project taught m…

Sep 18, 2020 · 5 shares · 1,283 followers View post →

All mentions

Emily Doucette, MPH
@eadouce · X

RT @PavlovSociety: What happens when you chronically activate fear engrams in ethanol-exposed mice⁉️ Check out this paper from @c_cincotta,…

Jul 23, 2021 · 3 shares · 466 followers View post →
Heidi Meyer
@heidithmeyer · X

RT @PavlovSociety: What happens when you chronically activate fear engrams in ethanol-exposed mice⁉️ Check out this paper from @c_cincotta,…

Jul 16, 2021 · 3 shares · 1,669 followers View post →
Pavlovian Society
@PavlovSociety · X

What happens when you chronically activate fear engrams in ethanol-exposed mice⁉️ Check out this paper from @c_cincotta, @nathenmurawski, @S_Grella, Olivia McKissick, @eadouce, & @okaysteve to find out! #FearConditioningFriday https://t.co/IQc2M6fXrB

Jul 16, 2021 · 15 likes · 3 shares · 1,923 followers View post →
Mo Costandi
@mocost · X

Can memory manipulation help treat alcohol addiction? https://t.co/5Br5mT87oX Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice https://t.co/IjftcdbPgu by @c_cincotta @nathenmurawski @S_Grella @eadouce & @okaysteve https://t.co/dpJFMhr2aG

Nov 21, 2020 · 8 likes · 32,772 followers View post →
Rey Dube (they/them)
@NeuroShreya · X

RT @c_cincotta: !!!!! my first first-author paper is officially published brb crying !!!!! Time for some sappiness - this project taught m…

Sep 18, 2020 · 5 shares · 234 followers View post →
Rosaura Brisuela @roswitta.bsky.social
@Roswitamind · X

RT @c_cincotta: !!!!! my first first-author paper is officially published brb crying !!!!! Time for some sappiness - this project taught m…

Sep 18, 2020 · 5 shares · 1,283 followers View post →
Boolivia ☻
@chanelrhodopsin · X

RT @c_cincotta: !!!!! my first first-author paper is officially published brb crying !!!!! Time for some sappiness - this project taught m…

Sep 18, 2020 · 5 shares · 376 followers View post →
bioRxiv Neuroscience
@biorxiv_neursci · X

Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice https://t.co/0ztMImugDv #biorxiv_neursci

Jul 2, 2020 · 1 like · 60,300 followers View post →
bioRxiv
@biorxivpreprint · X

Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice https://t.co/xYhIVJlMLe #bioRxiv

Jul 2, 2020 · 1 like · 137,963 followers View post →
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