Neurogastroenterol Motil March 2021 PMID 32955166

Saccharomyces boulardii CNCM I-745 modulates the microbiota-gut-brain axis in a humanized mouse model of Irritable Bowel Syndrome.

Marco Constante, Giada De Palma, Jun Lu, Jennifer Jury, Liam Rondeau, Alberto Caminero, Stephen M Collins, Elena F Verdu, Premysl Bercik

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Mentions

46
Peak: 20 in Sep 2020
across 3 sources since Sep 2020

Extended reach

156,551
potential audience

Total likes

119

Video views

488

Mentions per month

Sep 2020 – Mar 2021

Where it's discussed

  • X / Twitter41 posts
  • Facebook4 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions exhibit a high level of interest and engagement, with users referencing specific mechanisms such as indole production and gut motility. They use impactful language like 'improves anxiety-like behavior' and 'modulates the microbiota-gut-brain axis,' emphasizing the significance of the study's findings in understanding and potentially treating IBS, which enhances the perceived high impact of the publication.

AgreementStrong agreement

Most posts strongly support the findings, highlighting the probiotic's potential for treating gut and behavioral symptoms, with enthusiastic phrases like 'makes mice symptoms normal again' and 'new findings show.'

InterestHigh interest

Discussions consistently demonstrate high curiosity, referencing specific details such as gut dysfunction, anxiety behaviors, and mechanisms like pain pathways, indicating active engagement with the scientific content.

EngagementHigh engagement

Several posts analyze or connect the study's implications by mentioning gut-brain axis, microbiota modulation, and potential therapeutic applications, reflecting deep understanding and thoughtful discussion.

ImpactHigh impact

The posts suggest that the research is perceived as highly influential, possibly shaping future treatments for IBS or influencing further studies, as evidenced by phrases like 'potential target in IBS' and 'new findings.'

Abstract in brief

  • Gnotobiotic mice using microbiota from IBS+A patients showed both gut dysfunction and anxiety-like behavior, contrasting with those receiving healthy microbiota.
  • A study tested the probiotic yeast Saccharomyces boulardii (S. bou) on these mice, examining its effects after daily administration for two weeks.
  • Results indicated that S. bou improved gastrointestinal motility and reduced anxiety-like behavior, suggesting mechanisms involving pain pathways, microbiota modulation, and increased indole production.

Top posts

Most liked on X and Bluesky
Miranda van Tilburg
@DrvanTilburg · X

Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysfunction and anxiety like behaviors. Introducing a yeast made mice symptoms normal again. @NGMJournal @RomeGastroPsych @IBS_Maastricht https://t.co/WB3yeLpjaB

Mar 23, 2021 · 34 likes · 9 shares · 18,424 followers View post →
GutMicrobiota Health
@GMFHx · X

The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharomyces boulardii strain CNCM I-745 improves gastrointestinal motility and anxiety-like behavior https://t.co/SR72OMDNwF

Oct 20, 2020 · 30 likes · 12 shares · 35,555 followers View post →
GutMicrobiota Health
@GMFHx · X

The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharomyces boulardii strain CNCM I-745 improves gastrointestinal motility and anxiety-like behavior https://t.co/xuTTqo18xE

Sep 27, 2020 · 21 likes · 12 shares · 35,555 followers View post →
Neurogastro & Motil
@NGMJournal · X

Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome https://t.co/zHxVY3DepQ

Sep 23, 2020 · 19 likes · 6 shares · 2,526 followers View post →
Neurogastro & Motil
@NGMJournal · X

Read related study @VerduLab which found S. boulardii CNCM I‐745 improves anxiety‐like behavior in #IBS #microbiota humanized mouse model through modulation of pain pathways & indole production @ANMSociety @esnm_eu @AlbertoCaminer7 @McMasterU https://t.co/DULvNyTDdD

Feb 27, 2021 · 12 likes · 4 shares · 2,526 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @DrvanTilburg: Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysf…

Mar 24, 2021 · 9 shares · 11,325 followers View post →

All mentions

Ashish Chogle
@ashish_chogle · X

RT @DrvanTilburg: Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysf…

Mar 24, 2021 · 9 shares · 469 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @DrvanTilburg: Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysf…

Mar 24, 2021 · 9 shares · 11,325 followers View post →
Debi Massey
@debimasseywm · X

RT @DrvanTilburg: Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysf…

Mar 23, 2021 · 9 shares · 890 followers View post →
Daniel Keszthelyi MD PhD RFF
@IBS_Maastricht · X

RT @DrvanTilburg: Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysf…

Mar 23, 2021 · 9 shares · 3,002 followers View post →
Cecelia I. Nelson, PhD
@ThatDocStudent · X

RT @DrvanTilburg: Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysf…

Mar 23, 2021 · 9 shares · 552 followers View post →
Dr K Wildschut OLD AGE Psychiatrist
@DrK_W1984 · X

RT @DrvanTilburg: Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysf…

Mar 23, 2021 · 9 shares · 3,044 followers View post →
Doctor_David
@Doctor_David · X

RT @DrvanTilburg: Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysf…

Mar 23, 2021 · 9 shares · 2,693 followers View post →
Miranda van Tilburg
@DrvanTilburg · X

Yes your feelings are in your gut. Mice who receive microbiota from #IBS patients with anxiety similarly develop gut dysfunction and anxiety like behaviors. Introducing a yeast made mice symptoms normal again. @NGMJournal @RomeGastroPsych @IBS_Maastricht https://t.co/WB3yeLpjaB

Mar 23, 2021 · 34 likes · 9 shares · 18,424 followers View post →
ESNM.eu
@esnm_eu · X

RT @NGMJournal: Read related study @VerduLab which found S. boulardii CNCM I‐745 improves anxiety‐like behavior in #IBS #microbiota humaniz…

Feb 28, 2021 · 4 shares · 2,097 followers View post →
ANMS
@ANMSociety · X

RT @NGMJournal: Read related study @VerduLab which found S. boulardii CNCM I‐745 improves anxiety‐like behavior in #IBS #microbiota humaniz…

Feb 28, 2021 · 4 shares · 3,118 followers View post →
Purna Kashyap M.B.B.S., AGAF
@KashyapPurna · X

RT @NGMJournal: Read related study @VerduLab which found S. boulardii CNCM I‐745 improves anxiety‐like behavior in #IBS #microbiota humaniz…

Feb 27, 2021 · 4 shares · 1,625 followers View post →
Neurogastro & Motil
@NGMJournal · X

Read related study @VerduLab which found S. boulardii CNCM I‐745 improves anxiety‐like behavior in #IBS #microbiota humanized mouse model through modulation of pain pathways & indole production @ANMSociety @esnm_eu @AlbertoCaminer7 @McMasterU https://t.co/DULvNyTDdD

Feb 27, 2021 · 12 likes · 4 shares · 2,526 followers View post →
Qian Yuan, MD, PhD
@QianYuanMD · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Oct 20, 2020 · 12 shares · 665 followers View post →
Alyce Martin
@alyce_martin · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Oct 20, 2020 · 12 shares · 532 followers View post →
Salesianos Argentina
@salesianoarg1 · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Oct 20, 2020 · 12 shares · 605 followers View post →
balance ur bod
@balanceurbod · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Oct 20, 2020 · 12 shares · 119 followers View post →
Yolanda Sanz
@YolandaSanz_Lab · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Oct 20, 2020 · 12 shares · 457 followers View post →
Cristina de la Mata
@Crisirenedlm · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Oct 20, 2020 · 12 shares · 289 followers View post →
Alberto Caminero
@AlbertoCaminer7 · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Oct 20, 2020 · 12 shares · 325 followers View post →
Benjamin Gold
@BenjamminGold · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Oct 20, 2020 · 12 shares · 2,067 followers View post →
GutMicrobiota Health
@GMFHx · X

The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharomyces boulardii strain CNCM I-745 improves gastrointestinal motility and anxiety-like behavior https://t.co/SR72OMDNwF

Oct 20, 2020 · 30 likes · 12 shares · 35,555 followers View post →
Salesianos Argentina
@salesianoarg1 · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 28, 2020 · 12 shares · 605 followers View post →
han_gmm
@gmm_han · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 28, 2020 · 12 shares · 10 followers View post →
Ashish Tomar
@mithyAtva · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 28, 2020 · 12 shares · 274 followers View post →
Sneha Surya Narayana Murthy
@MurthySneha · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 28, 2020 · 12 shares · 427 followers View post →
Benjamin Gold
@BenjamminGold · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 28, 2020 · 12 shares · 2,067 followers View post →
Alberto Caminero
@AlbertoCaminer7 · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 27, 2020 · 12 shares · 325 followers View post →
Hello Phyta
@hellophyta · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 27, 2020 · 12 shares · 16 followers View post →
Dawn Auletta ☕️
@DawnAuletta · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 27, 2020 · 12 shares · 3,378 followers View post →
TSD
@TSDWD · X

RT @GMFHx: The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharom…

Sep 27, 2020 · 12 shares · 45 followers View post →
GutMicrobiota Health
@GMFHx · X

The gut-brain axis is a potential target in the context of IBS. New findings in in a humanized mouse model of IBS show Saccharomyces boulardii strain CNCM I-745 improves gastrointestinal motility and anxiety-like behavior https://t.co/xuTTqo18xE

Sep 27, 2020 · 21 likes · 12 shares · 35,555 followers View post →
ESNM.eu
@esnm_eu · X

RT @NGMJournal: Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Sy…

Sep 25, 2020 · 6 shares · 2,097 followers View post →
Marita Ostos
@MaritaOstos · X

RT @NGMJournal: Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Sy…

Sep 24, 2020 · 6 shares · 159 followers View post →
Alberto Caminero
@AlbertoCaminer7 · X

RT @NGMJournal: Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Sy…

Sep 23, 2020 · 6 shares · 325 followers View post →
Purna Kashyap M.B.B.S., AGAF
@KashyapPurna · X

RT @NGMJournal: Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Sy…

Sep 23, 2020 · 6 shares · 1,625 followers View post →
UCCpsychiatry
@UCCpsychiatry · X

RT @NGMJournal: Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Sy…

Sep 23, 2020 · 6 shares · 3,522 followers View post →
ANMS
@ANMSociety · X

RT @NGMJournal: Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Sy…

Sep 23, 2020 · 6 shares · 3,118 followers View post →
Neurogastro & Motil
@NGMJournal · X

Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome https://t.co/zHxVY3DepQ

Sep 23, 2020 · 19 likes · 6 shares · 2,526 followers View post →
Tulika
@tulika2709 · X

Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome https://t.co/IfgscrPha8

Sep 22, 2020 · 633 followers View post →
Symbiosis papers
@Symbiosispapers · X

Saccharomyces boulardii CNCM I-745 modulates the microbiota-gut-brain axis in a humanized mouse model of Irritable Bowel Syndrome. https://t.co/9hroNH9jJa

Sep 22, 2020 · 1,108 followers View post →
Microbiome Articles
@microbe_article · X

Saccharomyces boulardii cncm i-745 modulates the microbiota-gut-brain axis in a humanized mouse model of irritable bowel syndrome... - Constante M et al. - https://t.co/CuXdxOSqHS #microbiome

Sep 22, 2020 · 7,154 followers View post →