September 2020 PMID 32977548

Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials.

Caitlyn Vlasschaert, Chloe J Goss, Nathan G Pilkey, Sandra McKeown, Rachel M Holden

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Mentions

42
Peak: 4 in Apr 2025
across 4 sources since Sep 2020

Extended reach

1,171,244
potential audience

Total likes

22,872

Video views

1,144,962

Mentions per month

Sep 2020 – Jan 2026

Where it's discussed

  • News28 articles
  • X / Twitter6 posts
  • YouTube6 videos
  • Facebook2 posts

AI synopsis

What people are saying

The collective discussions reflect a cautious attitude toward vitamin K supplementation, emphasizing the limited and mixed evidence, as seen in posts questioning the evidence quality and mentioning biological mechanisms like MGP inhibiting vascular calcification. The tone varies from clinical skepticism to mild curiosity, contributing to a balanced view of potential but unproven benefits.

AgreementNeither agree nor disagree

Posters display mixed opinions, with some expressing skepticism about the effectiveness of vitamin K supplementation and others acknowledging gaps in current evidence.

InterestModerate interest

Discussions show a moderate level of interest, especially when referencing mechanisms like MGP and the potential role of K2, but some posts focus on general caution.

EngagementModerate engagement

Comments involve brief references to study findings and biological mechanisms, indicating some level of engagement but lacking detailed analysis.

ImpactNeutral impact

While some posts highlight the uncertain evidence and need for further research, overall, there’s limited indication of immediate significant impact on clinical practice.

Abstract in brief

  • The systematic review analyzed nine controlled trials to assess if vitamin K supplementation can prevent or reduce cardiovascular disease markers like artery calcification, atherosclerosis, and artery stiffness.
  • The evidence shows that vitamin K does not consistently prevent the progression of vascular calcification or artery stiffening, although some benefit might exist for individuals already showing calcification.
  • Despite improving the activation of certain proteins like MGP, the current studies' mixed results and short follow-up periods mean the role of vitamin K in reducing vascular calcification remains uncertain.]

Top posts

Most liked on X and Bluesky
Caitlyn Vlasschaert
@DrFlashHeart · X

Vitamin K-dependent proteins like MGP inhibit vascular calcification. Many with CKD are vitamin K-deficient or on antagonists like warfarin. So, does replacing vitamin K improve CV outcomes? Out today: our systematic review of the evidence https://t.co/4CnjGGw5Ze @QueensuDOM

Sep 23, 2020 · 15 likes · 1 share · 3,264 followers View post →
Nick Krontiris
@nick_krontiris · X

Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials (open access) https://t.co/LybV45VTjU #VitaminK

Sep 29, 2020 · 4 likes · 19,087 followers View post →
FoodProfs.com - Ernährungswissen
@FoodProfsCom · X

@Heidi1905 Ja, den Unterschied gibt es. Es gibt auch Hinweise, dass K2 einer Gefäßverkalkung entgegenwirken könnte. Aber die Studienlage ist hier einfach noch unzureichend. Quellen dazu: 1) https://t.co/Xu8S2KLxy3 2) https://t.co/G68spXcGzo

Feb 22, 2021 · 1 like · 144 followers View post →
ZahcM
@ZahcM · X

@ric_lbaum I would just get it from food. That should be sufficient. Haven't seen any good quality evidence for supplementation so far. See this review - https://t.co/riPU0ACkVI

Nov 11, 2021 · 1,919 followers View post →
Arun Rajasekaran, MD, FACP, FASN, FNKF
@Nephronpower · X

RT @DrFlashHeart: Vitamin K-dependent proteins like MGP inhibit vascular calcification. Many with CKD are vitamin K-deficient or on antagon…

Sep 23, 2020 · 1 share · 1,420 followers View post →
itstomd
@itstomd · X

@Champignome2 @BrandonLuuMD it does not completely eliminate the risk of hypercalcemia, especially when high doses of calcium or vitamin D are consumed. Factors such as kidney function, magnesium levels, and overall mineral balance also significantly influence calcium regulation https://t.co/gTvGzZARZO

Feb 10, 2025 · 446 followers View post →

All mentions

itstomd
@itstomd · X

@Champignome2 @BrandonLuuMD it does not completely eliminate the risk of hypercalcemia, especially when high doses of calcium or vitamin D are consumed. Factors such as kidney function, magnesium levels, and overall mineral balance also significantly influence calcium regulation https://t.co/gTvGzZARZO

Feb 10, 2025 · 446 followers View post →
ZahcM
@ZahcM · X

@ric_lbaum I would just get it from food. That should be sufficient. Haven't seen any good quality evidence for supplementation so far. See this review - https://t.co/riPU0ACkVI

Nov 11, 2021 · 1,919 followers View post →
FoodProfs.com - Ernährungswissen
@FoodProfsCom · X

@Heidi1905 Ja, den Unterschied gibt es. Es gibt auch Hinweise, dass K2 einer Gefäßverkalkung entgegenwirken könnte. Aber die Studienlage ist hier einfach noch unzureichend. Quellen dazu: 1) https://t.co/Xu8S2KLxy3 2) https://t.co/G68spXcGzo

Feb 22, 2021 · 1 like · 144 followers View post →
Nick Krontiris
@nick_krontiris · X

Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials (open access) https://t.co/LybV45VTjU #VitaminK

Sep 29, 2020 · 4 likes · 19,087 followers View post →
Arun Rajasekaran, MD, FACP, FASN, FNKF
@Nephronpower · X

RT @DrFlashHeart: Vitamin K-dependent proteins like MGP inhibit vascular calcification. Many with CKD are vitamin K-deficient or on antagon…

Sep 23, 2020 · 1 share · 1,420 followers View post →
Caitlyn Vlasschaert
@DrFlashHeart · X

Vitamin K-dependent proteins like MGP inhibit vascular calcification. Many with CKD are vitamin K-deficient or on antagonists like warfarin. So, does replacing vitamin K improve CV outcomes? Out today: our systematic review of the evidence https://t.co/4CnjGGw5Ze @QueensuDOM

Sep 23, 2020 · 15 likes · 1 share · 3,264 followers View post →