Vitamin K-dependent proteins like MGP inhibit vascular calcification. Many with CKD are vitamin K-deficient or on antagonists like warfarin. So, does replacing vitamin K improve CV outcomes? Out today: our systematic review of the evidence https://t.co/4CnjGGw5Ze @QueensuDOM
Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials.
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Sep 2020 – Jan 2026Where it's discussed
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News28 articles
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X / Twitter6 posts
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YouTube6 videos
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Facebook2 posts
AI synopsis
What people are saying
The collective discussions reflect a cautious attitude toward vitamin K supplementation, emphasizing the limited and mixed evidence, as seen in posts questioning the evidence quality and mentioning biological mechanisms like MGP inhibiting vascular calcification. The tone varies from clinical skepticism to mild curiosity, contributing to a balanced view of potential but unproven benefits.
Posters display mixed opinions, with some expressing skepticism about the effectiveness of vitamin K supplementation and others acknowledging gaps in current evidence.
Discussions show a moderate level of interest, especially when referencing mechanisms like MGP and the potential role of K2, but some posts focus on general caution.
Comments involve brief references to study findings and biological mechanisms, indicating some level of engagement but lacking detailed analysis.
While some posts highlight the uncertain evidence and need for further research, overall, there’s limited indication of immediate significant impact on clinical practice.
Abstract in brief
- The systematic review analyzed nine controlled trials to assess if vitamin K supplementation can prevent or reduce cardiovascular disease markers like artery calcification, atherosclerosis, and artery stiffness.
- The evidence shows that vitamin K does not consistently prevent the progression of vascular calcification or artery stiffening, although some benefit might exist for individuals already showing calcification.
- Despite improving the activation of certain proteins like MGP, the current studies' mixed results and short follow-up periods mean the role of vitamin K in reducing vascular calcification remains uncertain.]
Top posts
Most liked on X and BlueskyVitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials (open access) https://t.co/LybV45VTjU #VitaminK
@Heidi1905 Ja, den Unterschied gibt es. Es gibt auch Hinweise, dass K2 einer Gefäßverkalkung entgegenwirken könnte. Aber die Studienlage ist hier einfach noch unzureichend. Quellen dazu: 1) https://t.co/Xu8S2KLxy3 2) https://t.co/G68spXcGzo
@ric_lbaum I would just get it from food. That should be sufficient. Haven't seen any good quality evidence for supplementation so far. See this review - https://t.co/riPU0ACkVI
RT @DrFlashHeart: Vitamin K-dependent proteins like MGP inhibit vascular calcification. Many with CKD are vitamin K-deficient or on antagon…
@Champignome2 @BrandonLuuMD it does not completely eliminate the risk of hypercalcemia, especially when high doses of calcium or vitamin D are consumed. Factors such as kidney function, magnesium levels, and overall mineral balance also significantly influence calcium regulation https://t.co/gTvGzZARZO
All mentions
Vitamin K2 and Vascular Calcification in Hemodialysis Patients
This study examined whether vitamin K2 supplementation could slow vascular calcification in hemodialysis patients. After 18 months, there was no significant reduction in coronary artery calcification or other…
The Effectiveness of Daily Vitamin K2 on Vascular Calcification
Vitamin K2 has numerous health benefits, especially its impact on blood vessels. Studies show K2 MK7 may halt artery calcification, but a recent trial found no significant benefit in reducing vascular calcification in…
Vitamin K2 and Vascular Calcification in Hemodialysis Patients
This study examined whether vitamin K2 supplementation can reduce vascular calcification in hemodialysis patients. After 18 months, no significant differences in coronary artery calcification or cardiac outcomes were…
Vitamin K2 and Vascular Calcification in Hemodialysis Patients
This video discusses a clinical trial examining the effect of vitamin K2 supplementation on vascular calcification in hemodialysis patients. Despite reducing markers of deficiency, it did not significantly impact…
Vitamin K2 and Vascular Calcification in Hemodialysis Patients
This study examined whether vitamin K2 supplementation could slow vascular calcification in hemodialysis patients. Results showed no significant reduction in calcification scores or major cardiac events after 18 months…
Calcium Supplements and Heart Health Risks Explained
This video discusses the potential risks of calcium supplements for your heart, highlighting recent studies showing an association with increased coronary artery calcification and implications for cardiovascular health.
Calcium Supplementation Risks and Benefits Explained
Calcium is vital for health, especially in preventing osteoporosis. However, high calcium intake can pose significant risks such as cardiovascular issues. This video discusses the importance of managing calcium…
@Champignome2 @BrandonLuuMD it does not completely eliminate the risk of hypercalcemia, especially when high doses of calcium or vitamin D are consumed. Factors such as kidney function, magnesium levels, and overall mineral balance also significantly influence calcium regulation https://t.co/gTvGzZARZO
@ric_lbaum I would just get it from food. That should be sufficient. Haven't seen any good quality evidence for supplementation so far. See this review - https://t.co/riPU0ACkVI
@Heidi1905 Ja, den Unterschied gibt es. Es gibt auch Hinweise, dass K2 einer Gefäßverkalkung entgegenwirken könnte. Aber die Studienlage ist hier einfach noch unzureichend. Quellen dazu: 1) https://t.co/Xu8S2KLxy3 2) https://t.co/G68spXcGzo
Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials (open access) https://t.co/LybV45VTjU #VitaminK
RT @DrFlashHeart: Vitamin K-dependent proteins like MGP inhibit vascular calcification. Many with CKD are vitamin K-deficient or on antagon…
Vitamin K-dependent proteins like MGP inhibit vascular calcification. Many with CKD are vitamin K-deficient or on antagonists like warfarin. So, does replacing vitamin K improve CV outcomes? Out today: our systematic review of the evidence https://t.co/4CnjGGw5Ze @QueensuDOM