Acta Crystallogr D Struct Biol October 2020 PMID 33021501

The crystal structure of the tetrameric human vasohibin-1-SVBP complex reveals a variable arm region within the structural core.

Akihito Ikeda, Seia Urata, Tadashi Ando, Yasuhiro Suzuki, Yasufumi Sato, Tatsuya Nishino

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Peak: 2 in Apr 2021

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The group's discussions highlight key aspects like the discovery of a variable arm region in the structure, with phrases such as 'reveals a variable arm region' and references to structural insights, showing appreciation for the detailed findings. The tone is neutral and informative, indicating an overall acknowledgment of the research's scientific value without overly enthusiastic or dismissive sentiments.

AgreementModerate agreement

The posts acknowledge the significance of the structural findings, suggesting a general support or recognition of its importance in the field.

InterestModerate interest

The discussions reflect moderate curiosity, primarily focusing on the structural details and their implications.

EngagementNeutral engagement

Compared to deeper scientific discussions, most posts are brief and mainly share the publication without extensive analysis.

ImpactModerate impact

While the structure appears to be noteworthy for specialists, the overall perceived impact on broader biomedical fields seems modest.

Abstract in brief

Vasohibins play a crucial role in regulating processes like angiogenesis, tumor growth, and neuronal differentiation through their interaction with the small vasohibin-binding protein (SVBP).
Recent studies, including crystal structure determinations, have revealed insights into the complex's formation and function, but the regulatory mechanisms remain unclear.
This research specifically highlights the discovery of a novel domain-swapped heterotetramer structure that may influence enzyme activity due to the stabilization provided by conserved residues and differences in molecular dynamics compared to simpler structures.

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All mentions

Structure and Function of Human Vasohibin1-SVBP Complex Revealed by Crystal Analysis

The crystal structure of the tetrameric human vasohibin1SVBP complex reveals a variable arm region within the structural core. Vasohibins regulate processes like angiogenesis, tumor growth, and neuronal differentiation…

International Union of Crystallography · Apr 15, 2021 38 views

Structural Insights into Human Vasohibin-1 and SVBP Complex

The crystal structure of the human vasohibin-1-SVBP complex reveals a domain-swapped heterotetramer. Vasohibins regulate angiogenesis, tumor growth, and neuronal differentiation. This study offers new insights into…

International Union of Crystallography · Apr 15, 2021 27 views

African Synchrotron

@AfSynchrotron · X

The crystal structure of the tetrameric human vasohibin-1–SVBP complex reveals a variable arm region within the structural core https://t.co/tJojql3IYS via @ActaCrystD https://t.co/41OvQrjNIo

Oct 1, 2020 · 2,923 followers View post →

Structural Biology

@ActaCrystD · X

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