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Nat Commun October 2020 PMID 33024120

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study).

Yifei Zhang, Yanyun Gu, Huahui Ren, Shujie Wang, Huanzi Zhong, Xinjie Zhao, Jing Ma, Xuejiang Gu, Yaoming Xue, Shan Huang, Jialin Yang, Li Chen, Gang Chen, Shen Qu, Jun Liang

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Mentions

19
Peak: 9 in Oct 2020
across 3 sources since Oct 2020

Extended reach

27,605
potential audience

Total likes

54

Video views

1,620

Mentions per month

Oct 2020 – Oct 2023

Where it's discussed

  • X / Twitter12 posts
  • News5 articles
  • YouTube2 videos

AI synopsis

What people are saying

The posts collectively indicate a balanced curiosity about the research's findings, with some posts referencing the microbial mechanisms involved, such as the inhibition of Ruminococcus bromii, and others sharing personal experiences with berberine’s gastrointestinal effects. The tone varies from scientific to cautious, illustrating both interest and skepticism about the implications of the study.

AgreementModerate agreement

Most discussions acknowledge the positive findings about berberine and probiotics improving blood sugar control, suggesting general support for the study's results.

InterestModerate interest

Participants show moderate interest, with some expressing caution or personal experiences, but many focus on the therapeutic potential.

EngagementModerate engagement

Posts include scientific references, personalized opinions, and cautions about dosage, indicating a reasonably deep engagement with the material.

ImpactModerate impact

The discussions reflect recognition of the study's significance in understanding microbial influences on diabetes management, highlighting its potential importance for future treatments.

Abstract in brief

  • This study explored how gut microbiota, probiotics, and berberine (BBR) can help manage type 2 diabetes (T2D), showing that BBR can significantly improve blood sugar control and acts through microbial changes in the gut.
  • A 12-week clinical trial with 409 newly diagnosed T2D patients found BBR and probiotics to be more effective than placebo in reducing glycated hemoglobin levels, although BBR also caused more gastrointestinal side effects.
  • The research identified that BBR’s blood sugar-lowering effects are linked to its ability to inhibit a gut bacterium, Ruminococcus bromii, which affects the transformation of certain compounds, revealing a microbial mechanism behind its anti-diabetic action.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Ciara Wright PhD, Positive Nutrition
@CiaraGlenville · X

@emmiskyten @Fighting_LC Just be cautious with dose on berberine, it’s a strong anti microbial so can cause herx and at high levels could reduce good bacteria/ be a bit too strong. It’s tricky as the dose comparing it to metf (for sugar control) is quite high https://t.co/Cxkfx71TZG

Jul 28, 2023 · 3 likes · 3,042 followers View post →
Steven M. Weil
@smweilhermes · X

@HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @shashiiyengar @Mindzatwork @Grimhood @DrPalmquist @heniek_htw Berberine adversely effects my bowel function Nat Commun, 2020 vol. 11(1) p. 5015 Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) Zhang, Y; Gu, Y; Ren, H; Wang, S; Zhong, H; Zhao, X; Ma, J; Gu, X; Xue, Y; Huang, S; Yang,

Sep 12, 2023 · 3 likes · 302 followers View post →
SEMiPYP
@SEMiPYP · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) by Yifei Zhang et al. ⤵️ https://t.co/B2jdd8gSXB @NatureComms #microbiota #microbiome #probiotics #T2D #Diabetes https://t.co/OwKn6yRHux

Oct 14, 2020 · 2 likes · 2 shares · 1,587 followers View post →
Metagenomics Papers
@metagenomic_lit · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). https://t.co/jKyAyoGPwV

Oct 8, 2020 · 1 like · 3,692 followers View post →
OccuWorld
@OccuWorld · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes. https://t.co/rXStUBwFy8

Oct 31, 2020 · 8,737 followers View post →
Rocky Mtn Naturals
@RkyMtnNaturals · X

RT @SEMiPYP: Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) by Yifei Zhang et al. ⤵️ htt…

Oct 14, 2020 · 2 shares · 5,184 followers View post →

All mentions

Steven M. Weil
@smweilhermes · X

@HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @shashiiyengar @Mindzatwork @Grimhood @DrPalmquist @heniek_htw Berberine adversely effects my bowel function Nat Commun, 2020 vol. 11(1) p. 5015 Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) Zhang, Y; Gu, Y; Ren, H; Wang, S; Zhong, H; Zhao, X; Ma, J; Gu, X; Xue, Y; Huang, S; Yang,

Sep 12, 2023 · 3 likes · 302 followers View post →
Ciara Wright PhD, Positive Nutrition
@CiaraGlenville · X

@emmiskyten @Fighting_LC Just be cautious with dose on berberine, it’s a strong anti microbial so can cause herx and at high levels could reduce good bacteria/ be a bit too strong. It’s tricky as the dose comparing it to metf (for sugar control) is quite high https://t.co/Cxkfx71TZG

Jul 28, 2023 · 3 likes · 3,042 followers View post →
市川俊輔　Shunsuke Ichikawa
@Shunsuke_chon · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) https://t.co/XRNzQXohZd

Nov 26, 2020 · 184 followers View post →
OccuWorld
@OccuWorld · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes. https://t.co/rXStUBwFy8

Oct 31, 2020 · 8,737 followers View post →
SEMiPYP
@SEMiPYP · X

RT @SEMiPYP: Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) by Yifei Zhang et al. ⤵️ htt…

Oct 14, 2020 · 2 shares · 1,587 followers View post →
Rocky Mtn Naturals
@RkyMtnNaturals · X

RT @SEMiPYP: Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) by Yifei Zhang et al. ⤵️ htt…

Oct 14, 2020 · 2 shares · 5,184 followers View post →
SEMiPYP
@SEMiPYP · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) by Yifei Zhang et al. ⤵️ https://t.co/B2jdd8gSXB @NatureComms #microbiota #microbiome #probiotics #T2D #Diabetes https://t.co/OwKn6yRHux

Oct 14, 2020 · 2 likes · 2 shares · 1,587 followers View post →
Metagenomics Papers
@metagenomic_lit · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). https://t.co/jKyAyoGPwV

Oct 8, 2020 · 1 like · 3,692 followers View post →
micropapers
@micro_papers · X

NC/ Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). https://t.co/LTas3PEmi9

Oct 8, 2020 · 331 followers View post →
Symbiosis papers
@Symbiosispapers · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). https://t.co/5hOPNz8owe

Oct 8, 2020 · 1,108 followers View post →
maxkrish
@hscelebrities · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) https://t.co/SyfcjqVIhQ

Oct 6, 2020 · 110 followers View post →
maxkrish
@hscelebrities · X

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) https://t.co/3hvA2FMnV7

Oct 6, 2020 · 110 followers View post →