ACS Nano November 2020 PMID 33034446

Microfluidic Cell Stretching for Highly Effective Gene Delivery into Hard-to-Transfect Primary Cells.

Jeongsoo Hur, Inae Park, Kyung Min Lim, Junsang Doh, Ssang-Goo Cho, Aram J Chung

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Mentions

19
Peak: 13 in Oct 2020
across 3 sources since Oct 2020

Extended reach

65,001
potential audience

Total likes

43

Video views

174

Mentions per month

Oct 2020 – Nov 2020

Where it's discussed

  • X / Twitter14 posts
  • YouTube3 videos
  • News2 articles

AI synopsis

What people are saying

The discussions emphasize the innovative microfluidic method for gene delivery, highlighting its high efficiency and practical advantages such as low cost and rapid operation. Words like 'highly effective,' 'superior,' and 'achievement' reflect strong positive sentiment and recognition of potential impact, while technical references indicate substantial engagement with the research specifics.

AgreementModerate agreement

Most discussions express positive support and approval of the article’s findings, indicating general agreement with its significance.

InterestHigh interest

The discussions demonstrate high interest through mentions of specific techniques, high efficiency, and technological innovation.

EngagementModerate engagement

Posts reference technical details like microfluidic flow patterns and cell stretching, showing moderate to deep engagement with the research methods.

ImpactHigh impact

The emphasis on high delivery efficiency, cost-effectiveness, and potential for advancements suggests that the discussion sees this work as impactful and influential.

Abstract in brief

  • Cell therapy and cellular engineering traditionally rely on methods like electroporation or viral transduction for internalizing materials into primary cells, but these methods have limitations such as high toxicity and complexity.
  • A new intracellular delivery platform using inertial flow in a T-junction microchannel effectively stretches cells, allowing various nanomaterials (like plasmid DNA and nanoparticles) to be internalized into difficult-to-transfect cells.
  • This innovative method shows up to 98% delivery efficiency, is cost-effective (less than $1), operates at high speed (1 million cells per minute), and minimizes disruption to cells, promising significant advancements in cell-based research.

Top posts

Most liked on X and Bluesky
ACS Nano
@acsnano · X

High speed microscopy video showing a method to elongate cells by rapid flow through a microfluidic chamber toward a cavity. https://t.co/EddFnwINXW by Aram J. Chung @ac467 Korea University /CJD https://t.co/PnXQ4MXwg2

Oct 12, 2020 · 15 likes · 5 shares · 42,310 followers View post →
uFluidix Inc.
@uFluidix · X

In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfection yield and delivery efficiency (up to 98%) which is superior to many of the current technologies. https://t.co/O3ggrbfxPT #genedelivery

Oct 14, 2020 · 11 likes · 6 shares · 4,480 followers View post →
Aram Chung
@ac467 · X

It turned out well :) #acsnano #intracellulardelivery #transfection #genedelivery #microfluidics @acsnano https://t.co/Nu3zVNaTx5 https://t.co/PGIGM4XMWa

Nov 24, 2020 · 11 likes · 2 shares · 243 followers View post →
FindLight
@FindLightInc · X

RT @uFluidix: In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfectio…

Nov 5, 2020 · 6 shares · 8,658 followers View post →
Gary Beane
@pollinus66 · X

RT @ac467: It turned out well :) #acsnano #intracellulardelivery #transfection #genedelivery #microfluidics @acsnano https://t.co/Nu3zVNaT…

Nov 24, 2020 · 2 shares · 2,027 followers View post →
Gary Beane
@pollinus66 · X

RT @uFluidix: In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfectio…

Oct 14, 2020 · 6 shares · 2,027 followers View post →

All mentions

Amos Chungwon Lee
@ChoongwonLee · X

RT @ac467: It turned out well :) #acsnano #intracellulardelivery #transfection #genedelivery #microfluidics @acsnano https://t.co/Nu3zVNaT…

Nov 24, 2020 · 2 shares · 1,381 followers View post →
Gary Beane
@pollinus66 · X

RT @ac467: It turned out well :) #acsnano #intracellulardelivery #transfection #genedelivery #microfluidics @acsnano https://t.co/Nu3zVNaT…

Nov 24, 2020 · 2 shares · 2,027 followers View post →
Aram Chung
@ac467 · X

It turned out well :) #acsnano #intracellulardelivery #transfection #genedelivery #microfluidics @acsnano https://t.co/Nu3zVNaTx5 https://t.co/PGIGM4XMWa

Nov 24, 2020 · 11 likes · 2 shares · 243 followers View post →
FindLight
@FindLightInc · X

RT @uFluidix: In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfectio…

Nov 5, 2020 · 6 shares · 8,658 followers View post →
Qwoook
@Qwoook3 · X

RT @uFluidix: In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfectio…

Oct 15, 2020 · 6 shares · 57 followers View post →
Carola Romani
@romani_carola · X

RT @uFluidix: In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfectio…

Oct 15, 2020 · 6 shares · 82 followers View post →
Lucien Weiss
@LucienWeissLab · X

RT @uFluidix: In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfectio…

Oct 15, 2020 · 6 shares · 424 followers View post →
Gary Beane
@pollinus66 · X

RT @uFluidix: In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfectio…

Oct 14, 2020 · 6 shares · 2,027 followers View post →
Aram Chung
@ac467 · X

RT @uFluidix: In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfectio…

Oct 14, 2020 · 6 shares · 243 followers View post →
uFluidix Inc.
@uFluidix · X

In this recent article, the flow patterns in a #microfluidic T-junction #microchannel are used to achieve a high #transfection yield and delivery efficiency (up to 98%) which is superior to many of the current technologies. https://t.co/O3ggrbfxPT #genedelivery

Oct 14, 2020 · 11 likes · 6 shares · 4,480 followers View post →
SF - Advanced Technologies
@SolfluorI · X

RT @acsnano: High speed microscopy video showing a method to elongate cells by rapid flow through a microfluidic chamber toward a cavity. h…

Oct 12, 2020 · 5 shares · 194 followers View post →
ACS Nano
@acsnano · X

High speed microscopy video showing a method to elongate cells by rapid flow through a microfluidic chamber toward a cavity. https://t.co/EddFnwINXW by Aram J. Chung @ac467 Korea University /CJD https://t.co/PnXQ4MXwg2

Oct 12, 2020 · 15 likes · 5 shares · 42,310 followers View post →
MyJournals
@myjournals · X

[ASAP] Microfluidic Cell Stretching for Highly Effective Gene Delivery into Hard-to-Transfect Primary Cells https://t.co/0Sb8QeemNY

Oct 9, 2020 · 557 followers View post →
Gary Beane
@pollinus66 · X

RT @ac467: Our work on microfluidic gene delivery into hard-to-transfect primary cells published in @acsnano! https://t.co/NGVwIWTRHb

Oct 9, 2020 · 1 share · 2,027 followers View post →