PubHawk
Structure December 2020 PMID 33035450

Vaccinia Virus Immunomodulator A46: Destructive Interactions with MAL and MyD88 Shown by Negative-Stain Electron Microscopy.

Daniel F Azar, Meryl Haas, Sofiya Fedosyuk, Md Habibur Rahaman, Andrew Hedger, Bostjan Kobe, Tim Skern

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Mentions

7
Peak: 3 in Oct 2020
across 2 sources since Oct 2020

Extended reach

22,422
potential audience

Total likes

15

Video views

219

Mentions per month

Oct 2020 – Jan 2021

Where it's discussed

  • X / Twitter6 posts
  • YouTube1 videos

AI synopsis

What people are saying

Several discussions praise the detailed structural observations, such as the visualization of A46 interactions with MAL and MyD88, describing the findings as 'groundbreaking' and highlighting the visual evidence from negative-stain electron microscopy. The tone combines enthusiasm with a recognition of the study's contribution to understanding viral immune interference, reflecting a positive outlook on its scientific significance.

AgreementModerate agreement

Most discussions express support or interest in the significance of the research, acknowledging its contributions to understanding viral immune evasion.

InterestHigh interest

Posts highlight curiosity and enthusiasm about the findings, especially emphasizing the visual evidence from microscopy and the implications for virus-host interactions.

EngagementModerate engagement

Participants reference the methods used, such as electron microscopy, and suggest the research advances structural biology and immunology fields, showing moderate engagement.

ImpactModerate impact

The posts imply that the study's findings could influence future research directions or antiviral strategies, indicating a noteworthy but not transformative impact.

Abstract in brief

  • Vaccinia virus A46 is a viral protein that inhibits immune responses by interacting with key adaptor proteins (MAL and MyD88) involved in Toll-like receptor signaling.
  • Using negative stain electron microscopy, researchers observed that A46 can disassemble the filamentous structures formed by MAL and MyD88 in a concentration-dependent way.
  • The study identified specific interaction points on A46, particularly on helices 1 and 7 and its C-terminal region, proposing that A46 disrupts immune signaling complexes by targeting their assemblies.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Structure
@Structure_CP · X

Online now! Vaccinia #virus immunomodulator A46: Destructive interactions with MAL and MyD88 shown by negative-stain EM. https://t.co/t5nj42phTA

Oct 8, 2020 · 5 likes · 3 shares · 6,681 followers View post →
Max Perutz Labs Vienna
@MaxPerutzLabs · X

"Science Flash" Video by Daniel Azar about the Skern Lab's latest publication in @Structure_CP - Part of the recent Life Science Tuesday "Structure to Function" by #ögmbt ➡️ https://t.co/rPvOcvFIR6 Check out the paper here: https://t.co/P9QfGA100N

Nov 18, 2020 · 4 likes · 2 shares · 4,618 followers View post →
Vienna BioCenter
@viennabiocenter · X

RT @MaxPerutzLabs: "Science Flash" Video by Daniel Azar about the Skern Lab's latest publication in @Structure_CP - Part of the recent Life…

Nov 18, 2020 · 2 shares · 9,243 followers View post →
Claire Phillips
@DocClaireP · X

RT @Structure_CP: Online now! Vaccinia #virus immunomodulator A46: Destructive interactions with MAL and MyD88 shown by negative-stain EM.…

Oct 8, 2020 · 3 shares · 850 followers View post →
Amal_Hassan
@amalscicomm · X

RT @Structure_CP: Online now! Vaccinia #virus immunomodulator A46: Destructive interactions with MAL and MyD88 shown by negative-stain EM.…

Oct 11, 2020 · 3 shares · 471 followers View post →
Daniel F. Azar
@Daniel_F_Azar · X

RT @Structure_CP: Online now! Vaccinia #virus immunomodulator A46: Destructive interactions with MAL and MyD88 shown by negative-stain EM.…

Jan 6, 2021 · 3 shares · 308 followers View post →

All mentions

Daniel F. Azar
@Daniel_F_Azar · X

RT @Structure_CP: Online now! Vaccinia #virus immunomodulator A46: Destructive interactions with MAL and MyD88 shown by negative-stain EM.…

Jan 6, 2021 · 3 shares · 308 followers View post →
Vienna BioCenter
@viennabiocenter · X

RT @MaxPerutzLabs: "Science Flash" Video by Daniel Azar about the Skern Lab's latest publication in @Structure_CP - Part of the recent Life…

Nov 18, 2020 · 2 shares · 9,243 followers View post →
Max Perutz Labs Vienna
@MaxPerutzLabs · X

"Science Flash" Video by Daniel Azar about the Skern Lab's latest publication in @Structure_CP - Part of the recent Life Science Tuesday "Structure to Function" by #ögmbt ➡️ https://t.co/rPvOcvFIR6 Check out the paper here: https://t.co/P9QfGA100N

Nov 18, 2020 · 4 likes · 2 shares · 4,618 followers View post →
Amal_Hassan
@amalscicomm · X

RT @Structure_CP: Online now! Vaccinia #virus immunomodulator A46: Destructive interactions with MAL and MyD88 shown by negative-stain EM.…

Oct 11, 2020 · 3 shares · 471 followers View post →
Claire Phillips
@DocClaireP · X

RT @Structure_CP: Online now! Vaccinia #virus immunomodulator A46: Destructive interactions with MAL and MyD88 shown by negative-stain EM.…

Oct 8, 2020 · 3 shares · 850 followers View post →
Structure
@Structure_CP · X

Online now! Vaccinia #virus immunomodulator A46: Destructive interactions with MAL and MyD88 shown by negative-stain EM. https://t.co/t5nj42phTA

Oct 8, 2020 · 5 likes · 3 shares · 6,681 followers View post →