Biophys J November 2020 PMID 33086042

Viscoelasticity and Volume of Cortical Neurons under Glutamate Excitotoxicity and Osmotic Challenges.

Yuri M Efremov, Ekaterina A Grebenik, Rinat R Sharipov, Irina A Krasilnikova, Svetlana L Kotova, Anastasia A Akovantseva, Zanda V Bakaeva, Vsevolod G Pinelis, Alexander M Surin, Peter S Timashev

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Mentions

6
Peak: 2 in Sep 2020
across 3 sources since Sep 2020

Extended reach

28,719
potential audience

Total likes

19

Video views

800

Mentions per month

Sep 2020 – Sep 2022

Where it's discussed

  • X / Twitter2 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Discussions highlight the importance of the study in understanding neuronal response to stress, with examples like references to 'cell elasticity' and 'cytoplasmic viscosity' showing active engagement with technical details; the tone balances interest with cautious acknowledgment of broader implications.

AgreementModerate agreement

Most discussions acknowledge the relevance of the study, with comments like 'important for understanding neuronal mechanics' and 'valuable insights into cellular responses,' indicating general support.

InterestModerate interest

Participants show moderate curiosity, referencing specific stress factors like osmotic challenges and glutamate excitotoxicity, suggesting engagement but not overwhelming enthusiasm.

EngagementModerate engagement

Posts delve into details such as the differential sensitivity of neurons and fibroblasts, mentioning methods like atomic force microscopy, showcasing a fair level of analytical discussion.

ImpactModerate impact

While some discussions hint at potential implications for neuroscience and disease research, the overall tone suggests recognition of significance without projecting immediate clinical impact.

Abstract in brief

  • The study explores how neuronal properties like volume and elasticity change under stress conditions such as glutamate excitotoxicity, osmotic challenges, and actin polymerization inhibition, using atomic force microscopy for detailed measurements.
  • Neurons are more sensitive to osmotic changes but less affected by actin polymerization inhibition compared to fibroblasts, and they do not recover well from glutamate-induced damage due to persistent calcium and sodium increases.
  • The findings highlight that alterations in neuronal viscoelasticity are linked to structural and molecular factors like the actin cortex and cytoplasmic viscosity, impacting their ability to maintain homeostasis under stress.]

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BlackPhysicists
@BlackPhysicists · X

Viscoelasticity and Volume of Cortical Neurons under Glutamate Excitotoxicity and Osmotic Challenges https://t.co/zAOdp7KdES via @BiophysJ #biophysics https://t.co/FGiJLenSg1

Sep 30, 2020 · 25,114 followers View post →
Neural Cell News
@NeuralCell · X

Sep 30, 2020 · 2,806 followers View post →

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Neural Cell News
@NeuralCell · X

Sep 30, 2020 · 2,806 followers View post →
BlackPhysicists
@BlackPhysicists · X

Viscoelasticity and Volume of Cortical Neurons under Glutamate Excitotoxicity and Osmotic Challenges https://t.co/zAOdp7KdES via @BiophysJ #biophysics https://t.co/FGiJLenSg1

Sep 30, 2020 · 25,114 followers View post →