October 2020 PMID 33097048

The peri-menopause in a woman's life: a systemic inflammatory phase that enables later neurodegenerative disease.

Micheline McCarthy, Ami P Raval

Mentions

85
Peak: 15 in May 2022
across 4 sources since Oct 2020

Extended reach

301,550
potential audience

Total likes

1,292

Video views

56,436

Mentions per month

Oct 2020 – Sep 2025

Where it's discussed

  • X / Twitter52 posts
  • News22 articles
  • YouTube8 videos
  • Facebook3 posts

AI synopsis

What people are saying

The discussions reveal strong agreement with the article, as seen in posts referencing the systemic inflammatory phase during peri-menopause and its potential long-term effects, such as neurodegenerative diseases. The tone often includes personal reflections and calls for further research, indicating high interest and moderate engagement about the article’s implications for women's health.

AgreementModerate agreement

Most discussions acknowledge the research's findings about hormonal changes and inflammation during peri-menopause, supporting its conclusions.

InterestHigh interest

The discussions show a high level of curiosity, with posts sharing personal experiences, referencing studies, and emphasizing implications for women's health.

EngagementModerate engagement

Posts demonstrate active engagement, including referencing related work, asking questions, and sharing ideas that deepen the conversation.

ImpactModerate impact

Participants recognize the significance of the research, relating it to health issues like neurodegenerative diseases, autoimmune conditions, and broader hormonal effects.

Abstract in brief

  • The peri-menopause involves significant hormonal changes in women and increases the risk of cerebral ischemia and Alzheimer’s disease.
  • There are two stages: the early menopausal transition with regular menstrual cycles and the late transition characterized by longer periods without menstruation leading up to menopause.
  • Research indicates that the menopausal transition is pro-inflammatory, affecting estrogen's role in regulating neurological systems and the innate immune response through estrogen receptor-beta mechanisms.

Top posts

Most liked on X and Bluesky
Dr Claire Taylor
@drclairetaylor · X

9/ why do woman have less culprit lesions? This may tie in with hormonal differences and the fact women are more prone to autoimmune and inflammatory diseases. This is a good article on oestrogen and peri-menopause https://t.co/xaTU2lgxbB

May 28, 2022 · 63 likes · 9 shares · 64,692 followers View post →
Madam Mitochondria
@Madam_Mito · X

The sudden change in trajectory during menopause is disastrous. I believe it is this

Oct 12, 2023 · 35 likes · 7 shares · 10,294 followers View post →
Madam Mitochondria
@Madam_Mito · X

https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrous cycle rather than a menstrual cycle making them poor models for female #aging https://t.co/C0xufnn9CV

May 18, 2024 · 29 likes · 13 shares · 10,294 followers View post →
Lara Briden
@LaraBriden · X

"Compelling evidence" that hormonal changes during the #menopause transition drive a systemic inflammatory state. https://t.co/jqN9vsMDFC

Mar 13, 2023 · 17 likes · 3 shares · 7,503 followers View post →
TheCreativeNERDD | Late DX AuDHD
@anamariayesdesn · X

Apr 26, 2022 · 6 likes · 1,708 followers View post →
Richmond Stace - The Pain Coach
@painphysio · X

.@ThisisDavina We need to understand the nervous-endocrine-autonomic-immune ensemble together with the person’s story. Peri-menopause could be inflammatory: https://t.co/ysOPd3Pazs #menopauserevolution #Menopause #DavinaMenopause #thepaincoach

May 2, 2022 · 5 likes · 2 shares · 9,718 followers View post →

All mentions

Ralph Bennett
@RBennettIV · X

RT @Madam_Mito: The sudden change in trajectory during menopause is disastrous. I believe it is this

Aug 3, 2025 · 7 shares · 372 followers View post →
Greenlandshark
@greenlandsharky · X

RT @Madam_Mito: The sudden change in trajectory during menopause is disastrous. I believe it is this

Aug 3, 2025 · 7 shares · 314 followers View post →
CJara
@cjarao1 · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 5, 2025 · 13 shares · 19 followers View post →
iArmandoVBaneado
@iArmandoVBanned · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 4, 2025 · 13 shares · 70 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 4, 2025 · 13 shares · 188 followers View post →
P123
@P1231032850 · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 4, 2025 · 13 shares · 3,177 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 4, 2025 · 13 shares · 10,294 followers View post →
EpowersDeCelis
@Epowers100 · X

Nov 21, 2024 · 1,076 followers View post →
ArmedAndGentle
@ArmedAndGentle · X

@maddenifico She is proof that pre-menopausal females sometimes go stupid. Hormonal changes affect brain function. See "The peri-menopause in a woman’s life: a systemic inflammatory phase that enables later neurodegenerative disease."

Oct 31, 2024 · 534 followers View post →
MissFadia 2
@2Missfadia · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

Jul 28, 2024 · 13 shares · 36 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

Jul 26, 2024 · 13 shares · 188 followers View post →
Qivshi
@Qivshi1 · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

Jul 26, 2024 · 13 shares · 842 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

Jul 26, 2024 · 13 shares · 10,294 followers View post →
nike
@wot_mikey · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 18, 2024 · 13 shares · 473 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 18, 2024 · 13 shares · 574 followers View post →
John Greene
@Greene_Thoughts · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 18, 2024 · 13 shares · 1,673 followers View post →
Shams Salah Mahdi
@ShamsPath · X

RT @Madam_Mito: https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrou…

May 18, 2024 · 13 shares · 1,423 followers View post →
Madam Mitochondria
@Madam_Mito · X

https://t.co/j67KAgmaQS The key difference between human and rodent reproductive senescence is that rodents have an estrous cycle rather than a menstrual cycle making them poor models for female #aging https://t.co/C0xufnn9CV

May 18, 2024 · 29 likes · 13 shares · 10,294 followers View post →
Mind Your Science!
@MindYourSci · X

RT @Madam_Mito: The sudden change in trajectory during menopause is disastrous. I believe it is this

Jan 16, 2024 · 7 shares · 133 followers View post →
Marta Noya (Martouta)
@MartoutaTech · X

RT @Madam_Mito: The sudden change in trajectory during menopause is disastrous. I believe it is this

Jan 15, 2024 · 7 shares · 1,114 followers View post →
Coco
@AproposCoco · X

RT @Madam_Mito: The sudden change in trajectory during menopause is disastrous. I believe it is this

Jan 15, 2024 · 7 shares · 578 followers View post →
Madam Mitochondria
@Madam_Mito · X

The sudden change in trajectory during menopause is disastrous. I believe it is this

Oct 12, 2023 · 35 likes · 7 shares · 10,294 followers View post →
HeartfulEarthCuisine
@HeartfulCuisine · X

RT @LaraBriden: "Compelling evidence" that hormonal changes during the #menopause transition drive a systemic inflammatory state. https://t…

Mar 14, 2023 · 3 shares · 1,427 followers View post →
Vaclav Kirsner, PhD
@bioZhena · X

RT @LaraBriden: "Compelling evidence" that hormonal changes during the #menopause transition drive a systemic inflammatory state. https://t…

Mar 13, 2023 · 3 shares · 579 followers View post →
Lara Briden
@LaraBriden · X

"Compelling evidence" that hormonal changes during the #menopause transition drive a systemic inflammatory state. https://t.co/jqN9vsMDFC

Mar 13, 2023 · 17 likes · 3 shares · 7,503 followers View post →
Save Liz Nevra
@SaveLizNevra · X

RT @emily_rj: @laurenancona @ahandvanish @SaveLiz Sure! I’ve thought about this a lot Here’s more thoughts Serotonin Syndrome via MCAD an…

Sep 12, 2022 · 1 share · 704 followers View post →
Emily Johnson (is on Mastadon and Bsky)
@emily_rj · X

@laurenancona @ahandvanish @SaveLiz Sure! I’ve thought about this a lot Here’s more thoughts Serotonin Syndrome via MCAD and Long (Virus) is part of it A lot of LC folks find estrogen peaks before periods feel worse, and constant inflammation drives early menopause so thanks MCAD https://t.co/ntg9R28F23 https://t.co/6m5CSOxBdI

Sep 10, 2022 · 3 likes · 1 share · 7,892 followers View post →
DarvinEmmi
@DarvinEmmi · X

Bu östrojen ve perimenopoz hakkında iyi bir makale. https://t.co/lWW1WVrOxs Kadınlar daha yaşlıydı ve önceden var olan diyabet ve inme/GİA prevalansı önemli ölçüde daha yüksekti. STEMI ve COVID-19 ile başvuran erkekler daha sık göğüs ağrısı ile başvururken,

Aug 4, 2022 · 418 followers View post →
终结者
@zhongjiezhe11 · X

RT @drclairetaylor: 9/ why do woman have less culprit lesions? This may tie in with hormonal differences and the fact women are more prone…

May 31, 2022 · 9 shares · 227 followers View post →
Dr LG (is a longhauler)
@subversivepsych · X

The peri-menopause in a woman’s life: a systemic inflammatory phase that enables later neurodegenerative disease | Journal of Neuroinflammation | Full Text https://t.co/bnJSyxfxjV

May 30, 2022 · 4,666 followers View post →
Hi2u
@RETsetLife · X

RT @drclairetaylor: 9/ why do woman have less culprit lesions? This may tie in with hormonal differences and the fact women are more prone…

May 28, 2022 · 9 shares · 421 followers View post →
TrueBlueBroad
@emc_mcdonald · X

RT @drclairetaylor: 9/ why do woman have less culprit lesions? This may tie in with hormonal differences and the fact women are more prone…

May 28, 2022 · 9 shares · 19,511 followers View post →
Dr Kate Cushing #SaveOurNHS
@KateCushing2 · X

RT @drclairetaylor: 9/ why do woman have less culprit lesions? This may tie in with hormonal differences and the fact women are more prone…

May 28, 2022 · 9 shares · 7,837 followers View post →
Olenka Rocha
@rocha_olenka · X

RT @drclairetaylor: 9/ why do woman have less culprit lesions? This may tie in with hormonal differences and the fact women are more prone…

May 28, 2022 · 9 shares · 195 followers View post →
plague ralph
@x3r0gx4 · X

RT @drclairetaylor: 9/ why do woman have less culprit lesions? This may tie in with hormonal differences and the fact women are more prone…

May 28, 2022 · 9 shares · 6,906 followers View post →
Dr Claire Taylor
@drclairetaylor · X

9/ why do woman have less culprit lesions? This may tie in with hormonal differences and the fact women are more prone to autoimmune and inflammatory diseases. This is a good article on oestrogen and peri-menopause https://t.co/xaTU2lgxbB

May 28, 2022 · 63 likes · 9 shares · 64,692 followers View post →
Lieve Van Stappen
@lievevanstappen · X

RT @painphysio: Links to work @ThisisDavina referred to in her menopause programme, which seemed to be helpful for people. Pls share. http…

May 6, 2022 · 3 shares · 40 followers View post →
Anna Harding
@hardanna · X

RT @painphysio: Links to work @ThisisDavina referred to in her menopause programme, which seemed to be helpful for people. Pls share. http…

May 4, 2022 · 3 shares · 169 followers View post →
Sonya Fazeli
@centrefocused · X

RT @painphysio: Links to work @ThisisDavina referred to in her menopause programme, which seemed to be helpful for people. Pls share. http…

May 4, 2022 · 3 shares · 81 followers View post →
Richmond Stace - The Pain Coach
@painphysio · X

Links to work @ThisisDavina referred to in her menopause programme, which seemed to be helpful for people. Pls share. https://t.co/EQkqRyd9qx https://t.co/e7MSjTJ9Q7 https://t.co/ysOPd3Pazs https://t.co/btX0hgSeAl #menopause #menopausesupport #thepaincoach #Davinasmenopause

May 4, 2022 · 3 likes · 3 shares · 9,718 followers View post →
Pippa Jones
@pippaliciousj · X

RT @painphysio: .@ThisisDavina We need to understand the nervous-endocrine-autonomic-immune ensemble together with the person’s story. P…

May 2, 2022 · 2 shares · 5,512 followers View post →
anju jaggi
@AnjuJaggi · X

RT @painphysio: .@ThisisDavina We need to understand the nervous-endocrine-autonomic-immune ensemble together with the person’s story. P…

May 2, 2022 · 2 shares · 12,512 followers View post →
Richmond Stace - The Pain Coach
@painphysio · X

.@ThisisDavina We need to understand the nervous-endocrine-autonomic-immune ensemble together with the person’s story. Peri-menopause could be inflammatory: https://t.co/ysOPd3Pazs #menopauserevolution #Menopause #DavinaMenopause #thepaincoach

May 2, 2022 · 5 likes · 2 shares · 9,718 followers View post →
TheCreativeNERDD | Late DX AuDHD
@anamariayesdesn · X

Apr 26, 2022 · 6 likes · 1,708 followers View post →
Richelle Flanagan
@RichelleFlan · X

@BrundinPatrik @AlbertoEspay @MaluTansey And what about the impact of declining estrogen “There is increasing and compelling evidence showing that estrogen decline during the menopausal transition drives a systemic inflammatory state. “ https://t.co/v3Yax4epaM …

Mar 14, 2022 · 5,661 followers View post →
Jewels
@faeryfancier · X

@Lola_Chambers8 @missphaven74 @kyotolover12 Or she could, you know, do some research on whether breast pain in early menopause was a common thing before 2021. Oh, look - it was! Here's scholarly articles and studies on it from 2018, 2020, and 2010. https://t.co/aBMzTcMwZE https://t.co/ZtJsFt6Ai5 https://t.co/4rXv1M3UCZ https://t.co/KcbFvlFZB5

Jan 5, 2022 · 1 like · 5,872 followers View post →
Jewels
@faeryfancier · X

@missphaven74 @kyotolover12 Uh...yes, yes, it is. My grandmother went through *the exact same thing* going into menopause. Here's scholarly articles and studies on it from 2018, 2020, and 2010. So. Yeah. Very normal. https://t.co/aBMzTcMwZE https://t.co/ZtJsFt6Ai5 https://t.co/4rXv1M3UCZ https://t.co/GcuSTdopb0

Jan 5, 2022 · 1 like · 5,872 followers View post →
Umbereen S Nehal, MD, MPH, MBA
@usnehal · X

@teenmd & others on #womenshealth #menstrualhealth let's chat on this cuz the plausible link is that hormonal state affects immunity or vaccine not vice versa as is wrongly spread via #misinformation by #antivaxx. Mostly, dearth of #womenshealth #data https://t.co/bdidvPEexw

Sep 6, 2021 · 1 like · 6,981 followers View post →
Mikki Williden PhD
@MikkiWilliden · X

The peri-menopause in a woman’s life: a systemic inflammatory phase that enables later neurodegenerative disease https://t.co/5uiTj864DX

Nov 25, 2020 · 2,243 followers View post →
mitopapers
@mito_papers · X

The peri-menopause in a woman's life: a systemic inflammatory phase that enables later neurodegenerative disease. https://t.co/lspBk9myr4 https://t.co/FzP2k54Dsd

Oct 26, 2020 · 145 followers View post →
Ariakas Enoreth
@Aenoreth · X

The peri-menopause in a woman’s life: a systemic inflammatory phase that enables later neurodegenerative disease https://t.co/O1JA0HkJBT

Oct 26, 2020 · 1,010 followers View post →
Inflammasome
@Inflamma_some · X

The peri-menopause in a woman's life: a systemic inflammatory phase that enables later neurodegenerative disease. https://t.co/kpTERUYG70 https://t.co/12svnMkEFF

Oct 25, 2020 · 303 followers View post →